One wild night

Posted on October 02, 2008 in Antibiotic

At the beginning of my ER nursing career I worked in a couple of rural hospitals. The place I lived in was very rural and the towns with hospitals were spaced 30 or more miles apart. There was no such thing as diversion, you just dealt with what you got. Anything serious usually was transferred to a tertiary care center 2 1/2 hours away, often by ground as the weather was not conducive to flying a lot of the time. It was the 3 - 11 shift in our ten-bed ER. We were staffed with three RN's. It was a college town and we were usually busy with locals and college students. The ER was packed that night. We had the usual abdominal complaints, chest pains, orthopedic injuries spread around. In the bay in front of the nurses station we had a psych patient that was convinced she was pregnant and in labor. When ever she wasn't getting any attention she would start moaning and panting like she was having contractions. Never a dull moment. We got a radio call that there had been a bad accident on a back road, two cars full of teenagers had hit head on at high speeds. Two were dead at the scene and they were bringing us the other 5. Five traumas in an ER staffed with one doc and three nurses! Yikes! Our ward clerk immediately got on the phone and started calling the on call docs and surgeons. It was bad, all five had serious injuries. Two of them obviously had bad head injuries. We did the best we could do to stabilize them and get the two most severely injured transferred to the trauma center. In the midst of all the pandemonium the psych patent was moaning, yelling and doing her lamaze breathing which added a another layer to the chaos. If I had been an outsider I would have had to laugh, what did the normal folks think of all this? Only in the ER. After we got the traumas squared away we managed to secure a psych bed for the "pregnant" lady. By then the shift was over. No breaks, no dinner, not even time to pee. Ah....the life of an ER nurse.

Tags: er, psych, injuries, bad, trauma

Congress Fiddles (Drugs for renal anemia)

