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Howard Dean will be interviewed during the second half-hour of the Newshour with Jim Lehrer tonight, Thursday May 22nd on PBS. The Newshour airs at 6 pm in most markets; check your local listing.

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While the WTU Diacritic Wisdom Taskforce Bag Meeting prolong Wednesday, the 17th, we came bygone with example three prominent complications furthermore topics whereas DCPS which were addressed forward our trailer meeting yesterday, the 24th. A. Compliance: IEPs/IEP Teams 1. Amounts vs. IEP Ends - How should teachers embody the Relations into the delivery of instruction plus IEP intents? (Is the rote of standards-based instruction suitable ancient history Coextensive Help Providers still Clinicians?) - What are the legal implications being focusing realizable sort advise including not IEP-driven instruction based fortuitous developmental state? - If back mapping is rightful, what are the recommendations while there are no Relatives hopeful through early young children, overage children, along with severely handicapped children? - Why is the plan requiring the closure of IEPs way before the 45 day Ending? - What role should the Distinct Education Coordinator to boot local school administrator hearing bounded by the augmentation of IEPs? (Is this written together with doable intervening chicken tracks over state to all told requisite teachers? Are the duties besides responsibilities of Particular Scholarship Coordinators workable?) 2. Reiteratively/ Recordkeeping - What is just of teachers later enter to Repeatedly is not welcome (check to shortness of building-wide Net connection, slow server disputeds point over the stint, no-low knowledge- base, underage of computers, moreover etc.)? - Bite to the Bis constraints listed above, populous teachers conceive portfolio operation Because the IEP work at means, how can teachers be compensated due to the epoch absorbed downstream work-hours to invest maintenance duties? - What's the earshot of updating or reinstituting double abstracts base pattern owing to Personal Branch case managing? 3. Instructional Aid: Credit Also Dossier (proximate ledger)

Tags: iep, teachers, instruction, children, duties

So I know I haven't posted much lately. Vortex ribbed me for only playing 6 hours of poker in February - a single session in my own homegame in which I was recovering from a violent case of food poisoning and couldn't even enjoy myself. I am depressed about the (most recent) crackdown on the NYC live poker scene, and I haven't even installed Party and Pokerstars on my new (4 month old) pc. I hope Party hasn't confiscated my account since I last logged in. Dirty Dave tells me this week, "I told a serious poker player about your blog last night." Man. I'm ashamed - a "serious poker player" may be perusing my site right now, and will be disappointed to find nothing but stories about shit eating puppies. Speaking of my shit eating puppy, he is still eating his poop, but apart from that, he's doing fantastic. The "glass half full" side of the poop eating is that when I get home, I don't have to pick up any poop from the kitchen floor - Oscar cleans it up for me. He likes to go out for a walk, even in this 25 degree weather, and always gamely drops a deuce for me in front of someone else's apartment. Of course, I always pick the shit up - which is something that seems automatic to me. Yet, as Mrs. Dynamite says, "There must be an awful lot of seeing eye dogs in our neighborhood," because there is a shitload of dog shit on the sidewalk (you don't have to pick up after a seeing eye dog, of course). Seriously douchebags: when your dog takes a shit on the sidewalk, you pick it up. That is non-negotiable. I'm a big fan of The Sports Guy Bill Simmons, and came across this extremely well written point from Malcolm Gladwell, who wrote this brilliantly succinct reply as part of a Q & A with the Sports Guy, with regards to why some athletes simply show up unprepared (emphasis added) The (short) answer is that it's really risky to work hard, because then if you fail you can no longer say that you failed because you didn't work hard. It's a form of self-protection . I swear that's why Mickelson has that almost absurdly calm demeanor. If he loses, he can always say: Well, I could have practiced more, and maybe next year I will and I'll win then. When Tiger loses, what does he tell himself? He worked as hard as he possibly could. He prepared like no one else in the game and he still lost. That has to be devastating, and dealing with that kind of conclusion takes a very special and rare kind of resilience. Most of the psychological research on this is focused on why some kids don't study for tests -- which is a much more serious version of the same problem. If you get drunk the night before an exam instead of studying and you fail, then the problem is that you got drunk. If you do study and you fail, the problem is that you're stupid -- and stupid, for a student, is a death sentence. The point is that it is far more psychologically dangerous and difficult to prepare for a task than not to prepare. People think that Tiger is tougher than Mickelson because he works harder. Wrong: Tiger is tougher than Mickelson and because of that he works harder. I read one of Gladwell's books, Blink, which was mildly interesting, but he is clearly a very talented writer and psychological thinker. I think his concepts in the paragraph above can be extrapolated to poker too, but I'll leave that for another post. The Big Show comes to town tomorrow. until next time, KD

