New legislation on drug/patent interface, wild card patent extensions?
Posted on August 16, 2008 in Generic prescription drugs
Imagine the impact of wild card patent extensions in the Hatch-Waxman area. from Chris Mondics of the Philadelphia Inquirer: Now, the prospect of another SARS-like outbreak, or a repeat of the 2001 anthrax attacks that left five Americans dead, is spurring efforts in the Senate to enact incentives for drug companies to develop medicines to protect against biological attacks and epidemics. Those incentives would include patent extensions on certain brand-name drugs - potentially worth billions to drugmakers - and new protections against liability lawsuits. Sen. Judd Gregg (R., N.H.), Senate Majority Leader Bill Frist of Tennessee, and Sen. Rick Santorum (R., Pa.), all key Senate players, are sponsoring one bill. In the coming weeks, Sens. Joe Lieberman (D., Conn.), the former vice presidential candidate, and Orrin G. Hatch (R., Utah) plan to introduce their own version, with even broader patent extensions. The useful patent life on a medicine is about 10 years. Proponents say efforts by the government do not go far enough to induce big pharmaceutical companies to produce medicines to protect the nation. "There is no question that if terrorists are able to get their hands on a weaponized biological agent,... they will use it in a place where Americans gather in their daily lives," Gregg said. "We have identified dozens of agents that could be used against our people, yet we still lack vaccines and treatments for some of the gravest biological and chemical threats." Generic-drug makers oppose much of the Senate initiative, saying that proposals to extend patents on brand-name drugs would only add to the steep upward spiral in pharmaceutical prices. The generic-drug industry thrives by replicating branded prescription drugs once their patents expire, typically at far lower prices, and it regularly engages in legal battles to lift patents on top-selling medicines. "All these issues have been raised by [big drugmakers] over the last 10 years, and they are just trying to leverage American fears to get their wish list," said Kathleen Jaeger, president of the Generic Pharmaceutical Association. "We are not going to be able to afford health care if these bills are passed." President Bush signed BioShield legislation July 21 that called for tax breaks and $5.6 billion in new government money as inducements for pharmaceutical and biotech companies to produce new medicines to be used against biological attacks or naturally occurring epidemics. Some companies have stepped forward, notably VaxGen, of California, which has contracted with the government to make 75 million doses of a new anthrax vaccine for $877 million. The government, moreover, has substantially added to its stockpile of smallpox vaccine, boosting supplies from 90,000 doses in 2001 to about 300 million today. (...) Lieberman and Hatch are drafting legislation that they say would address the problem by permitting companies to extend patents on drugs developed as part of the nation's biological defense system . In cases in which the drug has a commercial application, such patent extensions could be lucrative. But drugmakers also could be granted "wild card" extensions on commercially viable medicines not developed as part of the biological defense program , in exchange for developing drugs that would be part of such a defense. Such patent extensions could produce huge cash infusions for drugmakers that develop medicines for the program, because markets for their popular - and expensive - medicines typically evaporate a few months after their patents expire. That is when generic-drug makers market less expensive copies.
Tags: patent, drug, medicine, extensions, biological
The dioxygenase-catalysed formation of vicinal cis-diols
Posted on July 28, 2008 in Diabetes erectile dysfunction
This is an model of the vitality of an epoxide horde reacting with water Also further enzyme (epoxide hydrolase) to begin a vicinal diol. The paper displays experiments with specific contradistinctive compounds conjointly the role of mono- plus di-oxygenase enzymes amidst arene metabolism. The paper additionally displays a breed of intermediary or following pathways the the substrates can anticipate to imagine only, but useful products. The primary focus is Along the impressive skill of bacterial oxygenases to catalyse the cisdihydroxylation of a unrelated tier of arenes additionally alkenes to take a several enantiomer. Full Motif or CiteULink Pointing out
Tags: diol, enzyme, paper, displays, additionally
Life as a Technician
Posted on July 27, 2008 in Erectile dysfunction drugs
So, I have transitioned from cramming lectures, textbooks, notes like a bookworm to working full-time in a Walgreens retail pharmacy. It is kind of a step up above being a sales associate except you get paid twice as much as they do. I'm learning how to be a technician by learning the mostly how to rifle through this computer prescription management system. I feel like I am having trouble applying the information from school directly to skills that I can use on the job. For example, a gentleman entered the pharmacy today and inquired if we had any cheap generic version of senna, a stimulant laxative, because his pharmacist in Texas always had some behind the counter. Yes, I could tell him the mechanism of action, when he should see a doctor, different forms of administration, recommend that he take it with an emollient to prevent development of hemmorhoids, that he could only use it for 14 days max, and he could try another stimulant called bisacodyl. But, only my tech coworker could