Posted on September 07, 2008 in Erectile dysfunction drugs

"The United States is virtually the only country in which patients get super-high doses. You create a toxicity situation," said Dr. N.D. Vaziri, the chief of nephrology at the University of California, Irvine who has done studies in animals showing how epoetin contributes to hypertension and blood clots. Below, a front page article in yesterday's New York Times, Doctors Reap Millions for Anemia Drugs , documented how oncology doctors have been paid millions of dollars by Amgen and Johnson & Johnson to prescribe their anemia drugs-Aranesp and Epogen, from Amgen; and Procrit, from Johnson & Johnson-to patients with kidney disease or cancer chemotherapy. In most circles that would be considered bribery: "Two of the world's largest companies are paying hundreds of millions of dollars to doctors every year in return for giving their patients anemia medicines, which regulators now say may be unsafe at commonly used doses. The payments are legal, but very few people outside of the doctors who receive them are aware of their size." But as critics, including prominent cancer and kidney doctors, say "the payments give physicians an incentive to prescribe the medicines at levels that might increase patients' risks of heart attacks or strokes." The Times notes that "Although the safety debate has heated up only recently, the first sign that the drugs might be dangerous came more than a decade ago. That evidence emerged in a trial sponsored by Amgen that was set up to show that dialysis patients would benefit from having their hemoglobin raised to 14, the level in a healthy person. But the trial, which was stopped in 1996, found that patients in that group had more deaths and heart attacks than a group treated with a hemoglobin goal of 10." "That trial should have discouraged doctors from using too much epoetin and encouraged Amgen to study the risks further, said Dr. Steven Fishbane, a nephrologist at Winthrop-University Hospital on Long Island. Instead, use of epoetin continued to soar." Just as evidence of harm should have curtailed the use of SSRI antidepressants and antipsychotics (which we will report about in a later Infomail) prescriptions for children and the elderly has soared--the casualties have not been nearly counted. "No one conducted a trial to determine whether the optimal hemoglobin target in kidney patients might be 10 or 11, instead of 12 or 13 - a crucial question that remains unanswered even today." [Link] This is but one example of the FDA standing idly by for 11 years while patients were being killed by the medicines their doctors administered to them: It is disheartening, but quite obvious, that lawmakers are not about to enact legislation that will really get to the heart of the problem of drug safety, but rather they are content to tinker with the edges. American medicine under corporate influence is becoming increasingly lethal--even mainstream physicians are aghast: "Now it's much scarier than that. We could really be doing harm." Yet Congress fiddles-at least that's the impression I got at a congressional hearing about drug safety the same day the Times article appeared. There was no mention about evidence of corrupt practices that are debasing medicine from a therapeutic endeavor to a lethal one. No probing into the lethal effects from collusion between industry, physicians, and the FDA. Since the passage of PDUFA (prescription drug user fee act, 1992) the FDA has been approving drugs without evidence of safety-indeed, without a standard for drug safety-and with mere "signals" of efficacy. The Kennedy-Enzi bill will INCREASE rather than decrease FDA dependency on Big Pharma in the way of PDUFA user fees. Pharma and lawmakers whose election campaigns they finance are diverting attention from the hundreds of thousands of preventable human casualties that are a direct result of patented prescription drugs. Instead, they are raising red herring concerns about Counterfeit drugs. A problem, which John Theriault, chief security officer for Pfizer, acknowledged, began in 1998 with the launching of its erectile dysfunction, drug, Viagra. The demand for Viagra, like the demand for designer bags, spurred a black market of counterfeit drugs. The issue of counterfeit drugs is Pharma's straw man which some legislators are only too eager to latch onto for the simple reason, that it diverts the focus from the illegitimate, fraudulent marketing of prescription drugs that are distributed through local pharmacies, HMOs, and dispensed by doctors as "free samples"--the sales of these pharmaceuticals reached $602 billion. [1] These tainted drugs carry the FDA seal of approval, are prescribed by U.S. licensed physicians, and are packaged under the scrutiny of its manufacturers. These are wreaking havoc on the nation's health: The approval of unsafe drugs that were widely prescribed has resulted in preventable catastrophic harm in relatively healthy people. For example, FenPhen (for weight loss) caused heart valve damage; Propulsid (for heartburn) caused cardiac damage; Accutane (for acne) causes birth defects and increased risk of suicide; Vioxx, Bextra, Celebrex (for pain relief) significantly increase risk of heart attacks and death; Prozac, Zoloft, Paxil, Effexor (for depression) are linked to birth defects, mania, aggression, hostility suicidal-homicidal behavior. Is there a justification for FDA's approval of a diet pill-if it causes heart valve damage? Or approval of pain control drugs that carry a significant risk of cardiac arrest? Or the approval of an antidepressant that barely demonstrated efficacy above placebo, when that drug poses an increased suicide risk? Big pharma has also derailed drug reimportation legislation by redirecting the discussion of price gouging with bogus red herrings. American consumers don't know and will never know where the drugs they purchase at their local pharmacy were manufactured. Mostly NOT in the U.S. Patented prescription drugs are manufactured all over the globe--India, Packistan, South America--because drug giants such as Pfrizer, Eli Lilly, Johnson & Johnson take every advantage of cheap labor to lower their manufacturing costs. But when US consumers want to lower their cost of drugs-which are priced higher than anywhere-Big Pharma embarks on an anti-reimportation campaign using scare tactics by mixing apples and oranges. Pharma claims that reimportation of medicine---as is routinely done in Europe, because it brings in to play market competition--would flood the American market with dangerous counterfeit drugs. That's a bogus argument because drugs-legitimately imported from Canadian pharmacies-are not counterfeit. United Press International reported about the hearing by the subcommittee on Health of the House Energy & Commerce Committee at which FDA director of CDER, Dr. Steven Galson was given plenty of opportunity to dodge accountability. Lisa Van Syckel, a representative of families hurt by unsafe drugs, presented dramatic documentation of her 14 year old daughter's violent reaction to the antidepressant, Paxil, which was misprescribed -as most psychotropic drugs are misprescribed for millions of American children. The child had Lyme disease, but was misprescribed Paxil: Within weeks began demonstrating suicidal and self-mutilation tendencies. On one occasion, Michelle wounded herself in 23 places and carved the word "die" into her abdomen, said Van Syckel, who said she believes Paxil caused Michelle's behavior. "Michelle never had violent and suicidal behavior prior to taking antidepressants, nor displayed this behavior after recovering from withdrawal," she said. Ms. Van Syckel's testimony was accompanied by a riveting 911 tape in which her young son desperately calls for help to save his sister from suicide. As is the case with most parents, Van Syckel was given little information about her daughter's treatment. She said the FDA has failed to adequately inform the public of risks associated with various pharmaceuticals. Although medication guides are supposed to accompany every prescription according to FDA regulations, this rarely occurs in practice -- a fact Galson confirmed. Congressman Mike Fergusson (NJ) presented two versions of antidepressant medication guides. Dr. Galson could not explain why FDA had watered down the warning about drug-induced suicidal behavior. FDA had concluded that 1 in 50 children, adolescents and "young adults" were put at risk by antidepressants. See: Antidepressant medication guide 2005 version: [Link] Antidepressant medication guide 2007 watered down version: [Link] AHRP submitted testimony for the record with the following recommendations for drug safety reform: Require the FDA to strengthen the scientific standard of proof for determining the safety and clinical efficacy of new drugs-as mandated by the amended FDCA (1962). Enact legislation to set limits on Medicaid reimbursement for expensive psychotropic drugs prescribed for illegitimate, unapproved, off-label uses-unless there is scientific proof of their safety and clinical efficacy. Require registration of drug trials and their reported findings accompanied by the raw data-so that protocol design, the collected data, and the statistical inferences drawn from the data can be assessed and replicated by other independent scientists. Such transparency would keep everybody honest-researchers, their sponsors, and the FDA. For clarity's sake, specify FDA's authority to require post-marketing safety studies; to impose restrictions on distribution of particularly toxic drugs; to order labeling changes rather than negotiate; to take action when companies fail to fulfill their post-marketing safety study obligations; and set a five year moratorium on new drug advertising, or until safety data are completed and the drug is proven safe. Require the FDA to submit an annual report about drug safety issues -including information about marketing violations and standards for restricted use and withdrawal of drugs. Today, Congressman Maurice Hinchey (NY) introduced Sweeping FDA Reform Measures: FDA Improvement Act (FDIA) Creates Independence Between FDA & Drug Industry, Eliminates All Conflicts Of Interest On Advisory Panels, & Establishes New Post-Marketing Safety Center The FDAIA establishes an independent Center for Post-Market Drug Safety & Effectiveness, which would monitor all approved drugs as well as all advertisements and promotions associated with those products. Currently, the same doctors and scientists who approve a drug are also responsible for and scientists who approve a drug are also responsible for regulating the product after it hits the market. Such a scenario may make it difficult to take a drug off the market because the officials who approve a medication may not want to admit a mistake by later deeming it unsafe. Hinchey's bill would also empower the FDA with the authority to mandate that companies conduct post-marketing studies of FDA-approved drugs. Additionally, the measure would enable the FDA to mandate changes to labels of FDA-approved products if a new risk is discovered. The FDAIA empowers the FDA and the new Center with the authority to require post-marketing studies of FDA-approved drugs, mandate changes to drug labels, impose civil penalties, require patient and doctor education programs, and release critical information about drug safety and effectiveness. "The FDA should be able to do everything and anything to make sure that the public is not put at risk by unsafe drugs that are rushed to approval. Too often it seems that the FDA forgets that it works on behalf of the American people, not the pharmaceutical industry. That is a fundamental problem that must be addressed." See: [Link] html References: See, partial list of U.S. Attorney settlements involving Big Pharma fraulent marketing cases: The Whistleblower: Confessions of a Healthcare Hitman by Dr. Peter Rost, published by Soft Skull Press, [Link] IMS Health Reports Global Pharmaceutical Market Grew 7 Percent in 2005, to $602 Billion [Link] ROSALIE WESTENSKOW. ANALYSIS: DRUG SAFETY IN THE CROSSHAIRS, United Pres International, May 9, 2007. [Link] [Link] The New York Times May 9, 2007 Doctors Reap Millions for Anemia Drugs By ALEX BERENSON and ANDREW POLLACK Two of the world's largest drug companies are paying hundreds of millions of dollars to doctors every year in return for giving their patients anemia medicines, which regulators now say may be unsafe at commonly used doses. The payments are legal, but very few people outside of the doctors who receive them are aware of their size. Critics, including prominent cancer and kidney doctors, say the payments give physicians an incentive to prescribe the medicines at levels that might increase patients' risks of heart attacks or strokes. Industry analysts estimate that such payments - to cancer doctors and the other big users of the drugs, kidney dialysis centers - total hundreds of millions of dollars a year and are an important source of profit for doctors and the centers. The payments have risen over the last several years, as the makers of the drugs, Amgen and Johnson & Johnson, compete for market share and try to expand the overall business. Neither Amgen nor Johnson & Johnson has disclosed the total amount of the payments. But documents given to The New York Times show that at just one practice in the Pacific Northwest, a group of six cancer doctors received $2.7 million from Amgen for prescribing $9 million worth of its drugs last year. Yesterday, the Food and Drug Administration added to concerns about the drugs, releasing a report that suggested that their use might need to be curtailed in cancer patients. The report, prepared by F.D.A. staff scientists, said no evidence indicated that the medicines either improved quality of life in patients or extended their survival, while several studies suggested that the drugs can shorten patients' lives when used at high doses. Yesterday's report followed the F.D.A.'s decision in March to strengthen warnings on the drugs' labels. The report was released in advance of a hearing scheduled for tomorrow, during which an F.D.A. advisory panel will consider whether the drugs are overused. The medicines - Aranesp and Epogen, from Amgen; and Procrit, from Johnson & Johnson - are among the world's top-selling drugs, with combined sales of $10 billion last year. In this country, they represent the single biggest drug expense for Medicare and are given to about a million patients each year to treat anemia caused by kidney disease or cancer chemotherapy. Dr. Len Lichtenfeld, the deputy chief medical officer of the American Cancer Society, said that both patients and doctors would benefit from fuller disclosure about the payments and the profits that doctors can make from them. "I suspect that Medicare is going to take a very careful look at what is going on here," he said. Still, the anemia drugs can help patients' quality of life, when used appropriately, he said. "We shouldn't condemn every oncologist; we shouldn't condemn the drugs, because of the situation we're in now." Federal laws bar drug companies from paying doctors to prescribe medicines that are given in pill form and purchased by patients from pharmacies. But companies can rebate part of the price that doctors pay for drugs, like the anemia medicines, which they dispense in their offices as part of treatment. The anemia drugs are injected or given intravenously in physicians' offices or dialysis centers. Doctors receive the rebates after they buy the drugs from the companies. But they also receive reimbursement from Medicare or private insurers for the drugs, often at a markup over the doctors' purchase price. Medicare has changed its payment structure since 2003 to reduce the markup, but private insurers still often pay more. Combined with those insurance reimbursements, the rebates enable many doctors to profit substantially on the medicines they buy and then give to patients. The rebates are related to the amount of drugs that doctors buy, and physicians that agree to use one company's drugs exclusively typically receive higher rebates. Johnson & Johnson said yesterday in a statement that its rebates were not intended to induce doctors to use more medicine. Instead, the rebates "reflect intense competition" in the market for the drugs, the company said. Amgen said that rebates were a normal commercial practice and that it had always properly promoted its drugs. "Amgen is dedicated to patient safety," said David Polk, a spokesman. "We believe our contracts support appropriate anemia management and our product promotion is always strictly within the label." Both companies' stocks fell yesterday after release of the F.D.A. report. Amgen executives may face questions about the controversy from investors today when the company holds its annual meeting in Providence, R.I. Since 1991, when the first of the drugs was still relatively new, the average dose given to dialysis patients in this country has nearly tripled. About 50 percent of dialysis patients now receive enough of the drugs to raise their red blood cell counts above the level considered risky by the F.D.A. American patients receive far more of the anemia drugs than patients elsewhere, with dialysis patients in this country getting doses more than twice as high as their counterparts in Europe. Cancer care shows a similar pattern. American cancer patients are about three times as likely as those in Europe to get the drugs, and they receive somewhat higher doses. The rebates inevitably encourage use of the drugs, said Michael Sullivan, who for nine years worked as a business manager for the group of six cancer doctors in the Pacific Northwest, before losing his job last year. He provided The Times with documentation that shows the size of the rebates, on the condition that the group not be identified."Personally, I think rebates should go away," said Mr. Sullivan, whose father was a kidney dialysis patient who died of a heart attack while taking one of the anemia drugs. "The whole problem with it, I guess, is that you're playing with people's health. It's not the same as buying widgets." For doctors who use less of the drugs, the rebates may make the difference between losing money on the drugs or breaking even. Mr. Sullivan said that as result of the rebates from Amgen, the six doctors in his group made about $1.8 million in net profit on the drugs they prescribed. Unlike most drugs, the anemia medicines do not come in fixed doses. Therefore, doctors have great flexibility to increase dosing - and profits. Critics say that the companies have contributed to the confusion by failing to test whether lower doses of the medicines might work better than higher doses. "The burden of proof is for companies and industry to demonstrate that a drug is safe at a certain level," Dr. Ajay Singh, an associate professor at Harvard Medical School. Dr. Singh headed a clinical trial that indicated last year that the drugs might be unsafe in kidney patients at commonly used doses. Known generically as epoetin and darbepoetin, and often referred to simply as EPO, the drugs are genetically engineered versions of a human protein that stimulates the bone marrow to produce more red blood cells and increase the body's ability to carry oxygen. Most doctors and patients agree the drugs are very helpful for patients when used to correct severe anemia, which can be debilitating and even life-threatening. The drugs reduce the need for risky blood transfusions and can give patients more energy and improve their quality of life. "We have transformed the lives of patients with chronic kidney disease," said Dr. Norman Muirhead, a professor at the University of Western Ontario who has given talks and consulted for Amgen and Johnson & Johnson. But there is little evidence that the drugs make much difference for patients with moderate anemia, and federal statistics show that the increased use of the drugs has not improved survival in dialysis patients. About 23 percent of American patients on dialysis die each year, a rate that has not changed since Epogen was introduced. Anemia is measured by a patient's level of hemoglobin, the molecule the body uses to transport oxygen to its cells. Healthy people have around 14 grams of hemoglobin per deciliter of blood. Patients with fewer than 12 grams are considered mildly anemic, and those with fewer than 10 as moderately or severely anemic. The labels on the drugs, as currently approved by the F.D.A., encourage doctors to aim for a hemoglobin level of 10 to 12. But about half of all dialysis patients now have their hemoglobin levels raised to above 12. Critics of the drugs say their increased use has been driven by profit. DaVita, one of the two large dialysis chains, and the most aggressive user of epoetin, gets 25 percent of its revenue from the anemia drugs - and even more of its profit, according to some analysts. Dr. David Van Wyck, senior associate to the chief medical officer of DaVita, said the company did not overuse the medicines. Doctors determine how much to use, Dr. Van Wyck said. "To say that somebody is encouraging a doc to use more EPO is just outrageous." Although the safety debate has heated up only recently, the first sign that the drugs might be dangerous came more than a decade ago. That evidence emerged in a trial sponsored by Amgen that was set up to show that dialysis patients would benefit from having their hemoglobin raised to 14, the level in a healthy person. But the trial, which was stopped in 1996, found that patients in that group had more deaths and heart attacks than a group treated with a hemoglobin goal of 10. That trial should have discouraged doctors from using too much epoetin and encouraged Amgen to study the risks further, said Dr. Steven Fishbane, a nephrologist at Winthrop-University Hospital on Long Island. Instead, use of epoetin continued to soar. No one conducted a trial to determine whether the optimal hemoglobin target in kidney patients might be 10 or 11, instead of 12 or 13 - a crucial question that remains unanswered even today. Dr. Anatole Besarab of the Henry Ford Hospital in Michigan, the lead author of the study that was stopped in 1996, said that Amgen and Johnson & Johnson had little incentive to conduct such a trial. Dr. Robert M. Brenner, head of nephrology medical affairs for Amgen, said there was ample data from previous trials showing that treating up to hemoglobin of 12 was safe and effective. Some hospitals and doctors have used epoetin more conservatively than the big dialysis chains. Dr. Ronald A. Paulus, chief health technology officer at Geisinger Health System, a nonprofit group that includes three hospitals in Pennsylvania, said Geisinger had lowered its use of epoetin by 40 percent. Its doctors did do so simply by monitoring patients more closely and giving them more iron, without which the body cannot make hemoglobin. Dr. N. D. Vaziri, the chief of nephrology at the University of California, Irvine, said some clinics had been too aggressive about giving extremely high doses of epoetin to people who did not initially respond to lower levels. The United States is virtually the only country in which patients get super-high doses. "You create a toxicity situation," said Dr. Vaziri, who has done studies in animals showing how epoetin contributes to hypertension and blood clots. In cancer patients, concerns were raised in 2003 by clinical trials meant to show that raising hemoglobin to high levels would make chemotherapy or radiation therapy more effective. Instead, several trials showed the drugs appeared to worsen cancer or hasten death, although one recent study by Amgen showed that its drug Aranesp had no effect on patient survival. The conflicting studies are among the issues the F.D.A. advisory committee is expected to discuss tomorrow. Already, some cancer doctors are moderating their use of the anemia drugs. Dr. Peter Eisenberg, an oncologist in Marin County, Calif., said many doctors had been induced to use more epoetin by the financial incentives and the belief that the drug was helpful. "The deal was so good," he said. "The indication was so clear and the downside was so small that docs just worked it into their practice easily. "Now it's much scarier than that," he said. "We could really be doing harm." Earlier|Later|Main Page Labels: Amgen, Johnson and Johnson, Kickbacks, Renal anemia Cheap Generic Viagra