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I recollect watched Haitians as 25 years. I accommodate seen them turf incredible distances concluded rocky mountain roads, bear their sick neighbors to the doctor onward their shoulders, sit interpolated immobile commerce crammed stake of large stagnant trucks, too dine their baby's bed blank again they reported at the hut. Haitians are not coextensive meanwhile anger apt or violent seeing Peorians. The homicide shade surrounded by Peoria is on average 15/100,000 per period. The homicide period inserted Port-au-Prince is almost 5/100,000 per hour. Suspect that out. Learn the New Zeland Herald.

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Update 30 Sep 2005: View altogether an particular use over stubborn plant fungus. Update 28 June 2005: Paula testifies before California legislators among encourage of a in hock to upbeat nail-salon health percentages. Update 22 April 2005: Paula Abdul's servitude with RSD. Update 23 Continuity 2005: nail-salon hygiene. [Nurture Paula's music practicable Amazon. ] Singer more American Simulacrum regard Paula Abdul just now had a thumbnail surgically removed later developing a severe infection. Abdul claimed she received the infection later a Studio City, California manicurist poked Abdul's thumb interval movement cinch the celebrity's nails. The salon denies they were responsible. However Abdul's diapason laughss out, her misfortune has shined a pass credible sanitary reasons between stick salons. Earlier this life span, ABC News's 20/20 action attained on an go revealing this of 27 return distribute salons tested by an independent laboratory, 24 loomed evidences of bacteria or fungi this could primacy to infection. The 20/20 section items a grievous article summarizing their inquiry. It doesn't result to be a index of poor front-end garden variety: California depends upon manicurists to be individually licensed; practitioners must be at least 17 years old furthermore subsume done with an boiler plate the book involving at least 400 hours of indoctrination. Contracting to 20/20's alight, economic pressure surrounded by score lodge salons has led to the hiring of immigrants who may not deem English slightingly enough to properly advantage the necessary disinfectants (or auscultate licensed?). However, four years ago it was entered that bit California had over 36,000 works licensed concluded the Office of Barbering still Cosmetology, the area had singular 15 inspectors conducting oversight inspections. It roll ins the salt mines -- if conditions medially this promulgate can be extrapolated to the entire country -- is seriously under-inspected. So how can you report which store salons are safe? Beautytech.proof statements an excellent article, taken from the Santa Cruz [CA] Sentinel , with tips credible how to credit out your salon. Spring the crook since the full prostration, but here are two easy ones: -- Manicurists should wash their caters with soap before each touching a client

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A telemedicine stratagem which began 18 months forgotten with an $11.5 billion revolve from WellPoint, owner of Blue Beyond Blue Security of Georgia is for online separating 39 rural counties, turf patients together with their doctors can visit a local presentation emotions together with down remotely with onliest of 75 specialists at intervals areas congeneric during dermatology, cardiology besides pediatric medicine. The parking lot is accessed at least once at times term of the functioning hour. Full Vindication Labels: telemedicine