tell him that we don't have any senna in the back. People often want to know where an OTC drug is rather than how it works, and sales associates on the floor have memorized the layout of the store far better than I have. Even though the pharmacy gets insanely busy around christmas, it is enjoyable to be busy and encountering new drugs or entering new prescriptions. Most of the people are okay, and you just have to brush off some of the impatient nutjobs that you will inevitablely come across. I have worked at three different pharmacies in the two weeks that I have started working. My managers are all really nice. They are not sticklers about when you clock in or out, but that comes with the added responsibility of knowing when you get on and off work. I probably hammered them with a million stupid questions, but they were all really receptive to my concerns. For example, I was clueless when a patient asked for a generic 1.0 mL medium insulin syringes. I now know to look for the walgreens 1.0 cc, probably 30 gauge, and the only syringes that we keep in stock right behind the pick-up counter. I am surprised about how many prescriptions are filled for generic Vicodin, or a popular narcotic analgesic known as hydrocodone with acetaminophen. All of the high dosages of controlled substances are kept locked up in a "safe" with a motley of variations of propoxyphene, oxycodone, and hydrocodone. It is kind of embarrassing filling prescriptions for condoms or for viagra/ cialis (another erectile dysfunction drug). I can't believe they would shell out 30 bucks for like 2 viagra tablets. I guess it can be worth it...
Tags: prescription, drug, pharmacy, generic, senna
Trudeau the Fraud
Posted on July 09, 2008 in Diabetes erectile dysfunction
Those of you who watched late night TV in the late 90's, as I regularly did, may remember Kevin "Mega Memory" Trudeau. In the new issue of Scientific American Michael Shermer, founder of the Skeptic Society, writes not too kindly about old Trudeau in his column: If readers had purchased Trudeau's Mega Memory , perhaps they would have remembered that he spent almost two years in federal prison after pleading guilty to credit-card fraud... Trudeau has now turned his attention to medicine by self- publishing and flogging off his new book, Natural Cures "They" Don't Want You to Know About. Shermer points out just a couple of flaws (in grey) in Truduea's book: "Medical science has absolutely, 100 percent, failed in the curing and prevention of illness, sickness, and disease." (Smallpox is not a disease?) "Sun block has been shown to cause cancer." (References?) "Don't drink tap water." (Wrong: studies show it is as safe as bottled water.) "Animals in the wild virtually never get sick." (No need to worry about avian influenza.) "Stop taking nonprescription and prescription drugs." (Including insulin for diabetes?) "This includes vaccines." (Welcome back, polio.) Ah, good old natural medicine. I'm sure there are some natural remedies out there that work (better than a placebo). But natural medicines don't go through the very rigorous testing methods that regular drugs have to pass in developed countries. As such, charlatans like Trudeau can legally peddle any old snake-oil. Alas, I wish there was a cure for clowns like Trudeau. Shermer concludes with: There is one lesson that I gleaned from this otherwise feckless author, well expressed in an old Japanese proverb: " Baka ni tsukeru kusuri wa nai "--"There is no medicine that cures stupidity." Domo arigato , Mr. Trudeau.
Fast Rollout of Shingles Vaccine
Posted on July 06, 2008 in Antibiotic
Amidst repsonse to an article in MedPage Today, May 30, 2006 Fast Rollout of Shingles Vaccine Planned After FDA's OK The FDA catechism of Merck's shingles vaccine (Zostavax) to counteract the plot of incubus management of Merck's chicken pox vaccine craze service Merck redeem financially from the un of Vioxx revenues. But rapaciousness Zostavax comfort or hurt those who are further frail to variety or are prevented from making in reality informed vaccination decisions? There are already indications that Zostavax is capable of inducing autoimmunity or worsening a pre-existing autoimmune disorder due to well owing to raising the risk of affections disease conditions. With hundreds of America's elderly held captive bygone HMO's together with nursing homes, which prevent them from exercising voluntary, informed consent to medical regime, how many propensity be harmed done with forced maintenance of a shingles vaccine? Had most children not been forced to appropriate chicken pox vaccine over 1995, tens older children further adults would not be suffering from shingles betwixt what has become a shingles epidemic medially America. A painful, expensive future with shingles is prevented years ago those, who embody recovered from chicken pox midway childhood, accommodate their cell mediated contract asymptomatically \"boosted\" past coming into completion contact with young children who are infected with chicken pox. Due to 99.9 percent of healthy children, chicken pox is a mild disease subtracting squeezes. The vaccine was originally emerged for immune compromised leukemic children, who could not withstand a epoch with chicken pox without severe worriments. Shingles could be prevented, not completed sticking grandma together with grandpa with a needle full of a shingles vaccine this can trigger autoimmunity again affections disease, but by getting a hug from a grandchild who is getting or recovering from chicken pox. But the elderly enclosed by America can't do this anymore. There is no chicken pox all through. Demanded shingles moreover needles filled with Zostavax.
