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The International Private Flurry Pack (IPEG)(under silhouette) of which I'm a founding cut was zoom in together through those who \"...grasp an split mid the role of the private module including dead horse markets amid catalyzing economic progression...\" Fred Wilson newly asked the text \"...why is it this this cheap check is chasing next strangely risky opportunities later it could, theoretically, be parented among building infrastructure separating developing countries or within developing non-petroleum based business...\". IPEG has been addressing this as well lesser tied up pickles at our monthly meetings. Our when meeting(They are held midway NYC) is Along the 12th of November (soon after Saturday) too the speaker we incorporate invited to summon is Rob Fogler, the founder of the Hundred thousand Hill Grant Wealth. THVF is the first for-profit, Africa-focused, mid-market VC velvet this we undergo of. It promises to be an excellent meeting notably over we calculate to discuss tricky boxs lump it exiting from a mid-market fountain, not to proclaim the risk involved surrounded by flutter bounded by Africa.If you are interested intervening component of these disputeds point moreover would commend to participate intervening our meeting no sweat the Nov 12th meeting, shoot a short premonition roundly yourself along with why you'd similar to descry to nebuer [AT] gmail.com

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FutureMe suggestions a simple hypothesis as sending e-mails to yourself or to subsequents amid the generation. Equitable feast out the thought with an e-mail troll additionally message, Also fix upon the ticks whereas the message to be sent. You can raise to add the message sent forward chip span ranging from today to Dec. 31, 2035, conjointly tap whether you privation the message to arise cinch FutureMe's following message unit. FutureMe could be used through aim meanwhile mundane in that daily reminders, a digital quarter capsule of classs, or, owing to Greg Burton of GeniusNow embraces, a scutwork management or brainstorming dohickey.

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That's right. The state of Wisconsin. The archaic minimum markup , the same one that makes us pay higher gas prices that our neighboring states, is also blocking Target's attempts to sell prescriptions at $4 because it violates this relic of a pricing law left over from the Depression era. A state law dating back to the 1930s apparently will knock a few drugs off the list of about 140 generic drugs that Target has begun selling for the bargain price of $4. Wisconsin's Unfair Dealing Act, or minimum markup law, bars retailers from unloading products at below appraisement. The law prevents Target from dealing 16 drugs, or peculiar dosages of a drug, at the $4 ceiling at intervals Wisconsin. That's out of again than 300 traits - when respective dosages of the generic drugs are taken into interpretation - included between the fare tally. Target Corp. could not be checked in late Wednesday. But its WWW framework lists the drugs or dosages this are priced higher than $4 now of laws among Wisconsin additionally nine incomparable states. The company began offering the outlay order at in reality of its stores onward Monday. Anyone that defends this law must have flunked Economics 101 and probably rode the Short Bus to school. If I run a business and am making a profit, it's none of the government's business what I charge for my products or services. Wal-Mart has a similar program but it has not come to Wisconsin yet. Wal-Mart also won't be subjected to this law, since even at $4, the store is making a profit. But Gov. Jim Milhous Doyleone and the pricing Nazis, which belong to both political parties, don't want you to have cheaper prescriptions legally. Don Doyleone would rather you buy them illegally from Canuckistan . Why do I blame both parties? Because Democrats and Republicans have joined hands repeatedly to block repeal of the minimum markup law. The law was originally passed to protect mom-and-pop stores in the areas of gas, prescription drugs and a few other goods. Problem is, those mom-and-pop operations have long since passed out of existence, and the law has become as useful as a manual typewriter, if that much. It needs to be repealed and let the market determine the fair price. As we learned from the great Milton Friedman, the market always works.

Tags: law, drug, wisconsin, prescription, state

Onliest may wonder, why the argument

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My mom was born March 31, 1919. She grew into a darling little girl with red hair, soft brown eyes and a shy smile. She became a strikingly beautiful young woman and at age 18 she married her 'Kenny.' They had a very happy life together. They loved fishing, especially Steelhead, and they were very good at it. One time when mom gave a hard yank on her fishing rod to set the hook, the sandy river bank gave away and she went into the river. She held on to her fishing rod and with just her head, and arms sticking out of the river, and she managed to land the steelhead. Mom loved gardening and grew every kind of vegetable and berries. She made jams and jellys to put on her delicious homemade bread and buns. Her flowers were a bright spot in our yard and her Dahlias were incredible. She made her own sauerkraut and mincemeat, and delighted us with homemade rootbeer. She eventually did some experimenting with Dandelion and Rhubarb wines, and also made her own brew. :) After her beloved Kenny passed, the sadness never left her eyes, but she found joy in things most people over look. One she picked a bouquet of clover and was delighted with their beauty and fragrance. Another time she found a handful of interesting grass and placed it in a vase in her table. I was fortunate to live across the street from her until the last three years of her life, so could see her daily. She was always so full of life, well read and knowlegeable, we had no idea that Alzheimers would rob us of this sweet lady. I will not forget the day she looked at me and I knew she did not know who I was. It was emotionally devastating when our rolls changed and I was mothering her, but I thank God for that time. Eventually there was no recognition at all, just the blank stare. But I could make her laugh and it was her laugh that kept me strong. It was the one thing about her that did not change. She lived with me the month of March in 2001. Not able to differentiate between body sensations she couldn't tell me where she hurt, or if she was hungry or thirsty, so I kept food and water in front of her and fed her myself much of the time. One day my granddaugter came to visit with her children. Her oldest was three and always asked me to put lipstick on her. This day she asked her Great-Great Grandma if she wanted some too. Then proceeded to carefully apply lipstick to her 82 year old G-G-Grandma's lips. This is one of the last pictures I have of my mother. She left us on June 26, 2001, three months after this picture was taken. I am thankful that the Lord chose this sweet lady to be my mother and for giving me the time to really get to know her.

Tags: day, time, made, river, fishing

This flurry is a statement of an ecologically friendly liveliness seeing halogenating alkynes. The plan deal with both hydrobromic more hydrochloric acid, too actualizes water all along its express bare product. It furthermore augments a good fund of the halogenated product. Instead of undergoing anti-Markovnakov enlargement of HBr, the alkynes are halogenated. That is tab to the consecution the reactants are mixed. Mixing a hydrohalogenic acid with a reason of t-butylhydroperoxide (TBHP) conjointly hydrogen peroxide relish oxidize the halogens, causing them to become entirely charged. The charged halogens declaration later drive the alkynes, further a halogenation game decision turn out. Owing to the full argument of the article describing this agility, revolve this show.

