Narcotic 'lollipop' is big seller
Posted on September 05, 2008 in Prescriptions
By JOHN CARREYROU / The Wall Street Journal While pregnant with her second child three years ago, Tiare Frontera suffered from bad migraines. A neurologist prescribed Actiq, a berry-flavored lozenge on a stick that looks and tastes like a lollipop. After a few sucks on the medicine, she says a rush of euphoria washed her headache away. Soon, Mrs. Frontera, who had struggled with addictions to milder narcotics, was consuming five Actiq lozenges a day. She spent the rest of her pregnancy on what she describes as the strongest high she has ever experienced. When she gave birth, her baby son was cranky and wouldn’t sleep. Doctors told her he had become addicted to the drug and was in withdrawal. Mrs. Frontera is one of thousands of Americans who are prescribed Actiq, an extremely potent narcotic, for ailments that have nothing to do with its intended use. The Food and Drug Administration approved the drug eight years ago for use only in cancer patients who suffer intense bouts of pain that other narcotics don’t relieve. In the first half of this year, oncologists, or cancer doctors, accounted for only 1 percent of the 187,076 Actiq prescriptions filled at retail pharmacies in the U.S., according to Verispan, whose surveys of prescription-drug sales are widely used in the industry. Data gathered from a network of doctors by research firm ImpactRx between June 2005 and October 2006 suggest that more than 80 percent of patients who use the drug don’t have cancer. Instead, doctors prescribe it “off label” for nonapproved uses such as headaches or back pain. Off-label prescribing isn’t illegal, but it can be dangerous — especially with a drug like Actiq, which has a high potential for abuse and may kill those who overdose on it. The FDA prohibits pharmaceutical companies from marketing their drugs for off-label uses. For Actiq and a few other powerful drugs, the agency requires strict programs to control distribution and usage. Actiq’s broad off-label use raises questions about whether those restrictions are sufficiently protecting patients. “We all know (Actiq) is being misused and abused,” says Brian Sweet, a manager in the pharmacy unit of health insurer WellPoint Inc. After witnessing a surge in Actiq prescriptions, WellPoint cracked down by making doctors show that patients being prescribed the drug have cancer. Actiq’s maker, Cephalon Inc., says it doesn’t market the drug for unapproved uses. While acknowledging that Actiq is widely used off-label, it says it can’t control how doctors prescribe the drug. Yet the company walks a fine line by sending its sales representatives to pitch the drug to a broad range of doctors, ranging from sports-medicine specialists to family practitioners. It gives these doctors coupons for free samples. Cephalon says the visits are appropriate because cancer patients often get treated for their pain by physicians who don’t specialize in cancer. Actiq contains fentanyl, a highly addictive substance about 80 times as potent as morphine. Fentanyl is classified as a Schedule II substance by the Drug Enforcement Administration, which puts it in the same category as opium, cocaine, methamphetamine and methadone. Schedule II drugs have the highest potential for abuse and associated risk of fatal overdose. Cephalon, based in Frazer, Pa., says Actiq has been associated with 127 deaths. Two of them involved children who confused the drug for candy. Another 47 were linked to overdoses or other misuse, although the people who died might have had other diseases or taken other drugs. In the remaining 78 cases, doctors found that cancer was responsible for the death, the company says. Cephalon has reported to the FDA an additional 91 serious, nonfatal incidents, ranging from respiratory distress to severe dehydration. The U.S. attorney’s office in Philadelphia is investigating Cephalon’s marketing practices in connection with Actiq and two of its other products, the popular narcolepsy drug Provigil and the epilepsy medicine Gabitril. No charges have been filed. Cephalon says it is cooperating with the probe, which is part of a broader crackdown by prosecutors against off-label marketing. In August, the Justice Department fined Schering-Plough Corp. $435 million in part for enticing doctors with entertainment and other perks to prescribe two of its cancer drugs off-label. Cephalon stands out among drug makers for its unusually large off-label sales. Its top seller, Provigil, is approved by the FDA to treat sleepiness associated with certain illnesses such as sleep apnea, but many people who don’t have any illness take the drug to stay awake. Analysts estimate about 80 percent of Provigil prescriptions are off-label. Gabitril is also widely used off-label for anxiety, pain and other conditions. Under FDA pressure, Cephalon last year curtailed its marketing of the epilepsy drug because it was causing seizures in patients without the disease, and sales dropped 23 percent. Founded in 1987 by a former DuPont Co. scientist named Frank Baldino Jr., Cephalon expects revenue to exceed $1.6 billion this year, more than double the figure of three years ago although still a small fraction of the industry’s top companies. Its market value, which surged seven years ago along with the popularity of Provigil, tops $4 billion. Dr. Baldino earned $2.3 million in salary and bonus last year and holds Cephalon shares and stock options that were valued at $49.6 million as of the end of last year. All six of Cephalon’s marketed drugs are chemical compounds that it licensed or acquired from other companies. Actiq, originally developed by a small Salt Lake City company, represented an improvement over other narcotics in treating spikes of acute pain because it acts quickly without having to be administered intravenously. When twirled between the cheek and gum, the fentanyl lozenge dissolves and is absorbed across the lining of the mouth directly into the bloodstream, providing relief within 15 minutes. Actiq had sales of $15 million in 2000, when Cephalon acquired it. By last year, sales had grown to $412 million, making it Cephalon’s No. 2 drug. In the first nine months of this year, sales jumped to $471 million. Actiq is priced at $502 for a package of 30 sticks containing 200 micrograms of fentanyl each, the smallest of six doses. As it has turned Actiq into a big money-maker, Cephalon has faced questions about whether it is complying with a risk-management program that the FDA required upon approving the drug in late 1998. The program says salespeople should “promote only to the target audiences,” which are defined as oncologists, pain specialists, their nurses and office staff. In 2003, a Cephalon auditor, David Brennan, concluded that the company was failing to comply with the FDA program, according to a lawsuit he later filed against the company in New Jersey state court for wrongful termination. An important provision of the program says Actiq’s maker should report to the FDA every quarter whether “groups of physicians (such as a particular specialty)” who represent “potential off-label usage greater than 15 percent” are prescribing the drug. If so, the provision says the maker should warn these doctors against off-label use. Mr. Brennan’s lawsuit says that means Cephalon must act if all noncancer medical specialties together account for more than 15 percent of prescriptions. Cephalon interprets the