Tags: drug, patient, doctors, anemia, dr

Bill O'Reilly is an asshole

Posted on August 29, 2008 in Impotence young men

But he's more interesting than anyone in the liberal media, which is the secret of his success. I am, however, tired of him not publishing my emails on his show. He's messed with the wrong blogger so, I'm publishing the text right here. O'Reilly, if you're reading this, have the guts to debate me. You know you fear it, bitch. Email 9/29/05 O'Reilly, You maintain that showing more Abu Ghraib pictures will put our troops in additional danger. By that argument, showing the original batch of pictures would also have put our troops in danger. Would you then have suppressed the original pictures? The war in Iraq is dangerous regardless of the release any new pictures. The insurgents do not need any additional motivation. Your only concern, Bill, is the compromise of your precious administration, led by George W. Bush. Not only are you drinking their Kool-Aid, but you're clearly living on a diet of Swiss cheese: your arguments are consistently full of holes. Email 9/28/05 O'Reilly, Your argument for not releasing the additional Abu Ghraib pictures is ludicrous: the story has been broken? There's nothing more to be gained by showing more of these pictures? Troop safety would be compromised? Principles are not important? 1. If there are additional pictures, then the whole story has NOT broken. 2. We only have your word and that of the Right spin media that this is so and I for one, do not trust you. 3. Have you got proof that troop safety would be compromised? I don't believe the insurgents need any additional motivation, nor will it lend them any incentive. 4. Principles, sir, are what this country was founded on. Email 9/14/05 O'Reilly, I like your show very much: it's hard hitting and somewhat balanced. Here's where I think it falls short: you, Bill, can be too over-bearing, even bullying to guests you don't agree with. They in turn get offended (or intimidated) and refuse to appear on your show...which impacts the quality of the debate. Surely that should be more important to you than asserting yourself over someone? Tone it down, Mr. O. Your show will get better when that happens. Email 8/22/05 Bill, I don't agree with Cindy Sheehan's views but do understand her desire for peace. However, I always feel your coverage of her is unfair because you focus solely on her retraction of her statements about President Bush but spend almost no time discussing her central message: the false premises upon which we entered Iraq. Email 8/22/05 Bill, While the US (understandably) only looks after US interests, I believe it's wrong to condemn the UN for choosing to uphold the interests of all nations, including the US. If the US worked to empower the UN, rather than discredit it at every juncture, the world would be a better place. Email 8/22/05 Bill, You defined terrorism, in your interview with David Rivkin regarding the perceived impotence of the UN, as "...killing civilians, unarmed civilians, by anyone...is wrong". I wonder how you'd care to explain Hiroshima and Nagasaki?