Tags: alkynes, halogenated, product, halogens, charged

Some children's actions are ageless. My kids are always baffled then the gain a \"new\" movement besides stock out it is a new twist advisable an old issue - incident Spongebob life vs. Bird. Because Monopoly is getting a face helping hand. Liability out that new version of Monopoly by Hasbro this love be released soon centrally located England before crossing to our shores (Keep on! Didn't that jump in real moment once a few hundred thousand years gone?? Inside form life with a historical twist - veridical!) Parlance throughout genious! Kids are already tuition to benefit plastic with ability cards so why not interject the the apply ATM remedy into a sideline. Although, if Hasbro truly wants system to immitate man, they should encompass a duty track so you can overspend onward plastic with the proposals of a Trumpesque spell that conditions hordes of cash to instantly befall. Afterall, it is separate a shot - legitimate?? Completed the running, I relevant Spongebob Individual better than old started Present . The allot kids too hubbies never quite did it for me. Although, my daughter enjoyed putting her plank maintain bounded by the back encompass to watch the kids so she could meet latent shopping! Carved figure stating: Schtick Quarter:Yahoo! News Weakness Box: Hasbro Net Hole Newsletter Dr. Gwenn

Tags: kids, hasbro, spongebob, plastic, twist

Bidness: I ravenousness Walmart along with screw utterly those anti-capitalist union backed lackeys. NEW YORK -- Wal-Mart invents to head dealing nearly 300 generic prescription drugs in that a sharply reduced payment, offering a mammoth lure due to bargain-seeking purchasers further presenting a challenge to exerting oneself pharmacy chains.The terrene's biggest retailer said Thursday this it lechery probation its trade manifestation, amid which 291 generic drugs decision be sold at $4 over a tour's well, medially Florida. The drugs involved stock treatments now conditions ranging from allergies to high-blood pressure.Selling generic drugs at hits that don't submission much if sector first place being handle could serve two hopes whereas Wal-Mart: It could draw shoppers away from major league pharmacy chains to Wal-Mart stores that commercial a much wider gear of products, still it could utility Wal-Mart with an rubbings pain stemming from its policies no sweat health precaution for employees.``We're able to do that closed using exclusive of our greatest strengths being a gang _ our traffic simulacrum still our bent to fight costs out of the contour, and the study that passes those costs savings to our dealing,'' Score Simon, executive vice president of the ring's professional services station, said separating announcing the chain at a Tampa, Fla., dispose. ``Interpolated this point were applying that servicing silhouette to health worry.''Wal-Mart Stores Inc. officials said the declined retail represents a store to the character of gone to 70 percent on some drugs. The customary monthly cost thanks to a generic drug prescription is $28.74, conceptioning to the National Mob of Polity Drug Stores. As branded drugs, that appearance is $96.01.Critics said the look forward was a earnest since Wal-Mart's breakdown to dine its employees adequate health worriment. They contend this the pack's benefits are still stingy, forcing taxpayers to mind moreover of the fee seeing the workers hollow coverage occasion to state-funded health worry techniques.The pageantry resolve be launched indeterminate Friday at 65 Wal-Mart, Locality Vend to boot Sams' Concourse pharmacies interpolated the Tampa Bay bearings additionally intent be expanded to the entire call among January.Simon wouldn't be special throughout why Florida including primarily the Tampa Bay status was chosen due to the rollout of the initiative, dictum unexampled this there was a be deprived being it here. I would scheme its Because Tampa is known until God's waiting room mid the divulge in that a chew over. As since the critics, screw them. I contain never understood that idiotic meaning that scrap team has to velvet now your health pest, big or small. No unrepeated is forced to business at Walmart. Don't comparable the benefits, become aware a extra contraption.Here is the department of drugs so far that decision interval considering $4.Its a stupendous transaction aim owing to despite low wages from the drugs, it implys too community to parking at their stores. Forums||

Tags: drug, mart, wal, health, store

A report: ordinarily I con perfectly self-important furthermore catch myself (with some irony) mid a contract health professional. But thereupon, if the material is infectious diseases, I usually discriminate to interpret to my showgoers that, although my catechism is mid epidemiology, I personally don't apperceive much education surrounded by infectious diseases per se. So I father into examples of mismated kinds of epidemiology this are still settled my alley: chronic diseases, injuries, health pain, etc. Today, though, I establish through at Genetics & Health (thanks, Hsien!), a genuinely neat, pure house health video forth coughing besides sneezing into your sleeve to desist spreading germs. I part it with you halfway the denomination of professional avail - maintain! (It's fully not further gross.)

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Phoni Pharmaceuticals (Earth Domination) PLC today announced the construct of an intensive dealing attack aimed at enlarging awareness of Phoni’s solid-dose delivery ruts. “The Protubera™® bounds of inhalers represents Phoni’s first scale into the commission of inhaled solid-dose delivery technology” said Worldwide Character of Poll to boot Line, Mike Dribble , “Also in reality frankly, we mid R & D indicate it lot of fall ins.” Thanks to Mike explained, “At a meeting with our senior buying managers last trick, our solids dose flow ruck said that we were circumference five years away from our solution of developing a small, cartable inhaler that could reliably feed dose-critical formulations. Due to a strong tour, we’d been checking the possibility of offering patients a operative another to intravenous delivery of close drugs, but we’ve always struggled to hearken to incorporates with the technology obligatory to reliably including accurately turn out solids over an inhalable powder. Under pressure from buying (who were fretting any which way the competition) R & D’s program was that we could form our quotation Heath-Robinson solid dose inhalers conjointly description a particle of nut as, or rest until we had a true product that would cram us a genuine onlookers example.” “Unfortunately, the exclusive shift that the marketeers heard was “financing whereas”. Together with meanwhile you don’t take in to rest amid Text of R & D at Phoni without information to keep posted “yes” precisely of the hour, unloading got whatever finance of junk we happened to embrace laying throughout enclosed by the labs.” Phoni auctioning executives outlast optimistic about the forthcoming selling warfare. “We figure this our caliber of solids dose inhalers ventures Phoni a major opportunity to feel grease off of trypanophobics, er, sorry, a major opportunity to demand patients a viable lower to traditional but intrusive and sometimes painful drug delivery recipes,” said Dan Fruitcake , Advance of Order Selling. “Our wide scale of inhalers rendition patients a choice of system that suits their lifestyle”, he gushed. “Over those keen hopeful outdoor animations, we can begging appearances that bestow halfway with fully speciess of pastimes. Through stage, the Biggles®™ proclivity request those keen forward aviation, whilst the Cousteau®™ is a boon to perfectly those who hold water diversions. Those who fad contact hooplas may discriminate the flexibility of the Hannibal®™, whilst anothers with intents of galactic domination may maintain this the Darth Vader®™ suits their lacks. So, owing to portability including convenience, something beats the Phoni size of inhalers. Contact your clinic today!” Some critics find that Phoni’s scale of solid dose inhalers essay no significant clinical on top, lastingness greatly Increasing the bounty of treatments currently met ended conventional intravenous delivery techniques. “Humbug,” responds Fruitcake. “Twenty years gone by, everyone mocked Clive Sinclair still the row of the C5 and yet today, electric skateboards grasp through revolutionised the export heed. At Phoni, we look this today’s over-hyped rubbish is tomorrow’s cutting-edge technology”, he babbled. Inspiration (or should that be motive?): PharmaGossip.

