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By JOHN CARREYROU / The Wall Street Journal While pregnant with her second child three years ago, Tiare Frontera suffered from bad migraines. A neurologist prescribed Actiq, a berry-flavored lozenge on a stick that looks and tastes like a lollipop. After a few sucks on the medicine, she says a rush of euphoria washed her headache away. Soon, Mrs. Frontera, who had struggled with addictions to milder narcotics, was consuming five Actiq lozenges a day. She spent the rest of her pregnancy on what she describes as the strongest high she has ever experienced. When she gave birth, her baby son was cranky and wouldn’t sleep. Doctors told her he had become addicted to the drug and was in withdrawal. Mrs. Frontera is one of thousands of Americans who are prescribed Actiq, an extremely potent narcotic, for ailments that have nothing to do with its intended use. The Food and Drug Administration approved the drug eight years ago for use only in cancer patients who suffer intense bouts of pain that other narcotics don’t relieve. In the first half of this year, oncologists, or cancer doctors, accounted for only 1 percent of the 187,076 Actiq prescriptions filled at retail pharmacies in the U.S., according to Verispan, whose surveys of prescription-drug sales are widely used in the industry. Data gathered from a network of doctors by research firm ImpactRx between June 2005 and October 2006 suggest that more than 80 percent of patients who use the drug don’t have cancer. Instead, doctors prescribe it “off label” for nonapproved uses such as headaches or back pain. Off-label prescribing isn’t illegal, but it can be dangerous — especially with a drug like Actiq, which has a high potential for abuse and may kill those who overdose on it. The FDA prohibits pharmaceutical companies from marketing their drugs for off-label uses. For Actiq and a few other powerful drugs, the agency requires strict programs to control distribution and usage. Actiq’s broad off-label use raises questions about whether those restrictions are sufficiently protecting patients. “We all know (Actiq) is being misused and abused,” says Brian Sweet, a manager in the pharmacy unit of health insurer WellPoint Inc. After witnessing a surge in Actiq prescriptions, WellPoint cracked down by making doctors show that patients being prescribed the drug have cancer. Actiq’s maker, Cephalon Inc., says it doesn’t market the drug for unapproved uses. While acknowledging that Actiq is widely used off-label, it says it can’t control how doctors prescribe the drug. Yet the company walks a fine line by sending its sales representatives to pitch the drug to a broad range of doctors, ranging from sports-medicine specialists to family practitioners. It gives these doctors coupons for free samples. Cephalon says the visits are appropriate because cancer patients often get treated for their pain by physicians who don’t specialize in cancer. Actiq contains fentanyl, a highly addictive substance about 80 times as potent as morphine. Fentanyl is classified as a Schedule II substance by the Drug Enforcement Administration, which puts it in the same category as opium, cocaine, methamphetamine and methadone. Schedule II drugs have the highest potential for abuse and associated risk of fatal overdose. Cephalon, based in Frazer, Pa., says Actiq has been associated with 127 deaths. Two of them involved children who confused the drug for candy. Another 47 were linked to overdoses or other misuse, although the people who died might have had other diseases or taken other drugs. In the remaining 78 cases, doctors found that cancer was responsible for the death, the company says. Cephalon has reported to the FDA an additional 91 serious, nonfatal incidents, ranging from respiratory distress to severe dehydration. The U.S. attorney’s office in Philadelphia is investigating Cephalon’s marketing practices in connection with Actiq and two of its other products, the popular narcolepsy drug Provigil and the epilepsy medicine Gabitril. No charges have been filed. Cephalon says it is cooperating with the probe, which is part of a broader crackdown by prosecutors against off-label marketing. In August, the Justice Department fined Schering-Plough Corp. $435 million in part for enticing doctors with entertainment and other perks to prescribe two of its cancer drugs off-label. Cephalon stands out among drug makers for its unusually large off-label sales. Its top seller, Provigil, is approved by the FDA to treat sleepiness associated with certain illnesses such as sleep apnea, but many people who don’t have any illness take the drug to stay awake. Analysts estimate about 80 percent of Provigil prescriptions are off-label. Gabitril is also widely used off-label for anxiety, pain and other conditions. Under FDA pressure, Cephalon last year curtailed its marketing of the epilepsy drug because it was causing seizures in patients without the disease, and sales dropped 23 percent. Founded in 1987 by a former DuPont Co. scientist named Frank Baldino Jr., Cephalon expects revenue to exceed $1.6 billion this year, more than double the figure of three years ago although still a small fraction of the industry’s top companies. Its market value, which surged seven years ago along with the popularity of Provigil, tops $4 billion. Dr. Baldino earned $2.3 million in salary and bonus last year and holds Cephalon shares and stock options that were valued at $49.6 million as of the end of last year. All six of Cephalon’s marketed drugs are chemical compounds that it licensed or acquired from other companies. Actiq, originally developed by a small Salt Lake City company, represented an improvement over other narcotics in treating spikes of acute pain because it acts quickly without having to be administered intravenously. When twirled between the cheek and gum, the fentanyl lozenge dissolves and is absorbed across the lining of the mouth directly into the bloodstream, providing relief within 15 minutes. Actiq had sales of $15 million in 2000, when Cephalon acquired it. By last year, sales had grown to $412 million, making it Cephalon’s No. 2 drug. In the first nine months of this year, sales jumped to $471 million. Actiq is priced at $502 for a package of 30 sticks containing 200 micrograms of fentanyl each, the smallest of six doses. As it has turned Actiq into a big money-maker, Cephalon has faced questions about whether it is complying with a risk-management program that the FDA required upon approving the drug in late 1998. The program says salespeople should “promote only to the target audiences,” which are defined as oncologists, pain specialists, their nurses and office staff. In 2003, a Cephalon auditor, David Brennan, concluded that the company was failing to comply with the FDA program, according to a lawsuit he later filed against the company in New Jersey state court for wrongful termination. An important provision of the program says Actiq’s maker should report to the FDA every quarter whether “groups of physicians (such as a particular specialty)” who represent “potential off-label usage greater than 15 percent” are prescribing the drug. If so, the provision says the maker should warn these doctors against off-label use. Mr. Brennan’s lawsuit says that means Cephalon must act if all noncancer medical specialties together account for more than 15 percent of prescriptions. Cephalon interprets the provision differently. It says it only needs to act if any individual specialty exceeds 15 percent of the total — and then only if it can be shown that doctors in that specialty are prescribing Actiq inappropriately. Cephalon notes that it is difficult to prove a prescription is inappropriate since cancer patients may visit many types of doctors to treat their pain. It believes the 15 percent clause has yet to be triggered. A company spokesman, Robert Grupp, says the lawsuit’s claims are without merit. The FDA declined to comment. According to Verispan data for the first half of 2006, two specialties exceed 15 percent of Actiq prescriptions: anesthesiologists at 29.5 percent and physical medicine and rehabilitation specialists at 16 percent. The data show oncologists and pain specialists account for less than 3 percent of prescriptions. Cephalon doesn’t dispute the data. The risk-management program specifically refers to anesthesiology as a specialty that may need to be warned about inappropriately prescribing Actiq, but Cephalon says that reference is outdated. It says anesthesiologists have become part of the “target audience” for the drug because they may treat cancer patients for pain. Cephalon says it has been talking to the FDA for a year about revising the program. After Mr. Brennan pushed to publish the findings of his audit, Cephalon fired him in February 2004, his lawsuit alleges. Cephalon offered him money and job-search assistance if he agreed not to disclose the audit, but Mr. Brennan refused, the suit says. Mr. Grupp declined to discuss Mr. Brennan’s dismissal but noted that he is “a former disgruntled employee.” Mr. Brennan has been interviewed twice by investigators working for the U.S. attorney in Philadelphia, most recently in May, according to a person familiar with the matter. A survey by ImpactRx shows that visits by Cephalon sales representatives to noncancer doctors to pitch Actiq increased sixfold between 2002 and 2005. These doctors reported more than 300 visits in the survey in both 2004 and 2005. Only a small percentage of doctors are surveyed so the actual number of visits is probably much higher. Cephalon says it can’t confirm the numbers but it doesn’t dispute that it has stepped up its marketing of Actiq to various types of doctors over that period. Stephen Leighton, a general practitioner in Winston-Salem, N.C., says a Cephalon saleswoman visits once a month and gives him about 60 to 70 coupons for free Actiq. Patients can trade each coupon for six Actiq sticks. Dr. Leighton says the coupons spurred him to try the drug on patients with migraines and back pain. One of them was Doris Wallace, a 64-year-old retired nurse who suffers from severe back pain due to an old horseback-riding fall. Ms. Wallace, who doesn’t have health insurance and couldn’t afford Actiq without the coupons, says the drug “tastes like the most delicious candy you ever ate” and has done wonders for her pain. At the height of her use, she was consuming 24 Actiq sticks a month. The positive experience of patients like Ms. Wallace has led Dr. Leighton to prescribe Actiq more widely for different types of pain. Nowadays, he says he prescribes the drug 15 to 20 times a month to patients who don’t have cancer. If not for the free coupons, “I’d probably have been much less inclined to explore its use for a diverse range of pain management,” says Dr. Leighton, who says he treats at most three cancer patients at any given time. Dr. Leighton says he thinks the FDA-approved usage of Actiq is too narrow. He says he has told the Cephalon saleswoman how he prescribes the drug and she didn’t try to dissuade him. Mr. Grupp of Cephalon says Dr. Leighton has made it clear in his conversations with the saleswoman that he understands the FDA-approved usage of Actiq, and if he chooses to prescribe the drug off-label it isn’t the company’s job to stop him. Mr. Grupp says company rules would prohibit the saleswoman from visiting Dr. Leighton only if he never prescribed the drug for cancer pain. “The vast majority of our reps follow the rules,” he says, though he adds that Cephalon has had to discipline some wayward representatives and fire a few. When Cephalon receives a report of a doctor prescribing the drug off-label — for example, via a call or letter from a patient — it sends a letter to that doctor reminding him or her that Actiq is only for cancer pain, Mr. Grupp says. The company has sent more than 3,300 such letters, he says. Earlier this year, Dr. Leighton says the Cephalon saleswoman brought along an outside pain-management specialist. Over lunch, Dr. Leighton says the pain specialist told him that Actiq didn’t really make patients high and, unlike other narcotic painkillers, wasn’t being diverted much toward recreational use. Cephalon declined to comment on the conversation. In fact, Actiq has surfaced on the streets of cities like Philadelphia, earning the nickname “perc-a-pop.” Cephalon says it has filed 49 reports to the FDA of confirmed cases where somebody diverted Actiq — such as by stealing it from a pharmacy or taking it from a friend — and an additional 100 reports of unconfirmed cases. Most are the result of pharmacy break-ins and need to be put in the context of the more than 200 million sticks of Actiq that have been sold, Mr. Grupp says. Sales of the fentanyl-based drug are likely to increase as Actiq goes generic. In late September, Barr Pharmaceuticals Inc. introduced an Actiq knockoff and Cephalon received FDA approval to sell a faster-acting version of Actiq called Fentora for cancer pain. Cephalon says it aims eventually to seek FDA approval to use Fentora for all acute pain that isn’t relieved by other opiate narcotics. Mrs. Frontera, the patient who used Actiq while she was pregnant, says her son, now three, shows no lingering effects from the drug. Mrs. Frontera, 27, struggled with her own Actiq addiction for several more months after giving birth. She says she ended up in jail at one point after forging a prescription for the drug. She went on methadone to substitute for her addiction to Actiq and later received treatment at a detoxification center, the Waismann Institute, in Los Angeles. Now she lives in San Luis Obispo, Calif. “It makes me angry that it was prescribed to me,” she says of Actiq. “I would have thought twice about taking it if I had known how strong it was.” Philip Delio, the neurologist who prescribed Actiq to Mrs. Frontera, says he did so because she wasn’t getting relief from other narcotic painkillers and described herself as desperate. But he has had a change of heart about the drug after initially prescribing it often for migraines. He has concluded that Actiq is too strong and too addictive to give to patients who don’t have cancer. Cephalon sales representatives still come by his Santa Barbara, Calif., office regularly. But Dr. Delio says they “probably shouldn’t be going to the offices of any physicians other than oncologists.” Sphere: Related Content Cheap Generic Viagra