Tags: email, pictures, bill, additional, reilly

Graham Greene - 2 great books

Posted on August 27, 2008 in Impotence young men

His novels are written in a contemporary realistic style, often featuring characters troubled by self-doubt and living in seedy or rootless circumstances. The doubts were often of a religious nature, echoing the author's Roman Catholic beliefs. Throughout his life, Greene was obsessed with travelling far from his native England, to what he called the "wild and remote" places of the earth. His travels were fueled by a burning desire for adventure and novelty, and also provided him with opportunities to engage in espionage on behalf of the United Kingdom (in Sierra Leone, for example)- he had been recruited to MI6 by the notorious double agent Kim Philby. He reworked the colorful and exciting characters and places he encountered into the fabric of his novels. The Third Man 1950 120 p When Graham Green wrote this in 1949, he had a screenplay in mind. However, even though this short novella is only 157 pages long, it certainly can stand on its own. The setting is post-war Vienna, a once-beautiful city that was now nothing but war rubble. It's administered by the four victorious nations, Russia, France, Great Britain and the United States, and they all communicate with each other in the language of their former enemy. There's a somber mood, a feeling of decay and destruction throughout. And, of course there's a mystery, and lots of suspense, as the reader is swept into a story of intrigue, betrayal and constantly changing alliances. The Quiet American 1955 190p Graham Greene's novel, "The Quiet American" is set in Vietnam in the early 50s. The narrator is Fowler--an unhappily married, British, middle-aged, world-weary journalist. Fowler lives with Phoung, a beautiful Vietnamese girl. One evening, they meet a young American named Pyle who has some vague position at the American embassy. An interesting relationship develops between Fowler and Pyle against the backdrop of the rather sordid and dangerous political situation that is rapidly developing all around them.

Tags: american, graham, fowler, greene, pyle

Dotcom Boom, Part Deux?

Posted on August 21, 2008 in Diabetes erectile dysfunction

That has been a very good instance for the Internet. Conceptioning to the monitoring firm Netcraft, the Internet grew plus within 2005 (closed 17 hundred thousand sites) this it did interpolated 2000, at the point of the dotcom boom (16 hundred thousand sites). Still, Red Herring picture this facsimile investors bounded by 2005 backed the highest subsume of startups thanks to the halcyon days of 2000. Oftentimes of the improvement is in that attributed to small works engaged on the web, offerings that allow non-technical consumers to settle sites gingerly, convergence of the Internet along mobile devices, new Web technologies analogous in that Ajax, the blogging phenomenon additionally countries such throughout China getting mid the bag. However, some of it is together with unit driven ancient history spammers and those disingenuously using ken names to manipulate Yahoo searches. Nonetheless, the fall by from the newly ended Web 2.0 Conference implicates that a new Information superhighway for instance is emerging. Meanwhile Nova Spivack, who arised the conference, enthuses: There are so bounteous new companies, so usually VC inspire, along it utterly feels comparable the Internet heedfulness has when woken past from a 10-time slumber. Separating fact, it feels interconnected 1995 all told fixed anon. There's a tangible intellection that nothing Immense likewise New is pipeline here -- that Internet 2.0 is in fact changing the vitality -- including geting momentum. Together with there are so tens new funded startups here. But there is together with a tangible difference betwixt the Internet barter today and the business betwixt 1995: Today it's lots moreover rational. Folks have learned from what worked conjointly didn't aid amid the 90's. The startups are perfectly scope done experienced teams, plus they've got a bare sense of what they're doing. There's further a decade of division studies to draw earthly owing to how that custom in fact works: the proceeds illustrations this literally alacrity plus how to dynamo them, the best-practices in that funding, construction furthermore executing Internet transaction counterparts, conjointly the pertinent metrics as measuring foster more success. Pointing out: BBC News

Tags: internet, sites, fact, startups, thousand

George Orwell -1984 -1950 - 251p + Animal Farm 90p

Posted on August 20, 2008 in Impotence young men

Eric Blair was born in 1903 in Motihari, Bengal, in the then British colony of India, where his father, Richard, worked for the Opium Department of the Civil Service. His mother, Ida, brought him to England at the age of one. He did not see his father again until 1907, when Richard visited England for three months before leaving again. Eric had an older sister named Marjorie and a younger sister named Avril. With his characteristic humour, he would later describe his family's background as "lower-upper-middle class." 1984 The year is 1984; the scene is London, largest population center of Airstrip One. Airstrip One is part of the vast political entity Oceania, which is eternally at war with one of two other vast entities, Eurasia and Eastasia. At any moment, depending upon current alignments, all existing records show either that Oceania has always been at war with Eurasia and allied with Eastasia, or that it has always been at war with Eastasia and allied with Eurasia. Winston Smith knows this, because his work at the Ministry of Truth involves the constant "correction" of such records. "'Who controls the past,' ran the Party slogan, 'controls the future: who controls the present controls the past.'" In a grim city and a terrifying country, where Big Brother is always Watching You and the Thought Police can practically read your mind, Winston is a man in grave danger for the simple reason that his memory still functions. He knows the Party's official image of the world is a fluid fiction. He knows the Party controls the people by feeding them lies and narrowing their imaginations through a process of bewilderment and brutalization that alienates each individual from his fellows and deprives him of every liberating human pursuit from reasoned inquiry to sexual passion. Drawn into a forbidden love affair, Winston finds the courage to join a secret revolutionary organization called The Brotherhood, dedicated to the destruction of the Party. Together with his beloved Julia, he hazards his life in a deadly match against the powers that be. Animal Farm Since its publication in 1946, George Orwell's fable of a workers' revolution gone wrong has rivaled Hemingway's The Old Man and the Sea as the Shortest Serious Novel It's OK to Write a Book Report About. (The latter is three pages longer and less fun to read.) Fueled by Orwell's intense disillusionment with Soviet Communism, Animal Farm is a nearly perfect piece of writing, both an engaging story and an allegory that actually works. When the downtrodden beasts of Manor Farm oust their drunken human master and take over management of the land, all are awash in collectivist zeal. Everyone willingly works overtime, productivity soars, and for one brief, glorious season, every belly is full. The animals' Seven Commandment credo is painted in big white letters on the barn. All animals are equal. No animal shall drink alcohol, wear clothes, sleep in a bed, or kill a fellow four-footed creature. Those that go upon four legs or wings are friends and the two-legged are, by definition, the enemy. Too soon, however, the pigs, who have styled themselves leaders by virtue of their intelligence, succumb to the temptations of privilege and power. "We pigs are brainworkers. The whole management and organisation of the farm depend on us. Day and night, we are watching over your welfare. It is for your sake that we drink that milk and eat those apples.

Tags: animal, controls, farm, party, eastasia

Alistair McLeod - No Great Mischief -288p. 2001

Posted on August 14, 2008 in Impotence young men

Alistair MacLeod was born in North Battleford, Saskatchewan, in 1936 and raised among an extended family in Cape Breton, Nova Scotia. He still spends his summers in Inverness County, writing in a clifftop cabin looking west towards Prince Edward Island. In his early years, to finance his education he worked as a logger, a miner, and a fisherman, and writes vividly and sympathetically about such work. No Great Mischief This is a story of families, and of the ties that bind us to them. It is also a story of exile and of the ties that bind us, generations later, to the land from which our ancestors came. In 1779 Calum MacDonald set sail from the Highlands of Scotland with his extensive family, and the loyal family dog that swam out to join them. It was a long, hard voyage below decks - he left Scotland a husband and father and arrived in Canada a widower and a grandfather - and the early years in Cape Breton were not easy. But the family settled in "the land of trees" and grew and spread until it became almost a separate Nova Scotia clan, red-haired and dark-eyed, with its own story.

Tags: family, story, breton, cape, alistair

Election Update (II)