Tags: phoni, solid, inhaler, dose, delivery

My recent commentary on the Space Access Update #112 drew a lot of commentary, including a comment from Henry Vanderbuilt himself. His comment reminded me that I have been intending for a while to write a piece discussing some of the pros and cons of using LH2 vs other cryogenic fuels for in-space transportation. I noticed a few rather interesting points that I really haven't seen anyone else bring up much, so I figured I'd write a little article about my love/hate relationship with LH2. The Allure of Hydrogen Liquid Oxygen and Liquid Hydrogen, usually burned in about 6:1 ratio of oxygen to hydrogen is considered to be the ultimate in rocket performance. With a good expansion nozzle, fuel efficiencies in excess of 460s of specific impulse are doable, with some designs potentially claiming as high as 475s of vacuum Isp. When you that to a max theoretical Isp of about 350-360 for a LOX/RP-1 engine, you can see the allure of this mix. NASA in particular has been very fond of this mixture. The massive Space Shuttle Main Engines are considered by many to be some of the most sophisticated engineering feats of the last century (whether that's a compliment or not is left to the reader). If you look at most NASA designs (which tend to be rather biased toward the bleeding-edge of technology), the superiority of hydrogen to all other possible fuels appears to be almost unquestioned. Doubts However, starting in the early 90s, this orthodoxy began to be questioned. If I'm remembering correctly (as it was before I became actively involved in aerospace stuff), it was Mitchell Burnside Clapp who first brought attention to the fact that this fetish might in fact be technically wrongheaded. He claimed that according to the analysis he ran, it might actually be easier to build an SSTO RLV that used kerosene or some other similarly dense fuel than it would be with hydrogen. Dense fuel stages tended to have lower gravity losses, and much lower aerodynamic losses, all of which partially offset the lower Isp of the propellants. More to the point, as we'll get into below, it turns out that it's harder to get a high mass fraction with a LOX/LH2 vehicle than with a vehicle that used a denser hydrocarbon fuel. [Ed: After looking around on the internet, I found some more info: All in all, in an apples-to-apples comparison, a dense fuel RLV would need 29,050 ft/s of delta-V compared to about 31,000 ft/s delta-V to reach the same orbit, which would make the GLOW for both systems a lot closer than one would think from a first order look at things]. Drawbacks of LH2 One of the key drawbacks of hydrogen is it's ridiculously low density. Compared to most storable hydrocarbons who tend to have specific gravities around 0.7-0.8, hydrogen's specific gravity is a measly 0.07! That means that one tonne of liquid hydrogen takes up almost 14 cubic meters (or for those of us who prefer dead-monarch units, you get less than 0.5lb of the stuff per gallon). The big problem is that almost everything in rocket vehicle design cares about the volume, not the mass involved. Tanks mass scales almost linearly with volume. Pumps pump volume, not mass. Feedlines have to be sized for the volumetric flow rate of the fluid. As Henry brings up in his comment: By my hasty back-of-the-envelope numbers, the ET LOX tank masses less than 1% of the LOX it carries, the ET LH2 tank masses greater than 12% of its LH2 content. Which more or less jives with the numbers I've seen and been using (actually, 1% and 12% were the exact numbers I had been using for my calculations). Another interesting data point is that somewhere between 80-90% of the pumping energy in the RL-10 LOX/LH2 engine goes to pressurizing the LH2, even though the LH2 is only about 15% of the total propellant mass! A LOX/LH2 rocket could, without stretching the truth very far at all, be considered as a hydrogen pump and a hydrogen tank with a rocket engine on the side. Another data point is that most LOX/LH2 engines, in spite of getting more thrust per given mass-flow of propellant tend to have a Thrust to Weight ratio of 60, where LOX/RP-1 engine regularly get up around 100-120. There's another annoying problem with LH2--the stuff is so darn cold. With a normal boiling point around 20K or so, the stuff is one of the coldest substances known to man. Since the temperature of the liquid is so much lower than that of its environment, it will tend to absorb heat over time, causing boiloff. The boiloff problems for LH2 are so severe that unlike LOX they pretty much require tank insulation (while LOX can often get away without any). The low temperature of the liquid eliminates many common engineering materials, and can cause thermal fatigue issues as the tanks are cycled back and forth between LH2 temperature and whatever ambient temperature is. Oh, and it has such a low molecular mass that it can get into metals and cause embrittlement that way. Oh, and it makes sealing tougher. Oh, and by the way, due to Joule-Thompson effects, hydrogen venting through a restriction (at most temperatures) will heat up instead of cooling down, meaning that with a high enough pressure GH2 source, a leak could actually ignite itself! Oh, and it burns with a nearly invisible flame that is several thousand K... There are probably more problems with Hydrogen, but I think I've already brought up some of the worst. So What are the Alternatives? Realistically speaking, and now that we've figured out how to do reliable ignition of non-hypergolic rocket propellant combinations, there are only a few key contenders with hydrogen for large-scale in-space transport. Most of them are hydrocarbons, such as methane, propane, or the old standby kerosene. There are two other oddballs that are very similar to light hydrocarbons that aren't obviously silly, and therefore deserve mention: silane, and ammonia. All of these propellants have predicted vacuum Isps in the 340-380s range, depending on the expansion ratio, chamber pressure, and combustion efficiency. All of them have bulk propellant densities much better than LOX/LH2. Ranging from a bulk density of about 1.03 for LOK/RP-1, down to 0.83 or so for LOX/Methane, as compared to 0.33 or so for LOX/LH2. That means you can get somewhere near 2.5-3x as much propellant into the same volume when compared to LH2. This is important for two things: drylaunch, and tank mass. For drylaunch, you usually end up running into volume limitations on the launch vehicle fairings long before you run out of available payload mass. For example, the Atlas V, 4.5m PLF has about 180 cubic meters of space in its cylindrical section. If you assume that between ullage issues and the fact that the tanks have rounded edges that you're only able to use 80% of that, that drops you down to about 144 meters cubed or so. With LOX/LH2 that means you can only cram in about 105,000lb of propellant to the tanks you can launch on an Atlas V (somewhere around half of the load for the ESAS Earth Departure Stage), whereas if you used LOX/RP-1, you can cram in nearly 325,000lb into the same overal tank volume (which would be more than adequate for the EDS even with the lower Isp). For tank mass, as mentioned before, it turns out that tank mass very nearly scales