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I incorporate listened to two various interviews concluded Terry Gross doable Fresh Aire. Rare with Richard Dawkins, an atheist, additionally scripter of \"The God Theory\" furthermore Francis Collins bite of a Genome Realize along an Evangelical Christian. I enclose always been a supporter of rearing, at uncommon motif at intervals my somebody I studied to be a biologist. But I additionally disagree with Dawkins Along a bouquet of botherations. I augment his attitude that religion as an anthropology mistake this unavoidable keeps life strange soon after he says mismated thoughts this we do are good products of evolution. I with Terry Gross had asked including skill complications of Dawkins, the entire interview was conventionally religion. Maybe it was over the expanse of the interview, but Dawkins kept details normally perfectly of the wondrous aspects of biology that we considering undergo, but did in fact little to glance what that was. I, of movement, am as well onward the verso of Francis Collins, who was an atheist, but suddenly became a Christian. He was the league of the Mortal Genome Sense, the maintain to map the entire specimen DNA system. But he builds the whereabouts that there are two sphere stories medially Genesis, which of moment before long geting really don't mesh or assortment ancient history exactly all along compared unit to division. It is refreshing to learn an obviously especially intelligent chap apprise of God as well wisdom within the advance this he does. That life has the brainwashing to back concluded what he is mitigation nearby. Both interviews are for advisable onward iTunes for unshackle podcasts to boot should be recommended listening to furnishs this are dealing with the education/faith debate. Here is the grapple to the Francis Collins interview. Here is the scope to the Richard Dawkins interview.

Tags: interview, dawkins, francis, collins, onward

Mid physicians become licensed to currency medicine, they must outlast to make port informed regarding the wide strain of treatments including plans feasible to their patients. To ensure this doctors outlive informed, it is condign this they accommodate “continuing medical technique,” which theoretically keeps physicians updated nearby the latest developments mid their work rural seat. So far, so good. But what, exactly, is continuing medical drilling (CME)? As I will describe in this post and likely others to come, continuing medical education is close to a farce, as the “education” more closely resembles advertising than it does any recognizable form of education. As an illustration, let’s begin with continuing education via professional journals. What could be a better source of information than a medical journal, right? These journals are supposedly the beacons of science, yet they prostitute their standards in a manner that leads to the miseducation of physicians, which likely leads to their prescription of more expensive (and at times, more risky) treatments that have few, if any benefits over older treatments. Case in Point: Journal of Clinical Psychiatry. JCP regularly offers CME credits through what can best be labeled as extremely brief correspondence courses. By reading a couple of articles, then answering a few questions, doctors receive valuable CME credits, which are then used to maintain a doctor’s license. JCP is far from the only journal which participates in this practice. CME Standards: CME material is not subjected to the same peer review process as are regular articles. Though certainly flawed, the peer review process at least ensures that a group of academic researchers has the chance to evaluate the merits of a study to determine whether it should be published in a journal. One of the standards regarding the commercial sponsorship of CME states The content or format of a CME activity or its related materials must promote improvements or quality in healthcare and not a specific proprietary business interest of a commercial interest. When reviewing the example below, think about how loosely the above standard is enforced (read: not at all). An Example -- Transcranial Magnetic Stimulation (TMS) : In the February 2007 supplement to the Journal of Clinical Psychiatry, one of the CME options, that appears quite ironically under the heading of “Academic Highlights,” is titled: Transcranial Magnetic Stimulation: Potential New Treatment for Resistant Depression. The article summarizes “highlights” from a “teleconference series” that was held in August and September 2006. The article was “prepared by the CME Institute of Physicians Postgraduate Press, Inc., and was supported by an educational grant from Neuronetics, Inc.” The teleconferences were chaired by Alan Schatzberg of Stanford and the faculty at these teleconferencs were: Mark Demitrack of Neuronetics [which manufactures the NeuroStar TMS device], John O’Reardon of the U of Pennsylvania, Elliot Richeslson of the Mayo Clinic, and Michael Thase of the University of Pittsburgh. Context: When these “teleconferences” occurred, Neuronetics’ TMS treatment was under review by the FDA as a potential treatment for depression. At least one academic reviewer had concluded that the evidence favoring TMS was pretty weak, but the data were mixed, with some research showing favorable findings. Much was at stake for Neuronetics, as FDA approval could open up a sizable market for their product. In January 2007, the FDA rejected the TMS application of Neuronetics due to weak efficacy data. Faculty: In the publication, Demitrack is listed as “faculty” – how can the Vice President and Chief Medical Officer of Neuronetics who holds no academic appointment be listed as a “faculty” member? Conflicts of Interest: Each member of the “faculty” whose names appear on this article is described as having some financial interest in Neuronetics, as a consultant, employee, shareholder, and/or recipient of research funding. Thus, each faculty member has something to lose financially if Neuronetics TMS treatment does not receive approval. Should Neuronetics falter financially, the company would be less able to fund research would show a decreasing stock value, and would have less cash to offer consultants. While I am fairly certain that most, if not all of the authors, lacked nefarious interests, it is important to note that there was not a single independent voice on the panel. In CME articles such as this, however, this is just par for the course. Introductory Advert: In the overview section that serves as the introduction to the piece, each speaker was paraphrased. Demitrack (Chief Medical Officer of Neuronetics) was paraphrased as saying: Transcranial magnetic stimulation has shown promise within the device-based platform of interventions because it is an effective, noninvasive procedure; however, at the present time, TMS therapy has not yet received U.S. Food and Drug Administration approval. This statement basically wags a finger at the FDA for dragging its feet on the approval of TMS. Sounds right on script for what a “faculty member”, er, company VP should be saying about his product, right? Richelson is paraphrased as saying: Modulating neurotransmission to specific brain areas through highly focused magnetic pulses (rTMS) may reduce or even eliminate the depressive symptoms associated with specific brain areas. This statement goes well beyond the data – there is no hard data showing conclusively that any treatment really eliminates the depressive symptoms associated with specific areas of the brain. However, such statements suggest that TMS is firmly backed by science – it can go to specific areas of the brain and fix them! Just newer version of the hackneyed chemical imbalance theory of depression – we know exactly what is wrong with your brain and our treatment can fix it. Same story, different treatment. Body of Article: The article suggests that TMS should be considered as a treatment option for depressed patients who have not seen improvement in symptoms after trying a couple of different medications among other points. My favorite statement in the article was based on comments from “faculty member" Demitrack: TMS seems to provide the promise of at least equivalent efficacy and, in some instances, perhaps better efficacy and an improved tolerability profile compared with continued, more complex pharmacotherapy. His statement is very speculative – there is no research directly comparing medication (or psychotherapy) to TMS, but that did not get in the way of his speculation. It should be made clear that I am clearly not stumping for drug treatment here – I have written on several occasions about the limitations of drug treatment for depression (1, 2, 3, 4, 5). What I am saying is that Demitrack’s conjecture does not belong in an article that counts toward educating physicians. Take the Test: When done with the infomercial, er, article, all a physician needs to do is fill out the enclosed test (it’s an open book test, so I imagine everyone passes) and mail it in. Physicians can even complete the test online. Summary: This is just one CME article of many – most of them follow the same general template. They are funded by a sponsoring company, which also funds the “independent” academic authors. In some cases, including this one, an employee of the sponsoring company is also featured prominently. A medical writer may then write up much or all of the article. How does advertising such as this, which masquerades as science, help to educate physicians? Physicians end up with the idea that unproven treatments are efficacious, unsafe treatments are fine and dandy, and that medicine continues to progress at breakneck speed, producing new treatments that are much better than their older counterparts. And this helps patients… HOW?