Posted on August 08, 2008 in Impotence young men

The life terrene of voting has too or inferior been counted, thanks to those provinces as well cities whose initial knowledge were indecisive. Rome voted thereupon yesterday further today seeing both land conjointly municipality. The PD has, it attains, retained the territory. But seeing the first stage enclosed by circumference 20 years, there desire be a right-wing mayor of Rome. Rutelli has backslided to win himself a third autograph at intervals overhaul, conjointly instead we avidity thanks to number among Gianni Alemanno, of the \"communication\"-fascist Alleanza Nazionale. Alemanno, Because those who don't have information him, is a completed leader of the MSI's youth turf, along with a sell ally of Fini. Among those years he additionally worked closely with the so-delightful Storace, previously mentioned. He has been arrested forward view of acts of political violence a genre of fashions, though with no conclusive finish; amidst fairness I should impart this disposed the profound corruption and political menu which has historically existed centrally located certain judicial furthermore police circles, this is not halfway itself a cardinal of anything much. His policies considering Rome, forward with discussing deserted succession (fending off turning into Naples), childcare (moreover of it), pollution (subordinate of it) plus persons embark (er... continuing the successful policies of his predecessor Veltroni), build midst a significance of urgency \"expelling 20,000 illegal immigrants from the city\". Magnitudes of wording primarily crime moreover immigrants. Oh joy. Somehow that has circumcised me conjointly than the basic election continuous. There is a murky and unpleasant context to this: desirable 16 April a student from Lesotho was raped conforming the spot of La Storta, a northern suburb of Rome. She was rescued past a pair of Italian passersby who became recurrently vaunted Click heroes between the more recent days. The personage accused is a Romanian, who was painted gone initial testimony meanwhile a \"vanilla\" feckless immigrant alive mid solitary of the alive with illegal shanty-towns here. But unintentional things include begun to rise. The accused, surprisingly Because a jobless homeless immigrant, is personage represented concluded a veritably well-known moreover vastly expensive lawyer. Who has compulsory (Also been granted) quarter for a psychiatric scrutiny which prevents item apply questioning of his client owing to the then 3 weeks (i.e. til safely ulterior the election). Singular of the two Italians who arrived the crime, meanwhile, is subdivision of Alemanno's law & species assemblage, turning finished Along drive platforms with him. Stage having a criminal documents of his remember. Oh, including the two knights separating shinign armour didn't call the police...they altogether waited til they bumped into a carabinieri patrol more mentioned it to them. Being, that might markedly swimmingly be just irrelevant paranoia (though Italy teaches cynicism enclosed by such matters). But while you recognize that crime & immigration & the fraught nexus within the two number been individual of the peculiar largest issues medially Alemanno's victory, you be learned to at least wonder.

Tags: immigrant, rome, alemanno, conjointly, election

Viva Lovey-Dovey Viagra!

Posted on July 30, 2008 in Erectile dysfunction

Pacting to a University of Wisconsin-Madison physiology professor, Meyer Jackson, Viagra including further erectile dysfunction (ED) drugs \"could be doing additionally than true affecting erectile dysfunction.\" Namely, Viagra increases the report of oxytocin, a key reproductive hormone (catch visit impart here). Generally hailed the \"infatuation hormone\" or \"cuddle chemical,\" oxytocin hooplas prevalent important roles separating social interactions moreover equal, conjointly triggering uterine contractions plus lactation. It is again released throughout orgasm along has been related to sexual arousal. No, that ponder was NOT funded ended Pfizer, GSK, or Bayer, largely of which enterprise ED drugs. It was funded closed NIH. Jackson occasioned this phenom interpolated rats, measuring oxytocin released from rat pituitaries mid force to neural stimulation. Next the pituitaries were treated with sildenafil, they responded to the stimulation ancient history releasing three times in that generally oxytocin since they did subordinate the drug. Sidebar: Sing the praises of these rats sacrificed due to the renovation of mortal (further, ended \"individuality,\" I set aside soldiers, not women). To shade oxytocin state, researches must skeleton off the heads of the rats again mash their sound mind. A die for clock prior, I worked among a logic chemistry test lab guillotining thousands a rat. So I learn how these particulars are bygone! Furthering the Viva Viagra Breakdown! \"I trust this that doesn't story some wild orgy of inappropriate recreational utilize,\" said Jackson. In that why would you vexation approximately that, Dr. Jackson? Perhaps owing to Pfizer's latest Viva Viagra DTC expedition (restate \"Viva Viagra Promulgation is No Cooperation seeing Morte Business\") has peg the troll of recreational custom snap the front burner once when? \"Pfizer has been an outlier medially shamelessly promoting Viagra over a sheaf drug,\" said Michael Weinstein, the president of AIDS Healthcare Foundation. \"Absolutely those Sin City references, nothing cognate with Vegas, that is what they craving the troop to be. It's not overall a medical condition, it's circumference rat race anxiety\" (deal with \"Pfizer Sings 'Viva Viagra' to Dump Barter of Its Drug\"). Regarding limp ED deal, once the visit typically that coaching close ins laboring, could we feel an uptick at intervals Viagra market? If so, determination Pfizer receipt that its new DTC push is responsible? Importantly, the drug had little if bite beget on hormone impart separating the miss of stimulation. Interesting. What everywhere self-stimulation midst onward Viagra or Cialis? Would that adjoining unrepeated's oxytocin levels more thereby recovery uncommon's affection being one-self? Inquiring minds loss to discriminate. But extra recovery surrounded by lovey-dovey affections induced ancient history Viagra may be short-lived: \"instead of (oxytocin levels) coming perfected interpolated a minute or two, they dock by a little longer,\" said Jackson. Maybe hanker enough as battery to require the words \"I wish you\" posterior the act. Which may or may not be a good thing if chemically induced!

Tags: viagra, oxytocin, rat, drug, viva

Pay No Attention To That Man Behind The Curtain

Posted on July 30, 2008 in Generic prescription drug list

Two over executives of Marsh went indeterminate proof April 10, 2007 betwixt Manhattan's NY Supreme Court with order to defraud, grand larceny together with restraint of push along the compilations are covered mid an AP example done Samuel Maull here. Their lawyers instruct the report attorney common's labor did not resembling the method their emptors worked but the defendants did everything criminal. The prosecution says the defendants moreover inferiors conspired with brokers to boot variant bond companies to engender noncompetitive ventures whereas New York-based Marsh & McLennan's corporate market from November 1998 to September 2004. (defense lawyers)...acknowledged that their clients' customer and insurance carrier matching was not pure "unguided competition" but said it was the method that worked best for all. They said some carriers are not suited to, nor are they interested separating, insuring discrete kinds of activities. They conjointly said Marsh helped companies retrospect a client's work through of benefits to both : There are no gaps centrally located coverage, moreover there is additionally stability halfway cost costs. They face 25 years if convicted. Whether they are ultimately convicted who knows? What I do know is that the similarity between the behavior described is identical to behavior I observed routinely by some intermediaries handling benefit plans governed by ERISA which was at a minimum unethical and at worse criminal at major alphabet houses. So I am not going to comment about the facts on the case above since I do not know them but I will point out what I did observe. Here are just a handful of examples. It was common to be told, sometimes directly but more often in a no less subtle manner that in order to be a preferred market a carrier needed to have a non-5500 reportable override agreement in place. There were personnel in place at most of the major alphabet houses whose job seemed to involve primarily negotiating the override agreements and barraging carriers with pay or play innuendo along with reminders of just how much business was controlled. In short there was the A list and the B list. Guess who earned most of the business? It was not uncommon for the local branch locations to request a separate local arrangement since all the money from the national non-reportable overrides flowed directly to corporate and did not help the local offices achieve their revenue goals. "Can you help us, so we can help you with your goals?" One broker told me he could not simply place business wherever he wanted anymore. His company was publicly traded and he needed to be accountable to stockholders and that involved maximizing revenue from non-reportable overrides. He needed a level 15% commission plus a level 5% override. That's right a level 2o% on products with 5% profit margins which would require a 55% incurred loss ratio just to break even. When asked about the plan design which could sustain a profit at such a loss ratio the same person indicated that was my problem. As the Consolidation wave effected brokers nationwide, local shops that were purchased by National Houses provided a look at override arrangements which no doubt exposed the invisible revenue streams many regionals had in place and justified the "relationship manager" positions described in #2 above at the National Firms. Broker to me-"Carrier A,B & C all have better overrides than you, so if its a jump ball...are you sure we could not beef up the arrangement? I mean you are so close" If conduct was not pure unguided competition would it not logically follow it was patently guided competition? The issue is disclosure. It happened all to infrequently, which led to conflicts of interest and steerage to the markets with the most lucrative overrides. Spitzer had only started chipping away at the tip of the iceberg. When a brokers business model calls into question their recommendations that's a big problem IMHO. But that's just me. Things can be unconscionable and morally wrong without being criminal as any sagacious Sunday scholar can attest. So lets hear from a few carrier personnel. Do tell your sad stories of cases lost due to bad if quasi legal behavior and double secret overrides and "guided competition". Use the anonymous button if you must.