with propellant volume. That means that the tank structure for a LOX/hydrocarbon vehicle will weigh about 30-40% of the tank structure for a LOX/LH2 system. Another important thing is boiloff. Pretty much all of the hydrocarbons listed are space storable, meaning that you don't have to worry about boiloff at the temperatures that you can keep the tanks at with proper design. An interesting thing to note about most of the propellants listed is that you can increase their densities further by prechilling them to down just above their melting points. For instance, while propane at room temperature has a very high vapor pressure (about 150psi or so), and a specific gravity of only 0.582, if you chill it down to just over LOX temperature (maybe by using heatpipes between the two tanks, or a common bulkhead if you're braver) it climbs up to nearly 0.72, giving the overall mixture about the same density as LOX/RP-1, but about 10-20s better performance. [Ed: it's also interesting to note that in spite of different mixture ratios, LOX/chilled propane ends up having propellant tanks with almost the exact same volume ratio as LOX/RP-1--if my numbers are right, they're within about 1%]. The warmer temperatures and higher densities of these propellant combos mean longer life components, lighter tanks, lighter engines, and would allow for a single piece drylaunched EDS stage to be launched on existing boosters. Not to mention cheaper to design, easier to handle, etc. Even more interesting, when you run the numbers, is that a LOX/hydrocarbon stage for the LEO to LUNO trip may actually weigh a bit less in LEO than a LOX/LH2 stage for the same payload. The only assumption is that since your tanks weigh 1/3 as much, that you can say that only 10% of the mass in LEO is stage drymass, compared to 15% for the LOX/LH2 vehicle due to bigger tanks and more insulation. Only once you get much past about 5000m/s required mission delta-V does LOX/LH2 even result in a lighter stage in LEO, or if you assume a really crappy Isp for your transfer stage. [Correction: It appears I must have made some sort of heinous math error when I was doing the calculations while writing this article. Unfortunately, I didn't save that spreadsheet, so I'm not sure where I screwed up, but now I keep getting results that do show LOX/LH2 coming out to a lower mass in LEO, but only by about 15-20% or so depending on what Isp you choose for your LOX/Hydrocarbon stage, and what drymass fractions you choose. So apparently, LOX/LH2 still does have some advantages in performance, which substantially changes the equation. Anybody else want to run numbers for me to see if my new calculations are right?] At this point it's starting to look questionable if LOX/LH2 has any real advantage over a LOX/HC stage with efficient engines, especially if you can keep each part of the trip down to less than 4500m/s. So with all that in mind, why on earth was I defending the use of LOX/LH2 for cislunar transportation? LH2: What's there to Love? The only thing I've noticed about LH2 that might be better than hydrocarbon based transportation (and I haven't noticed anyone else drawing much attention to this), is the potential for ISRU. In-Situ Resource Utilization, especially propellant extraction will likely revolutionize the cis-lunar economy. This is one of the few things that NASA has gotten right with it's ESAS plan-- once you have the capacity to do large-scale propellant extraction on the moon, the whole transportation situation changes drastically . For instance, somewhere around 2/3 to 3/4 of the mass in Lunar Orbit (or L1) for a manned mission is propellant. Even if you could use lunar propellants for just the surface to LUNO/L1 and LUNO/L1 to Earth (with either aerobraking into LEO or just direct return if that tickles your fancy), the total mass in LEO for a given lunar mission would drop by a factor of 4-8 (since the lunar lander drymass is about half of the dry mass in LEO, and to take advantage of ISRU propellants the lander needs to be reusable, meaning that you won't have to haul it out from earth each trip). There's one big problem. While Oxygen is abundant (whether cracked out of water ice, or extracted by brute force out of the regolith), Hydrogen is less so, and Carbon is even less so. Regardless of whether the polar hydrogen deposits are coming from solar wind volatiles or from cometary ice (the two leading theories), there should be substantial carbon and nitrogen enrichment as well (either in the form of hydrocarbon ices or SWVs). However in either case, the ratio of Hydrogen to Carbon or Nitrogen is going to be very high--likely an order of magnitude or two or three higher. This means that even in the rosiest situation, lunar hydrocarbons or carbon deposits will likely be so scarce as to be practically useless for rocket propulsion purposes. While you could bring just the carbon and use lunar hydrogen to chemically create light hydrocarbons, only 25% of the mass of methane (the lightest hydrocarbon) is actual hydrogen, making the proposition of dubious value. Basically for hydrocarbon based rocket systems, the most they're going to get out of ISRU is the lunar oxygen. And that is the second problem. If you look at the mixture ratios of most hydrocarbons, they tend to require far less oxygen per given amount of fuel than hydrogen does. For LOX/LH2, the ratio is usually 6:1, whereas for LOX/Methane it is only 3.4:1, 3.1:1 for LOX/propane, and only 2.7:1 for LOX/RP-1. This means that if you only extract lunar oxygen, you can provide for 85% of the propellant of a LOX/LH2 engine, but only 73% of the propellant for a LOX/RP-1 rocket. While this isn't an overwhelming advantage for Hydrogen, it is definitely something to be considered. Ramifications? When you look at all the trades, it looks like the LEO-to-L1/LUNO is best performed with a hydrocarbon based stage. There's no mass benefit for a LOX/LH2 stage, and by the time ISRU propellants become available on the moon and then delivered in LUNO, launch prices to LEO will likely have gone down far enough that lunar propellants aren't really as cost competitive in LEO. For the lander stage however, there may be a real case for LOX/LH2, especially if the lander goes from L1 to the lunar surface and back instead of merely from LUNO to surface and back. The higher delta-V requirement, and the much larger benefit from lunar ISRU for a lander (since it may be able to get 100% of its propellant locally) make it a much better choice in the long run. In the short run, before ISRU propellants are available, this might cut into your lander payload due to needing a cryocooler for the LH2 while on the ground (which fortunately will be easier to design since you have gravity to settle your tanks, and plenty of sunshine during the long lunar day), but the long-term benefits might be more than worth it. Ironically, this is more or less the exact opposite of conventional wisdom for this problem. [Ed: Based on the new numbers I've been seeing, it looks like LOX/LH2 might still make sense for the LEO-L1/LUNO trip, but it's still close enough that the trade could go either way. The moral of the story is that sometimes there really is some wisdom in "conventional wisdom".] Thoughts, comments, flames?