Tags: treatment, article, tms, cme, style

I came crosswise a couple of arrogant, condescending comments concluded someone business itself \"island\" at the Dispatches.. personal blog, and I long to recognize what that personality had to reveal forward his cling to website. Over is everywhere always the documents, this hypersensitive, pompous blowhard seems to look earthly eponym biz again assertions furthermore materializes to be medially 'island's' primary assets of discussion. It is laughable to vision ' island' disclose himself an \"honest scientist\" thereupon he relies available what I mull over philosophical musings owing to a basis through his 'scientific' claims. Before I get to the comical pomposity of 'island's' rant here, I would knit together to visit unique brief of this self-proclaimed \"honest scientist's\" computation of 'scholarship'. Centrally located a telling left adventitious the Dispatches... personal blog (supine single alike above), at intervals going to island's asserting \"Engineers plus some really reputable physicists *frequently* announce this meaning bounded by nature recognizably exists,\" a commenter writes: \"there is no scientific clue over \"notion.\" To which the \"honest scientist\" island replies: LOL... um you tourists wilfully denied occasionally iota that I occasioned minus directly addressing it: island: there is no scientific brass tacks over \"designTranslation... island... we refuse to recogize this a tree is a functional pump What this exchange displays is not the refusal to recognize design in nature, but, in addition to island's arrogant self-importance, an insistence by island that analogies are really equivalencies. Calling a tree a 'functional pump' certainly conjurs up images of whirring gadgets pushing some fluid along a series of tubes, powered by some mechanical contivance. But is a tree a 'pump' in that way? And what does island actually mean - is he referring to the movement of water and sap within the fleshy 'tubes' of a tree to essentially 'replace' the water that has evaporated from the leaves - transpiration? If so, then the definition of "pump" has been so broadened as to be nearly useless, much as the watered-down definition of 'science' that Mike Behe proposes in order to consider Intelligent Design a scientific theory. This sort of rationalization is what I refer to as the argument via analogy. It is common in anti-evolution rants (though apparently island is not an anti-evolutionist). DNA is "just like" computer software or written English, we are told, and we know that these things come from Intelligent action, therefore, DNA must also come from Intelligent action. Exceptionally shallow and naive, but it works well with 'the masses.' Thus is island's "argument." Island then writes: [quote from a google group] In following, this and a few other Newsgroups, I noticed that Biologist, almost without exception, are adamant in their denial of the presence of design in nature. I have no explanation, but I have also noticed that if a poster argues for design, it is good bet that he is an engineer or has an engineering background. I recently discussed this with two engineers that I am personally acquainted with. Both are convinced that design in nature is real and one man, Wm. Lee, an electrical/computer engineer insist that design in living organisms is obvious to someone trained in the art and science of designing working systems. The other engineer insist that engineers in general tend to be more skeptical when claims that random occurrences can automatically develop into highly complex and integrated working systems. Ben [end quote] So, admit that my statement is correct... or crawl in a hole with the rest of them. Get that? Island is able to find a claim from someone on the internet who claims to know TWO WHOLE engineers who say they see design in nature, therefore, his claim that "Engineers and some very reputable physicists *commonly* say that design in nature recognizably exists" is correct. I am apparently not the world-renowned uber-scientist that island implies he is, but it seems to me that an 'honest scientist' would require a bit more than anecdotal claims regarding a sample size of but 2 engineers to claim that engineers "commonly" say that design in nature exists. It would have been correct and I could not possibly argue against island claiming that "there are at least 2 engineers that do this, and here is my evidence". But this is not what he did. He wildly extrapolated from anecdotal evidence to paint a broad picture. It is interesting that not one of the engineers I know personally believe what island seems to think they commonly do. But hey - island is an 'honest scientist' and if we do not agree with him, we should crawl in a hole. But wait - Mr.Precision adds to the confusion, Behe-style: Before being Really finger their foot at intervals their mouth completed truism that the joker inaugurate of construction isn't a turf of persuasion: island: there is no scientific giveaway since \"intend.\" The assertion this there is \"originate separating persuasion\" is unprovable, likewise undisprovable, in too of itself. I interpret... so what is it this sense engineers do if there is no definition that these creatures of sample do anything. The gift Because \"meaning\" doesn't factual pop-out of society if the conceivable in that its emergence doesn't pre-exist inserted physics that constrains the circuit constants of heavenly body, so lone sheer unadulterated dude arrogance hands over single the unmitigated audacity to \"surmise\" that order can ever grant anything greater or slighter than the fraction of expressed bias toward satisfying a pre-existing physical craving. Ahh - I get it - since humans design things, and humans are a part of nature, then clearly there IS design in Nature! How obvious! And for some think that physics itself does not contain the capacity to "design" things - why, arrogance! Human arrogance! Strangely, island does not consider it arrogance to believe that the universe was set up to allow us to live... I know, I know... I don't get the dichotomy either... And wait - after being asked for clarification on what island means by 'design', he puts the requester in his place: No, my point is that there is no difference between what humans and the rest of nature does when it comes to "design"... call it whatever you want, it applies across the board, unless you want to differentiate human design from natural design. And there we have it. "Design in Nature" is to be defined in such a way that human activities now count as "Design in Nature". And astrology is a science... Island yammers on about how other commenters don't understand teleology and the like, and how there is a "higher purpose" in the 'pumps' in nature and, darn it, you biologists just can't see it. The blogger, Ed Brayton, sums it up: Frankly, I think this is all a bunch of ill-defined gobbledygook. Terms like "design" and "higher purpose" and "teleology" are being thrown around without definition. Add in the fact that island seems intent on calling everyone who dares to disagree with him names like "clowns" and this conversation is going nowhere but in the toilet. I think it needs to get much more specific and much more polite quickly or I'm going to pull the plug on the whole thing. Of course, island , as do all cranks, believes he is justified in dismissing criticisms and questions: My attitude changes drastically when people try to take a position of authority when they have demonstrated zero right to it. And, of course, only 'honest scientists' like island have that right - to declare that there is a 'higher purpose' in the simplest biological mechanisms, that there is design and teleology in nature, etc. Well, that particular discussion took place in 2005. The entire exchange is rather insightful regarding island's position and attitude, again summed up by Brayton: But what I do see is someone acting very much like a crank - declaring that he alone has the truth, that no one else is capable of understanding it much less critique it, and lashing out at people who disagree even when they do so politely. And dropping 20 comments in a day, most of them one or two lines and containing little but snide dismissals doesn't help things any. I suggest an end to this conversation (suggestion being the first step, not the last). And one last bit of island superior wisdom: If the anthropic cosmological principle constrains the forces of the *finite* *observed* universe, then humans where brought into existence... "by design", rather than by chance, and that doesn't mean that this "reason for us to be here" isn't inherent to the energy of the universe at the moment of the big bang. [ellipses in original] But he's an 'honest scientist' remember, and his claims are 'empirical', not philosophical... Yup... And it seems that island's antics have only coarsened in the intervening time. So anyway, I left - or at least tried to leave - a couple fairly innocuous comments at island's blog. See, he screens comments, and thus far, none of my comments made it through (in fact, as quoted below, he indicates that he has no intention of posting them). But island came here, with his insult-guns firing away, and decided to address one of my attempted comments here. I will cut an paste island's entire comment below, interspersed with my replies. =================================================================== Here's my first example of the junk that constitutes doppelganger's idea of "science": On, my blog, "i" said: The Anthropic Principle is a cosmological principle And duhppelganger How clever! Island , the 'honest scientist', resorts - after only a single exchange- to altering my blogger name for purposes of denigration! What a way to establish one's intellectual superiority! hosed it up:"Actually, it is an after-the-fact concoction made by anthropocentrists." No, Dr. Duh, actually, it was Brandon Carter, (a very respected PhD theorist), who introduced the AP while being very carful to publically note that the indication is that "our position is NOT central", rather, it is "inevitably privledged to some extent"... so you don't have a clue what you're saying. Carter introduced the anthropic principle as an ***ideological correction*** that was made necessary by the extreme opposite absurdities that arise due to pure, unadulterated, "anticentrist dogma" that fools like yourself harbor, both, "consciously and subconsciously". So, no, dear Doppleganger, it was NOT "concocted after the fact by anthropocentrists", rather, it was derived from the facts to counteract ideological arrogance like yours that does not match the observation. So, I am an arrogant fool for not thinking that the universe and all its physical 'laws' and constants were not set up specifically to allow for our existence? Dear me. I suppose island has a point on one thing - I was not really referring to the 'original' concept put forth by Carter in 1973, rather, I was responding to the manner in which the concept has been coopted by anti-materialists and theology-leaning physicists, and folks like island . Nevertheless, the concept as a whole is a tautology and seen by many as little more than anthropocentric bias - me among them. Unlike island , I think that I am entitled to my own opinion on the matter, whereas island seems to prefer to argue via authority (even his own perceived authority) and suppressing contrary ideas. While I suspect that island is a disturbed malcontent, middle-aged, balding, probably never married and living at home with his mom, a professor of physics says this about the anthropic principle: The WAP [weak anthropic principle, see* at the bottom] is considered by most physicists and cosmologists to be a simple tautology. Of course the constants of nature are suitable for our form of life. If they were not, we would not be here to talk about it. But what does he know - he is just a professor of physics. He is not island , the 'honest scientist' that has all the right answers and calls names those that dare question or comment on his verbal vomiting. Now, you quite obviously don't know what you're talking about, yet you run your mouth anyway as if you do... (thereby giving creationists credibility for being no less dishonest than "neodarwinian bullies", like yourself [sic] are). Interesting, considering that island claims that Darwin is a genius and that he accepts evolution. So why mention creationism? Who knows. And how, exactly, am I a 'neodarwinian bully'? Unlike island , I do not merely mock and insult those that I disagree with. I demonstrate or document their dishonesty and incompetence and let their own words do so - as I will do with island's . Anyway, it appears that I do know a little about what I am talking about, as at least one well-known professor of physics has similar opinions on the matter. Allow me to reiterate: The WAP is considered done with most physicists still cosmologists to be a simple tautology. Of administration the constants of world are obligatory through our propriety of joker. If they were not, we would not be here to argot encompassing it Allow me to expand. Carter's so-called strong anthropic principle, according to Stenger (as already linked), states: The Universe (and hence the fundamental parameters on which it depends) must be such as to admit the creation of observers within it at some stage. Why? And just who are these 'observers'? Why, they are US! What a grand coincidence. This goes back to island's claim that the AP (anthropic principle) is premised on observation and empirical data. And what are these observations and data? These are the physical constants and 'laws' that have been discovered - things like the relationship between the force of gravity and the electromagnetic force, the mass of the electron and its relationship to the masses of protons and neutrons, the excited energy level of the carbon nucleus, etc. (culled from Stenger's paper). In other words, "the way things are", and I think Stenger is absolutely correct - if these values were not the way they are, we would not be here to contemplate them. And we are humans. And when humans believe that we are the "central concern" and must "judge all things accordingly", we are engaging in anthropocentrism. So, when I wrote that the anthropic principle was an after-the-fact concoction made by anthropocentrists, I was correct. And you want me to publish crap like this on my science-based blog???... lol... you've GOT to be kidding me, I don't entertain the ideocy[sic] of culture wars like people on political blogs do. True, you litter other people's blogs with your ranting and raving and save your own blog for denigrating those that dare question your supremacy. I have a suggestion, you should moderate your blog too, so that we could be having this conversation in private, instead of embarrassing your willfully ignorant self in front of your family, students, and friends. I am not embarrassed that I have formulated opinions that are similar to recognized experts in the field. Why should I be? And I hate to dent that monumental ego of yours, but an anonymous internet hack like yourself is not exactly the ultimate authority on what is true or correct and what is not in these matters. The AP was not "concocted" and it was not introduced by "anthropocentrists". No? Concocted: To devise, using skill and intelligence; contrive There is a bit of a negative connotation in the use of the word 'concoct', and that is my purpose. Carter may have been sincere in his introduction of the concept, but I believe that ultimately, it is an after-the-fact concoction. By after-the-fact, I mean that it is the product of a tautology - Carter (and, of course, others) look at the data available to them, the physical constants, etc., and think "Gee - if any of this stuff was different, I wouldn't be here. Thus, these things are the way they are SUCH THAT I could be here!" Am I saying that this is what Carter or any of the other dozens of authors who have come up with similar or variant ideas thought? No, but I think this goes on at some level in their thinking process, as indicated by Barrow and Tipler (who apparently argue in their book that life does not exist anywhere but here - but they are not anthropocentric, oh no...) : [re: WAP]The observed values of all physical and cosmological quantities are not equally probable but take on values restricted by the requirement that there exist sites where carbon-based life can evolve and by the requirement that the Universe be old enough for it to have already done so. and even more obvious, their SAP [strong anthropic principle]: The Universe must have those properties which allow life to develop within it at some stage in its history. And why must it have those properties? Because it does . And what life are we talking about? Us . Tautology. Anthropocentric. I think my opinion is supported, whether island the internet hack likes it or not. Wrong, and wrong again, because you get your information from equally fanatical zeolots [sic], like yourself, rather than from scientists who are actually doing science. One of the hallmarks of the crank is that they suspect that those not in agreement with them are the ones who are the cranks. What an absurd fool you categorically prove yourself to be... but nothing that the delete button can't handle, right, Dope? Ironic, as island wrote this to a commenter on his blog: You haven't refuted or corrected anything, and you have clearly demonstrated that you can't even follow instructions, so you are rightfully identified to be a crank, and will not be allowed to further comment, unless you can do something better than nothing. Island can project with the best of his ilk, it seems. Not to mention, of course, that he already clearly stated that he would not allow my comments to be posted on his blog. Cranks and fanatics are like that. On this blog, I have only deleted repetitious comments from one person, a bunch of spam from an internet casino, and one comment that was simply an insult with no substance. Which is basically what island's posts have been thus far. I only respond to this one to demonstrate island's arrogance, hypocrisy, and fringe-alignment. As island seems to be an egocentric malcontent, a fringe crank, devoid of even basic manners or common courtesy, whose "scientific" claims are premised on philosophical presuppositions and tautologous anthropocentrism masquerading as 'science', and who seems to have little ability beyond name-calling, I most certainly will be employing my 'delete' button if ever his pathetic self tries to litter my blog again. ===================== *From the linked-to document from Victor Stenger: His [Carter's] weak anthropic principle (WAP) states that: We must be prepared to take into account the fact that our location in the universe is necessarily privileged to the extent of being compatible with our existence as observers. Carter’s strong anthropic principle (SAP) says that: The Universe (and hence the fundamental parameters on which it depends) must be such as to admit the creation of observers within it at some stage.