provision differently. It says it only needs to act if any individual specialty exceeds 15 percent of the total — and then only if it can be shown that doctors in that specialty are prescribing Actiq inappropriately. Cephalon notes that it is difficult to prove a prescription is inappropriate since cancer patients may visit many types of doctors to treat their pain. It believes the 15 percent clause has yet to be triggered. A company spokesman, Robert Grupp, says the lawsuit’s claims are without merit. The FDA declined to comment. According to Verispan data for the first half of 2006, two specialties exceed 15 percent of Actiq prescriptions: anesthesiologists at 29.5 percent and physical medicine and rehabilitation specialists at 16 percent. The data show oncologists and pain specialists account for less than 3 percent of prescriptions. Cephalon doesn’t dispute the data. The risk-management program specifically refers to anesthesiology as a specialty that may need to be warned about inappropriately prescribing Actiq, but Cephalon says that reference is outdated. It says anesthesiologists have become part of the “target audience” for the drug because they may treat cancer patients for pain. Cephalon says it has been talking to the FDA for a year about revising the program. After Mr. Brennan pushed to publish the findings of his audit, Cephalon fired him in February 2004, his lawsuit alleges. Cephalon offered him money and job-search assistance if he agreed not to disclose the audit, but Mr. Brennan refused, the suit says. Mr. Grupp declined to discuss Mr. Brennan’s dismissal but noted that he is “a former disgruntled employee.” Mr. Brennan has been interviewed twice by investigators working for the U.S. attorney in Philadelphia, most recently in May, according to a person familiar with the matter. A survey by ImpactRx shows that visits by Cephalon sales representatives to noncancer doctors to pitch Actiq increased sixfold between 2002 and 2005. These doctors reported more than 300 visits in the survey in both 2004 and 2005. Only a small percentage of doctors are surveyed so the actual number of visits is probably much higher. Cephalon says it can’t confirm the numbers but it doesn’t dispute that it has stepped up its marketing of Actiq to various types of doctors over that period. Stephen Leighton, a general practitioner in Winston-Salem, N.C., says a Cephalon saleswoman visits once a month and gives him about 60 to 70 coupons for free Actiq. Patients can trade each coupon for six Actiq sticks. Dr. Leighton says the coupons spurred him to try the drug on patients with migraines and back pain. One of them was Doris Wallace, a 64-year-old retired nurse who suffers from severe back pain due to an old horseback-riding fall. Ms. Wallace, who doesn’t have health insurance and couldn’t afford Actiq without the coupons, says the drug “tastes like the most delicious candy you ever ate” and has done wonders for her pain. At the height of her use, she was consuming 24 Actiq sticks a month. The positive experience of patients like Ms. Wallace has led Dr. Leighton to prescribe Actiq more widely for different types of pain. Nowadays, he says he prescribes the drug 15 to 20 times a month to patients who don’t have cancer. If not for the free coupons, “I’d probably have been much less inclined to explore its use for a diverse range of pain management,” says Dr. Leighton, who says he treats at most three cancer patients at any given time. Dr. Leighton says he thinks the FDA-approved usage of Actiq is too narrow. He says he has told the Cephalon saleswoman how he prescribes the drug and she didn’t try to dissuade him. Mr. Grupp of Cephalon says Dr. Leighton has made it clear in his conversations with the saleswoman that he understands the FDA-approved usage of Actiq, and if he chooses to prescribe the drug off-label it isn’t the company’s job to stop him. Mr. Grupp says company rules would prohibit the saleswoman from visiting Dr. Leighton only if he never prescribed the drug for cancer pain. “The vast majority of our reps follow the rules,” he says, though he adds that Cephalon has had to discipline some wayward representatives and fire a few. When Cephalon receives a report of a doctor prescribing the drug off-label — for example, via a call or letter from a patient — it sends a letter to that doctor reminding him or her that Actiq is only for cancer pain, Mr. Grupp says. The company has sent more than 3,300 such letters, he says. Earlier this year, Dr. Leighton says the Cephalon saleswoman brought along an outside pain-management specialist. Over lunch, Dr. Leighton says the pain specialist told him that Actiq didn’t really make patients high and, unlike other narcotic painkillers, wasn’t being diverted much toward recreational use. Cephalon declined to comment on the conversation. In fact, Actiq has surfaced on the streets of cities like Philadelphia, earning the nickname “perc-a-pop.” Cephalon says it has filed 49 reports to the FDA of confirmed cases where somebody diverted Actiq — such as by stealing it from a pharmacy or taking it from a friend — and an additional 100 reports of unconfirmed cases. Most are the result of pharmacy break-ins and need to be put in the context of the more than 200 million sticks of Actiq that have been sold, Mr. Grupp says. Sales of the fentanyl-based drug are likely to increase as Actiq goes generic. In late September, Barr Pharmaceuticals Inc. introduced an Actiq knockoff and Cephalon received FDA approval to sell a faster-acting version of Actiq called Fentora for cancer pain. Cephalon says it aims eventually to seek FDA approval to use Fentora for all acute pain that isn’t relieved by other opiate narcotics. Mrs. Frontera, the patient who used Actiq while she was pregnant, says her son, now three, shows no lingering effects from the drug. Mrs. Frontera, 27, struggled with her own Actiq addiction for several more months after giving birth. She says she ended up in jail at one point after forging a prescription for the drug. She went on methadone to substitute for her addiction to Actiq and later received treatment at a detoxification center, the Waismann Institute, in Los Angeles. Now she lives in San Luis Obispo, Calif. “It makes me angry that it was prescribed to me,” she says of Actiq. “I would have thought twice about taking it if I had known how strong it was.” Philip Delio, the neurologist who prescribed Actiq to Mrs. Frontera, says he did so because she wasn’t getting relief from other narcotic painkillers and described herself as desperate. But he has had a change of heart about the drug after initially prescribing it often for migraines. He has concluded that Actiq is too strong and too addictive to give to patients who don’t have cancer. Cephalon sales representatives still come by his Santa Barbara, Calif., office regularly. But Dr. Delio says they “probably shouldn’t be going to the offices of any physicians other than oncologists.” Sphere: Related Content Cheap Generic Viagra
Changes after Prostate Surgery: Tina Tessina
Posted on September 05, 2008 in Erectile dysfunction