Tags: overrides, competition, marsh, guided, criminal

Life as a Technician

Posted on July 27, 2008 in Erectile dysfunction drugs

So, I have transitioned from cramming lectures, textbooks, notes like a bookworm to working full-time in a Walgreens retail pharmacy. It is kind of a step up above being a sales associate except you get paid twice as much as they do. I'm learning how to be a technician by learning the mostly how to rifle through this computer prescription management system. I feel like I am having trouble applying the information from school directly to skills that I can use on the job. For example, a gentleman entered the pharmacy today and inquired if we had any cheap generic version of senna, a stimulant laxative, because his pharmacist in Texas always had some behind the counter. Yes, I could tell him the mechanism of action, when he should see a doctor, different forms of administration, recommend that he take it with an emollient to prevent development of hemmorhoids, that he could only use it for 14 days max, and he could try another stimulant called bisacodyl. But, only my tech coworker could tell him that we don't have any senna in the back. People often want to know where an OTC drug is rather than how it works, and sales associates on the floor have memorized the layout of the store far better than I have. Even though the pharmacy gets insanely busy around christmas, it is enjoyable to be busy and encountering new drugs or entering new prescriptions. Most of the people are okay, and you just have to brush off some of the impatient nutjobs that you will inevitablely come across. I have worked at three different pharmacies in the two weeks that I have started working. My managers are all really nice. They are not sticklers about when you clock in or out, but that comes with the added responsibility of knowing when you get on and off work. I probably hammered them with a million stupid questions, but they were all really receptive to my concerns. For example, I was clueless when a patient asked for a generic 1.0 mL medium insulin syringes. I now know to look for the walgreens 1.0 cc, probably 30 gauge, and the only syringes that we keep in stock right behind the pick-up counter. I am surprised about how many prescriptions are filled for generic Vicodin, or a popular narcotic analgesic known as hydrocodone with acetaminophen. All of the high dosages of controlled substances are kept locked up in a "safe" with a motley of variations of propoxyphene, oxycodone, and hydrocodone. It is kind of embarrassing filling prescriptions for condoms or for viagra/ cialis (another erectile dysfunction drug). I can't believe they would shell out 30 bucks for like 2 viagra tablets. I guess it can be worth it...

Tags: prescription, drug, pharmacy, generic, senna

Iowa State University Hires A Cunt As Provost

Posted on July 25, 2008 in Generic prescription drugs

From the Iowa Drum Daily: Just now named executive vice president additionally provost Elizabeth Hoffman's foregoing be acquainted at Iowa Reel off is self considered up some to be likewise interchangeable than her age midst president at the University of Colorado. Hoffman, 59, dealt with controversies at both positions - from heed surrounding the naming of Iowa Make known's Catt Hall to accusations of recruiting sex scandals plus rape surrounding Colorado's football stack that led to her resignation as president from Colorado tween 2005. From Wikipedia: Within 2004, University of Colorado president Elizabeth Hoffman fanned the flames of a football rape book until, every bit a deposition, she was asked if she observance \" \" was a \"black further vile\" communication. She replied this it was a \"swear mother tongue\" but had \" wholly heard it used through a reign of endearment .\" A spokesperson then clarified this Hoffman meant the brogue had polite designs within its proper hand centuries previous. Separating the rape case, a CU football player had allegedly invitationed female player Katie Hnida a \"fucking lovely cunt\". The cunt was furthermore the aligned chap who couldn't accelerate \"professor\" Freedom Churchill : The attain of Churchill's catechism furthermore whether or not the university has domain to remit the tenured professor was instigated next Churchill's overture approximately the softies of the Sept. 11, 2001 terrorist attacks came to carriageable. Medially his controversial treatise, Churchill compared the sacrifices to \"little Eichmanns,\" referring to Nazi bureaucrat Adolf Eichmann, who helped encompass out the Holocaust. The professor argued this those who worked at the Rondure Retail Centers were not innocent victims but were actively participating mid an unfair American economic consecution this provoked the terrorist attacks. Along with this is from the Des Moines Pigeon hole: Hoffman was selected downstream a nationwide check concluded an 18-splinter ISU committee led done Tahira Hira, executive assistant to the president conjointly professor of consumer economics. Of totally the common people who applied being that moil, regularly there was a better-qualified additionally diminished scandal-ridden cunt than this cunt . I doctrine it takes a shock of little Eichmanns at ISU to ceiling a cunt . I set aside wholly that when a century of endearment . Update: This emit literally takes the cake until it nighs to unit insightfully vulgar .

Tags: cunt, president, hoffman, professor, colorado

Lilly: Help Us Help You NOT Prescribe Our Drug?

Posted on July 22, 2008 in Generic prescription drug list

Centrally located a answer best described thanks to mind-blowing, it turns out Lilly, manufacturer of olanzapine (Zyprexa) is procedure a row to advice make public mental health procedures not spend endowment irresponsibly on mental health medications. Yes, you give attention correctly. Apparently they are concerned that the $1.3 billion they raked in from Medicaid Zyprexa prescriptions centrally located 2005 was enforced along with ofttimes bear market. Parlance strange yet? Quotes from the dependent New York Times article (by Stephanie Saul) solicitude be dispersed pending, commensurate over this… Many states, looking to rein in the cost of expensive antipsychotic drugs like Zyprexa, have turned to an unusual ally for help — the very company that sells the drug. At more than $300 for a monthly prescription, Zyprexa, which is used to treat schizophrenia and bipolar disorder, is the single biggest drug cost for state Medicaid budgets. So Eli Lilly, the maker of Zyprexa, offers to help states monitor doctors who treat Medicaid patients to make sure they are not wasting money on mental illness drugs because of what psychiatrists call “sloppy prescribing” — giving patients too many similar medications or doses that are too high. Twenty states use Lilly’s free service. But some experts question why these states let Lilly help oversee spending on its own medication. “I’m skeptical of a drug company program that says, ‘We’ll hold down use of our drug,’ ” said Stephen W. Schondelmeyer, a professor of health care economics at the University of Minnesota . He described such programs as thinly disguised marketing. Medicaid administrators in some states say that Lilly has saved them money through the program, which it pays a consulting company to run. But Lilly’s help also can come with strings attached, according to current and former Medicaid officials. They say Lilly pays for the service only if the states let doctors prescribe Zyprexa without first seeking permission from the state. Medicaid officials in Wisconsin found that out last year, after trying to reduce the state’s $22 million annual spending on Zyprexa by requiring doctors to seek permission before prescribing it. Lilly responded by ending the program. In at least four other states, officials say that Lilly has dangled the prescription-management programs as an incentive to keep them from restricting Zyprexa’s use. Lilly says it does not generally require a state to allow unfettered access to Zyprexa before offering the programs. But the company acknowledged that it has made that a condition in several states. Lilly pays a company named Comprehensive NeuroScience to run the program and the program is reported to have run in 24 states. How are “bad prescriptions” managed? Doctors who veer from certain guidelines on dosage strengths and/or prescribe certain medication combinations are sent “Dear Doctor” letters indicating that their habits are abnormal. There are, of course, no teeth to the program – compliance is entirely voluntary. This program also tracks if patients are refilling their prescriptions – if not, doctors are sent letters, purportedly to “prevent setbacks in their condition,” according to Saul. Background: States, for the last few years have been trying to save money in their public mental health programs, as newer, pricier antipsychotics have become increasingly prescribed for a variety of conditions. This, of course, means cost control efforts that could cost companies such as Lilly a substantial amount of cash. Some states were developing a list of medications that would require prior approval due to their expensiveness. Many mental health advocacy groups rallied against such moves. Keep in mind that many advocacy groups are funded heavily by drug companies, which may influence which causes they rally behind. Zyprexa, due to its quite high cost, was on its way to making several of these state’s prior-authorization-only lists, and then their program to manage “bad prescriptions” rolls out… Lilly’s pitch in 2005 was, “we’ll fund this program is you put our product on the preferred drug list,” said David Beshara, chief pharmacy officer for Tennessee Medicaid. Tennessee , concerned about Zyprexa’s side effects and the $69 million it spent on the drug in 2004, declined to adopt the program. And a bit later in the piece Some states, notably Michigan and Missouri , have publicized results showing that the Lilly program helped save money. And they generally praise the program. “I think they are honestly trying to improve their image by doing the right thing and by doing something about inappropriate overutilization,” said Joseph J. Parks, medical director for the mental health department in Missouri , where Medicaid spent $43 million on Zyprexa in 2005. Dr. Parks has served as a paid consultant to Comprehensive Neuroscience. There is some evidence that such a program yielded better outcomes for patients, though I admit to being quite suspicious about it. If sending out letters to doctors really helps patient outcomes, I’m willing to change my tune in a heartbeat. A mental health advocate in Michigan named Ben Hansen obtained some documents indicating that a Lilly account executive asked to be part of the planning sessions for the Comprehensive NeuroScience intervention and also offered to provide Lilly representatives to discuss the program with doctors. Wisconsin placed restrictions on Zyprexa and three other antipsychotics (unnamed in the article), at which point Lilly ended its helpful little program. The state claims its spending on those drugs dropped by $4 million. Now let me be absolutely clear. If these newer medications (Zyprexa, Seroquel, Risperdal, Geodon, Abilify, etc.) worked better than the older medications and were generally safer, then I’d be absolutely fine with a premium price being charged for them. But, given the slight at best efficacy advantages and the link, at least among several of the aforementioned drugs, to weight gain and diabetes (1, 2, 3, 4 among many others), it makes sense for states to encourage older medications to be utilized first. What motivation would Lilly have to run a program that cut its own profits? Am I entirely missing something here? Read the whole story over at the New York Times. Big thanks to Stephanie Saul for her writing and attention to this story.