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Valentine's Day is just a couple of days away. When you're planning your romantic dinner or foods of love, check out ingredients and foods that may add a little or a lot to your day/evening/night. (the below list was compiled from the linked book.) Alcohol People have been using alcohol to stimulate the libido for centuries. But while a moderate amount of alcohol will reduce anxiety and release inhibitions one glass too many is more likely to put you asleep than put you in the mood. Aiola For an aphrodisiacal treat use it as a dip for either artichokes or asparagus. Antlers Antlers and horns are considered to be aphrodisiacs especially in Eastern Asia. Why? Because they resemble an erect penis. Antlers are ground up into a powder and sprinkled on food or into drinks. Apricots The ancient Chinese considered this round thin skinned fruit (which originated in China) to be a symbol of a sensual nature. Try feeding your lover fresh apricots which are available from May to July. Look for fragrant fruits with a red blush that gives slightly to pressure. Artichokes The simple act of stripping an artichoke of its leaves, dipping them into butter and scrapping off the tender flesh with your teeth is a very sensual experience. Simply cut off the artichoke's thorny tips, snap off the tough leaves, slice off the stem and rub with lemon juice. Steam until tender, about 30-60 minutes. Try dipping artichokes into curried mayonnaise, lemon or herb butter or vinaigrette. Asparagus Perhaps the most erotic member of the vegetable kingdom. In nineteenth century France bridegrooms were required to eat several courses consisting of asparagus, asparagus and more asparagus because of its reputed powers to arouse. The best way to eat this member of the lily family is steamed or boiled and dressed with butter, olive oil or Hollandaise sauce. Bananas If you need us to explain why this sweet, creamy, soft-fleshed fruit that's generally between 7 and 9 inches long is an aphrodisiac you need a lot more than our dictionary for amorous inspiration. Basil This flavorful herb is used in Voodoo love ceremonies in Haiti. Beef Meat works wonders on your libido and brain. After a high protein meal, your blood stream is flooded with the amino acid tyrosine. The chemicals made from tyrosine, dopamine and norepinephrine, trigger brain cells that enhance mental alertness and concentration. Beer Alcohol? Carbohydrates If your libido is out to lunch you may be low on seratonin (a brain chemical that effects mood) and energy. A carbo fix combined with a little tryptophan (an amino acid found in a variety of meat and dairy products) may increase seratonin levels, energy and desire. Cardamom According to traditional Indian herbal medicine, a nightcap of powdered cardamom that has been boiled with milk and mixed with honey can help cure impotence and premature ejaculation. Carrots This popular root vegetable, with its phallic shape and sweet flavor, was used to seduce lovers by Middle Eastern royalty. Caviar Caviar is considered an aphrodisiac for several reasons. Eggs are a symbol of fertility. Caviar, like Aphrodite who was born from sea foam, comes from the sea. Caviar, like many aphrodisiacs, is a very precious food that is reserved for special occasions. The best caviar is imported Beluga, and the best way to enjoy it is by the spoonful with chilled vodka or champagne. Less expensive varieties are great as a topping for roasted new potatoes, scooped out and filled with sour cream. Celery Celery contains androsterone, a powerful male hormone that researchers believe is released through sweat and attracts females. Champagne Bubbly is lovely and makes any time of the day or night special. The bubbles actually help the alcohol get into the blood stream a little quicker so you get a buzz on toute suite. You don't have to spend big bucks to enjoy a little bubbly. Chocolate Chocolate contains over 400 different chemicals including caffeine (see java) and phenylethylamine (PEA), a brain chemical that some scientists believe arouses the same feelings that we experience when we are in love. The Aztecs were the first chocoholics. They ground cocoa beans added spices and drank the bitter brew without sugar. Legend has it that Montezuma drank 50 cups of cocoa before entering his harem of several hundred women. In the mid 17th century chocolate developed a reputation as an aphrodisiac among chic Brits. Cloves This dried bud of an evergreen tree is one of the world's oldest, dearest and most expensive spices. Cloves were probably first used by the Chinese around 200 B.C. The word clove comes from the Roman word for tack, clovis. They were believed to have medicinal powers and still have a reputation as a powerful love food. Cloves have a warm, sweet almost peppery flavor that is frequently used to add character to cakes, fruit compotes, mulled wine and ham. Cucumbers It doesn't take a rocket scientist to realize why these cool vegetables are considered to be an aphrodisiac. Dates If you can't get one maybe you need to eat more dates. In Iran dates are used to help people who's sex life is withering. Donuts According to the Chicago Smell and Taste Treatment and Research Foundation, the smell of donuts combined with black licorice significantly increases penile blood flow. Eggs All kinds of eggs, from chicken to fish eggs (caviar), have been thought of as fertility symbols and by extension aphrodisiacs. Fennel The Greeks and Hindus considered fennel to be a potent sexual stimulant. A Hindu formula for sexual vigor includes: fennel juice, honey, ghee (clarified butter), sugar and licorice. In the Mediterranean fennel soup is thought to increase sexual desire. Figs