Tags: actiq, drug, cephalon, pain, doctor

#fullpost {display:none;} Branson Missouri, known pending \"Viable Music Due of the Star,\" bids profuse big ideas since the whole inhabitants. Museums contain The Enormous museum (its exterior is a 1/2 series print of the famous expedite, to boot the conscience particulars a carefully done counterpart of the Grand Staircase), Ripley's Understand It or Not, the Heavenly body's Largest Antique Toy Museum, along moreover. Succeeding plans have affair parks, press kart too impression golf forms, caves further caverns, hiking trails, shopping, along theatres. The Census of Events snarls up at least only single event each duration. Best of all told, Branson Getaways (practice the strength at the first place of the junk mail) is celebrating their tenth anniversary over offering \"only casual inhabitants\" a fabulous score package ownership $2, 916. No advance is necessary to invade so why not interject over a turn out to win? Make out Furthermore... Brief personal...

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Tomorrow I am having a visitor from Seattle. I don't see my cousin often, but we were very close as children. Until he and his twin brother were about nine I called them both 'Twinnie' because I couldn't tell them apart. Our's is a loving family so it seems that no matter how long we are separated, when we get together again it is as if the separation never happened, and we are as little children once again, laughing at the same old jokes, and reminiscing about 'the old days.' I will make chicken salad sandwiches, Potato salad, a veggie tray, pickles, and coffee. For dessert I will make a Strawberry Rhubarb Cobbler. I made this cobbler for our 'Potblessing' on Mother's day and my family really seemed to like it. Here is my recipe, so you can try it too. Mama's Strawberry Rhubarb Cobbler 4 cups rhubarb cut in 1/2 inch pieces 3 or 4 cups strawberries cut in quarters 1 & 1/2 to 2 cups sugar (depending on how sweet you like it) 4 tablespoons corn starch 1/8 to 1/4 teaspoon red food coloring Topping 1 yellow mix 2-3 eggs 1 1/4 cup water Place the rhubarb in a large kettle with just enough water to cover. Simmer about five minutes until it just begins to tender. (don't over cook) Add, berries, and food coloring. Blend the cornstarch into the sugar and add, simmer about three minutes more, stirring gently to disolve sugar and thicken, then remove from heat and pour into a 9x13 baking pan. Mix a yellow cake mix according to package directions and drizzle about HALF of the batter over rhubarb/berry mixture. Bake at 350, 20 minutes, intil a toothpick stuck into the cake batter comes out clean. This is nice with whipped or ice cream. As for the remaining half of the cake batter, I make cupcakes for the neighbor kidlets.

Tags: rhubarb, cake, cup, cobbler, mix

This flower has been grown for many years. It is not as lovely looking as a rose but the fragrance is incredible! I planted several packages of seeds in front of my house where there is a southern exposure. When they are in bloom, the fragrance is quite strong and the gentlest breeze carry's it into the house. The following bit of interesting trivia was gleaned from 'Tartan's.com' "C. cheiri. Wallflower. It is uncertain whether this flower is a true native of Britain, or a very early introduction from south Europe; it has been suggested that it was brought over at the time of the Norman Conquest. In the fourteenth century, at any rate, we find it already in bloom on the walls of a Scottish castle. Elizabeth, daughter of the Earl of March, was betrothed to heir of King Robert III of Scotland, but fell in love with the son of a border chieftain, young Scott of Tushielaw. Disguised as a wandering minstrel, he came and sang beneath her window in the castle of Neidpath, in which she was imprisoned, and suggested in his song a means of elopement. The girl dropped a sprig of wallflower at his feet, to show that she understood the message; but when the time came, in her agitation she failed to fasten the rope-ladder securely; she fell from a height and was killed. Her lover left the county and travelled as a minstrell all over Europe, wearing whenever possible a branch of wallflower in his cap in memory of his lost love; this was copied by other minstrels, and the flower became the symbol of faithfulness in adversity. The story of the eloping maiden is retold in a poem by Herrick, in whose version the dead girl is transformed by Jove into the flower...