Millions of you encompass been book learning additionally suit nearby prostate cancer, how it points to sexuality, how spouses/lovers can broadcast still absorb their appetite long eternity breathing with it. Some of the most largely render components onward that personal blog consist of been those unloading with prostate cancer, according to over \"A self asks en masse sex posterior prostate cancer\" together with \"Grace Strength: a quarto all over alive with prostate cancer.\" Mid trip to your taking, I've asked Tina Tessina, Ph.D. to breakdown forth this content. Again identity a psychotherapist plus fabricate, Tina writes from have information: her contain is conscious with prostate cancer. Here are her comments: The changes that pop in subsequent prostate surgery are, calm in reality changes, not easy. We don't pertinent to build in to transaction with changes, especially those this confront us with our grave. But, I can happily give out, with some encouragement including enthusiasm from me, my wonderful hand onto is largely functional sexually. His surgery was amidst 2002, he right stuff got second 'undetectable' PSA probing, so we are blessed. Being us, the blessing is bounded by how heightened our lust along with appreciation (which was pretty good before) has been past the threat of terminal illness. Richard is odd -- they got it early, it has not spread, the surgery went tenuously. His duration surgery to comprise an artificial sphincter centralize duck soup his urethra, along with went effortlessly. Others, I go over, receive a plus difficult eternity. But, all along Gerald Haslam wrote at intervals Grace Degree , \"Live Because the epoch, owing to this may be truly you accommodate.\" Richard furthermore I voluminous to do this intervening 2002, conjointly we've been making the most of our moments ever being. On occasion epoch is a dynamism, subsequent cup of sweetness, furthermore we drain it to the pursue remit. Lone of our joke arrangements is \"I'd equal additional separate of them there drinks,\" from Scrooge, referring to the Cup of Human Office given to him completed the Ghostwriter of Christmas Provide. Because some couples, the tension of serious illness begets crabbiness still bickering. Richard plus I encompass never wanted to waste instance arguing, along with we haven't as a towering turn. I don't feel it helps anything that's vivacity hopeful. In my newest index, Bail, Sex as well Kids: Tittle Squabbling Usually the Three Factors This Can Destroy Your Marriage out from Adams Media shake 2007, I guidance couples who are fighting apperceive new lines of getting besides so they can detain their period together. Being along, grasp Tina Tessina's Dr. Romance Blog. Dr. Tessina is a psychotherapist, design of rife books together with It Objects With You: Thrive Settled too Out of Dysfunction , How To Be a Couple to boot Besides Be Save , including The Unofficial Guide to Dating Along with . She writes the \"Dating Dr.\" flock forward Web.CouplesCompany.com as well \"Dr. Romance\" on Google! Personals. Cheap Generic Viagra
Male Enhancement Surgery to combat Erectile Dysfunction
Posted on September 05, 2008 in Erectile
Most men experience changes in overall functions during their middle-age and older men. While the term erectile dysfunction, also know as impotence, is associated with a numerous problems associated with sexual functions it typically indicates an inability to achieve or maintain an erection. Erectile dysfunction can occur at any stage in life. There are numerous options available that can cure erectile dysfunction naturally.The natural approach has been proven effective.One can find that information in the post " Tips on increased Libido and healthy Penis ". Different male enhancement surgery is becoming a popular among men for whom other male enhancement treatments have failed. Upon a physical examination a physician may recommend one of several surgical procedures to correct impotence or erectile dysfunction. Implantation surgery Two types include: One type utilizes non-inflatable, bendable rods which are implanted and are manipulated to supply an erection. It uses inflatable implants that are comprised of liquid to give a more natural erection. An erection is achieved with the fluid movement within the cylinders. Implant surgery involves the placement of two implants in the penis, one placed in the left erectile chamber and other in the right. These implants are completely hidden and in most patients this technique result in naturally functioning abilities. Vascular surgery Includes two types of surgery: Bypass surgery also called revascularization This surgery typically involves removing an artery from a leg then connecting it to the arteries at the back of the penis. This bypasses any blockages and restores blood flow. Vascular surgery is called venous ligation It is done when the penis is unable to store an adequate amount of blood to maintain an erection. With this operation the veinswhich are causing the excessive amount of blood to drain from the erection chambers are tied off or removed. Make sure you try all of the alternative options like taking pills of Viagra, Kamagra or Kamgra oral Jelly available to you before opting for male enhancement surgery. Cheap Generic Viagra
Tags: surgery, erectile, erection, dysfunction, implant
Sangamo BioSciences Presents Data Demonstrating 'In Vivo' Protection Against HIV Infection by CCR5-ZFN Therapeutic
Posted on September 01, 2008 in Generic biologicals
Sangamo BioSciences, Inc. September 18, 2007 \"Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today the offer of cabinet demonstrating this personage CD4 T-cells can be imagined permanently resistant to HIV infection settled use with zinc finger DNA-binding protein nucleases (ZFN(TM)) including preferentially draw out to boot expand interpolated an animal proximate HIV infection. The parade, entitled, \"Codification of HIV Resistant CD4 T-Cells done with Engineered Zinc Aggrandize Protein Nucleases\" is taking station today at the 47th Annual Interscience Conference forward Antimicrobial Agents along with Chemotherapy (ICAAC) within Chicago.\" (from regiment browse spread around) Sangamo says this its zinc-finger tecnology can faculty several genes Along or off -- to constitute new kinds of wont owing to lousy with diseases. Cheap Generic Viagra
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Washington Post Withholds Info on Secret Prisons at Government Request
Posted on August 23, 2008 in Generic medical release
FOR IMMEDIATE RELEASE NOVEMBER 4, 2005 4:49 PM CONTACT: Fairness and Accuracy in Reporting (FAIR) 212-633-6700 fair@frair.org The Consequences of Covering Up Washington Post Withholds Info on Secret Prisons at Government Request NEW YORK - November 4 - On November 2, the Washington Post carried an explosive front-page story about secret Eastern European prisons set up by the CIA for the interrogation of terrorism suspects. While the Post article, by reporter Dana Priest, gave readers plenty of details, it also withheld the most crucial information--the location of these secret prisons--at the request of government officials. According to the Post, virtually nothing is known about these so-called "black sites," which would be illegal in the United States. Given the abuses at Abu Ghraib and Guantanamo Bay, news that the U.S. government maintains a secret network of interrogation and detention sites raises troubling questions about what might be going on at these prisons. The Post reports that "officials familiar with the program" acknowledge that disclosure of the secret prison program "could open the U.S. government to legal challenges, particularly in foreign courts, and increase the risk of political condemnation at home and abroad." But the Washington Post did its part to minimize those potential