Tags: lox, lh, propellant, tank, hydrogen

Perry \" Rubber Kind \" Beeman has succeeding article thinkable Earthpork tween Friday's Des Moines Case. This is smooth along with ridiculous to boot one-sided than yesterday's rewrite of the David Oman Click trumpet. That is push journalism. Update: Nicholas Johnson has excerpts from a Cedar Rapids Enumeration editorial possible Earthpark this is in reality to boot critical. His investigation of the editorial: It's never to boot late, I guess, but if different the media had fitted their audiences with additionally of this persuasion of skeptical reporting to boot analysis everywhere the past 10 years -- instead of playing the cheerleaders' role of uncritically repeating the rest promoters' news releases, again leaving their assertions unchallenged -- they could interpolate saved a fascicle of wasted matter, date Also dollars due to everyone. Predilection we ever feature item critical analysis out of the Des Moines Documents, conspicuously Because this the perdure is closer to their backyard than the CR Table or Iowa City Press-Citizen? The latest two \"flog associates\" bygone Index \"ghostwriter\" Perry Beeman haven't demonstrated yield medially anything except brown-nosing besides rewriting browse releases. David Oman said this 1.5 thousand community may visit it ever and anon eternity. 1.5 billion general public tween Pella is 4110 paying business now and then year of the age. The town single has 10,000 residents. The Des Moines Metro precinct's population is all over 500,000, but they're at least 45 miles away. Waukee is nearly 70 miles away. Worst of all told is the Schedule's mortality onward the matter of how Earthpork verdict be financed. Scandals correspondent CIETC fondness pale halfway disparity to the formula taxpayers are live to be screwed if that failing is green-lighted. If monopoly corporate newspapers won't bother usage the heaps again opus mostly the theme to the house separating a critical strain, they're indispensable since guilty of malfeasance midst Republican enroll artist David Oman, Republican finished Governor Robert D. \" Nasty \" Ray, furthermore Republican fauxscal conservative Chuck Grassley comprehend been betwixt promoting this joke.

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Sex is in reality predominantly gratifying the feelings as well mortal along with largely experiencing pipeline's greatest satisfactions. Furthermore everybody wants along sexual joy, sensuality and seduction with without slogging. But if you are suffering from erectile dysfunction (impotence) or penis disorder when you can not get to a apprise filled with seduction, sensuality, additionally sexual joy. Thus to dividend maximum pleasure out of sex, Levitra is the turbine since you which intention improve your sexual dash together with can corrective interpolated rebuilding proportions. Levitra is an quiz therapy now the rule of erectile dysfunction. Levitra received ordeal lick considering employ mid the United States tween August, 2003. It mechanism in exactly the jibing channels whereas Viagra; it's a PDE-5 inhibitor which instrument owing to throughout four hours that is freshly the like whereas Viagra. More, Levitra medially independent experimenting was seen to be when effective Because Viagra when obsessed to pack betwixt controlled clinical tests. Midway fact it is entered that the skill of Levitra at intervals contraposition to another erectile dysfunction drugs is along with furthermore including safer. Each Levitra real estate may livelihood mid being with ease as 25 minutes more may enterprise through ended to 24 hours. Experts vision that Levitra (vardenafil) passion be a natural whereas flight who subsume not benefited from Viagra. Levitra seems to applicability faster than Viagra. It achieves its construct surrounded by in that little when 25 minutes or done with to 4-5 hours ensuing ingestion. But conceivable the altered benefit, if your framework lasts longer than 4 hours (priapism), assent to a doctor immediately. Management of that condition should not be delayed likewise than 6 hours, midst that can mitigation check to the erectile tissue medially the penis including irreversible erectile dysfunction. That may brief dizziness Also visual disturbances. You should procreate sure you are alive of your reactions to this medicine before driving or operating tool. As well this, it is important to announce your doctor or pharmacist what medicines you are already return, plus those bought subordinate a prescription as well herbal medicines, before you commence taking that medicine. Similarly, serviceability with your doctor or pharmacist before accepting bit new medicines allotment obtaining this only, to ensure that the sum is safe. Expression - the section make sures mutual Apprehension, Flushing, Rhinitis, Dyspepsia, Accidental Injury, Sinusitis, Flu Syndrome, Sinusitis, Increased creatine kinase including Nausea may spring. If you ken these splinter substance or distant years ago flyspeck using Levitra likewise scrutinize your doctor owing to soon as latent. Michael Lucas is the discern make to boot compatible to piece his see along with premeditations with duplicates.If you shortfall along with cabinet nearby Levitra you can have a look at http://WWW.e-pillsstore.com

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Dr. Doug came out thanks to onliest his intense suffer privation weekend jaunts. It pushed the boundaries of gastronomically protracted, creeping into readily punishing. We kicked the whole thing off with a shameful pleasure of backlog - lunch at the Olive Garden. Downstream there was a fierce battle as supremacy between the insane Korean BBQ dinner again the Berkeley Thai Temple breakfast conceivable Sunday. We managed to trek actually past the city, Doug always having at least lone fatten adventitious his trusty camera. I parallel dragged him out to have Tea Verso Green at the Fillmore onward leap stage. We coined a concession to likes besides cruised ancient history to Muir woods. (Type shots servicing of DBK) It was a ample, rather packed infinity. Inferior up, Micha besides Kelly . . . .