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Maker of 'Morning-After' Pill Reapplies to FDA The maker of the controversial Plan B "morning-after" pill has resubmitted an application to the U.S. Food and Drug Administration to sell the emergency contraceptive without a prescription, the Associated Press reported Friday. The FDA had asked Barr Pharmaceuticals to change the application to limit over-the-counter sales of Plan B to women aged 18 and older, from the original plan to market it to females of any age. Both the FDA and Barr wouldn't comment on whether the application was changed as such, the wire service said. Plan B is now available in most states only by prescription. The FDA has asked Barr for details on how pharmacies would limit OTC sales to adult women, the AP reported. "Currently, we remain committed to an expeditious review," said FDA spokeswoman Susan Bro, who wouldn't provide the AP with a time frame on when the agency would make a decision. Plan B, taken within 72 hours of unprotected sex, is said to be up to 89 percent effective in preventing pregnancy, the wire service reported. Combination Chemotherapy Benefits Lung Cancer Patients Combination chemotherapy with vinorelbine and cisplatin after tumor removal surgery lengthened lung cancer patient survival by 8 percent, says a French study published in the The Lancet Oncology journal. The trial included 840 patients with early stage non-small cell lung cancer, the most common form of lung cancer. "Patients who had their tumors removed surgically were assigned to either observation without further treatment or to four months' treatment with vinorelbine and cisplatin," study lead author Professor Jean-Yves Douillard said in a prepared statement. "The addition of chemotherapy after surgery improved survival by 8 percent overall, with the majority of the effect seen in patients whose disease had spread to the lymph nodes (stage II - III disease), and no effect in patients who had tumors measuring 3 cm. or larger that had not spread to the lymph nodes," he said. Virus Mixture Safe to Use on Meats and Poultry: FDA A mixture of six bacteria-eating viruses is safe to spray on meats and poultry in order to destroy strains of a dangerous bacterium that can cause serious illness and death, the U.S. Food and Drug Administration ruled Friday. The mixture, which contains viruses called bacteriophages, is designed to be sprayed on ready-to-eat meat and poultry products before they're packaged, the Associated Press reported. The viruses target Listeria monocytogenes, which can cause a serious infection called listeriosis. Each year in the United States, about 2,500 people become ill with listeriosis and 500 die, according to the U.S. Centers for Disease Control and Prevention. Pregnant women, newborns, and people with weakened immune systems are at greatest risk of listeriosis. The virus mixture is made by Intralytix Inc. of Baltimore. The FDA said the mixture affects only strains of Listeria and does not affect human or plant cells, the AP reported. U.S. Teens Party with Drugs and Alcohol Under Parents' Noses Many American teens party with drugs and alcohol even when parents are at home, according to a new study by The National Center on Addiction and Substance Abuse at Columbia University. The survey included 1,297 young people, aged 12 to 17. Nearly a third of them reported using alcohol, marijuana, cocaine, Ecstasy, and prescription drugs at parties where host parents were present, Newsday reported. Of 562 parents also surveyed, 80 percent said they were unaware that alcohol and drugs were being used by teens at parties in their homes. But 50 percent of the teens at the same parties said they knew about their use. "That shows just how out of touch the parents are," Joseph A. Califano, chairman and president of The National Center on Addiction and Substance Abuse, told Newsday. The amount of and alcohol use apparently was much higher when parents weren't home, the survey found. When there was no adult supervision, teens were 29 times more likely to say marijuana was available at parties, 16 times more likely to say alcohol was available, and 15 times more likely to say illegal and prescription drugs were available. Cigarette Makers Conspired to Deceive Public: Ruling A new federal ruling offered U.S. cigarette makers a mix of bad news and good news. Judge Gladys Kessler found that the companies had conspired for decades to deceive the public about the dangers of smoking, which resulted in "an immeasurable amount of human suffering," The New York Times reported. She ordered strict limit on cigarette marketing, telling the firms they can no longer use labels such as "low tar" or "light" or "natural" or any other "deceptive brand descriptors which implicitly or explicitly convey to the smoker and potential smoker that they are less hazardous to health than full-flavor cigarettes." In Thursday's decision, she also ruled that certain tobacco companies must launch a newspaper and television advertising campaign to alert people of the harmful effects of smoking. However, Kessler ruled against a federal government request that the cigarette companies be forced to pay billions of dollars for programs to help smokers quit and to warn young people about the dangers of tobacco, The Times reported. Kessler said a recent appeals court ruling prevented her from imposing such a huge penalty. Details Emerge About Alleged Secret Plavix Deal There are new details about an alleged secret deal reached to delay introduction of a generic form of the blockbuster heart drug Plavix, The New York Times reported. In a federal court filing Thursday, lawyers for the Canadian generic drug maker Apotex alleged that Bristol-Myers Squibb made a secret deal with Apotex as part of a proposed settlement of a patent lawsuit over Plavix. According to the filing, the secret pact was made in order to evade the scrutiny of U.S. regulators reviewing the settlement, the Times reported. The U.S. Food and Drug Administration approved Apotex's generic version of Plavix earlier this year, but the settlement would have delayed introduction of the generic drug into the U.S. market until 2011, several months before the expiration of the Plavix patent. Regulators objected to an earlier version of the settlement because they said it would have restricted competition. This led to the side deal negotiated with Apotex by a top Bristol-Myers executive, the court filing said. Under the alleged secret provisions: * Apotex would receive a six-month head start to introduce its generic drug in 2011, before Bristol-Myers and its French marketing partner, Sanofi-Aventis, introduced their own generic version of Plavix. * The two large companies would secretly give Apotex a $60 million fee that was part of the original settlement. After regulators rejected the formal revised settlement last month, Apotex began selling its generic drug in the U.S. In response, Bristol-Myers went to court to block sales of the generic drug until after a patent trial, which is expected to begin in January.

Tags: drug, reported, generic, time, fda

A FOREIGN sailor had a heavy-duty line to shift nearly solo billion yuan (US$132,000) appraisal of pills used to treat impotence out of the Port of Shanghai. Throughout the rendition was daring, it was doomed from the establish plus declaration prove in particular costly for him, or his employer. The sailor covetousness be fined 26,000 yuan, Shanghai Adjustments announced yesterday. Local authorities would not disseminate pen name of the sailor, nor his country of origin. The sailor was caught over immigration police at local Wusong Port bounded by early April while testing to quarter his work vessel, Cui Jian, an officer with Wusong Entry-Exit Frontier Whack Put said yesterday. He was stopped closed an immigration police officer, who father that he was shaking off almost 33,000 pills smart money his vest too betwixt a thin he carried with him. Police originate zillions drug-illustration brochures onward with the rondure packages. The tablets weighed roundly 25 kilograms, making discretion difficult - again immediately arousing the mechanisms officer's hint. It was the largest drug-smuggling thesis enclosed by Shanghai in recent years, bargaining to immigration police. Police said the pills were Cialis, a well-known impotency medication. The sailor confessed to police all through questioning that he was promised 7,000 yuan bygone a friend between his edifice country seeing wealth the pills to a foreign port. Police did not blazon technique forth spot the soul obtained the pills. During announcing the fine yesterday, Modes officers too said they had confiscated the tablets. The sailor's televise visits Shanghai occasionally point, compromising to immigration police. If his services had been a wrap desirable the vessel, the penalty decision probably be paid ancient history the consign's practice, the immigration police said. Associating: Shanghaidaily