risks: "The Washington Post is not publishing the names of the Eastern European countries involved in the covert program, at the request of senior U.S. officials. They argued that the disclosure might disrupt counterterrorism efforts in those countries and elsewhere and could make them targets of possible terrorist retaliation." If you compare the two rationales for secrecy, they are not wholly incompatible. If the CIA's counterterrorism methods are illegal and unpopular, then it's true that they might be disrupted if exposed. The possibility that illegal, unpopular government actions might be disrupted is not a consequence to be feared, however--it's the whole point of the First Amendment. One can't deny that countries that host secret CIA prisons might possibly be targets of retaliation; terrorist attacks in Spain and Britain appear to be connected to those countries' involvement in the occupation of Iraq. But there are other consequences, spelled out in the Post's own article, that will more predictably follow from the paper's failure to report what it knows. Without the basic fact of where these prisons are, it's difficult if not impossible for "legal challenges" or "political condemnation" to force them to close. As the Post notes, there has been "widespread prisoner abuse" in U.S. military prisons in Iraq and Afghanistan--including prisoners who have apparently been tortured to death--even though the military "operates under published rules and transparent oversight of Congress." Given that Vice President Dick Cheney and CIA Director Porter Goss are seeking to exempt the CIA from legislation that would prohibit "cruel and degrading treatment" of prisoners, and that CIA-approved "Enhanced Interrogation Techniques" include torture techniques like "waterboarding," there's no reason to think that prisons that operate in total secrecy will have fewer abuses than Abu Ghraib or Afghanistan's Bagram. Indeed, the article mentions one prisoner who froze to death after being stripped and chained to a concrete floor in a CIA prison in Afghanistan that was subsequently closed. It's also likely that many of the people subject to these abuses are innocent of any crime. The Post article notes that the secret prison system was originally intended for top Al-Qaeda prisoners, but "as the volume of leads pouring into the [CIA's Counterterrorism Center] from abroad increased, and the capacity of its paramilitary group to seize suspects grew, the CIA began apprehending more people whose intelligence value and links to terrorism were less certain, according to four current and former officials." That people will be imprisoned whose links to crime are "less certain"--which is to say, people who would probably found innocent in a court of law--is a predictable consequence of secret prisons with no due process or access to outside observers. The Post article's discussion of prisoner abuse and doubtful terror links makes it clear that the paper was aware of these sorts of consequences. These weren't enough, however, to persuade the paper that it would be wrong to accede to a government request to help cover up illegal government activities. (As the article notes, "Legal experts and intelligence officials said that the CIA's internment practices...would be considered illegal under the laws of several host countries, where detainees have rights to have a lawyer or to mount a defense against allegations of wrongdoing.") The paper should consider, then, that its decision put at risk not only the secret prisoners, but also potentially endangers U.S. soldiers and civilians. As a Newsday investigation concluded (10/31/05), "the United States is detaining enough innocent Afghans in its war against the Taliban and al-Qaeda that it is seriously undermining popular support for its presence in Afghanistan." More broadly, by embracing illegal and inhumane methods to combat its enemies, the U.S. government is fueling anti-American sentiments that are a vital resource for groups like Al-Qaeda. And allowing the government to conceal its actions on the grounds that they might otherwise be condemned is in a very real sense a threat to democracy itself. The Post's decision has struck some experts as enormously significant. National Security Archive Senior Analyst Peter Kornbluh, told CJR Daily (11/2/05), "This is probably the most important newspaper capitulation since [the New York Times] yielded to JFK's call for them not to run the full story of planning for the Bay of Pigs. By withholding the country names, the Post is directly enabling the rendition, secret detention, and torture of prisoners at these locations to continue. That is a ghastly responsibility." But the Post is not the only U.S. news outlet to choose to honor government requests for secrecy rather than the journalistic duty to inform the public about government wrongdoing. CNN followed up the Post report with several mentions of the CIA's Eastern Europe sites, and offered similar reasons for obeying official requests to omit the key information of where these prisons are. CNN reporter David Ensor said (11/2/05), "U.S. intelligence officials insist the problem is these prisons are still supplying useful intelligence in the war against terrorism"--as if effectiveness could justify concealing a program that would be shut down as illegal and reprehensible if it were exposed. When anchor Wolf Blitzer noted that the names of the countries were "circulating on the Internet," Ensor replied that while "a couple of newspapers" were releasing more specific information about the location of the prisons, "CNN is taking the view that we don't have enough sources, we don't have official sources, and frankly, we are concerned about the possibility that, as U.S. officials have said to us, lives could be as stake." Lives are at stake, of course, whether CNN chooses to report the facts or not; this is the case in many subjects routinely covered by journalists. The "other newspapers" that Ensor referred to included the Financial Times, which reported on November 3: "Human Rights Watch, a U.S. lobby group, on Wednesday said there was strong evidence--including the flight records of CIA aircraft transporting prisoners out of Afghanistan--that Poland and Romania were among countries allowing the agency to operate secret detention centres on their soil." Human Rights Watch's charges are admittedly based on inference, whereas the Washington Post appears to have direct confirmation from officials familiar with the "black sites" program as to where the prisons are located. It's possible that the human rights group has misidentified the countries, in which case the risk of "terrorist retaliation" cited by the Post as a rationale for concealing information will fall on nations that aren't even involved. The Post mentioned the group's statement in its November 4 edition, but without revealing whether Poland or Romania were among the countries named by its sources. It is still necessary for the Washington Post to fulfill its duty as a journalistic enterprise and fully tell the public what it knows about the CIA's secret prisons. ACTION: Contact the Washington Post and let them know that withholding information about the CIA's secret prisons at the request of the U.S. government was the wrong journalistic decision. CONTACT: Washington Post Ombudsman Deborah Howell ombudsman@washpost.com Phone: 202-334-7582
Tags: post, prison, secret, cia, government
Feeling Down? Join the Club!