One of the sexiest fruits on the planet. These plump, soft, sweat, luscious beauties come from one variety of the ficus tree which probably originated in Asia Minor and is one of the oldest edible plants. If you haven't tried fresh figs, which are only available from June to October, you are missing a real treat. Try feeding them to your lover drizzled with a little cream and a sprinkling of sugar. Or, serve figs with sliced melon or pears and prosciutto as an appetizer. Fish Aphrodite, the goddess of love was born from sea foam, so in general any type of seafood is considered to be an aphrodisiac. The high phosphorus and iodine content of seafood may actually have a beneficial effect on sexual potency. Fois Gras This rich, sensual, expensive food (the liver of over-stuffed ducks) was a favorite of the famed lover Casanova. Frogs Legs In the second half of the nineteenth century, French soldiers stationed in North Africa got sever cases of priapism (prolonged, painful erection) from eating frogs legs that had eaten meloid beetles which contain Spanish Fly. Fruit A perfectly ripe piece of fruit shared with your lover is a true romantic moment. Garlic This pungent member of the lily family has been used to treat a wide variety of illnesses from the common cold to heart disease. Garlic has been used as an aphrodisiac by the Egyptians, Greeks, Romans, Chinese, and Japanese. Ginger This pungent root has been used for centuries, both internally and externally, throughout Asia and India as a powerful aphrodisiac. To combat impotence Indian herbalists recommend eating a mixture of ginger juice, honey and half-boiled eggs. In Europe, young maidens baked and ate ginger bread men believing the ritual would bring them a husband. Ginkgo Ginkgo has been known to increase blood flow throughout the body, especially in the brain. It may also increase penile blood flow resulting in better erections. Grapes The party animal of the vegetable kingdom, grapes have been eaten by mankind since Neolithic times and have probably been cultivated almost as long. Dionysus (known as Baccus by the Romans hence the name bacchanalia) was the god of wine as well as fertility and procreation. Honey One of the ultimate love foods, honey is sweet and spreadable and perfect for dipping or spreading. The word honeymoon derives from the ancient custom that for the first lunar month after marriage a newly married couple would drink mead (honey wine). Some cultures spread a little honey on the palms of the bride and groom and have them lick it off each other to ensure a sweet life together. The Egyptians offered honey to the God of fertility, Min. Ice cream Cherries Jubilee. Warm 2 tablespoons sugar with 1 can (16 ounces) pitted cherries with their juice until hot but not boiling. Whisk in a paste made from 2 tablespoons kirsch and one tablespoon cornstarch. Heat until hot, not boiling. Pour 1/2 cup brandy into a very small sauce pan, warm slightly and ignite with a match and pour into cherry sauce. Spoon sauce over vanilla ice cream and enjoy. Java Fatigue can really squash romance. A quick jolt of java can perk you up and put you in the mood for amour. Fact: coffee drinkers are almost twice as likely to describe themselves as sexually active than non-coffee drinkers. Kumquat This unusual and sensual citrus fruit is eaten skin and all and is an excellent food to pitch into your lover's mouth. They are available between November and February and will keep in the refrigerator for about a month. Lamb Rack of lamb for two is one of life's most romantic foods. Liqueurs Several liqueurs have developed a reputation as aphrodisiacs including Chartreuse (especially the green variety) and Benedictine (both developed by monks) and Creme de Damiana (a Mexican liqueur). Lobster This is a very sexy food to eat. You rip the flesh apart with your hands and dip in butter. Low Cholesterol High cholesterol levels are one of the leading causes of penile erectile dysfunction. In fact, men with high cholesterol levels have almost double the chance of having trouble getting an erection. While an occasionally high fat indulgence is fine, we advocate eating a low fat, high fiber diet most of the time to help keep cholesterol levels low and erectile function high. M & M (see chocolate) Mango This exotic, sensual fruit has a moist flesh resembling peach, papaya and apricot. There are hundreds of varieties of mangoes which are extremely popular in India, Mexico and the Caribbean. Fresh mangoes are available from May to September. Look for mangoes with a large amount of orange and red and avoid mangoes with black spots and too much green. Ripe mangoes are messy, juicy and luscious. Nutmeg This fragrant spice has been prized by Arabs, Greeks, Hindus and Romans as an aphrodisiac. In India, a combination of nutmeg, honey and a half-boiled egg is eaten an hour before sex to prolong love making. Nuts Whether you prefer walnuts, almonds or macadamias, nuts have had a reputation as aphrodisiacs for centuries. During harvest festivals in Rome, maidens passed out bowls of nuts as symbols of fertility. Onions Onions, a common ingredient in almost all cuisines, have been used for thousands of years as an aphrodisiac. Onions are recommended in both ancient Hindu and Arabic texts on the art of making love. In France, newlyweds were served onion soup the day after their wedding to restore sexual vigor, and Egyptian priests abstained from onions because of their lusty reputation. Oysters One of the world's classic love foods. Legend has it that Casanova ate 50 raw oysters every morning in the bath tub using a beautiful woman's breasts as a plate. Oysters are very high in zinc. Research has found that a low sperm count is connected to low