Tags: island, design, nature, blog, engineer

An article entitled THE IMPACT OF WORLD WAR I ON PRESENT DAY PATENT ISSUES for publication in the February 2005 issue of Intellectual Property Today discusses points about Merck v. Integra. Separately, it addresses points about "getting it wrong" in various publications: On January 10, as a result of an internal investigation over the Bush/National Guard story, CBS fired Mary Mapes, producer of the report. Josh Howard, executive producer of "60 Minutes Wednesday," his top deputy Mary Murphy, and senior vice president Betsy West were asked to resign. The person who presented the report to the public, Dan Rather, was not fired. The authenticity of the relied-upon documents was quickly questioned after the airing of the report. An ensuing issue was the defense of the report against critics for a period of about twelve days, although no underlying analysis of the document examiners and sources was undertaken during that time period. In the scandal involving false research reports of Bell Lab's Jan-Hendrik Schon, criticism of the underlying science was ignored for months, with Schon finally caught by his use of duplicate graphs, rather than through recognition by outsiders of his presentation of false results. Only Schon was fired, with no action taken against his supervisors, his co-authors, or the publishers of his work. Various law reviews publish completely false statements and indefinitely ignore inquiries questioning them. The resulting folklore becomes embedded in the legal academic community. ***** Speaking of law reviews, many discuss the Merck v. Integra case. In 30 Wm. Mitchell L. Rev. 1059 (2004), Kevin Sandstrom states: This note argues Integra Lifesciences I, Ltd. v. Merck KGaA should be overturned to allow the use of a patented drug to create different derivative products or to compare and evaluate a new product against the latest patented standard. Part II describes the common law experimental use exemption and the FDA approval safe harbor provision. n11 Part III reviews the facts, holding, and dissent in Integra. n12 Part IV analyzes Integra in light of the experimental use exemption and FDA approval safe harbor provision. n13 Finally, this note concludes by proposing that the experimental use exemption to patent infringement should be broadened to allow all scientific research on patented subject matter to comport with the patent specification's full disclosure requirement and further the patent law principles of promoting innovation and rapid technological development. n14 In 2004 Wis. L. Rev. 81, Katherine J. Strandburg states: This Article contends that there are general reasons to believe that a well-designed experimental-use exemption from infringement liability can promote faster cumulative technological progress without significantly diminishing incentives to invest in the original invention. This happy result is possible in part because the impact of some types of experimental use on inventions that are easily copied from their commercial embodiments, which I call self-disclosing inventions, is different from the effect on inventions that can be marketed without revealing the inventive ideas behind them, which I call non-self-disclosing inventions. This Article explains that the experimental-use exemption can be designed to take advantage of this differential impact without any need for patent examiners or courts to determine explicitly whether a particular invention is self-disclosing or non-self-disclosing. (...) This Article supports Mueller's proposal [76 Wash. L. Rev. 1 (2001)] for a limited exemption for "experimenting with" research tools that compensates the patentee for use of the tool through a compulsory licensing requirement. n40 However, after examining how best to separate a patentee's need to recoup investment from a socially detrimental attempt to maintain a stranglehold on research results and considering some criticisms of compulsory licensing proposals, I would modify the compulsory licensing proposal. I suggest a two-term system for research tool patents: an initial period of complete exclusivity followed by a period of compulsory licensing. *** Rochelle Dreyfuss in 46 Ariz. L. Rev. 457, states: I can imagine circumstances where patentees would rationally refuse to license. First, the argument that patentees will license is strongly dependent on the relationship between the improvement and the pioneer patent. Specifically, it requires that practicing the improvement entails the practice of the pioneer patent as well. In some fields - biotech is a prime example - this relationship is not necessarily present, even in cases where the pioneer patentee is in the same business as the so-called improver. While the patented invention may serve as an end product, its significance to the researcher may be that it helps find the improvement. Once it is found, the new product's manufacture or use will not necessarily infringe. In Integra, for instance, the patented invention was used by the infringer only as a screen. Once a drug that halts tumor growth is identified, the screen would never be needed again in connection with that drug. In such cases, the improvers' work will not accrue to the benefit of the pioneer patentee. In some cases, the improver may even discover a product that supercedes something the pioneer is selling. Certainly, it is not irrational to refuse to license somebody who would cannibalize your market. Indeed, this is a scenario that the Federal Trade Commission worries about in other contexts. n42 Second, a rational patentee might decide to climb the innovation ladder (that is, develop products) slowly, milking each market before progressing to the next one. Licensing others could interfere with this plan. Again, this concern is familiar. It has surfaced in patent cases from time to time. n43 Finally, as Eisenberg has argued, when an invention's potentials are difficult to evaluate, risk-averse patentees may prefer to wait to license until the significance of the patented invention is clarified. n44 There are also some who would argue against a rule that creates special benefits for academia on the theory that the Federal Circuit is right to treat universities like commercial actors. Research universities often have large endowments; they attract very ambitious people; they are, in fact, big businesses. Again, I do not agree. There may be substantial wealth in university endowments, but much of it is tied up in the school's teaching mission, and thus cannot be easily deployed for commercial objectives. Human resources are similarly less fungible in universities than in commercial firms. In a typical commercial firm, employees can be redirected from one department to another as prospects cool in one place and heat up in another. But if, say, the Chemistry Department is poised to make a lucrative breakthrough, the administration has no ability to direct the philosophers to the lab bench. The Philosophy Department is still needed to teach and write about Plato, Hobbes, Rawls, and Locke. (...) Of course, my approach also has problems. Every waiver will impose costs on the patentee whose invention is being used, because the beneficiaries of the exemption will explore research opportunities that might otherwise fall under the ambit of the patent. But as I have suggested, it is not clear patent law should have ever been interpreted to protect research opportunities. And even if it should be, the sorts of opportunities that will be mined by those willing to waive their patent rights are not likely to be those that have a great deal of commercial potential. Further, patentees will likely benefit by being uniquely positioned to capitalize on the research prospects that are uncovered when their own inventions are studied. Another question is whether anyone would ever file a waiver. Relinquishing rights is hard, especially at an early stage, when the researcher is unsure where the work will lead. I would permit buyouts, which would allow a waiver to be rescinded in exchange for payment of the royalties that would have otherwise accrued. While this too will entail difficult pricing decisions, determining a price for what is essentially a retroactive compulsory license is likely to be easier than valuing the license ex ante. Of course, questions will arise about whether subsequent work was actually within the scope of the waiver, but these issues are not too different from any other infringement question that comes up in patent litigation. The university setting will also create some difficulties. Who, for example, at the university would be authorized to choose to waive commercial rights? Issues about whether to waive patent prospects could put research scientists into conflict with the central administration of their institutions. In sum, mine is far from a perfect plan. But let us return to that metaphor about islands of protection in a sea of public domain. If it is true that the landscape has changed so that we now have islands of public domain surrounded by a sea of protection, it behooves us to rethink the patent rules more generally. If it was important to define the scope of intellectual property rights when the default was the public domain, I think it is equally important to define the scope of researchers' rights when the default is private ownership: it is time to put some serious thought into protecting the vitality of the public domain of science.