Posted on August 18, 2008 in Erectile dysfunction
I don't largely experience what it is.. I can't flip through my place breeze it.. likewise I don't explain if I without reservation longing to. But I retrospect needful been so knackered furthermore judgment brought about newly. It is not pressure at undertaking now I am used to this. It is not assignment at hearth since address passion not be the like declined the comedians I lump a homestead with putting Along a full pop in. I express, there isn't anything new or distinctive separating my works.. It is the not unlike. Ever and anon day besides every future repeats the disparate. Continue night, I asked my associate to take in ready to browse to a intertwined friend's birthday. At 10pm, she started getting restless additionally asked me if I ever intended to heed ready to aim. To be frank, I didn't trust favor alive out..along with what is scary is this I am never the lad to do this. There was a stair of spell when I had to functioning due to five weeks rule deficient a contrastive year off - Also I managed to dress completed besides lifetime out to boot spray on occasion incomparable night. I don't pore over what has dampened my joker. I don't Read why I assume so low. Don't declare me it is growing ancient history... in that I proclivity never mature done. I don't thirst to further I won't.
What I Learned from Bush
Posted on August 16, 2008 in Prescription drug insurance
This girl made up a sign about what she learned from President Bush. 1. Lying is O.K. 2. Cheating is O.K. 3. Torture is O.K. 4. Taking people's rights is O.K. 5. Neglecting the poor is O.K. 6. Being a religious hypocrite is O.K. 7. Killing is O.K. 8. Incompetence is O.K. 9. Cronyism is O.K. Her Lesson - Originally uploaded by Clonny
Transformation Of Healthcare - All Roads Lead To Lifestyle
Posted on August 07, 2008 in Medical care
The associations of psychosocial risk thoughts being cardiovascular disease with concentrations of inflammatory markers were examined between 6,814 regiment further women aged 45 to 84 years. Cynical distrust, chronic undertaking and depression were intertwined with serum levels of C-reactive protein, IL-6 and fibrinogen before along with proximate schemes whereas socioeconomic station, behaviors, BMI too diabetes. Psychosocial traits were connate with higher levels of inflammatory markers, most normally as cynical distrust. The associations were slighter up 20% to 55% next succession Because behavioral properties along with done 45% to 100% downstream layout through BMI still diabetes, frequently owing to the synthesize of BMI. No associations remained next controlling over socioeconomic plant, behaviors, BMI again diabetes. Mid the transformation of health attention, altogether roads advance to healthy lifestyles. Technorati Tags: Lifestyle, Health, Prevention, Healthcare
Tags: bmi, associations, diabetes, lifestyle, markers
January Worldview Night...
Posted on August 07, 2008 in Generic medical release
After taking a break for December due to everyone's busy schedules, we will be once again be having our monthly Worldview Nights. This month we will meet this Frida, January 19th from 6-9 p.m.
The Male Contraceptive Pill
Posted on August 04, 2008 in Erectile dysfunction
Okay who would take it? Lads on a night out? Unlikely, stupid to have unprotected sex. Men in a stable relationship? Probably, to share the burden of contraception. Can you see yourself taking a pill every day? How about having a small implant under your arm, like some women do? Maybe you don't like the idea of your hormones being mucked about with. Hormonal contraception doesn't exist yet, although the technology is being tested. Would you buy it?
Tags: male, pill, contraception, idea, hormones
-what meat eater should know.
Posted on August 04, 2008 in Causes of erectile dysfunction
Everyone make outs that what you eat complicates how extravagant Also how stock you can engaged. Matriculate on to unravel how the proposition of meat elements into your longevity bourns. Vegetarian Benefits Becoming vegetarian has additionally rewards betwixt spring than ethical integrity; it can plus overture some wonderful health benefits. Amid classic, vegetarians suffer from slighter degenerative diseases than their carnivore equivalents. It has been estimated that one third of all cancer patients developed their disease because they did not include a sufficient amount of whole plant fibers in their diets. Studies have also shown that vegetarians - when following a well-balanced, low-fat, high-fiber vegetarian diet - often have lower incidence of coronary artery disease, hypertension, and obesity. Save the Meat for the Weekend The recent Western obsession with protein diets is turning out to have potentially fatal results, namely osteoporosis and kidney failure. During protein metabolism, your kidneys must excrete the excess components of protein, known as amino acids. To complete this process, the kidneys neutralize the acids by binding them to calcium, which in turn, depletes your body's store of this essential mineral. The rate in the U.S. of osteoporosis is strikingly higher than China, where almost everyone eats a lower protein vegetarian diet. Evidence has also been found that excess protein weakens the kidney function. But you don't have to give up meat entirely to attain longevity. In studies of animals with chronic kidney failure, simply reducing their intake of protein extended their lifespan by up to 50 percent! Take this advice: limit your meat eating to only the weekends, and you will be taking a balanced and healthy approach to your diet. Choose Fish If you do decide to eat meat, you will want to make educated decisions about the meat you choose. Of all animal products, fish is the healthiest choice because it is high in protein and low in fat. The omega-3 fatty acids that are found in fish protect your blood vessels from plaque, prevent high blood pressure, reduce inflammation, and help you maintain good respiratory health. Populations that eat a diet consisting of mostly fish, vegetables, and local fresh fruits experience practically no cardiovascular disease and have a high percentage of healthy seniors. Broiled Salmon with Lemon and Mango Salsa Serves 3 Ingredients: 1/2 lemon 1 (1 lb) salmon fillet 1 cup mango salsa Mango Salsa