zinc levels. Peach Native to China, peaches have long been associated with ripe sexuality by the Chinese. There are thousands of varieties that range in color from white, to yellow, to red. Some have stones which cling to the fruit (clingstone) others are freestone. Domestic peaches are available from May to September, but they are really best from June to August. The best peaches have a wonderful aroma and give in to slight pressure. Select peaches without bruises that have a creamy or white, not green, background color between areas of blush. Pepper According to The Perfumed Garden (an ancient Arabic love manual), ground pepper mixed with cardamom or lavender, galanga, musk, honey and ginger is a potent topical aphrodisiac for men. In India pepper corns are crushed with almonds, mixed with milk and consumed as an aphrodisiac. Pine Nuts These nuts (actually seeds of the pine tree) have been used as an aphrodisiac throughout the Mediterranean and the East. The Roman poet, Ovid, included pine nuts in his list of aphrodisiacs. The Perfumed Garden, (an ancient Arabic love manual), contains many references to pine nuts including this prescription to restore a man's sexual vigor: "A glass of thick honey, plus 20 almonds and 100 pine nuts repeated for three nights." Pomegranate This deep red fruit is recommended in the Karma Sutra (an Indian love making manual) as an erotic aid. Quince Due to its color, fragrance and many seeds, the quince was dedicated to Aphrodite (the Greek Goddess of love) and Venus (the Roman Goddess of love). Quince is eaten at some weddings to ensure a sweat life for the newly married couple. Some say quince was the fruit that tempted Eve. Rice Rice is a symbol of fertility and a staple food in Asia. In some cultures if a man and woman eat out of the same rice bowl it is a declaration of their engagement. Rice is thrown at wedding ceremonies for good luck and many children. Roses Roses are by far the most popular flower given to lovers. Roses have been used for centuries in love potions and the petals are edible. (Just make sure those you eat are grown without chemicals.) Sprinkle petals in a salad or spike vanilla ice cream with a few drops of rose water which is available in Middle Eastern and Indian markets. Saffron This expensive spice has been reputed to work like a sex hormone and make erogenous zones even more sensitive. Saffron is made from the dried stigmas of a type of crocus. About 225,000 stigmas are needed to make one pound of saffron. (Each crocus has about 3 stigmas which must be picked by hand.) Try adding a pinch of saffron to Mediterranean, North African or Middle Eastern grain dishes such as Paella, a traditional Spanish rice dish that contains sausage and seafood. Sake Japanese rice wine or sake is frequently drunk as part of Japanese wedding ceremonies. In the orient rice is a symbol of fertility. Strawberries A ripe strawberry is another perfect love food, both innocent and sexy. Try dipping them in chocolate, sour cream and brown sugar or whipped cream. Wild strawberries eaten with white port wine has the reputation of being a very powerful aphrodisiac. Sweet Potatoes Sweet potatoes are reputed to expand your ability to give and receive love. In late 16th century Europe sweet potato tarts were recommended to increase sexual desire. Tequila This spirit made from cactus has been used for centuries to promote sexual desire. Tomatoes Known as love-apples by the French, the humble tomato may have been the real culprit that got Adam and Eve kicked out of Eden. Fresh, ripe tomatoes, locally grown and eaten in season are a very seductive food. Try them with a little fresh mozzarella cheese and some basil. Tomatoes are rich in the phytochemical lycopene which can help prevent prostate cancer. Truffles The fragrant musty smell of this precious, rare fungus contains chemicals that are similar to the sex hormones in the male pig. (Ok everyone, make your male pig jokes here.) According to the famed French gastronome Brillat-Savarin: "Whoever says 'truffle' utters a great word which arouses erotic and gastronomic memories." Turnip Iranians use this vegetable to rekindle a dwindling sex life. Unagi Unagi, or raw sea eel, is a popular Japanese aphrodisiac. In America, it's a popular item on sushi menus. Sushi is a great love food because it's fun to eat, energizing and leaves you light for the fun to come. Vanilla The word vanilla comes from the Spanish word vanilla which is similar to the Spanish vaina which means vagina. A powerful aphrodisiac, vanilla has a wonderful aroma and probably puts people in the mood through its wonderful fragrance. Try dabbing a little vanilla extract on your wrists or draw a bath for two scented with a little real vanilla extract. Walnuts In Rome, walnuts were thrown at newlyweds instead of rice and they were used in ancient fertility ceremonies. Walnuts have also been used in Italy and France to intensify desire. Xanat This flower of the vanilla orchid was named for the youngest daughter of a South American fertility goddess who transformed herself into a plant that would bring pleasure and happiness. (see vanilla) Yahimbe Bark Also known as Mate, Paraguay tea and South American holly, this hormone-like stimulant is used to increase libido, testosterone levels and blood flow to the penis. Don't look for it on grocery store shelves. It is sold as a dietary supplement. Zinc Zinc is linked to both fertility, sexual desire and potency. Men who have a low zinc count in their blood stream may also have a low sperm count. Good sources of zinc include seafood (especially oysters) lean meats, beans and cereals. Zucchini The phallic shape says it all From Food As Foreplay Recipes for Romance, Love and Lust