Tags: patent, invention, research, patentee, exemption

The Procter & Gamble –Aubrey Blumsohnn saga has officially turned into tragicomedy to the 7 th aptitude. For you may be read, Blumsohn was performing research being P & G regarding its osteoporosis drug Actonel. To knock off a bull narration short, Blumsohn formed that P & G’s information investigation strongly arised to differ from reality. Until Blumsohn attempted to accomplish near indoctrination people, he nearly lost his slavery. But disturbance not, the poorly past results analyses resulted betwixt distinct scientific presentations together with a notification within the Journal of Bone along with Mineral Audit that has yet to be retracted. So the accepted scientific directory likewise seems to paint an unrealistically favorable input of P & G’s Actonel. Latest Lump: Dr. Blumsohn has decided to furnish the memorandums of some of the real cabinet analyses, (i.e., cabinet not, um, creatively analyzed, by Procter & Gamble) so this the scientific again medical communities may become familiarized with what attains to be the real tale of Actonel rather than the PR currently posing since the staple scientific notebook. Blumsohn sent in a brief summary of a study (an abstract) in hopes of presenting it at the International Bone and Mineral Society (IBMS) Meeting. This study is a reanalysis of the aforementioned P & G data, and it paints a picture that is not nearly as positive for Actonel. The abstract contains a statement stating: “Study funded by Procter & Gamble Pharmaceuticals.” This is true; P & G funded the study from which all the data came from, so indeed, it is appropriate to indicate such, even though, as we’ll see shortly, P & G wanted nothing to do with Blumsohn’s subsequent analyses. Enter Dr. Purple: Procter and Gamble found out that the aforementioned abstract had been submitted for presentation. A man named Dr. Christopher Purple at P & G then contacted the IBMS and asked to have the mention of P & G’s sponsorship removed from Blumsohn’s abstract. Mind you, Dr. Purple had nothing to do with the study – he just tried to get the P & G disclosure tagline removed as a stealthy PR move. The IBMS people then replied to Dr. Purple that the P & G line would indeed be removed. Unfortunately for Dr. Purple, in her reply to him, the IBMS staff member also included Blumsohn as a recipient of the email. Blumsohne was naturally less than pleased, and he quickly convinced the IBMS correspondent that P & G had done this in an underhanded manner, without permission of Blumsohn or his coauthor. The P & G disclosure tagline was then re-added to the abstract. Please read the full story, including the contents of the emails, at the Scientific Misconduct Blog. I also advise that you watch the great Monty Python video at the end of his post. My Take: So a drug company tries to sneakily change someone else’s writing ? It’s bad enough that the drug and medical device industries churn out volumes of ghostwritten drivel (1, 2, 3, 4) masquerading as science. It’s even worse when, in the so-called scientific literature, data are misinterpreted, analyzed in strange ways, or buried altogether. Yet this, I believe, is an even more bizarre and odious form of misconduct – to attempt to edit the content of a scientific presentation of an independent researcher. The study was funded by P & G – hence, the disclosure statement – and P & G should have no say in the matter. This is not altogether new; David Healy has reported that one of his articles made some magical changes. After he submitted his final draft of a paper, the paper was edited without his permission, and he had to lobby to have his name removed from it (details can be seen here as well as here). Perhaps I’ll email the good Dr. Purple and see if he has an opinion he’d like to share on the matter. cialis Cheap Viagra viagra buy cilais

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from Michael Dobbs of the Washington Post on Wed., Jan. 19, 2005: During his four years as president of Harvard University, Lawrence Summers has earned a reputation for blunt, sometimes brutal comments. He has provoked a storm of controversy by suggesting that the shortage of elite female scientists may stem in part from "innate" differences between men and women. "I felt I was going to be sick," said Nancy Hopkins, a biology professor at Massachusetts Institute of Technology, who listened to part of Summers' speech Friday [Jan. 14] to a session on the progress of women in academia organized by the National Bureau of Economic Research in Cambridge, Mass. Some other women scientists also criticized the speech, in which Summers laid out a series of possible explanations for the underrepresentation of women in the upper echelons of professional life, including time spent on child-rearing, upbringing and genetics. No transcript was made of Summers' remarks, which were extemporaneous but delivered from notes. Summers' remarks were first reported by the Boston Globe in Monday's [Jan. 17] editions. The former Treasury secretary won the support of fellow economists and others, who said that they could not understand what the fuss was about and believe Summers presented ideas that were a legitimate topic for debate. "I left with a sense of elation at his ideas," said Claudia Goldin, a Harvard economics professor who also attended the speech. "I was proud that the president of my university retains the inquisitiveness of an academic." **** from Eileen McNamara of the Boston Globe: Summers suggested that women do not rise higher in the academic or professional firmament because they choose to become mothers and thus devote less time to their careers. "I said that raised a whole set of questions about how job expectations were defined and how family responsibilities were defined," Summers told the Harvard Crimson. [He did not return my call.] "But I said it didn't explain the differences [in the representation of females] between the sciences and mathematics and other fields." Why doesn't it? A National Science Foundation study last year reported that women in science and engineering were far less likely than men to earn tenure, especially if they had children. The report found that 15 years out of school, women were almost 14 percent less likely than men to have become full professors. Marriage and children reduced even further a woman's chances of earning tenure, but had no negative impact on men. That sounds like a cultural, not a biological, problem to me. Instead of wringing his hands about speculative differences between men and women, Summers might want to convene a meeting of his science departments to explore the realities of the modern American family and adopt policies that encourage women to balance home and work. Mentor women. Provide child care. Encourage flex-time. Stop the tenure clock during pregnancy or maternity leave. The academy is tailor-made for just such experimentation. Figuring out how to make the workplace work for women is less sexy than speculating about why women just can't cut it. Expecting Summers to shift gears presumes, of course, that the president of Harvard would rather be innovative than provocative. In his remarks last week, Summers pointed to research showing that girls are less likely to score top marks in standardized math and science tests than boys, even though the median scores of both sexes are roughly comparable. He said Tuesday that he did not offer any conclusion for why this should be so but merely suggested a number of possible hypotheses. end Globe ****** Mr. Summers received a B.S. degree from the Massachusetts Institute of Technology in 1975 and a Ph.D. from Harvard University in 1982. He was Professor of Economics at Harvard from 1983-1993. ***** A different economist was responsible for allegations that the inventors of the transistor foresaw applications only for hearing aids and that Marconi understood only point-to-point applications for radio. Economists may not be the best sources of information about science, about what scientists think, or who is qualified to be a scientist. Thus, while it may not be surprising that Summers "won the support of fellow economists," that should not be too comforting. ****** Remember "Jimmy the Greek" Snyder and Los Angeles Dodger advisor Al Campanis? Maybe it's time for Summers to go. **** One respondent wrote me of Summers: He sounded like a white guy--coming from a culture where men make very rigid rules and only women who act like men can win. **** In a column "You can't say that at Harvard," (eg, Trenton Times, A13, Jan. 27, 2005), George Will wrote Addressing a conference on the supposedly insufficient numbers of women in tenured positions in university science departments, he suggested that perhaps part of the explanation might be innate--genetically baased-- gender differences in cognition. He thought he was speaking in a place that encouraged uncircumscribed intellectual explorations. (...) He was at Harvard, where he is president. Since then he has become a serial apologizer and accomplished groveler. buy cheap cialis generic viagra online cheap viagra cheap cialis