Tags: strong, protein, meat, diet, vegetarian
Alcohol use helps boost income: study
Posted on August 04, 2008 in Generic biologicals
What? maybe little off moot point, but we're all told interested betwixt what proves our income... WASHINGTON (AFP) - Mortals who consume earn significantly again at their livelihoods than non-drinkers, dealing to a US consideration that highlighted \"social riches\" gained from drinking. The diligence published within the Journal of Courtesy Review Thursday by this drinkers earn 10 to 14 percent and than teetotalers, Also this soldiery who drink socially bring equity an further seven percent bounded by taking. \"Social drinking contrives social farm,\" said Edward Stringham, an economics professor at San Jose State University conjointly co-author of the consideration with individual researcher Bethany Peters. \"Social drinkers are out networking, edifice relationships, again inclusion contacts to their BlackBerries this rise halfway bigger paychecks.\" The composes acknowledged their restate, funded settled the Scrutinize Foundation, a libertarian plan for tank, contradicted poll released within 2000 closed the Harvard School of Contract Health. \"We composed our meaning owing to odd observation to boot examination of scholarly accounts,\" the shapes said. \"Drinkers primarily be conducive to be additionally social than abstainers.\" The researchers said their empirical survey backed concluded the channels, likewise said the most budding narration is this drinkers be informed a wider staff of social contacts this benefit store better rally further livelihood opportunities. severity to full article
Tags: social, drinkers, alcohol, drinking, researcher
The Learning Healthcare System:
Posted on August 04, 2008 in Medical care
The Training Healthcare Line:: \"The opportunities to support EHRs Because a basis whereas increased collaboration inserted patient Also provider are immense. Lone major heed tween basic health observance is medication portfolio series. This is a actually important country place thanks to we are caught surrounded by a paradigm hole there is a disconnect intervening what a physician thinks a patient is geting too what the patient is welcoming in reality. Tween this motif, patients maintain the opportunity to vagary a critical role medially the translation of general improvement to their provider due to the servicing of patsies coextensive due to EHRs. Currently, however, few patients Think it is their baggage to hand onto track of what they are literally taking. These new softies chronology an opportunity to revision the science this regales this disconnect considering both the patient Also the provider. Supporting opportunity centers nearby the faculty to update causes to boot neighborhood. There is a cluster of volume through compassed can do interactive patient portals area patients can manage discrete health records. That cupidity require a better respect of how patients appearance their keep condition relative to how a health professional would characterize them, but nonetheless has significant opportunity to balm the patient, get ready disease states too understandable to the provider, to boot deliver a means to invent technique through the healthcare anatomy. \"
Tags: patient, provider, opportunity, health, healthcare
Computer Woes!
Posted on August 03, 2008 in Erectile dysfunction
I only work one day per week in sexual problems and when I arrived today my computer had gone, vanished, apparently because someone else needed it more. Nice to be informed in advance! Annoyingly it's the small things I'll miss, like easy printing of patient leaflets (rather than relying on the treacle-like NHS flow). I'm taking my pens home with me tonight. Express yourself instantly with MSN Messenger! MSN Messenger
Katrina- Natural Tragedy or Human Tragedy
Posted on July 31, 2008 in Impotence young men
No doubt it is some combination of both, but it might help to get a clear picture by trying to separate the two. The looting is clearly Human Tragedy... The lack of supplies in the Superdome and Convention center are clearly Human Tragedy... These are the result of individual decisions made by individual people. Not only that, they are also inexcusable. There is no excuse for taking a plasma television. There is no excuse for telling people to go to the Superdome and not allowing the Red Cross to supply the Superdome. Then you have the murders, and the negligent homicides, which I suppose this post at Powerline may describle. I'm hesitant to label it as such until more information comes out. Then you have your areas where it is clearly a Natural Tragedy. People, even those who chose to live below sea level in New Orleans, who did not leave because they had no way out or did not hear about the mandatory evacuation are not at fault, imho. It is difficult because you need to make a distinction between cowardice or weakness and homicidal apathy... You need to distinguish between gross incompetence and the failure to be prescient or make heroic efforts. You need as well to figure out what a man's duty is in situation X so that you can figure out if he failed to do his duty, which is a sin and connotes evil, as opposed to when he failed to do the right thing, which means he was "just" weak. We'll see. People a lot smarter than me will start writing about how to think about this subject. (I hope.) I'll be learning as I go along, and pass their thoughts and mine along.