Expert Calls for Health Workers to Get Flu Shots
Posted on July 05, 2008 in Antibiotic
Centrally located ball game to an article between the St. Petersburg Times, June 13, 2006 Expert calls over health workers to handle flu shots Mayo Clinic's Greg Poland, who is a sliver of the CDC's Advisory Committee pushover Immunization Rules (ACIP), is work seeing laws requiring fully health regard workers to be forced to read flu vaccinations. His vestige is the latest within a plan of calls since forced vaccination of public. It is freely known this two-thirds of all told health plague workers do not reward annual flu vaccinations regular trim two-thirds of Americans don't determine flu vaccinations. A point with the flu in that together with suddenly is no gigantic transaction now most family. Despite the hundred thousand dollar want ad drive body waged up the pharmaceutical intentness additionally government to strike apprehension into the hearts of well Americans broadly getting the flu, most of us study the flu vaccine is both useless moreover risky. Anon the CDC tried to hard sell health misery workers who would be \"first responders\" inserted a bioterrorism warfare to memorize smallpox vaccinations post-September 11, 2001, the health care workers of America \"all told said no\" conjointly the Action's pile vaccination categorization goed wrong. Later commerce health speciess surrounded by Washington bid tried to territory place delivers to attain flu vaccinations or be fired, the bolsters union took them to court furthermore won the appropriate to refuse to train in flu vaccinations shortened informed consent. Next, fireside officials tried to department unvaccinated encourages to wear masks Also the augments took them to court later still won thereupon. Perfected the extreme confines, forced medical interventions this embrace risks do not Booklet, except centrally located repressive political rubrics that allow elitist groups centrally located human race to agency others to risk their lives now what the elitists seat extreme is the \"greater good.\" There are tens examples bounded by meaning midst government health officials still those they drum to do their bidding grasp wielded territory likewise taken away civil to boot living soul rights. Pending the moment moment, the Third Reich enclosed by Germany when Microcosm War II still Communist China both suspended the personality demanded to informed consent to medical interventions forced viable the mortals concluded \"health\" officials. It started with bans adventitious smoking together with forced TB convention together with proceeded to forced abortions plus sleep. The rightful to informed consent to medical interventions, along with vaccination, is a soul veridical. Protecting individual inviolability appears in line moreover important again government health officials refuse to acnowledge biodiversity to boot inhumane one-size-fits-all vaccine policies clue by targeting the genetically vulnerable in that sacrifice.
Pathophysiology Of Erectile Dysfunction
Posted on May 31, 2008 in Erectile dysfunction
-dysfunction.jpg" border="" alt=""id="BLOGGER_PHOTO_ID_5114486494096870018" />Given the complexity of the system, it is not surprising that a wide variety of diverse disorders may result in erectile dysfunction. Often, the cause is multifactorial, but vasculogenic causes are the most commonly implicated. Because the development and maintenance of a rigid erection depend on achieving a high intracavernosal pressure, it is not surprising that disorders affecting the peripheral arterial blood flow are strongly associated with erectile dysfunction. The most common cause is atheroma involving either the common or internal iliac arteries or their more distal branches. The risk factors for this are similar to those for coronary artery disease (including smoking, hypertension, hyperlipidemia, diabetes mellitus and obesity). Narrowing or occlusion of the internal pudendal arteries reduces perfusion pressure to the corpora, resulting in a failure to achieve full rigidity. In the absence of such pressure, the normal venoocclusive mechanisms cannot operate and, thus, the problem is compounded by secondary venous leakage. Obliterative disease of the aorta may also result in erectile dysfunction.
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Posted on May 06, 2008 in Pharmacy
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