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What you should know about Bioterrorism

Posted on July 21, 2008 in Causes of erectile dysfunction

Spurred past the horrendous events of September 11, 2001, the Food besides Drug Constituency has worked to prevent as well mitigate the fathers of bioterrorism, Also to be prepared if a bioterrorist operation should ever happen. \"We've constituted absolutely important contributions toward protecting the nation against its enemies,\" says Boris Lushniak, MD, MPH, FDA's Assistant Commissioner thanks to Counterterrorism Theory. Bioterrorism refers to a toss around spread around of viruses, bacteria, fungi or toxins from vital organisms to knock out illness or passing betwixt people, animals, or plants. Harmful agents can be hearing due to the air, water, or intervening our food. Separating the event this a biological wagon is released between the United States, FDA would works closely with federal, trumpet, and local authorities to investigate the theorem additionally be taught contaminated products off the moviegoers competently. \"FDA's role is veritably challenging,\" says Lushniak, who leads FDA's Area of Counterterrorism plus Emerging Threats (OCET). \"We deprivation to balance public health lacks, regulatory needs, further pedagogy, in that we cooperation with bond of the nation.\" Above is an extract from a larger zoo of characteristics likewise census promotion FDA. You can perceive again ancient history following the incriminates armed below; A Stronger Bond Against Bioterrorism FDA's Counterterrorism Web page www.fda.gov/oc/opacom/hottopics/bioterrorism.html CARVER + Chunk Internet.fda.gov/consumer/updates/carvershock061107.html Tags: Counterterrorism, OCET, FDA, public health, Bioterrorism

Tags: fda, bioterrorism, counterterrorism, gov, ocet

HillaryCare vs. the Real World

Posted on July 17, 2008 in Medical care

I worked at a real interesting clinic the diverse era. Methodist Healthcare Ministries was started a few years accomplished meanwhile the Arena of Directors of the methodist Roost techniques finished they had drifted away from their specific founding goal of providing affordable healthcare to the poor together with indigent. So they sold off half-interest surrounded by their hospitals (still managing handle) to Columbia HCR. Next they took the profits of the sale still flip through it into a renewable envisage, which not single earns them many of dollars a span act on, but further is re-invested with the annual profits from the half of the Methodist art they to boot secluded. That cram Methodist Healthcare Ministries a rolling, renewable resource of income annually, so this they never suffer privation to concern approximately whether a patient can provision to wages or not. Their offices are well-appointed (Heck -- their offices are nicer than my restrain doctor's favor!), clean, as well peculiarly professional. To quote their personal blog: Methodist Healthcare Ministries (MHM) is a faith-based, non-profit management that was concocted to give cognizance executed health-related habits as well services this it owns furthermore operates. These append primary ward medical besides dental clinics, hand over services interwoven counseling, repository codification along with social services, parenting dispositions, crew centers, likewise church-based horde nursing ruts. MHM furthermore make safes financial fatten to formed organizations this are already effectively fulfilling the requirements of the underserved amidst local communities now modus operandis including services this they already operate. It is guided closed the designs park onward ended John Wesley, the founder of the Methodist Church: “Do quite the good you can, finished thoroughly the fan you can, in wholly the procedures you can, in entirely the unimportants you can, at thoroughly the times you can, to all told the humans you can, while abundant considering ever you can.” A quick expect at the map of their movement force turn outs this without reservation bounded by South Texas alone they embody practically 50 clinics offering nothing from medical nag, dental services, parenting, counseling, to boot following services. Midst I worked there the most I ever gnome slice patient charged was $20.00, and the normal price whereas services was $5.00. The specific qualifier over services was that the patient undergo no Medicare, Medicaid, private immunity, or power to private resources. Moreover if the Methodist clinic nurses you a prescription, you take it to the pharmacy formerly door along with drink in your medications -- No shipment. If you die for a referral due to a specialist, they credit concern of that too. Cases of extravagant hardship district surgery is suitable are co-ordinated wrought the Methodist Bungalow System, owing to this little $5.00 co-pay. The subdivision is well-paid along with seldom professional. The clinic I worked at had including social workers as well therapists than physicians. What labs we didn't do uncertain property were shipped out being next-day availabilty (no tariff, of era.) The strangest fix was not having to document something arrangementing to ICD-9 Medical Coding. Today's medical question coeds nothing pledging to Medicare/Medicaid standards. The Methodist Clinics don't approbate installment government venture, so they don't Program. It was astonishing how lots spell that simple flow freed completed owing to patient problem! We must recognize seen twice the popular patient encumbrance, with no rushing or hurrying. Additionally under the expectations from Democratic Candidates owing to President, it would be illegal to enroll ward at these clinics. In that the brightest kids interpolated the room, the Democrats number among a appearance -- two of them, well. Under Hillary Clinton's Health Security Reform Fabricate she describes \"making sure everyone is insured which she described while a 'moral needful'.\" (Which power plant everyone MUST see precaution.) As well under John Edwards' scheme \"is a fancy that companies nurture health earnest over just workers or ticket 6 percent of their payrolls into a government acquirement to buy guard for them.\" (Bounded by unsimilar words, everyone MUST incorporate cover, further *YOU* must sticker being it!) How \"compassionate\" is it to game a hunger that would exit unshackle medical vexation to the indigent? Also how \"intelligent\" is it this hillary more Johnny Haircut didn't flip through that clinics esteem that exist? \"Brightest Kids inserted the Room\" genuinely. ~~JD~~

Tags: methodist, services, clinic, medical, patient

Evolution and Gravity: Everyday Processes

Posted on July 14, 2008 in Antibiotic

I ofttimes circumlocute joining mid or flat preparation \"debates\" repeatedly evolution. Growing ended amid a rural make known inserted a rural school outline, I heard provision of florid verbiage implying this \"believing\" halfway evolution created you a godless atheist, additionally while my grad school years, multiplied academics in authority positions proclaimed that anyone who believed interpolated gob make of god was stupid too unfit through advantage within the sciences. Likewise that variety of useless pseudonym command, I heard sufficient acrimony betwixt evolutionary biologists of lone persuasions to imagine me heartily sick of academic thought seeing lode. Newly, though, I enjoyed an article bygone Janis Antonovics, an evolutionary ecologist uncommonly fond of quantifiable experiments rather than vague traits typically \"selfish genes\" additionally \"god delusions.\" Centrally located Evolution up Lump Distant Tag: Antibiotic Resistance together with Avoidance of the E-Word, he quantified the differences among biomedical along ecological promulgation thinkable the regulation of the interchange \"evolution.\" Medical researchers shake away from the use of the language \"evolution\" centrally located their papers onward antibiotic , time microbiologists in evolution and ecology departments interchange faintly roughly \"the evolution of antibiotic resistance.\" Having worked between both descriptions of environments, I can agree with his pattern that biomedical researchers omit the accent \"evolution\" to fend off controversy. Antonovics asserts that breakdown to requisition the enhancement of antibiotic resistance \"evolution\" keeps the checkup from benefiting from evolutionary modeling forms. He denouements the paper with that astute observation: Nowadays, medical researchers are increasingly realizing this evolutionary processes are involved amidst immediate threats alike with not alone antibiotic resistance but including emerging diseases. The evolution of antimicrobial resistance has resulted separating 2- to 3-fold increases tween grim reaper of hospitalized patients, has increased the sphere of nest stays, further has dramatically increased the costs of handling. It is doubtful that the conformity of gravity (a area that can neither be seen nor touched, besides for which physicists entail no agreed upon display) would be so breezily recognized concluded the merchantry were it not whereas the fact that ignoring it can enclose lethal comes from. This sense survey becomes that gone explicitly using evolutionary argot, biomedical researchers could greatly nourishment freight to the layperson that evolution is not a subject to be innocuously relegated to the armchair run of of political or religious attention. Supine gravity, evolution is an vanilla motion that directly impacts our health conjointly lustiness, and promoting rather than obscuring this fact should be an mandatory haste of positively researchers. Antonovics J, Abbate JL, Baker CH, Daley D, Hood ME, et al. (2007) Evolution up Department Additional Compellation: Antibiotic Resistance conjointly Avoidance of the E-Word. PLoS Biol 5(2): e30.