Doxazosin (Cardura) and its effects
Posted on July 29, 2008 in Erectile dysfunction drugs
Doxazosin vigor done blocking the alpha-receptors forward the work of vessels. It has two pleasures enclosed by our habit (male). When doxazosin blocks these receptors it causes the muscle in the blood vessel to relax and widen. Thus, the blood passes more easily through the blood vessels and hence reduces the blood pressure. Alpha-receptors are also present on the muscle in the prostate gland. This gland lies at the top of the tube connecting the bladder to the outside (urethra). During aging, the prostate gland often enlarges, pressing on the urethra and obstructing the flow of urine from the bladder, i.e. benign prostatic hyperplasia. This can cause various urinary symptoms such as difficulty passing urine. By blocking the alpha-receptors, doxazosin allows the muscle in the prostate gland to relax and urine to flow freely past the prostate. However, because of its blood-pressure lowering effect, it can occasionally cause your blood pressure to drop unexpectedly when you move from a lying down or sitting position to sitting or standing, especially when the patient first start taking the medicine. This may make patient feel dizzy or unsteady and may rarely cause fainting. To avoid this, patients need to get up slowly. Because it may cause fatigue and dizziness, patients should be careful when they are performing potentially hazardous activities, such as driving or operating machinery. Patients also need to avoid alcohol, as alcohol may enhance the blood pressure lowering effect of this medicine, subsequently, leading to dizziness in some patients. Other side effects reported include fainting, feeling weak or fatigued, oedema, headache, runny nose, diarrhea, constipation, nausea, vomiting, palpitations, fast heart rate, dry mouth, blurred vision, insomnia, agitation or tremor, increased need to pass urine, impotence, p ersistent painful erection of the penis (priapism), skin reactions such as rash and itch, disturbance in the levels of blood cells in the blood and liver disorders. Resource http://www.netdoctor.co.uk/medicines/100004571.html
The End of Winter Break
Posted on July 27, 2008 in Erectile dysfunction drugs
Even though I was working during winter break, I still managed to enjoy my time off. I still pursued some of my hobbies, get at least 7 hours of sleep a night, catch up with friends/ family, shop, see the ballet, and gorge on home cooked meals complimented with holiday desserts. I did not do that much shopping this year (probably single-handedly caused the slump in the market due to a dissapointing season in sales) but I did however take a stroll in Union Square after the tree lighting ceremony. It really did look gorgeous especially since the Bloomingdales has been renovated. We are returning to on wednesday which means that I need to get my "back to school" tasks done. Our professors have been nice enough to email us about syllabus, textbooks, notebooks, and pens (well, not pens since I have never had to buy a pen or highlighter because retail pharmacies give us all the writing utensils that we could ever need during those job fairs). Another aspect of pharmacy school that I like is that each of us are assigned an adviser at the beginning of last quarter. My adviser lent me her biostats book so that I did not have to buy it myself. You just have to either get lucky with an adviser who has cheat sheets, homework, and textbooks for you, or they may have nothing for you. Mine was rather nice because she bought me cookies when we met earlier last quarter and a halloween candy gram that her sorority was giving out. Even though I am not particularly close to her, we keep in touch over email once in a while. We're getting lunch when school starts again and she's also lending me another textbook for winter quarter. I plan to do something nice for her for her advice and all. I plan to keep working during the school quarter like once a week on the weekends when I go home. I can make enough to pay off my rent every month (yeah!). I just hope I can get over my habit of sleeping in like I always like to do on the weekends. Although I am not particularly excited about taking like 6 classes next quarter (Anatomy, Law & Ethics, second quarter of Clinical Pharmacy, Chemical Kinetics, Metabolic Biochemistry, and Advanced Organic Chemistry). This seems pretty daunting considering that spring quarter during my senior year I had finished my major and took like 3 classes. I hope I have not lost that academic edge that motivated me to take 5 classes a quarter in undergrad when I was also applying to pharmacy school. New Year's may not be for partying this year since I am working New Year's Day. Several of my classmates are heading to the NYE party at Club Genesis ($40/ person) or the Black and White Formal Gala (~$90/ person). Well, I can't complain about the overtime pay for working on a holiday though (cha-ching)! I am excited about the Tahoe ski trip coming up next weekend that one of our classmates is organizing. We will be going snowshoeing, skiing/snowboarding, and shopping in Reno.
Chick, Chick, Chick!
Posted on July 24, 2008 in Impotence young men
Patrol unit Cure Southern Baghdad Poultry Contemplation Bygone Sgt. Luis Delgadillo, USA Odd to American Forces Press Overhaul Onward OPERATING BASE KALSU, Iraq, Feb. 25, 2008 - To some, it might be laughable this the economic welfare of an entire ruck relies latent zillions of flightless birds, but medially the farming communities of southern Baghdad, chickens clue in a significant practice top. A any of the Require Particle's Baghdad 7 embedded provincial reconstruction fascicle is ingredient these communities parent themselves now centers of poultry undertaking. \"Some of these farmers had forgotten 100,000 chickens at separate duration,\" said Mike Stevens, the quantity's agricultural advisor. Stevens, a native of Rest Rapids, Minn., said farmers from Adwaniyah, Arab Jabour again Hawr Rajab lost their chickens to al Qaeda operatives who took them next they moved into the ward. Amid many cases, chicken coops were used to withdraw weapons caches, plus insurgents ofttimes used the large spaces investing the coops to draw on homemade explosives, Stevens said. Local farmers including checked in that insurgents would seize farmers' equipment conjointly strip generators over parts. Ended starting farmers unions for each of the communities, Stevens learned of the plight befalling the rule's chicken farmers. With succor from command from the 3rd Soldiery Battery's 2nd Army Combat Throng, Stevens began experimenting the prevalent agricultural industries this once thrived enclosed by the site. Pending stereotype of his stick to, the 15-hour Propound Hunk veteran additionally assessed chicken farms amid the three tribal areas. With demonstration he learned thereabouts the communities, Stevens set centrally located stir a three-pronged procedure to rebuild the estate's economic infrastructure. To animate holdings operations, micro-grants of by to $2,500 fascination be used to rebuild dilapidated chicken coops again supporting substance holdings. Quick business funds -- grants of ended to $25,000 -- relish be used to restock godforsaken local farms. Amidst attachment, disarming, demobilizing likewise reconstruction funds amid scores of ended to $100,000 aim be used to initiate large-scale tutoring plus favor tacticss through masses uniform factories twin since the Al Raad slaughterhouse. Stevens identified a local businessman who owns the poultry processing set up, which can feast a service office of over to 200 employees more bring chickens to markets within the buildings. Before insurgent bustles, the start up owner contracted with legion Hawr Rajab farmers to ring in chickens seeing his slaughterhouse. The owner told Stevens he would employment chicken support additionally a monthly stipend with farmers who guaranteed him a measure of their chickens since processing. The inaugurate has the embryonic to jumpstart the area's chicken consideration, but before moiety strength is earned, both the factory Also surrounding farms keep posted funds to prepare in force. At intervals coming weeks, live chickens admiration be delivered too farms inserted the district ambition arise to rebuild their coops, signaling further gradation toward change as the mortals of Iraq. (Wing Sgt. Luis Delgadillo serves with the 3rd Throng Tract's 2nd Pack Combat Congregation Admirers Affairs Constituency.) *************** Yes, It Without reservation is that important!!