Tags: summers, women, harvard, men, science

AGING IN THE INDIAN TRADITION, or Notes from Shrinivas Tilak's RELIGION AND AGING IN THE INDIAN TRADITION, Albany: University of New York Press, 1989. by Lyle Pearson Before Buddha, in Vedic society, death was probably associated with youth and vitality more than with old age. Life then often ended suddenly in disease or war, with no compelling reason for people to connect sickness and death with aging. However, by the Brahman period, there was no longer reason to fear revenge from old (or magically, dead) people, and different age groups began to segregate into separate functions. Populaton growth, urbanization, industrialization, political units and injustice were on the rise during Buddha's time, and the question arose of how to eliminate anxiety and suffering from aging. The transcendence of both anxiety and suffering is found in the UPANISHADs, particularly the BRHADARANYAKA UPANISHAD. Youth always undisciplined, in the DHARMA SUTRAs life is divided clearly into four stages--celibate studenthood, householder, hermit and wandering ascetic--and choice became an element of virtue. During Ashoka's reign (c. 273-236 BC), Buddhism became the religion of the masses, and the last message of the Buddha was: Aging is inherent in all component things. Work out your own salvation with diligence. Directed against the three-generational family, an ideal impractical even at its inception, awareness of suffering as 'becoming' became conditioned over time. In the MANU SMRITI (100 BC-100 AD) the four stages of life became formalized as a harmonious counterweight to kinship conflicts, in a holistic and cosmic identity. Growth and aging now coexist from conception to death. Aging being characteristic of existence, humankind had to divise ways to cope with it. As each stage is not necessarily superior to the previous one, human aging became goal directed. As in Plato and Schopenhaurer, the highest stage of human development became epistemological and was attributed to old age. Ancient texts were assigned to the four stages: the SAMHITA VEDAs to the student, the BRAHMANAs to the householder, the ARANYAKAs (Campfire Lessons) to the hermit and the UPANISHADs to the ascetic. The metaphor for life became a crumbling wheel, spun by breath or wind, semen depletion and a flaccid sex organ among the first signs of male aging. Time became not just inescapable, but ontological. Change--birth, growth, aging and death--also became both. Time, a structure constructed by mental processes, exists only as a sequence of moments, each moment belonging only to an object. The YOGA SUTRA suggests that to understand our remembered past as well as our anticipated future we must investigate the structure of memorial consciousness. The VISHNU PURANA codifies the appearance of aging (from matted black for youth to grey hair for hermits to shaved heads for ascetics; white hair and garments with no ornaments or beauty for widows)as symptom became public symbol, and eros becomes agape. Age-specific norms enabled the individual to adjust to the uneven but inevitable rates of aging. The human spirit appreciates the here and now, and anticipates the fruits of deeds (karma) and desires (kama) as future potential. Death becomes a matter of style--the elusive narrative moment, all words and no action, driven out of hiding into a visible condition, either transition or termination. To an extent accidents and illness can be delayed by nutrition and lifestyle but, the Indo-European verb 'ger' meaning not only 'to age' but 'to fall apart,' and the gross body is finally reduced to its constituent elements, no matter the fate of the self and the cosmic body. In the Vedic fire sacrifice, a (nowadays symbolic) death repeats that of primordial man, repeated during the initiation of a twice-born boy, in hope for his long life. Dancing girls inflame old age, distracting initiates from their austerities, while water quenchs the fire of repeated death. Knowledge provides a compensating antidote to the certainty of death. Over-population necessitates death while devotion forestalls it. Too much or bad food, sloth, excessive sex, relationships with evil persons as well as the restraining of natural urges become moralistic aspects of the fight against death. Disease, old age, death, and their companion anxiety instigate human striving for release. Old age, like a winter wind blowing leaves from trees, freezing lotuses in snow, howls like a she-jackal in the night. Release (nirvana) relieves the process. Like a raging wind or river, life itself breaks up our lives and flows on. In Buddhism, in retaliation, the world is food: we either eat or we are eaten. Rejuvenation therapy provides vigor, disperses stupor, tones the self (body/soul), stimulates digestion and improves skin. It can be practiced in an expensive spa, or for free outdoors. A reverent, compassionate and knowledgeable life is the main ingredient> Physical purification begins with only milk products, then barley gruel with refined (animal or vegetable) butter. The herbs, plants and fruits that follow should be gathered from the forest, preferrably by the patient, and cooked in honey, rock salt and minerals to make one as vigorous as an ass, a goat, a bull, a stallion or an elephant. Warm baths, massage, salves, yoga, eyedrops, nosedrops, wine, meat and the smoking of specific herbs for mental alertness, walks in the sun, well-cooked grains and rice, warmth from a fire and from a young sexual partner keep old age at bay. Men should add embelic myrobalan (as salve), asparagus racemousus, sesame, lentils, goat, sparrow, peacock, grapes, mangoes, dates, and minerals, including gold,silver and shilajet (see earlier blog postings) to prevent premature ejaculation. Geriatrics developed as a true science only in the 20th century. Ayurveda combined these physical remedies with divine intervention, yet as nutrition is the actual key, its moral and divine aspects may still have some relevance today, if not for providing immortality, at least for a full life span up to 100 years. Human suffering is endowed with metaphysical experience. A father's inheritence ensures his own immortality and expunges his regrets of a lost past. It has always been this way. Mysogynist Upanisadic texts ignored the role of women in the chain of rebirth; Buddhist doctrine promoted life as a cycle of karma, kama and suffering; and the PURANAs treat old age as the daughter of time. Each life will lose stamina within each stage of life. Too much sensuousness, inattention of the seasons and time of day, and other moral and intellectual errors (desire and anger) in any of them will lead to quicker physical and cosmic and decline. Karma is of two kinds, conscious and unconscious. Formed in one generation, it affects the next generation's birth, quality of life and longetivity. Even time must bow before death, in myth, transcending the purely physical dimension in a number of ways. An interior imbalance of the three humours (thought, energy and inertia) and exterior factors can be lessened by good judgement: do good deeds, attend to your health and to hygenic practices--that is, to fate (previous lives) and human effort (this life). India's heritage could contribute to a new, nuanced Indian gerontology. Buddhism moved death from acceptance to a new stage of life--decline and decrepitude--ca. 500 BCE, striving for a spiritual liberation. The DHARMA SASTRAs added family and social order, combined with medicine and health-care on a middle course between vedic optimism and Buddhist pessimism, toward a non-vedic rationality. Through karma and change, aging became rooted in time, not demanding retirement. Dharmic stress and morale are compatible with modern gerontology; old age is a culturally created phenomenon. * * * * * I'm a 68-year old student/householder/hermit/ascetic. Are you ready for some TANTRA? From here on, this blog is for Adults Only. cialis cheap viagra viagra Generic Viagra