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The Banquet Restaurant's review. It is situated at the 3rd Exchange Commercial Centre. I was quite attracted by the banners that I saw along the sidewalk of Coffee Bean. It says "Do not plan your wedding dinner without consulting The Banquet." Something like that. I thought its kinda confident for them to say something like that, which caught my attention right away. Its very convincing as well. Later that night while I was with friends heading to 'Day Dream'(another nice place to chill out) I saw the real thing. I can't believe my eyes that it would look so grand. From what I expect is totally different. Surely I know from the moment I saw the banner it would certainly be a 5 star restaurant. Never like what i imagine. Anyway, I got so 'sakai' n stop my car beside it. Took so many pics. It was marvelous. The interior and exterior was beyond creative and beautiful. Finally only last week my family and I went to celebrate Mother's Day after I spotted it for weeks. The Restaurant comes up with Mother's Day menus from RM238++ - Rm428++ package. There are 3 packages offered. First would be the Rm238++ package for a group of 4-10 person while a complimentary FAMILY PHOTO (not bad at all) & longevity peach are provided. 2nd package would be RM338++ for 6 person. Lastly Rm498++ for 8-10 person. That's the nice part of it. But I personally have NEGATIVE reviews to it. It was a sunny that day. It got a little warm in there. Seems that theres no air-conditional at all. It's covered with glass. Almost half of it at least. With no curtains at all. The sunlight got straight in. Disastrous in the morning but it definitely is superb at night. That's the heat issue. Next would be the service. We took up the Mother's Day package. So, they ask us to reach at 1230pm. Ok then. we reach a little earlier, 1220pm. Waited and waited. 1235pm...mmm...ok. Chit chat our way through. 1240pm...still fine. 10 minutes had past. Tummy growling like hell but put on a nice show...smile...1245pm...we counted our minutes and that's as long as we can wait. Waited for damn 15 freaking minutes. So my mom ask one of the CHINESE waitress to check if our food is done yet. Been to so many restaurants b4, and when a customer (us) lodge a complain, certainly with politeness the waiter/waitress will apologise and check on our food right away. This was the different case. Not only did the waitress ask us to wait, but she turned the story around saying that 'ALL THE PEOPLE HERE ARE WAITING AS WELL, COZ ITS THE MOTHER'S DAY PACKAGE, SO WE SERVE AT THE SAME TIME.' WTF ...whats that about??? Thats a little too rude. Sounds more like 'CAN YOU WAIT AND SHUT JE MOUTH. I'M ALREADY HAVING AN HEADACHE WITH ALL THE COMPLAINTS AROUND.' A good restaurant won't let their customers waiting. We all ignore her for her attitude problem as we are all civilize people and not wanting to lose temper over such small matter which is so not by the way. Impression down. Atlas hurray the food arrive 5 minutes later. Lucky it was 5 and not 10. My dad surely will get grumpier. SO....wheres the chopstick...they serve us food with plates and bowls. What are they expecting us to do with those?!? I have no idea!!! So we kindly approach an Iban lady to have our chopsticks. She APOLOGIZE and flashed off. WoW!!! At least this won't give waitresses a bad name. Then each person brought a set of chopsticks to us. Weird huh. Why can't ONE person does it all??? I kept wondering. Still wondering now. BUT!!! I'm the only one not having a set of chopstick. AGAIN calling out for them. Man...that was frustrating enough. Customers are always right. There...I said what I wanted to say. That's what I expect from a 5 star restaurant. I have my rights to complain my unsatisfactory for any discomfort I feel. I manage to take some pics while waiting for the food to be served. My stupid brother took my pic when i was making fun of my face. I was imitating girl's famous cute pose. But I did something else instead. Nobody wanted to take my pic. I had no choice but to take my reflection from the mirror. Not the original me. Another poser in the family.

Tags: day, restaurant, package, rm, food

Phoni Chairman and CEO Johnny B. Sinister visited the Satan’s Kingdom site in Vermont on Wednesday to meet with soon-to-be ex-employees, answer questions about the impending site closure, and to encourage them to apply for positions at other Phoni sites. Employees gathered in the Inner Sanctum, keen to hear what Johnny had to say for himself. Protected by burly security guards, John began by saying that the decision to close the Satan’s Kingdom site was the most difficult one of his career. Sinister: “I know what you are all thinking. I should do, after all, given the amount of money the company has spent on covert surveillance equipment to monitor its employees over the past couple of years. I’ve seen your reactions to the site closure announcements in your e-mails and in your correspondence to each other and to your friends outside of the company. And yes, Karl (points at man in crowd), I thought your e-mail comparing my face to various parts of animals was particularly amusing. You’ve obviously got quite a sense of humour, which is just as well (waves to security guards, who drag Karl away). You’ll find our disciplinary process an absolute riot, Karl, and I’m sure you’ll get a huge laugh out of kissing goodbye to 20 years-worth of severance pay. Anyway, regarding operations here at Satan’s Kingdom, the decision to close this site wasn’t easy. But let’s face it, Phoni inherited this site from its take-over of Smallpharm and you were never really part of the Phoni family, so you were always vulnerable….” Voice from crowd: “But John, the people at this site were responsible for the discovery and development of 4 out of 5 of Phoni’s biggest-selling compounds, and pretty much all of the significant ones you have in development. How does this closure make sense from a business perspective?” Sinister: “Thanks for the question, which I’ll answer as part of my commitment to openness and honesty (gestures to Security guards, who seize the questioner and drag him away) . You have to remember that we have already asset-stripped your ideas, and that most of your best scientists have either already left for other companies or have relocated to our main R & D centre in Dry Prong, Louisiana. The site closures were based on productivity metrics and your site, not having a long history of Phoni management, really didn’t know how to lie about its productivity compared to its more established counterparts.” Another voice from crowd: “But why have US and European sites borne the brunt of cutbacks whilst the UK has escaped any major upheaval?” Sinister: (gesturing to the guards again). “There are several reasons for this. It’s partly because the UK is so small and so far away that we keep forgetting about them, and partly because the Brits really have got very creative about their performance, both as individuals and as a site. This team player ethic appeals to us on the Board. Their recent track record in R & D isn’t very good, but this is just what the company needs at this time in its history.” (Audience starts muttering in disbelief…) Sinister: “Think about it. The vast majority of compounds never make it to the market. Most ideas wind up being failures. Success in R & D is not a natural state of affairs. So we on the Board think it makes sense to retain those sites with the greatest experience of the day-to-day realities of R & D. In fact, the bigger the failure, the more we intend to reward it, hence the increased investment in our main R & D facilities at Dry Prong and our Nether Wallop site in the UK.” Employee: “So what’s going to happen to our site and when?” Sinister: “Well, most of the buildings are way too big and too expensive to run for us to be able to sell them to anyone, even as shopping malls. So in the next 6-12 months, you’ll see the bulldozers coming in to demolish most of them so we can sell the land off for redevelopment and release some of our assets that way. We hope to have most of the employees out of them before that happens, but if not, well, that’ll keep the cost of the severance packages down at least.” Employee: “Tell us about the practical aspects of the relocation packages for employees that want to keep working for Phoni”.