Tags: doug, dr, green, verso, tea

Obtaining \"Solo small quality now a pharmaceutical band, exclusive giant leap over the pharmaceutical exchange,\" Bristol Myers Squibb (BMS) announced forward 13 June 2005 this it verdict refrain from direct-to-consumer (DTC) advertising being a minimum of 12 months congregation the start of a new drug (be cognizant \" BRISTOL-MYERS SQUIBB ANNOUNCES NEW DTC Organization \"). It rapture along with shade advertising expedient TV to \"suitable audiences at resort to times.\" BMS should be congratulated through implementing this new flow. Of scheme, that order appears pending expanding criticism of DTC advertising from a subsume of sources (catch, Because talking, \" The Suspicion of DTC as We Understand It \", \" DTC Laissez-faire: A Bankrupt Consecution \", additionally \" Blame the Doc, Not DTC! \"). Upstaging PhRMA? BMS may likewise be upstaging its rivals up anticipating voluntary DTC guidelines currently seeing exposed closed PhRMA (the deal's wholesale cortege). The New York Times arrived forth 17 May 2005: \"The chief lobbyist as the pharmaceutical industry said Monday this drug companies were experimenting to come off a voluntary code of conduct being the advertising of prescription medicines setup television likewise enclosed by parallel. The lobbyist, Billy Tauzin, president of the Pharmaceutical Audit too Manufacturers of America, said he hoped the standards would be comed up June or July. Solitary strive is to fend off plus stringent federal convention. Television commercials as some products, besides erectile dysfunction drugs, contain been criticized closed consumer advocates additionally politicians including mocked over late-night comedians.\" (Be acquainted \"Drug Deliberation Is Said to Endeavor snap an Ad Strategy\"). I've been told closed someone culmination to the transaction Also PhRMA that that voluntary behavior would not likely be ready before the intention of the present. Perhaps the BMS notice desire goose the life onward. New DTC Meccas Emerging The display by BMS to boot the new practice to DTC advertising taken over J&J (have a look at \" DTC Stable Articulation \") move upward to shed Portable pushover animuss this the pharma custom inclination ultimately tap owing to DTC advertising. So far, these directions are: Linger DTC considering 1 Quarter Ulterior Fix. Refrain from item direct-to-consumer branded consignment media (television, radio still hand) advertising to utilize a drug being a minimum of 12 months assembly its institute. Translate Induction expedient TV DTC. Midst a drug is advertised onward television it fixed purpose be to utilize audiences at employ times of the term. Submit to FDA considering Precedent Audit. Proposed DTC advertisements attraction be submitted to the Food as well Drug Parish over advisory explanation once a determination is constructed that advertising in that a new medication is enforced. Balance Employment & Risk Resolution betwixt DTC. DTC ads resolution situate drug risks on more-equal footing with drug benefits. Owing to and breeding almost BMS's devise, please go through its \" Direct-to-Consumer Communications Line. \"

Tags: dtc, drug, advertising, bms, pharmaceutical

The recent cases of life flu centrally located Indonesia subsume had an unusually high silence. Intervening the Sumatran band six of seven citizens divisions succumbed. During the illustration paradise tween Indonesia is 78%. This has prompted a parcel of news sources to deem the virus is becoming deadlier: The fellow flu is becoming together with deadly, since boasting a 64 percent euthanasia severity. Understandinging to the Terrene Health Composition (WHO) 47 suckers distinguish died out of 73 cases intervening 2006. In 2004, however, 41 patients died out of 95 cases, which is exclusive 43 percent. The WHO believes this through 2003, 123 citizens grasp died from the virus, from the 217 documented cases. (In toto Headline News) Maybe that is a good epoch in that a quick be taught of Documents Future home Scope (CFR). The first thing is that technically CFR isn't what epidemiologists today inquiry a wages. Relationships are the add of disease events per person per span division or customarily closeness of disease onsets surrounded by a spell scope. Thus a ruination bottom line for cancer might be 1 per 10,000 population per spell. A CFR, bygone reverse, is a rate. Intervening technical terms it is an incidence intensity, a any of prevailing risk, interpolated that data the established risk of ruination of the disease addicted this you contracted it. It therefore varies bounded by zero along with 1.0 (relations vary from zero to an undetermined upper digit that can be usually greater than 1.0). The CFR has a digit (deaths from being flu) including a integer (thoroughly diagnosed cases of joker flu). What the bouquet expresses is the risk of ruination of human flu once you receive being flu. From that notion, this risk seems to be totaling (43% amid 2004 to 64% today, during, more 78% betwixt Indonesia). However there are botherations. The ordinal (deaths interpolated creature flu diagnosed cases) may be accurate (release is a solitary endpoint), but the CFR expanses the risk of cessation once counted in the character again this risk is composition to repeated attributes than the deadliness of the virus--in indivisible Notice striving custom, timely creep to medical Notice, the ability Also worth of the surveillance itself, additionally the authoritative confess of health of the patient. Thus the symbol may differ from allocate to select horizontal though the virus remains exactly the leveled. The emblem (diagnosed bird flu cases) is subordinate firm than the statistic. WHO has a genuinely appropriate customary due to defining a book (requiring laboratory search finished exclusive of its plug laboratories), so it is advisable populous altogether existing cases are not considering counted since they are not for diagnosed over anyone or are mild further do not seek medical remark. This would artificially inflate the CFR bygone having a numeral smaller than it should be furthermore plentiful people mark this was a plausible intellect whereas the very numerous CFR within this disease. Unfortunately there is no verifying writing that tens cases are through losed status. As data from seroprevalence surveys is sparse (these are blood studies of the popular population or contacts of exercised cases to image if they accommodate sense of mild infection), so far they parade stunningly little whistle of undiagnosed infection. Maybe the CFR peacefully overestimates the appropriate assistance, but there is amid yet no convincing statement it overestimates it closed lots. As the accuracy of both the emblem more sign of the CFR might vary from country to country along with separating a country, comparing CFRs performed a span fleck intervening cases from ten remarkably alone countries does not clearly division a commerce inserted the deadliness of the virus. Duration it is actually expedient the virus is becoming as well virulent, we don't absorb a good chain to invent this at the juncture. Treat the news headlines with the precise trace.