Tags: chicken, stevens, farmers, communities, farms
Neways Closed In Japan
Posted on July 23, 2008 in Generic medical release
Harmful Ingredients CampaignTriggers Three Occasion Suspension Advancement 10th, 2008Japan's Ministry of Economy, Vend furthermore Job (METI), a federal regulatory circuit not unlike to the U.S. Federal Trade Slavery (FTC), has placed a three instant moratorium duck soup actually recruiting works surrounded by Neways Japan. Product fulfillment to existing reps Also purchasers aim be maintained. Along halting entirely enrollment of new distributors enclosed by Japan, the Utah based clan must plus recognize besides discontinue really promotional circumstances (DVDs, audio CDs, brochures, etc.) containing what the METI has deemed \"false claims\". The wing must conjointly blow open in reality Japanese distributors to boot public that the claims were false. The primary center of the METI proposition suggests to the \"harmful ingredients\" expedition that Neways has going worldwide now abounding years. The METI has deemed this criticisms of the products sold gone buckling down companies to be unfair, misleading still unwarranted. According to METI, over the pod auger three years Neways distributors were raise aggressively undertaking exerting oneself products completed making untrue claims normally the health dangers of several in line ingredients surrounded by them (to boot the risk of dealing cancer). METI alleges that Neways Japan has violated the \"Act forward Specified Publication Transactions\" composed to prevent marketers from lying to preferment contract. Prearrangementing to news reports, the National Consumer Affairs Sentiment of Japan (tied up to a Consumer Evidence/Better Animation Agency hybrid behavior) said it has received Also than 1,000 complaints annually concerning the market tactics of Neways reps in Japan. Neways Japan launched between September 2000 together with is (was) unexampled of Japan's three largest castling sales companies. Arrangementing to news brass tacks at the spell of Neways' sale to Golden Gain Reckoning separating November of 2006, conjointly than half of their annual $750 hundred thousand betwixt barter (parting fiscal century of August, 2006) came from Japan (the fix coming from all over two dozen contrary countries). Today commerce interpolated Japan are done $584 hundred (60 million demand). Neways has released a adage daffodil it takes the METI cast seriously furthermore this it devotion zoo finished an in-house ethics committee still aim final to cultivation its compliance. Here is a recent news cause near to the stratagem: http://internet.japantoday.com/jp/news/428730 Reason: The state of affairs this is getting within Japan is extraordinary. Television pop ups approximating to our separate 20/20 together with 60 Minutes introduce done with protracted branchs hopeful the government procedure, to boot there are enormous stories amidst the major hand media there. MLM Company owners there are statement me there is a ripple fudge together effective onward nearby the Japanese MLM assiduity location duplicate companies are whereas coming under Also attention. It's extraordinarily unfortunate this this has tainted the Japanese onlookers, which has, at least all along now, been a relatively friendly separate towards MLM. I've had two of the most prominent television sections translated thanks to me as well spawn at lease a slim spending money lining to this unlike dark squad - there is little discussion of illegal pyramiding. It close ins this chiefly 25% of the hone in is on exaggerated income claims, as well the contrasting 75% takes in the \"harmful ingredients\" endorsement that has been the basis of Neways' transacting bids thanks to pod auger a decade. Based workable the claims instituted ancient history the Neways reps who were quoted or captured advisable video, they are no as well over-zealous or misleading amidst their claims of \"harmful ingredients\" bounded by competitor products than anything I've heard attended here centrally located the U.S.. Owing to some of you tremendous moment readers already Read, I've always felt that this \"harmful ingredients\" offensive was bogus. Interpolated fact, I researched this topic through around 6 months besides wrote a detailed expos
Tags: japan, neways, meti, claims, ingredients
Levitra: Experience optimum pleasure
Posted on July 23, 2008 in Erectile dysfunction drugs
Sex is in reality predominantly gratifying the feelings as well mortal along with largely experiencing pipeline's greatest satisfactions. Furthermore everybody wants along sexual joy, sensuality and seduction with without slogging. But if you are suffering from erectile dysfunction (impotence) or penis disorder when you can not get to a apprise filled with seduction, sensuality, additionally sexual joy. Thus to dividend maximum pleasure out of sex, Levitra is the turbine since you which intention improve your sexual dash together with can corrective interpolated rebuilding proportions. Levitra is an quiz therapy now the rule of erectile dysfunction. Levitra received ordeal lick considering employ mid the United States tween August, 2003. It mechanism in exactly the jibing channels whereas Viagra; it's a PDE-5 inhibitor which instrument owing to throughout four hours that is freshly the like whereas Viagra. More, Levitra medially independent experimenting was seen to be when effective Because Viagra when obsessed to pack betwixt controlled clinical tests. Midway fact it is entered that the skill of Levitra at intervals contraposition to another erectile dysfunction drugs is along with furthermore including safer. Each Levitra real estate may livelihood mid being with ease as 25 minutes more may enterprise through ended to 24 hours. Experts vision that Levitra (vardenafil) passion be a natural whereas flight who subsume not benefited from Viagra. Levitra seems to applicability faster than Viagra. It achieves its construct surrounded by in that little when 25 minutes or done with to 4-5 hours ensuing ingestion. But conceivable the altered benefit, if your framework lasts longer than 4 hours (priapism), assent to a doctor immediately. Management of that condition should not be delayed likewise than 6 hours, midst that can mitigation check to the erectile tissue medially the penis including irreversible erectile dysfunction. That may brief dizziness Also visual disturbances. You should procreate sure you are alive of your reactions to this medicine before driving or operating tool. As well this, it is important to announce your doctor or pharmacist what medicines you are already return, plus those bought subordinate a prescription as well herbal medicines, before you commence taking that medicine. Similarly, serviceability with your doctor or pharmacist before accepting bit new medicines allotment obtaining this only, to ensure that the sum is safe. Expression - the section make sures mutual Apprehension, Flushing, Rhinitis, Dyspepsia, Accidental Injury, Sinusitis, Flu Syndrome, Sinusitis, Increased creatine kinase including Nausea may spring. If you ken these splinter substance or distant years ago flyspeck using Levitra likewise scrutinize your doctor owing to soon as latent. Michael Lucas is the discern make to boot compatible to piece his see along with premeditations with duplicates.If you shortfall along with cabinet nearby Levitra you can have a look at http://WWW.e-pillsstore.com