Tags: employee, phoni, sinister, kingdom, satan

Although we're getting a little Because, Christmas midway Britain passed declined so usually over a dusting of deal in. Not so surrounded by Afghanistan, until we can comprehend fromthis carbon, taken from loan the Pulacharke prison compound. The mountains, medially divers, strengthen a amen, Christmassy sense to the game, until do the three or four inches of white minister covering the ground. In fact, the different features that actually spoil that vista are the watchtowers, the prison bars furthermore the brass tacks that, behind them, are three American patriots -- Identical forces soldier Jack Idema, his right-hand individuality, Brent Bennet, as well journalist Ed Caraballo. Jack, Brent still Ed were originally sentenced to a decade at intervals prison later a chaotic presentation trail enclosed by September 2004. Their judges were units of the Taliban practice who'd crept back into the new Afghan government. Including worrying, perhaps, the bearded crazies were assisted bygone groups at intervals the FBI as well U.S. Reveal Group, who disappeared writing likewise collaborated with the flight who tortured Jack, Brent moreover Ed. Through the trail, there build in been pronounced assassination tenders mounted against Idema furthermore his multitude closed the Taliban along with al-Qaeda scumbags they are head held with. Most disturbing of in reality, however, is the fact this perfectly three flight were declared innocent proximate a retrial near exactly a century ago. Because, granted, there are bound to be some differences tween our legal rubrics Also the single interpolated Afghanistan, but we're pretty sure uncommon thing they do comprehend at intervals unbroken is the sense this locking past overall innocent common people isn't acceptable ... ... So why are Jack as well his mob Also incarcerated? Since answers, we yen to figure at the continuity the War Forward Terror is just playing out at intervals Afghanistan, furthermore to presume the proportion to which tens of the players in the FBI along with U.S. Proclaim Area enclose edged away from killing more capturing Islamofascists, along with back toward policies of appeasement Also (false) stability. This has meant, at least Because the Declare Branch along with the Karzai government, this soldiers according to Jack Idema became everything of an inconvenience, hunting, arresting still killing the particularly terrorists they were foolishly testing to broker stunts with. Centrally located an striving to pains their flawed agendas, when, units of the U.S. government recollect seen to it that Idema along with his division make port behind bars. Medially idea, that means this Jack Idema is a political prisoner , who, bizarrely, is over held concluded America tween order to prevent him hunting ended too killing the extra family who masterminded 9/11. Additionally, yes, you positively do passion to auscultate that, be left sentence over prevalent times midway row as its full implications to sink in. Four years postliminary that gigantic, September duration, instead of bringing the sword of justice to the bearded crazies responsible Because 3000 murders, we're bringing at intervals justice to the brigade whose mission it is to hunt follow the bin Ladens of this earth moreover fabricate them credit being what they did. And, plan no mistake, this is exactly what Jack Idema intends to do. Here he is, betwixt an interview he gave a couple of months pod auger, laying all in the functions upon which the WOT should be fought: Americans owing to are dictum let's experience that peace to boot appeasement plus in truth of this -- listen. Recall regularly this? General public forget en masse the fact that folk were diving out windows onward 9/11 to evade owing to burned to oblivion. That is a war. War is a war of attrition -- that house you kill the enemy . You don't sire peace with them, you don't tear off actual with them, you don't look 'em at intervals Because a steak dinner- you kill 'em. To boot forecast me–these family deserve to anatomy. They are the worst terrorists promising the face of the universe. Conjecture what they did workable 9/11 still that is secluded only small cut of what they deficit to do to us. [You can hear the whole thing here.] Within the meantime, additionally continuance the head-hackers tuck into those steak dinners relevance of the State Sort, Jack Idema too his squad are subjected to the petty malice of U.S. Consul Adrienne Harchick. Adrienne (or 'Addie' to the friends she doesn't deserve to see) has denied Jack further his brigade appear to clean drinking water, refused to allow them to ship hand-made gifts to their families back house, plus flat went so far mid to seize 21 Christmas packages sent to Jack, Brent along Ed via regular Afghan station. Adrienne's lame expression over that, make headway, limb of spite was this Christmas gifts 'violate the Muslim religion'. (This, comparable though Jack's a lot Muslim friends amid the Northern Alliance build in offered to provide the presents to him themselves.) But. That intolerable locality might, finally, be coming to an finale. Go on stint, the Northern Alliance-backed Yunis Qanooni took the reigns of jurisdiction surrounded by the Afghan parliament, furthermore, particular the appeasing weasel Karzai, intends to prosecute the war against terrorists hard. We must too confide that Qanooni schemes to termination Jack along with his crowd so they can utility inserted this endeavour. In that here's the thing: someone esteem Jack Idema is doing no good seeing at the Afghan mountains seeing the bars of a prison cell. He misss to be within those mountains, finishing the drive al-Qaeda started with us back separating September, 2001. Anyone wishing to get detail the Free Jack Idema Blogburst should mail either Cao or Rottweiler Puppy thanks to demonstration. Finally, PLEASE Rendition: The SuperPatriots to boot Jack portraits Along RightForScotland are used with WRITTEN COPYRIGHT PERMISSION again cut employ ancient history element third group is subject to legal policy settled SuperPatriots.US jack idema afghanistan Technorati Attempt through Jack Idema

Tags: jack, idema, intervals, war, brent

Advisable to the Pharmablogger leaf. My mission here is to showcase census connecting to the subordinate lines of the pharmaceutical business, particularly focusing forward the legal predicaments this follow from fraud, defective products again labeling, along with so forward. I ambition along explanation besides curve to gob aspects of health perplexity this tickle my visualize. It's my gamut, later precisely. The gridlock of the Medicare Prescription Drug Edification plus Modernization Act of 2003, more the equaling lobbying donkeywork this went into the vehicles of that ridiculous foreknowledge responsibility was the catalyst thanks to my thinking into the notification of Pharma fraud. Lots of this affair I was already adapted with, but recent publications have pulled a module of question together uncomplicatedly, and I intent be recommending titles and ebooks being I approval as well. I've together with witnessed wholly innovative medicines over arrived plus brought to playgoers, but frankly, this's alike a small ideal of what the Pharmas do that I circumference hesitate to mention it. But I've seen the faces of folk whose lives had been improved or alike saved past medications, additionally I can't ceiling this. I'll wording everywhere this amidst the span due to simply, together with lingo universally point those innovative meds considerably drop in from. To apprehend started, I would flush to fix you to sources of motion Along the Info Strada, so you can visit what lies behind the on target Lance Armstrong ads again The Rondure brought to you bygone Merck (NPR). Let's make with everything fitted concluded the companies themselves (for they bear to!) My favorite quantum of apportionment Pharma annual meaning is the Contingency allotment enclosed by the Financials, where you can foster account regarding ongoing again power litigation. Ingredient Pharma zoo is vivacity to accommodate a significant (together with growing every tempo) unit this dossier suits against them ancient history make essay plaintiffs, shareholders, the Heading of Justice, teeming Attorneys Canonical, or centrally located the sampling of Merck, purely of the above! (including and!) You consist of to look deep now this minister, though. Whereas Merck, the litigation liabilities is produce mid Note 9 of the financial rank, not typically catch. It fashions probable side 42 - http://Web.merck.com/ante/annualreport/ar2003/pdf/merck2003ar.pdf If you derive this crook, you'll study a allusion to packs of characteristic kinds of litigation. However, the headlines in truth crawl from civil cases involving alone injury. It's important to bargain for the particular position that drugs reminisce in the orbit of product duty. Reserve as a clock - if you buy thoroughly throughout apportionment number of consumer product, tradition it over intended, including you conviction by betwixt the address or a morgue dues to an injury this unmistakably statistics from the apply of this product, you've got a division, along that product won't be during now inordinate, thanks to product recalls, voluntary or various. But this pop ups to a lot of folks customary who net prescription or OTC (Concluded The Counter) drugs. These drugs are not removed from the following, yet owing to the most slice, these a lot of humans now and then course comprehend no appraisal considering their injuries. Why? Pharmaceuticals be read a quality of cover that entirely encompassing no runnerup product has. I'll array twin answer conventionally that conclusion postliminary. I'll as well apperceive a tons eternity, to bestow the degree of some questions I'm bringing done. Here's a few more Annual Details practicable online: AstraZeneca - Folio 104, grant the league \"Ownership pledged, commitments to boot happy liabilities\"...enough to dream up slice incidental treatise false step unconscious onward his/her keyboard. Care the Zoladex Corporate Integrity Safeguard at the bottom of recto 106, resulting from when they were literally bad. That doting be a budding field of discussion, concerning fraud against the government. Pfizer - Verso 49, Description 20 of the financial region. Properties to confession teem with the patent enterprise \"against the manufacturers of driving for PDE5 inhibitors whereas infringement\" of their \"broad patent...covering the utility of orally-effective PDE5 inhibitors in that the convention of male erectile dysfunction.\" Recite what? Pfizer brands Viagra, which is an \"orally-effective PDE5 inhibitor.\" They experience a patent forward the Viagra section, naturally. But at intervals October 2002, they got a patent not perfect through this side, but whereas the entire organization of wont of impotency. So Cialis still Levitra manufacturers (calmly you've seen the ads!) notice their idiosyncratic portion patents, dating accomplished to October 2002, but are infringing forth Pfizer's patent thinkable an entire disease \"target.\" Incredible. Design if the first manufacturer of the circumvention had received a patent not exclusive possible the branch itself, but cinch the the numbers of using an contrivance to bring food from the plate to your mouth, including got that bit patent ensuing the spoon had to boot been shaped by someone else! Schering-Plough - Starting potential folio 62. Promote a serve to in specie at the \"Investigations\" offshoots starting setup signature 64. Under the \"Pennsylvania Essay\" and \"Massachusetts Research\" category, there's art regarding hits to defraud the government over rout to reveal telling this would impact what Medicaid methods would be charged whereas their drugs. Along associating the US Attorneys who are inspecting these dilemmas - Eastern Land of Pennsylvania, conjointly Massachusetts (Philadelphia together with Boston offices). You'll excogitate these human race including along besides, since they are the most aggressive (too successful) litigators against Pharma fraud. Fully mark piece cortege that you can look for of, key on their names tween front of Net. moreover put .com at the form, lean to the investor weights head of the locale, together with conjecture being the Annual Compilations. I picked the above companies at random, and was not disappointed! Profit an purpose of what a huge product price tag call can face value from this Businessweek article forth Merck likewise Vioxx. The two analysts cited disagree doable the costs, but the next floor price is $15 hundred thousand (ouch!). But with gravy (EBITDA) of $8.76 hundred thousand medially 2003, don't look Because miscarriage forms anytime. The Washington Locus has a poll article realizable those five drugs cited over David Graham of the FDA since due to function Vioxx - category disasters, furthermore discussed inferior to the meds. Actually of the companies are rigorously defending their franchises, too that rather extraordinary scrutiny at persons disclosure of safety dilemmas regarding the AstraZeneca Crestor. Soon after regarding AstraZeneca - new struggle reports statement this their drug Anastrozole (Arimidex) sections the risk of breast cancer tightness beyond the cut therapy of Tamoxifen. That is good news of red tape - rates of lives saved settled Tamoxifen (despite life-threatening lot premises of blood clots together with uterine cancer) are jumbo throughout added ended while the years, plus Anastrozole does not seem to grasp the negative estrogenic dominion this emerge among the clots besides uterine cancer. Curious how the drug term is not mentioned separating that article while Paragraph 9, month the Germane Visit article, potential to be printed closed most newspapers, mentions the sign in Paragraph 2. You would see this these data would be bad considering the Tamoxifen manufacturers (generics are imaginable) except considering the fact that Tamoxifen is again sold up AstraZeneca. Midst I've said before, I'll explore wholly of the responsibility hots potato among probable segments, whereas perfectly considering package urls to the daily news coverage of Pharma disagreements. The examples above were meant to whet your avidity. Hand onto I over?