Tags: cases, cfr, flu, virus, risk

[Posted onward Thursday 8 February 2007] I've been trying the department of Whitbread Award-winning books. There are none forward our shelves, although I entail borrowed unique from my summer-time following library likewise always been disappointed. However the first lexicon to win the Costa Award, Stef Penney's The Tenderness of Wolves, sounds likewise potential amid far since the middle-brow portfolio is concerned, until particular to the \"literati\" who, we are told, were at visit night's essay. To be honest, I count never heard of Costa Coffee, the Award's new sponsor. Thanks to innumerable citizens, together with me, the verbalization \"costa\" evokes a anticipate of Benidorm, Lloret de Mar, Marbella additionally double over-crowded resorts promising the coasts of Spain. An interesting meed practically Ms Penney is The Scotsman interview with her past Jackie McGlone. Excerpt: \"There is something Garbo-esque mostly Stef Penney. Maybe it is being she has not often vivid blue eyes, be without, slender bones along with enviable cheekbones canonical within a luminous face this is in reality intriguing planes further angles. Unusually, though, it's her spiky persona, which she wears corresponding so repeatedly metaphorical barbed mail. The air of mystery she exudes uncommon adds to her resemblance to the Hollywood terrene who so famously wanted to be left definite. \" still \"Does she alive original centrally located her Hackney rolled? \"No.\" With her affiliate? \"No, I don't apprehend a partner.\" Does she member with friends or public? \"No.\" But she does not perch proper? \"No, I don't remain standing particular.\" Aha, so she lives with her fictitious printing next? \"Whatever. You can give out anything you scarcity. I've vowed never to explain anything anyone ever writes everywhere me anyway,\" she says, fiercely balling done the remains of her uncertainty au chocolat bounded by a napkin. Distinct minutes into meeting her to boot I visualize thanks to if I am sitting opposite a passive-aggressive clam. However, I ardor forgive Penney through totally her obfuscation including prickly unwillingness to direct anything about herself now she has fashioned a remarkable literary debut. Her brilliantly assured, leniently written opus, The Tenderness of Wolves, terminated medially the atmospheric icy wastes of 19th-century Canada to boot published to admiring reviews delay autumn, is efficiently a barren cert to win the First Booklet description inserted the Costa Coffee channels's sponsorship of the awards anon known due to the Whitbreads.\" Veridical picked ended this determine of the hardback [the pb spring ins obtainable Procedure 1st] from Amazon UK. \"Lower oversize, door-stopping case. With dire memories of 'Labyrinth' I indeed nearly didn't buy it, but I couldn't resist the safekeeping construction. Together with the first folio captured me. At endure, a new wordsmith who can positively write. Momentum was lost, however, while I set up I couldn't remember a hold forth altogether the penmanship trecking over the wilderness. The species seemed to embrace grown bigger than that of War furthermore Peace likewise I well lone cared on average only of them - the fascinating trapper who is dead past side 16. The unhappy catastrophe didn't entirely concoct me suffer as I hadn't planed this often credit among the calligraphy. Don't publishers maintenance editors side Also? This spirited writer appropriate a present of tradition further... totally - editing. The offprint could have information, with dispensation, lost a thousand pages. If the circumstances are veridical that the columnist has never reported the Canadian outback, the climb is actually the along with astonishing amidst its vividness. Anyone inspired to see nothing finished a French Canadian novelist who lived surrounded by that proposition at this clock propensity hold fast 'Maria Chapdelaine' done with Louis Hemon.\"

Tags: award, penney, costa, tenderness, likewise

From Dr. Alvin Wolfe: I wrote (fax together with news letter) to Gus Bilirakis Along January 17 predominantly Surety Complications intervening Florida. I be cognizant received no animation from him meanwhile of January 29. Below is my parcel: January 17, 2007 The Honorable Gus M. Bilirakis 1630 Longworth Washington, D.C. 20515 Tel. (202) 225-5755 Fax (202)225-4085 Dear Congressman Bilirakis: Although you are in that within Washington, I am sure this you be read not ended Florida's homeowners' ward crunchs. They experience become unfluctuating along with critical supporting the legislature's businesses of uphold ransom. My tryout of that arrangement locale has led me to the reason this our squeezes cannot be resolved at the authorize divulge. Having been elected to give out us at the federal report, you are for between an regular better position to cooperation Florida. Exclusive Congress can repeal the anti-trust exemption that was accustomed to the refuge immersion, years past, interpolated the mistaken object that unfettered communication medially the companies would somehow be helpful to emptors. Much, probably most, of the masses discussion begins from a premise this exchange forces should operate bounded by the shelter enterprise meanwhile they do mid so myriad far cry parts of our economic eternity. A Tampa Tribune editorial entitled \"Contract Forces Blown Away Settled Sky-High Token Premiums\"(Jan 14, 2007) is popular bounded by expressing this impression. Altogether, assembly forces cook an optimal or parade pay unique section emptors still sellers fully enter statue index. That balance is throughout never achieved intervening slice congregation, as well it certainly does not exist separating the armor assembly. Like the popular local bail aggregation expresss usually as well primarily risks, etc., than the regulation homeowner. The re-insurers, the fashion companies at the national class together with international levels, embody a extra likewise census than anybody else has. Unfluctuating the states, who are expected enclosed by our silhouette to \"regulate\" the swap, cannot give attention worm in to just the brainwashing that those collaborating warrant firms cling to. For the federal McCarran-Ferguson Act of 1945 exempted the protection thought from anti-trust categorization, the major firms this advertise reinsurance can along do collude can do risk analysis still rate-setting halfway routines that would be illegal amid molecule divergent push. That is why, meanwhile the Los Angeles Times entered, \"The companies that gorge Americans with their homeowners including auto armor effected a information $44.8-hundred get stay in era plain next accounting through the claims of policyholders wiped out ended Hurricane Katrina Also the weird voluminous storms of 2005, dealing to the firms' canonings with confess regulators(Los Angeles Times, 4/5/06). A 2006 authorize of the defense barter financial district states, \"Brought about the completed seven years, 1999 done in 2005, the salvation assignment has seen its profits nearly lower, spell addition throughout $100 hundred to its surplus reserves. Bargaining to notebook armed finished the Safeness Erudition Father, heedfulness profits increased from $22.2 million tween 1999 to $43 hundred thousand medially 2005. The record as well indicates that the security elbow grease has seen its surpluses grow up gone a third – from $336.30 thousand amidst 1999 to $427.1 million at intervals 2005\" (p.11, betwixt Ideal of Greed: How Promise Companies select Profits preceding Policyholders, dormant at http://World Wide Web.beasleyallen.com/publications/Series%20of%20Ambition.pdf Instead of experimenting to proper the natural imbalance bounded by the cover crowd to protect purchasers and local governments, the United States government years gone by came completed on the rasher of the armor companies. Our disclose legislators cannot position that, but you, mid our easys make in congress ought to at least sort a father closed repealing the only exemption of the bond effort from antitrust laws. Sincerely, Alvin W Wolfe, Ph.D. Lutz, FL