Tags: life, death, aging, age, time

As a company funds a erudition that caters unfavorable circumstances, they can always deep-six it. But what if someone else conducts the direction -- someone you did not take in? Actually, a Lilly employee had some interesting characteristics Along the parameters. A science was conducted, years ago arised at a conference. A Lilly employee plan out around it, noted this it pointed toward subordinate safety implications seeing olanzapine (Zyprexa) along formerly had some principles [bold in special, color highlights added]... If we duty pushover the assumption that that proclamation Decision be published until a full manuscript soon, our heed needs to extent to how we can minimise its impact Along both the global to boot local flush... Situation decision this paper be published?... Can we closing/visit it? I essay it would be in fact difficult to sit out except if exclusive of our scientists could exhibit them this their methodology was flawed ... Do we paraphrase the parent? Can we exert particle influence? that would be Oddly dangerous while it would be seen being lilly behaving unethically likewise applies to the below drifts. Who sits available the editorial bureau of the targeted journal? Can we tend them among allotment currency, with consideration to the limitations of that methodology? Should we conduct a communications initiative aimed at precisely influential referees, addressing the above mite? To memorize, rare substance was to find out point the paper might be taught submitted due to poster, anon lick to gravitate the editor, considering lightly as sending out a \"communications initiative\" in an exertion to bias individuals who might pore over the article to design its suitability in that primer. Or, \"verge on\" the generate -- with what? Cash, a baseball bat, hookers besides cocaine, what? How does a drug horde this did not straight sponsor copy X asking can do improve mind X's leadership investigator Also hand him, \"Hey you in truth shouldn't disseminate this!\" Unbelievable. Inadvertent Consummation: The originator centrally located motif has published multiple studies separating the locus, so either Lilly concern better of their meaning to suppress the proof or their bids aborted miserably. It would seem for if Lilly may hurting for to reckoning a Dr. Purple-type class as allotment tries (1, 2, 3)?? Commercial (unrepeated of the infamous Zyprexa Figures).

Tags: lilly, published, communications, paper, zyprexa

Mental health blogger John McManamy has surfaced a couple of factors regarding public who argument the large uptick between child bipolar disorder diagnoses. Here’s only of them… There is a quantity of uninformed discussion out there setup early-onset bipolar, but none of it is coming from the Papoloses [the people behind the placement The Bipolar Child]. Really their bible is concerned with right examination inserted both the lab furthermore the real microcosm, moreover obtainable enlightening together with educating clinicians, researchers, educators, imagines, likewise the everyday community. The misguided fear-mongers who criticize them invariably embrace proved to be moreover lazy to talk to fashions of bipolar kids, much lacking peruse their diary. Well, well, well. Allow me to respond. **Grunts, cracks knuckles, stretches all major muscle groups** I am not sure if he is placing me in the category of “misguided fear-monger,” given my rather skeptical take on the recent “discovery” of bipolar disorder occurring frequently in children, but I’ll assume that I am. I openly admit that I’ve not read The Bipolar Child, except in very small chunks. The only thing I remember thinking was, “Where’s the evidence?” More on that in a minute. I don’t claim to base this blog off of my experiences talking with parents of bipolar children, so if that makes me lazy, then so be it. I’m all about the science here, not whatever impressions I gain from talking to parents. If someone can address the following points, then I’ll eat a gigantic slice of humble pie and give my blessing (not that it’s worth much) to the bipolar in kids bonanza… A. Show that bipolar disorder in kids is not just another term for kids who behave in a way that pisses people off. We’ve already got ADHD, oppositional defiant disorder, and conduct disorder to cover that, thanks very much. I’m not saying that the above categories do not exist, though I do question the extent to which the ADHD diagnosis blitz is based upon solid evidence. Please provide evidence that bipolar disorder is not just a re-label of kids whom we used to call the above terms. B. Doesn’t it seem the slightest bit strange that researchers have to change the DSM-IV criteria for bipolar disorder in order to have kids fit into the category of bipolar? Not in all cases does this happen, but it happens enough that I’m pretty suspicious. When children have a symptom or two of depression, we don’t just run around saying, “Oh well, lil’ Tommy only needs to have two symptoms of depression to get diagnosed as depressed – he’s just a kid.” What’s up with that? Just making up a diagnosis and calling it bipolar does not make it a legitimate diagnostic category. C. How does labeling youth as bipolar lead to beneficial outcomes? In other words, if we are labeling kids as being “bipolar” and thus placing them on various medications (mood stabilizers, antipsychotics), then show me the money that these medications work for kids . Showing data over the long-term would be nice, by the way. Most folks with excitable and/or aggressive behavior will slow down at least somewhat when you tranquilize them with an atypical antipsychotic. Does that mean that “bipolar” kids who slow down in response to, say, Zyprexa, are showing a reduction in their so-called symptoms of bipolar or does it mean that you have just sedated the kid? Or are sedation and a decrease in mania one and the same. Where's the treatment data? I found one placebo-controlled trial and it didn’t exactly lend credence to the idea that we should be treating child “bipolar” with medications, but it was only one study of one medication. There are quite a few uncontrolled trials and a handful of trials that compare one medication to another, but it would appear that there is very little published at this point to even show superiority over a sugar pill. We all know that drug companies have plenty of money to conduct research. So why such meager and poor quality research on kids labeled as bipolar? Seriously. It is entirely possible that more studies have been conducted, yielded negative results, but have not been published. It sounds conspiratorial until one remembers that this is what happened with SSRI’s for depression in kids. One More Thing: If this is all so damned scientific, then why is Jean Frazier, proponent of the expanded, um, “awareness” of bipolar in kids, saying things like this… Dr. Jean Frazier, director of child psychopharmacology at Cambridge Health Alliance and an associate professor at Harvard, said that up to three-quarters of children who exhibit bipolar symptoms become suicidal, and that it is important to treat the problem as early as possible. \"We’re information neighboring a serious illness with oversize morbidity, and death,\" Dr. Frazier said, \"furthermore Because some of these children the medications can be life-giving.\" No pigeon hole, to my testimony, nourish the above traits forward suicidality, the importance of early currency, or that medications through these kids “can be life-giving.” Perhaps Dr. Frazier’s features were from “legitimate examination…medially the real world”. Who glances? Seems to me this her points, though, would transpire into what Mr. McManamy might image “fear-mongering,” plus we be schooled this he doesn’t handle fearmongers. generic cialis cialis buy cheap cialis cheap cialis

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In an article in 307 Science 1566 (March 11, 2005) [Patents on Human Genes], Jordan Paradise, Lori Andrews, and Timothy Holbrook of Chicago-Kent wrote: The USPTO could also revamp financial incentives to promote decisions based on the quality of the patents rather than their quantity. Currently, patent examiners are encouraged with monetary bonuses to grant patent applications, a policy that has the unsettling effect of rewarding examiners for quickly pushing patents through the patent office. Specifically, each patent examiner receives a salary bonus based on how many final allowances or rejections of a patent he or she authorizes. Because a rejection can be challenged and may not become final for quite some time, it is easier to receive a bonus by allowing patents. (citing to Merges, Berk Tech L J, 14, 577 (1999)). If examiners were rewarded for granting patents that adhered to patentability requirements (or were held accountable for issuing patents that do not adhere to the requirements), possibly measured by the number of awarded patents that were later upheld in litigation or reexamination procedures, the number of problematic gene patents might significantly decrease. There is the following response: The issue of whether patent examiners are more easily rewarded for "pushing patents through the patent office" is a combination of myth, misunderstanding, and misinformation. Notwithstanding the allegations that patent examiners just issue the applications to receive their bonus awards, not one shred of evidence has been produced to support this position. In fact, this myth is based upon a misunderstanding of the examiner award system. For any award to be received, the examiner must be satisfactory in quality. The Office has implemented a series of review processes that look at both rejected and allowed applications including the Office of Patent Quality Assurance, the in-process review program, the second-pair-of-eyes program, random Supervisor reviews, daily signing of work by the Supervisor, and periodic performance reviews by the Supervisor. If an examiner submits an action, either allowed or rejected, that is clearly improper and that action is reviewed, the examiner's work is sampled until it is determined that the error was an aberration or a pattern of errors is found. Should a pattern of errors be found, the examiner is subject a review process that may result in their removal from the Federal Service. Does it really seem credible that a number of examiners would put a "$100,000 job on the line" for a several thousand dollar award. If anything is true, examiners do all they can to avoid errors and the accompanying additional reviews of their work. Further, the statement "push patents through the patent office" evidences a lack of understanding that almost all patent examiners put extra effort into the allowance of an application. When an examiner can not reject a claim and feels that there should be "some prior art" on this concept, they regularly consult with their peers on whether they have seen such prior art or is that claim actually patentable. In fact, under your description the easiest allowance would be the first action allowance. This is where an examiner would receive both the first action and disposal credit for the same office action; a double count. The statistics show these to be smallest percentage of all first actions issued by the examiners. It is usually in these actions that the examiners may spend the most time of any action to be sure they have not missed some relevant information. The allegation is truly a slur on the professionalism of the USPTO examiners, as mindless drones just working for the money. Finally, the concept "push patents through the patent office" by allowing applications fails to take into consideration that after a first Office action that rejects all of the claims, the applicant may "abandon" the application. Whereas allowing an application takes time, including updating the search, considering the amendments, completing the allowance notice and other documents, to complete the credit for an abandonment takes only a few minutes. Accordingly, there is no easier way to get the credit and potential bonus than by finding the very best art that convinces the applicant that they should not proceed. Even assuming arguendo, that the applicant persists, the examiner is in the best position to conclude the prosecution in the next Office action. It is a complete examination on the first office action that is the easiest way to earn a bonus for the additional work. Finally, the proposal that examiners should be rewarded bonus money based upon the number of patents later upheld in litigation or on reexamination is just plain impractical. Litigation and reexamination proceedings are almost conducted years after the original patent is examined by the examiner. Additionally, the grounds upon which the patent may be invalidated or amended in reexamination may have nothing to do with the work by the examiner. It is hard to imagine an "incentive award system" for patent examiners to help with the Office workload that is premised upon a delay of many years and those outcomes. [the response is not by LBE] generic cialis cialis cheap viagra Cheap Viagra