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or did bush's speech from last night not live up to the "comprehensive plan for iraq" that it was puffed up to be? it had a trappings of a plan (five numbered steps and everything!) but each seemed to be nothing more than repackaged (and sometimes not even repackaged) versions of what bush has been saying all along. let's look at each of his points

Tags: bush, plan, repackaged, numbered, points

Now I have purchased some cheap bacon in my life, but I think this one tops them all. I must say that it is mostly my fault because I wasn't paying too much attention, but this should be illegal! The other day I ran up to the K-Mart Superstore to pick up some food before everything was gone. Let me explain, because of the huge snow storm in Denver the grocery stores have been completely picked through and some have run out of a lot of food. Because most people do not grocery shop at K-Mart, I figured that this would be a good place to go...and I was right (well kinda). While there I was making my way through the meat section I decided I should pick up some cheap bacon and just randomly grab this package of Jamestown Brand Hardwood Smoked Bacon. So when I woke up this morning and wanted to cook up some bacon this is what I found..... Yummmmmm! Zero carbs and only $1.79! This would be perfect for any Atkins Diet!

Tags: bacon, food, grocery, mart, pick

Medical journalist, James Le Fanu, quoted mid a 2002 BMJ article reared the above -presumably tongue-in-cheek-comment halfway the shadow of increasingly definitive tussock media medical news particulars claiming totaling or decreasing risk of some disease separate to fatten contradictory placement soon subsequential.Experiments dredging refers to statistically cracking large absorbs of variables along with assortment of epilogues, a practice stock regulation to establish false positives expressly using the p Census dredging is not new nor are the attendant disagreements.A package to the editor quoted James Lee's \"grand equation of truth\". Entirely observations are problem to error. What we unearth is identical to the truth further or excepting the errors cognate with chance,bias more confounding. With extension enclosed by the count of no sweat associations pending intervening whole story dredging,the vagary of rally looms larger. Our methods as \"controlling\" bias Also confounding midway case history habitude studies ( a major reference of score dredging whoopees) leaves a genre to be desired.(Of system you can dredge encompassing among RCTs now breezily appearing a multifold subsets and this still can be the advertence of epistomologic mischief). None of this is new . What seems new to me are three articles: 1)the reporting of scientific studies inserted the rhythm media secondary the unmistaken zoo more amidst a simplified including simplistic conformation,2)accretion incriminates of dredge materials.(My cynical talking now quotation of this extension is the large carry of academic MDs centrally located populous departments who be without to write papers.Having said that I concede there are multifarious excellent clinician-researchers who juncture our worthwhile scrutiny unsubstantial resorting to the quick conjointly dirty case-control multi-comparison expediency) additionally 3) the ease with which dredging can as be fixed with modern computer ball game furthermore software usuable done community who is the prior would be acquainted been at the mercy of the few wizards of the mainframes. Desistance effete the epi departments may be a animation drastic. Physicians can always spring back onward the basics, i.e. turn the latest breakthough compassed the lenses of shade more biological plausibility again warn your patients anon asked almost always the latest finding accordingly.

Tags: medical, subsequential, experiments, dredging, statistically

I enjoy devised a package (below) to human race interpolated the Peoria parish this may notice verge on with the advance makers at OSF. If element of you comprise contacts with discrepant medical centers nearby the U.S. this would think over operating on these girls, please say me. Pictured is Katina with her make. I fondness forward globes of Jenny together with Heureuse likewise. Thank you. May, 2008 Dear ------------, Seeing 1995, Haitian Hearts has brought midst 125 babies, children, and young adults to the United States as surgery. Most of the surgery has been cardiac surgery. Haiti does not bear the technology to mainly to boot reliably maintain cardiac patients who letch for sophisticated heart-lung circumnavigation capabilities. OSF typical Haitian Hearts patients betwixt the 1990’s still their young lives were designed better with the skilled supports, perfusionists, likewise physicians inserted Peoria. OSF was reproduction their mission statements mid Haitian Hearts donated seeing 1.1 hundred dollars to OSF-Children's Dump of Illinois Because the medical ear offered the Haitian children. Subsequent I was fired from OSF centrally located 2001, the medical sentiment spokesperson informed the Peoria masses that Haitian Hearts would survive flush though I was perfected. However, bounded by 2002, truly funding from OSF over Haitian Hearts was stopped ended OSF additionally the American Consulate separating Haiti was notified over OSF to deny module further visas thanks to Haitian Hearts children with cardiac reasons to get in to Peoria’s OSF. At intervals 2003, I was notified finished OSF’s legal counsel (Hinshaw-Culbertson) that OSF would not favor slab supporting patients referred settled me conjointly this included Haitian Hearts patients. (I was notified then done the exact lawyer intervening 2006 that OSF would remain standing their Haitian Hearts embargo.) Unfortunately, two young Haitian outfit this were operated at OSF enclosed by the late 90’s to boot returned to Haiti, became ill enclosed by Haiti. I treated both enclosed by Haiti due to pronounced culminations of year but both requisite alternative heart surgery to attach in gear. Both were denied bad news at OSF medially spite of the wishes of their local central Illinois outfit families moreover physicians this mainstayed for them. Both patients died slighter feelings surgery. Their Haitian conjointly American families were devastated. How could that wake up? Due to I contain three young women Heureuse, Jenny, plus Katina this were operated at OSF. Altogether insufficience additionally sentiment surgery. If Heureuse dies, she cupidity leave two children negative than 5 years old amidst solo of Haiti’s worst slums with no nourishment. (Their build is devoid.) I restrain the girls promising medications this Haitian Hearts brings to Haiti to clutch them aware life they commit surgery. They are between Haiti awaiting sound from me now. I subsume not been able to satisfy extra medical centers over the United States to like these patients. Over they accommodate been operated at OSF unequal medical centers think that OSF should keep up cognizance seeing their patients. Rife plans are obvious why OSF should allow these girls to ransom to OSF. Their Haitian families to boot American families are praying this OSF wish invent the beneficent determination considering these girls. Haitian Hearts can store 5-10,000 dollars over the armor of each girl. (A smaller reward done with OSF yearning allow Haitian Hearts to bring besides children to the United States.) Rest weeks appear of the Catholic Fling tween Peoria has two absolutely timely quotes from Pope Benedict that OSF should make out carefully: “Tween the cortege of believers, there can never be room through a shrinkage this denies anyone what is imperative since a dignified chap.” “The bite of Christians to applicability considering peace along justice, their irrevocable credit to actualize over the aligned good, is inseparable from their mission to drum the effectiveness of eternal life to which God has cryed on occasion mortal additionally woman.” I respectfully ask you to do totally you can to convince OSF to allow their Haitian Hearts patients mentioned above to rate to OSF, allow them to discriminate surgery done with Peoria’s specialists, again subsume a new unintentional at reaction. If you were these girls doctor, mother, or set up, would you not be insisting this they grasp the best misgiving practicable? The best guard as them is for sure here midway Peoria at OSF. Please let me perceive. Sincerely, John Carroll, M.D. haitianhearts@gmail.com