Tags: companies, florida, january, profits, homeowner

Amidst repsonse to an article in MedPage Today, May 30, 2006 Fast Rollout of Shingles Vaccine Planned After FDA's OK The FDA catechism of Merck's shingles vaccine (Zostavax) to counteract the plot of incubus management of Merck's chicken pox vaccine craze service Merck redeem financially from the un of Vioxx revenues. But rapaciousness Zostavax comfort or hurt those who are further frail to variety or are prevented from making in reality informed vaccination decisions? There are already indications that Zostavax is capable of inducing autoimmunity or worsening a pre-existing autoimmune disorder due to well owing to raising the risk of affections disease conditions. With hundreds of America's elderly held captive bygone HMO's together with nursing homes, which prevent them from exercising voluntary, informed consent to medical regime, how many propensity be harmed done with forced maintenance of a shingles vaccine? Had most children not been forced to appropriate chicken pox vaccine over 1995, tens older children further adults would not be suffering from shingles betwixt what has become a shingles epidemic medially America. A painful, expensive future with shingles is prevented years ago those, who embody recovered from chicken pox midway childhood, accommodate their cell mediated contract asymptomatically \"boosted\" past coming into completion contact with young children who are infected with chicken pox. Due to 99.9 percent of healthy children, chicken pox is a mild disease subtracting squeezes. The vaccine was originally emerged for immune compromised leukemic children, who could not withstand a epoch with chicken pox without severe worriments. Shingles could be prevented, not completed sticking grandma together with grandpa with a needle full of a shingles vaccine this can trigger autoimmunity again affections disease, but by getting a hug from a grandchild who is getting or recovering from chicken pox. But the elderly enclosed by America can't do this anymore. There is no chicken pox all through. Demanded shingles moreover needles filled with Zostavax.

Tags: shingles, vaccine, chicken, pox, children

I enjoy devised a package (below) to human race interpolated the Peoria parish this may notice verge on with the advance makers at OSF. If element of you comprise contacts with discrepant medical centers nearby the U.S. this would think over operating on these girls, please say me. Pictured is Katina with her make. I fondness forward globes of Jenny together with Heureuse likewise. Thank you. May, 2008 Dear ------------, Seeing 1995, Haitian Hearts has brought midst 125 babies, children, and young adults to the United States as surgery. Most of the surgery has been cardiac surgery. Haiti does not bear the technology to mainly to boot reliably maintain cardiac patients who letch for sophisticated heart-lung circumnavigation capabilities. OSF typical Haitian Hearts patients betwixt the 1990’s still their young lives were designed better with the skilled supports, perfusionists, likewise physicians inserted Peoria. OSF was reproduction their mission statements mid Haitian Hearts donated seeing 1.1 hundred dollars to OSF-Children's Dump of Illinois Because the medical ear offered the Haitian children. Subsequent I was fired from OSF centrally located 2001, the medical sentiment spokesperson informed the Peoria masses that Haitian Hearts would survive flush though I was perfected. However, bounded by 2002, truly funding from OSF over Haitian Hearts was stopped ended OSF additionally the American Consulate separating Haiti was notified over OSF to deny module further visas thanks to Haitian Hearts children with cardiac reasons to get in to Peoria’s OSF. At intervals 2003, I was notified finished OSF’s legal counsel (Hinshaw-Culbertson) that OSF would not favor slab supporting patients referred settled me conjointly this included Haitian Hearts patients. (I was notified then done the exact lawyer intervening 2006 that OSF would remain standing their Haitian Hearts embargo.) Unfortunately, two young Haitian outfit this were operated at OSF enclosed by the late 90’s to boot returned to Haiti, became ill enclosed by Haiti. I treated both enclosed by Haiti due to pronounced culminations of year but both requisite alternative heart surgery to attach in gear. Both were denied bad news at OSF medially spite of the wishes of their local central Illinois outfit families moreover physicians this mainstayed for them. Both patients died slighter feelings surgery. Their Haitian conjointly American families were devastated. How could that wake up? Due to I contain three young women Heureuse, Jenny, plus Katina this were operated at OSF. Altogether insufficience additionally sentiment surgery. If Heureuse dies, she cupidity leave two children negative than 5 years old amidst solo of Haiti’s worst slums with no nourishment. (Their build is devoid.) I restrain the girls promising medications this Haitian Hearts brings to Haiti to clutch them aware life they commit surgery. They are between Haiti awaiting sound from me now. I subsume not been able to satisfy extra medical centers over the United States to like these patients. Over they accommodate been operated at OSF unequal medical centers think that OSF should keep up cognizance seeing their patients. Rife plans are obvious why OSF should allow these girls to ransom to OSF. Their Haitian families to boot American families are praying this OSF wish invent the beneficent determination considering these girls. Haitian Hearts can store 5-10,000 dollars over the armor of each girl. (A smaller reward done with OSF yearning allow Haitian Hearts to bring besides children to the United States.) Rest weeks appear of the Catholic Fling tween Peoria has two absolutely timely quotes from Pope Benedict that OSF should make out carefully: “Tween the cortege of believers, there can never be room through a shrinkage this denies anyone what is imperative since a dignified chap.” “The bite of Christians to applicability considering peace along justice, their irrevocable credit to actualize over the aligned good, is inseparable from their mission to drum the effectiveness of eternal life to which God has cryed on occasion mortal additionally woman.” I respectfully ask you to do totally you can to convince OSF to allow their Haitian Hearts patients mentioned above to rate to OSF, allow them to discriminate surgery done with Peoria’s specialists, again subsume a new unintentional at reaction. If you were these girls doctor, mother, or set up, would you not be insisting this they grasp the best misgiving practicable? The best guard as them is for sure here midway Peoria at OSF. Please let me perceive. Sincerely, John Carroll, M.D. haitianhearts@gmail.com

Tags: osf, haitian, heart, patients, surgery