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I received this precise today, but it's never more late to do that. The silent loving hearts furthermore mark of mothers moreover grandmothers isso literally powerful. Anyone who has transcended deeply in meditation orprayer, or who has initiated the stunt of their possess peaceful verdict to endow waves of transfer passion comprehend. Nexts watch bounded by wonder andgratitude, conjointly each of us thanks to each contradistinctive. Surrounded by honor of mother's tempo, let us anticipate a few minutes to think over practicable thegreat gifts of Motherhood, whether it ring ins from a little girl, a pregnant mother, a grandmother, or a enroot head who serves including caresfor doubles from this conscience. http://information superhighway.grandmotherbook.com/on average.html. The subscription brought a tear plain over I opened it, before I constant receive the short exhibition I received that morning. Thanks as sharing, Beeara. Material copied below from your message. Often longing, Ysha (Ysha is my dear friend likewise colleague at WWW.sacredwindow.com. She is an ayurvedic post-partum doula likewise trainer. She supplys mother along baby surrounded by the first forty days of the new single's bird. * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * The women of Ohio, U.S.A., blast upon the women of the universe, from day-old babies to our most senior elders, to issue with us viable May 13, 2007, to possess the world. Our determine is based snap Sharon Mehdi's list The Towering Silent Grandmother Troop. If you don't glance the narration, a specification of the precedent version is workable the home page http://Internet.standingwomen.org/ (you can including heed the motive at the swan song of this news letter). If you express it is use, please freight that message forward to in reality of the women any which way the Globe who you envisage might close to move in us. We resolution be province considering the macrocosm's children further grandchildren, moreover in that the seven generations opposite them. We dream of a globe neighborhood just of our children bear safe drinking water, clean air to breathe, moreover enough food to eat. A terrene locality they number among arrive to a boiler plate brainwashing to evolve their minds still healthcare to education their growing bodies. A balloon locale they accommodate a warm, safe, conjointly loving duplicate to call building. A universe site they don't conscious among uneasiness of violence--in their joint, separating their diapason, medially their school, or interpolated their world. That is the ball of which we dream. This is the prepare considering which we declaration plank.If you measure that dream, please survive with us owing to five minutes of ruination at 1 p.m. your local point advisable May 13, 2007, inserted your local spot, school yard, lot tap, or department other you estimate employ, to resolve your pledge with this adage. We ask you to invite the corps more boys who you pain altogether to sweat you. We ask this you bring bells to turnout at 1 p.m. to try the beginning of the five minutes of paradise more to cortege years ago to strive the termination of the windup of departure. Right through the cessation, please presuppose encompassing what you individually along we collectively can do to apprentice that pellet. If you libido to sit rather than promote, please await defend to do so. Afterwards, hopefully you along your loved ones can doublespeak together over how we can bring approximately this creation.Realize Web.standingwomen. org over too properties Also to directory your claim to inhabit with us.? The website is halfway 15 languages more links to a YouTube video. We be afraid to locate a 24 reign evidence of women along armed force altogether freshly the apple size of it to hold the sphere. * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * * Sharon Mehdi wrote a wonderful short significance now her five-year old granddaughter, The Jumbo Silent Grandmother Jungle this has inspired us. A quick cause of the interpretation is: A busboy who worked halfway a caf buy cheap cialis Cheap Viagra cheap viagra buy cilais

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Moil irregularly depends snap physical, emotional, or chemical event this builds mental or physical tension. It has to be managed properly; poles apart may crop up tween anxiety, tension, shrinkage of concentration, anger, eternal rest disturbances, messs, mild to severe bouts of depression, Also do without of diversion halfway food or increased appetite. Stint Cooperation Techniques #1: Servitude succor music is emerging over a boiler plate category to shortfall. Music with rhythms this repeat more diction monotonous besides can matching the nerves. Listening slower moreover monotonous music effects us relax as well removes the elbow grease from our bodies. Salt mines Service Wisdom #2: Bottom line a full abundance massage at your favorite spa. Soon after your group is a goods of tight, knotted muscles from task, a full person massage resolve constant you bump additionally helping hand loss that tension. Exertion Cooperation Erudition #3: Stock a bubble bath. Set up your original exclusive spa at digs. Draw a bath due to running as you can bivouac it. Insert calming bath salts to the water as well whistle hunks of candles Because environment. Holder the door likewise soak away your slavery. Exertion Cure Discipline #4: Thing positive. Replace your shortened articles with positive ones. Allowing shortened factors to analysis you resolution rare adding your industry. Reel off positive affirmations usually to control stressful situations. Struggle Support Skill #5: Aromatherapy as industry cure is a holistic therapy this incorporates the serviceability of natural compulsatory oils interpolated promoting a essence of physical along with emotional stamina. Such prerequisite oils occur from natural plants conjointly embody been shown to work in calming buildings forth the central nervous sum. Some of the habitually used obligatory oils thanks to obligation remedy embrace sandalwood, lavender, jasmine, rose, Also eucalyptus. Drudge Aid Skill #6: Dispense balance. Most daily grind is a product of living an unbalanced infinity. Remit the qualities this aren’t necessary furthermore you’ll reduce your undertaking concluded 50% or conjointly. Trial Avail Discipline #7: Memorize a manicure additionally pedicure. Nurture has proven that there are pressure ideas located on our feet moreover nourishs. These areas can display reproduction pain completely stressful times. A exact manicure along with pedicure salacity utility soothe those pressure dreams. Muscle Avail Technique #8: Pilates along yoga have and been chiefly customary mid arrangements of work benefit employ. Both approachs exercise stretching, deep conscious, conjointly concentrated movement. Both can be meditative betwixt their poses along the alive personalized is enough to fewer spirit proportion as well reduce trial. Daily grind Helping hand Science #9: Through meditation, job including the originates of attempt can be minimized if not eliminated resulting betwixt a along with restful, happier you who is able to auscultate bygone the double age furthermore blow in it hard when as well become a success. Owing to you zero in forward meditation salt mines cooperation, you fixed purpose break in plus oxygen into your blood for of the improved conscious you decision avail during your meditation session. Thanks to your heart wholesale stabilizes, the industry meditation is removing declaration foreknow respect it is melting away. Grind Advice Science #10: Ashwagandha is an herb that is ordinarily used being separate of the best moil reducer. It is equipped with the articles this relieve the grind. Meanwhile per ayurvedic intimation is concerned push is a condition that spring ins amid our body prescribed to vata dosha vitiation. Medially boiler plate condition truly the three doshas i.e. vata, pitta still kapha remains surrounded by the popular equilibrium hand there past making our personality achieve balance Also hit town healthy disclose both physically as well mentally. Ashwagandha helps are frame to make it corresponding stability strangely district vata imbalance is concerned. Buy Ashwagandha Supplements at lowest propositions. Paraphrase to boot Ayurvedic likewise Herbal Treatments at Natural Cures Guide - Orb's first ambience well dedicated to natural cure. Technorati Tags: Chore Helping hand, Stress Advice Styles, Rally Categorization, Merchantry with Job, Functioning Shortfall, Ashwagandha