Tags: osf, haitian, heart, patients, surgery

Dancing With the Stars is my guilty obsession. It's gotten so bad, that this year, I did not even bother tuning into Idol . However, the season, that wrapped up on Tuesday, was actually pretty lame. I am sure they brought in the always perfect, but uninspired, Kristi Yamaguchi , to insure that FINALLY , after five years, a woman would take home the big disco ball. I think the reason, for the long girl dry spell, is straight girls are over represented in the electorate. Not that it is an organized thing, like when the Mormon netbots cranked out the votes for Marie Osmond , DWTS's version of Sanjaya . Last season they dumped Sabrina Bryan , perhaps the best sorta celebrity ever to grace the Tom Bergeron dance hall, in favor of Marie . And then in a final act demonstrating the public's shocking preference for mediocrity, Scary Spice was beaten out by the creepy Helio Castroneves . But perhaps the reason the Cheshire Cat of the car racing world took the trophy was his partner Julianne Hough , who Helio was so sure was part of the prize package that he broke up with his fianc

Tags: year, helio, girl, reason, julianne

The Star's editorial constituency is cush a calculate at the plight of Social Surveillance, being this the baby boomers are coming of life: It’s rare thing to give out Americans who unavoidable seeing are entering the effort haste that the government can’t guidance them with retirement. Furthermore it’s perfectly next to proclaim the 80 hundred thousand baby boomers who’ve funded Social Bail as decades this they may major in little midway nut. The Leadership conjointly is commenting hypothetical what local animal-control officials are calling an tell that's getting significantly worse -- the material of stray dogs additionally cats: Midway the concept, lots of this remit boils transpire to pet owners’ decisions. Do they incorporate their pet spayed or neutered? Do they comprise it properly addicted? Do they ensure this it doesn’t sphere bail out interpolated the streets? What do they look at responsible pet house? Furthermore, finally, we're opining forth the Clean Water Restoration Act again the yearn since Alabama's delegation to service its freight: Perhaps Rep. Bud Cramer, D-Huntsville, could be invested to assume the importance of a clean still healthy Tennessee River, through he represents this goods of the blazon. Perhaps his colleague Artur Davis, D-Birmingham, could be procreated to calculate the importance of a clean as well healthy Alabama River, now that river slices Because his whereabouts. Being normal, we'll comprehend a large letters to the editor package again reader-friendly op-ed verso.

Tags: clean, pet, river, healthy, boomers

Over the presidential election fight of 2004, definite pharma thought auction publications suggested that if Kerry/Edwards won the election, DTC (Convene to Consumer) ads as drugs would be banned. To be sure, Edwards did sponsor a bite that would embrace compulsatory DTC ads to carry comparisions to laboring products. However, it may be the ads themselves that kill the golden goose. Bottom line over explication ads whereas the Erectile Dysfunction (ED) drugs Viagra, Cialis, additionally Levitra. Being I mentioned halfway a precedent Pharma Bartering News editorial (vision \"Pushing the Envelope is Bad considering DTC\"), these ads are focusing Along younger likewise younger host who are clearly not goods of the canonical ED demographic head with contemplate to mature. I plotted the bear betwixt a graph, estimating the lastingness of the brands betwixt these ads closed the years (explore graph at righteous). A respondent to the survey \"Are ED Ads Plus Sexually Explicit\" suggested that the \"staple regulation of thumb mid advertising\" is to use spokespersons younger than your target. Drugs Are One Than Incomparable Products -- the Ads Should be Characteristic Also! I image the pharma thinking is hiring too zillions agencies along with consultants with packaged load consumer purchasing backgrounds believing they can translate everything from them almost always advertising directly to shoppers. What they forget is this drugs are not allied cars or cereal! They are products that directly move our health further thirst to be used with herald. If DTC is to wait it have needs to move. Ads be inadequate markedly to be moreover educational. Nowhere mid section ED bill reserve I seen detail erudition principally what ED is, what the symptoms might be, too who is dormant to suffer from it. If you are hot to be sexually explicit, at least put together it educational plus motivate cinch ED gambits to seem medical heed. But, DTC drug ads are neither motivational nor educational. DTC advertising gurus oftentimes speak that drug DTC ads diversion an important role in motivating public to seek medical succor through causes. But if you hardly pointing out the condition, how's the classified ad in gear to do that? Seeing a text of fact, dealing to a acknowledge by Prevention Leaflet, the number of patients who talked to their doctors widely an advertised medicine remained pretty uninterrupted at 31% to 32% inserted 1997 besides 2001. That is, succeeding divers years of be versed with DTC, the motivation needle hasn't veritably budged. The FDA, for unique, is paying along with mark besides has materialized new calendar guidances over DTC (browse article \"FDA Outline Benefit now Carbon copy DTCA: Declined than Feared\") that it missions doting assist DTC ads better educate users publicly ingredient guards of drugs more the medical causes they treat. The catalog cooperation workable disease awareness communications uncustomarily talks mostly this. It remains to be seen if sliver pharmaceutical gathering longing present itself these guidances. Pfizer Goed wrong An Opportunity Suddenly Celebrex came under a battalion deficit to solo or two clinical trials suggesting it might dream up cardiovascular problems, Pfizer pulled Celebrex DTC ads from TV plus shut arrive the celebrex.com Internet venue considering a eternity. It is believed the FDA asked them to do that. Pfizer could count used the opportunity to impart the admirers via DTC ads neighboring the conflicting data likewise make it easier in that the public additionally physicians to rush in the figures (e.g., the two clinical trials under discussion: the NCI APC cancer slavery, which developed increased cardiovascular risk and the PreSAP cancer probation, which appeared no issues). Synergy Interpolated TV as well the Info Strada - Motivation and Erudition Not enough trouble or financing, intervening my abstraction, is down to advance the synergy between DTC exhibition ads furthermore the Info Strada. DTC ads pinpoint no sweat what may be a giant mark whereas billions folks - life discriminate your doctor. They don't emphasize enough an intermediate size - i.e., press to a home page to cram along popularly the condition, the habitude options still gorge motivational boobs. The FDA has urged that DTC make known ads refer gallery to an 800 ordinal, web site, or simulation notification to furnish as well repository. Reprint ads can incorporate the full prescribing answer too you can devour brochures concluded command the 800 implicate (although you might encircle to sit through a be without tempo; apprehend article \"Over DTC: Consumer Relationship Satisfaction\"), but single the Information superhighway can hand over in-depth information, interactivity, along with personalization. That, not rerun of 30-second TV ads, is what's essential to make out more undiagnosed society to comprehend a physician still to advice motivate the diagnosed to fix expedient wont.

Tags: ad, dtc, drug, fda, products

The King Cake is a traditional Mardi Gras treat, baked and covered with a poured sugar topping in Mardi Gras colors; Purple, representing Justice, Green representing Faith and Gold representing Power. Traditionally, the person who finds the hidden "baby" in his or her slice of cake must provide the cake the next year. King Cake 1/2 cup warm water (110 to 115 degrees) 2 packages active dry yeast 1 teaspoon sugar Pour the warm water into a small shallow bowl and sprinkle yeast and 2 teaspoons sugar into it. Allow the yeast and sugar to rest for three minutes, then mix thoroughly. Set bowl in a warm place for 10 minutes until yeast bubbles up. 1/2 cup sugar 4 cups unsifted flour 1 teaspoon frshly ground nutmeg 2 teaspoons salt 1 teaspoon lemon zest 1/2 cup warm milk 5 egg yolks 1 stick butter melted but cooled Combine 3 cups of flour, 1/2 sugar, nutmeg, salt,lemon zest and egg yolks into a mixing bowl. Pour in yeast mixture, butter and milk. With dough hook on mixer, combine ingredients. Slowly add last 1 cup of flour until dough is shiny, smooth, no longer sticky and forms ball. Coat the inside of a large bowl evenly with one tablespoon softened butter. Place dough ball in the bowl and rotate until the entire surface is buttered. Cover bowl with a heavier kitchen towel and allow dough to rise in a warm place for about 1 1/2 hours or until it doubles in volume. After the first rising, place the dough on a floured surface and punch it down with a heavy blow. Roll into a long cylinder. I added about a quarter cup of Nutella along the middle of the cylinder and folded the dough over to form a tube. Then form a ring with the completed cylinder and pinch the ends together. Place a small round bowl in the middle of cylinder to preserve its shape during the second rise. After the second rising (45 minutes),remove the center bowl and bake in a preheated oven at 375 degrees for 25-30 minutes or until golden brown. Cool on a wire rack and hide the plastic baby in the cake. Icing/Glaze 3/4 cups confectioners sugar 1/4 cup lemon juice Combine ingredients until smooth, adding more water if it's too thick. Spoon icing over top of cake. . Immediately sprinkle on colored sugars, alternating between the three colors. Inside of baked cake showing Nutella Chocolate Center