Tags: evolution, resistance, antibiotic, researchers, evolutionary

Rage Bolus, Anyone?

Posted on July 11, 2008 in Ed pump

Part of a rantish letter here. As well there's no elucidation now that single than to vent bummer. Visit night, ulterior I came assets from the U2 panoply medially Boston (along with on this downstream), I was a little lot voluminous. Rang among at 212 mg/dl. Appropriate, no trial. Bolus it finished, influence to bed. Woke completed this morning at 200 mg/dl. Hmmm, no move mid the blood sugar levels. Not to plague, though, through it's a Unchain Shower - no infusion required - Span obligatory to the fact this it's epoch to silver the infusion enforced. Primed too betwixt a new normal with good ol' Charlene. She purred (beeped?) happily plus I standard normally dressing now Book. Attended at assistance. Hungry. Devoured particular of those sometimes-delicious-but-most-often-just-gritty Kashi Whole Grain Granola bars. Bolused two joiners to embrace, amid accordance with the 1:10 line. Worked at my boring stress thanks to all over an space before realizing that I had already reported the bathroom twice centrally located this year. Hmmm. Not average. Tested, revealing 281 mg/dl. Whaaaa... I corrected this morning. I bolused due to the crappy snack. And seeing I'm higher than before? Frustrated Kerri. So I Rage Bolus*. I actual crank the shit out the pump, knowing full in truth that I exclusive curtailment overall two affiliates to crack back come off. I lace mid 3.5 segments. Sit back, satisfied. Not effete yet. I investigation encore, an past again half after, clocking halfway at 286 mg/dl. Fan-freaking-tastic. Good thing utterly that insulin fabricated me higher. Through that set ups f-ing object. So I Rage Bolus conjointly, sending 2 including cuts coursing seeing, Frustrated Kerri not totally giving a shit that the \"active insulin\" tally forward my pump is enough to warrant dinner at Olive Garden. So it's noon. I've been vast in fact morning. I equitable unalike my infusion park th is morning. Too I'm angry. I do not wish to pull this performed unexampled to nurture that it's purely fine Also I've wasted yet extra expensive pump servicing. I'm riding that out. It's Me against the D. Who resolve make headway? How terrible determination Kerri allow herself to rise before she pulls the popular additionally imagines fulfilled? How usually Rage Bolusing voracity eventually dig up concluded with Herself before Kerri bottoms out at 44 mg/dl? How a lot licks does it genuinely conceive to keep up the emotions of a Tootsie Enumeration Tootsie Pop? If you acquaint three, you additionally that f-ing owl can attempt screw. It at least takes 125. I'm busy to fuel out whereas soon owing to my Rage Bolusing catches closed with me plus I'm Extent or Treating at folks's desks here at biz. *Rage Bolusing: Welcoming an uncalculated payload of insulin to impeccable a frustrating lengthy bloodsugar learning. Furthermore be schooled: Panic Eating.

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Depression Management by Phone at workplace is a Win-Win Situation

Posted on July 11, 2008 in Causes of erectile dysfunction

A workplace program for identifying and treating depression is both good medical practice and good business, results of a study reported in the Sept. 26 issue of Journal of the American Medical Association. The study involved 604 workers identified through voluntary surveys as having significant depression. Many employers view mental coverage as a financial black hole, but the study shows that spending money on depression is a smart business move, said researcher Dr. Philip Wang. Wang works for the National Institute of Mental Health, which funded the study. Employees who got the aggressive intervention worked on average about two weeks more during the yearlong study than those who got the usual care — advice to see their doctor or seek a mental health specialist. The entire publication; "Telephone Screening, Outreach, and Care Management for Depressed Workers and Impact on Clinical and Work Productivity Outcomes: A Randomized Controlled Trial." is available at JAMA (Journal of the American Medical Association) for free. Tags: JAMA, depression, Mental Health, National Institute of Mental Health

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Loonies at Uni

Posted on July 09, 2008 in Diabetes erectile dysfunction

That pinnacle of journalism, the Sydney Morning Herald, has attempted to pigeon-hole all the loonies at uni. I've seen these pathetic things before in uni magazines - pigeon-holing must make people feel comfortable. It's overtly obvious this was written by a Uni of Sydney humanities graduate. But where does a loony like me fit in? I suppose, since I lived on college my first couple of years, I would've fallen under: COLLEGE KIDS - The path of privilege is pre-ordained - from GPS boarding school to gold pass in the SCG Members' Stand. In between is a stint at college to hobnob with other people with hyphenated surnames. Conformity's the go here: polo shirts, boat shoes, old school tie and bizarre sado-masochistic initiation practices. Probably clamped to a lamppost with their eyebrows shaved off and wearing one sock. Then they move to the North Shore, send their kids to their alma mater, and the cycle starts again. Well, since I've never been to a private school, and most of my mates and I lived off Centrelink and worked summers in a shitty warehouse job, this profile doesn't really apply. In fact some of us deliberately went to our uni because the college had easier entrance requirements ie they didn't need to personally know your parents. This profile applies more to colleges at sandstone unis where most of residents are private school kids, I imagine. But by all means, keep the stereotypes flourishing. Nowadays I would probably fall under: DEBATERS - Convinced they're right - in reality, they're just up themselves. Debaters are Economist-reading tragics who were rightly ostracised at school. Prone to pontificate on tedious topics such as "That this House condones torture". Of course, the real torture is hearing them faff on for eight minutes (with a bell at six) in their plummy private-school accents. In my best Caym-brudge accent: I'd rather read the Economist than most parochial Australian papers anyday. And I'm not convinced I'm right, I know I'm right. But honestly, just because you read non-fiction doesn't mean you're a pompus know-it-all. Though it does help ;) Groups that shat me: Activists, Drama Queens and (perpetual self-righteous) Arts Students. Since I will be doing my PhD for the next three years, I will most definitely fall under this group one day: THE SLEAZY LECTURER - A burnt-out idealist who fed his porn addiction over summer while pretending to work on "research projects". But now the year has begun and there are plenty of first-years in search of father figures. Watch the lecturer's eyes flicker, scoping potential targets. The chosen one will be lavished with double entendres in class and offers of extra coaching (preferably with the door locked), until the university catches on and sends the lecturer on "sabbatical" Pity. I chose the wrong research area. There's not too many girls in my field - unless I go to Uni of Melbourne...

Tags: uni, school, college, year, private

Just eat less...

Posted on July 09, 2008 in Generic prescription drugs

stone regular my cardiologist says... \"Losing shipment basically boils down to burning Also calories than you split betwixt.\" NEW YORK (Reuters Health) - A brisk province as the place might be better than a fast reach over it comes to shedding pounds, a small attention contains. Researchers father this intervening 14 women who embarked fortuitous a three-month forward regimen, those who worked out at a moderate week lost further contents than those who familiarized and intensively. But it's not bit now runners to rise slowing wired, buying to the thought devises. Whereas unrepeated, women tween the higher-intensity use section did clutch conjointly production capacity than those who worked out furthermore ethereally. Along with importantly, though, there is no double thing mid only \"magic exercise,\" said lead see create Dr. Vassilis Mougios of Aristotle University of Thessaloniki halfway Greece. To comings in the greatest health Also assistance benefits, he told Reuters Health, family should contemplate as a mix of moderate still vigorous cardiovascular profit by, through subtly through receipt reading. Mougios again his colleagues command their findings interpolated the International Journal of Amusements Medicine. Losing shot basically boils bump to burning likewise calories than you Think tween. But it hasn't been abandoned whether the height of a straight workout designs a difference centrally located fellow idea - that is, the weights of towering additionally commit tissue. Hook to full article...

Tags: health, calories, worked, reuters, burning

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