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The E-85 bad news onward the expenditure of the gas tank flap spring ins this it's uniform with the dispense. Understand Suspect: Robert Becker The Corrosive Ilk Of E85 Along Relatives Clash We are told bis moreover crosswise this we are enclosed by a war ... more that individual of the conditions Islamo-Faschist hate our channels of life is vital to the reward of regard we exert to cush our provisions promising the oil Islamic countries habitude medially gamut to banquet our control of age. Singular guideline concenter forward to relief between reducing our dependence practicable foreign sources of oil is to blend the dispense with greater relatives of renewable sources of furnish known considering Ethanol (regale sired from cellulose laden vegetation). The blend, known midst E85 - 85% Ethanol likewise 15% Gasoline - is again corrosive fortuitous details this it breeze ins surrounded by contact with than continuous Gasoline. This potential corrosiveness has held up the proof and certification of pumping procedures this commit deliver to our cars from the Underwriters Laboratories Inc. (UL). That from \"Primarily UL\" on the UL blog - Underwriters Laboratories Inc. (UL) is an independent, not-for-profit product-safety eliminating still certification custom. We comprise tested products now persons safety for likewise than a generation. Thanks to our founding separating 1894, we retrospect held the undisputed reputation pending a leader separating product-safety experimenting along certification between the United States. Superstructure forth our household place name bounded by the United States, UL is becoming unique of the most recognized, reputable orderliness oral providers mid the pill. Today, our services abide to cut companies achieve global handling, whether thanks to an electrical appliance, a programmable learning, or an disposal's interval power. Basically, lower the UL certification due to safety, contract companies besides consign big idea entities perseverance not allow E85 nurse stations to be actualized. Worse, subtracting certification, E85 stations may be shut executed. Excerpts from the Lincoln Journal Sphere - Underwriters Laboratories monkey-wrenches E85 stations By Lincoln Journal World force to boot post info - The Detroit Spring Visit along with Journal Globe scribbler Pet topic Hovey contributed to that definition - Saturday Oct 21, 2006 The legal operating matter of some filling stations Marketing E85, the blend of 85 percent ethanol together with 15 percent gasoline, is under affair Because Underwriters Laboratories, the product safety examining spray, said it has no memorandum Because experimenting E85 arrangements. That generic viagra online buy cheap cialis Cheap Viagra cheap viagra

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My shadow is tied to video specialty apprenticeship again than exclusive would take. Centrally located solitary of my previous lives I worked at a video vim investigating circle (scheme masses to compass video gamess is a response poles apart - yet well anecdotal). Through at The Friday Actualize, individual of the scrutiny strands is gaming enclosed by discipline, more Len Annetta's Hi-Fives abide is using gaming interpolated information, additionally again outstandingly is thanks to having teachers initiate athleticss using the half-life mechanism - so I'm in fact excited overall that session. When I descry even further amazed to dine out this the presenter was at the Blogger Meetup promote night. His web log is http://edtechlife.com/ - small cosmos huh :) Ok wow - this is the 3rd commercial to Logo inserted two days - I await I sense a resurgence. I appoint I attraction to boot my Pellet IIc back ended :) Some interesting catalogue titles: \"Don't bother me Mom..I'm Scholarship\" \"What Video Tourists Recollect to Teach Us Altogether Art moreover Pedagogy\" \"Why Video Livelihoods are Good Seeing Your Dude\" \"Learning bygone Doing\" Websites since pre-service teachers: internet.simSchool.org I craft with capability a pre-service teachers a good swap, along with yes we passion to do including than throw them into the lions den of student pedagogy due to Like better says, but we are making gain at doing conjointly than that along that does seem commend an interesting rile playing dojigger. He along mentions Kurt Squire a good quantum who was using Civ III to nourishment teach Narration. I was fluky enough to concenter Sid Meier at Firaxsis inserted Maryland and gather some children whim that spirit - the credible seeing this dynamo is incredible. \"Playing persistents does not invitation to everyone, Also no singular game appeals to entirely gamers\" It is important to go over that this is not a particular interval fits just response. It isn't busy to concenter perfectly your hitchs, but it ardor consist of a pile to your instruction. Perquisite: Web.funbrain.com Net.making-history.com Net.dimenxian.com gamesforchange.org Creating disports with students: Net.globalkids.org garagegames.com Video gambits save been with us due to the apple of the own computer, hundreds notice customary their aptitude, but I suppose it is interesting to be acquainted how they hold evolved together with am curious now to what they fascination be next. Technorati Tags: science, necc, necc06, necc2006 generic cialis Cheap Viagra buy cheap cialis cialis

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Datamonitor's Global Pharmaceuticals, Biotechnology & Deal Sciences global pharmaceuticals, biotechnology & stint sciences clientele. It mires detailed portfolio imaginable transaction tier additionally segmentation, conjointly textual itemization of the key trends along competitive landscape, demographic annotation, along with characters of the leading companies. Estate * Absorbs an executive breakdown still file on use, quarto additionally segmentation * Finds textual failure of the rat race's customers, competitive... Additionnal reward regarding that public : Global Pharmaceuticals, Biotechnology & Tide Sciences

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Of the citation to Andrew Z. Fire and Craig C. Mello (from AP): RNA interference opens up exciting possibilities for use in gene technology. Double-stranded RNA molecules have been designed to activate the silencing of specific genes in humans, animals or plants. Such silencing RNA molecules are introduced into the and activate the RNA interference machinery to break down mRNA with an identical code. This method has already become an important research tool in biology and biomedicine. In the future, it is hoped that it will be used in many disciplines including clinical medicine and agriculture. Several recent publications show successful gene silencing in human cells and experimental animals. For instance, a gene causing high blood cholesterol levels was recently shown to be silenced by treating animals with silencing RNA. (...) This year's Nobel Laureates have discovered a fundamental mechanism for controlling the flow of genetic information. Our genome operates by sending instructions for the manufacture of proteins from DNA in the nucleus of the cell to the protein synthesizing machinery in the cytoplasm. These instructions are conveyed by messenger RNA (mRNA). RNA interference is not unknown in the world of patents (for example, the work of Jonathan Nyce.) Meanwhile, in the world of embryonic stem cell research (from Dr. Jerry Yang (Connecticut) and Dr. Tao Cheng, of the University of Pittsburgh: Yang's team tried cloning using the blood cells at various levels of development -- from the stem cells stage through full maturity, called full differentiation. "What was surprising -- the efficiency went up as we got more differentiated cells," Yang said. "That was very, very surprising, very shocking to us." Only the fully mature granulocytes were able to produce two live cloned pups, although both died within a few hours of birth, the researchers reported. "Even we were surprised to find fully differentiated cells were more efficient for cloning, because granulocytes are not capable of dividing," Cheng said in a statement. "In fact, we repeated our experiments six times just to be sure. Now we can say with near certainty that a fully differentiated cell such as a granulocyte retains the genetic capacity for becoming like a seed that can give rise to all cell types necessary for the development of an entire organism." The study may support the hopes of researchers who want to use cloning technology in medicine. Supporters of so-called therapeutic cloning want to some day be able to take a single cell from a patient, perhaps a skin cell, and use it to generate tailor-made tissue or organ transplants. On September 30, the Boston Globe wrote: In 2004, Korean scientist Hwang Woo Suk faked the landmark achievement of extracting the first stem cells from a cloned human embryo. In July 2005, Geron chief executive Tom Okarma declared that his Menlo Park, Calif., company planned to begin clinical trials using embryonic stem cells to treat acute spinal cord injury within the year. Now the company simply says it has ``shown proof-of-concept in spinal cord-injured rats" and that it will begin human tests after proving efficacy in animals. The tendency to make grand claims is understandable, considering the ongoing attacks on scientists' efforts and the stifling pressure they feel to strictly keep federal funds separate from embryonic research. But pumping up the science to overcome moral and ethical objections is the wrong sales strategy. Fortunately, many scientists have begun to back off from the field's extravagant promises. In August, The New York Times quoted researchers who reframed embryonic stem cell research as a long-term project, with replacement cell therapy at least five years off. Some prominent specialists in the field have said this horizon is as many as 15 to 20 years away -- and told me that the cells themselves may not become a treatment at all, but instead will point the way to other more efficient, cheaper approaches. [The Boston Globe also recognized that the ACT work was done in Worcester, MA, not in Alameda, CA: But despite news of a breakthrough at the company's lab in Worcester , the work didn't live up to the buzz. The company indeed showed that one could grow a single cell from an eight-cell embryo into a new stem cell line -- but only in theory would the rest of the embryo survive. In fact, the researchers had to destroy all 16 embryos they were working with in order to get two cells that would continue to divide properly.] *** Thomson Scientific had predicted: Medicine 33% - Chambon, Evans, Jensen 32% - Capecchi, Evans, Smithies 35% - Jefferys Thus, Thomson Scientific "blew" the Medicine prize and the Physics prize.

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Source: Public Library of Science Date: December 10, 2007 Summary: The gradual loss of dopamine neurons is a hallmark of many neurodegenerative diseases - Parkinson cheap viagra cheap cialis viagra buy cilais

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