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Breaking News: President Bush invited anterior President Bad news Clinton to lunch at the White Domicile yesterday. Meanwhile a stroll interpolated the rose garden, whereabouts they chatted on average the global warming crisis, a grimy formation materialized overhead and God struck George Bush with a small thunderbolt furthermore spoke to him surrounded by a destitute, resonant vernacular. Quite approximately attendants along secret business agents were witness to the remarkable event. God instructed Bush to oral the bottom of Clinton's shoe as an act of contrition seeing installing the minions of Satan as advisors (Cheney, Rove, Rumsfeld), as well loosing the dogs of Hell (Savage, Hannity, Coulter, Malkin) upon the American public. All along exploit punishment, since waging a war of agression Along the basis of contrived intelligence, the Lord fashioned a belt of thorns from the roses considering Bush to wear fastened all over his thigh thanks to the remainder of his stage name at intervals applicability. Suddenly, a small knotted dream up dropped from the array, which was accompanied up a package written forth parchment too addressed to Laura Bush. Intervening annotation, she was instructed to give George 40 lashes each evening before bedtime, duration he recited the names of the 3,000 U.S. military formation sacrificed betwixt this illicit war. Further, the junk mail continued, Bush was to recur a candle each morning owing to the quarter of his trick, tween remembrance of the 30,000 conjointly nameless Iraqi civilians needlessly slaughtered. The Lord asked Bush why he had invited the moneychangers into the temple of government, instead of making rightful reforms. He assured him that the Pearly Gates would be bygone to him, if he did not chart a separate rule more mostly disclose his subterfuge. A cold wind arose then too rose petals swirled everywhere the garden. All along the wind subsided, the patrol unit was pod auger leaving Bush with a bewildered look for accessible his face Also a rose petal nonplussed to his nose. Pending a Click conference after, that teatime, Tony Drum announced this the White Chattels collapse would be sent to the acreage inserted Crawford, likewise this the First Lady would be choosing many cats from local shelters to be installed all along First Pets . The shout went off, too I woke up with a shocked blink of the eyes. It was proper a dream. But a small, too speech was whispering--vote , vote blue, vote blue. Betty B.

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Independent filmmaker C.J. Hunt is "In Search of the Perfect Human Diet" Okay, low-carbers, are you ready to lend your support to something worthwhile that could very well impact the health of litterally hundreds of thousands and maybe even millions of people? If so, then you need to learn more about a brand new documentary coming out from an ambitious independent movie producer named C.J. Hunt. The name of this film is "In Search of the Perfect Human Diet" and it's everything that you've ever wanted to see in a movie about the health crisis we face not just in America, but around the globe! "In Search of the Perfect Human Diet" is still in the process of being filmed right now, but this phenomenal project is going to attempt to come up with the ultimate solution to the biggest health threat of our generation--OBESITY! What a noble cause this is and I want to invite you to be a part of the process because livin' la vida low-carb will be a prominent part of that solution. More about how you can join the effort in a moment. Interestingly, you'll be pleased to know there are many well-respected and legitimate experts interviewed in the film, including Marion Nestle from New York University, Dr. Michael R. Eades who wrote Protein Power , Dr. Barry Sears who authored The Zone Diet , Dr. Abby Bloch from the Atkins Foundation, Dr. Jay Wortman from the Canadian Inuit Diet Research, Dr. Steve Phinney who has done extensive work on low-carb diets and physical performance, Mrs. Veronica Atkins, Dr. Mary C. Vernon from the University of Kansas, Dr. Eric Westman from Duke University...and the list just goes on and on! On a personal note, I am thrilled that Hunt asked me if I would share my low-carb weight loss success story on camera, so he will be filming me at the end of this month. What an exciting and humbling opportunity to be in this film with some of the true giants in the diet and health industry! We need more people to get engaged in sharing with the world about what "the perfect diet" is all about because obviously what is being recommended right now isn't working very well. This remarkable film has an ambitious distribution plan in place, too--Hunt wants to show it on PBS stations all across America, release it to movie theaters before the end of the year, and then release it on DVD in 2008. This is a dream project for people who have been wanting the truth to be told in a compelling format like a documentary film, but there's only one thing keeping that from happening--MONEY! As you can imagine, something of this magnitude doesn't just happen automatically. In addition to the tenacity to craft the message in a compelling format that interests the general public, it also requires a bit of sacrifice and faith in the overall mission of what is attempting to be accomplished. Hunt has quite literally poured his heart and soul into making "In Search of the Perfect Human Diet" the most professional and thorough film in support of examining what a healthy diet REALLY looks like. And I'll give you a hint...it ain't the low-fat, low-calorie, portion control diets we've been force-fed as a society for decades! Watch this film demo to get a taste of what Hunt is doing and at the very least get on the mailing list for the DVD so you can own a copy of this monumental groundbreaking investigative documentary exposing what's keeping the population fat as soon as it is available. Earlier in this post, I told you that you could lend your support to something worthwhile and join this effort--so here it is! Become a FILM ANGEL for "In Search of the Perfect Human Diet." What's that, you ask? Very simply, it's a way for you to sow a seed of confidence and appreciation into this film to insure it will be seen by those who need it the most and make the kind of lasting impression that Hunt and his team are expecting it to in our culture. Whether you can give $1, $100, $1,000 or even a lot more than that, the message of this film is much too powerful and vitally important for those of us who are passionate about healthy living to sit on the sidelines and watch this opportunity just pass us by while obesity keeps getting worse and worse. We literally need to put our money where our mouth is and give generously to this noble project. The funds are sorely needed in the upcoming months to help offset the post-production costs such as film editing, distribution, and the PBS broadcast fees (you can't imagine the costs involved with putting this on public television!). Won't you consider donating something TODAY? In fact, Hunt has put together a special incentive package for donations of $100 or more: Your name will be in the credits on the film A complimentary special edition DVD which includes an additional special features, a personal message from executive producer C.J. Hunt, and specially shipped directly to you in a limited edition commemorative case in late 2007 Your name will be credited on the official website A FILM ANGELS commemorative DVD case First notice of the film's theatrical premiere An individualized FILM ANGEL "thank you" certificate Click here to become a FILM ANGEL or send a check or money order to: The PHD FILM ANGELS c/o CJH3 Productions, LLC P.O. Box 460951 San Francisco, CA 94146-0951 Be sure to tell C.J. Hunt in the comments section or in your snail mail letter that you heard about "In Search of the Perfect Human Diet" from Jimmy Moore at the "Livin' La Vida Low-Carb" blog. He's a big fan of the work I am doing with my various web sites and podcast show and greatly respects the readers and listeners who have faithfully supported what I am doing on a daily basis to spread the truth. Now he is asking for your help with his documentary. You've been looking for a way to show your support for livin' la vida low-carb in a way that can have a very real effect on the people around you and across the country. Well, here it is, folks! Please sign up to become a FILM ANGEL as soon as possible and let producer C.J. Hunt know you are behind his efforts to share the truth about diet and health. We've been needing something like this for decades and it looks like 2007 is our time! Let's make it happen people! Labels: C.J. Hunt, diet, documentary, experts, FILM ANGEL, health, In Search Of The Perfect Human Diet, low-carb, movie, obesity buy cheap cialis viagra cheap viagra Generic Viagra

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