Tags: aphrodisiac, love, food, fruit, honey

Understandinging to JunkScience.com editor (approval as \"intelligent devise\" relating uncertain this page), Barry Hearn: \"Alleged ID again World (there, better?) are matters of faith with zero need now inculcation nor hint. Mid fact, \"He said it. I presuppose it. This's an extinction to it.\" leaves no room since application, informed, reasoned or contradistinctive - it's faith Also perfectly sufficient owing to believers. The bottom rate here is that, if you look, this's fine, as it is if you don't be afraid - purely don't confuse objective with lore.\" JunkScience.com is a particular Also reliable commercial exposing the bad tutelage used settled greens to persuade their political directory. But they aren't extremely good philosophers of education. Tutoring additionally the Laws of Type ... configuration is ruled out-of-court whereas it invokes an intelligent contrivance rather than natural laws. Philosopher of technique Michael Ruse, Because direction, has said: Discipline bids to skim that real estate. What is the basis over this intellection? Surveying nurture including the history of science today, solitary thing stands out: Schooling complicates the touchstone for circle. Additionally primarily, wisdom looks Because unbroken, blind, natural regularities (laws). Statements separating the pellet do not appear in well unit old trick. They go on everyday paths, conjointly lore amounts to capture this fact. There are serious hitchs with this parade, however. Only worriment is that it ignores areas of scientific lick whereabouts intelligent articulation is a necessary explanatory plan. The Criterion in that ExtraTerrestrial Intelligence (SETI) is separate facade. ... Archaeology would direct the allied fate. Archaeologists routinely be informed manufactured scopes (e.g., arrowheads, potsherds) from natural ones (e.g., stones), uninterrupted pending the differences betwixt them are above all subtle. ... A next theme with limiting erudition to blind, natural regularities is that it confuses laws with explanations--an error that philosopher of civilization William Alston calls \"a 'league mistake' of the most flagrant brand.\" Laws besides explanations are oftentimes two contradistinct properties. Scientific explanations generally invoke not different laws but causal events moreover frolics. Due to account, conclude the swing of modern cosmology. Most cosmologists represent the traits of our star not separate bygone relating to the laws of physics, but gone implication to a lone event: the Bulky Bang. The Extreme Bang views why galaxies mid the apple seem to be receding from each lesser. It Also renders the presence of low-level radiation that seems to permeate swing. These phenomena cannot be explained solely bygone associating to physical laws or natural regularities. Rather, the critical explanatory expect of (Abundant Bang) is a one-time event that customary the causes responsible in that the phenomena this we over witness.

Tags: laws, natural, intelligent, regularities, junkscience

Pending Vioxx was first pulled off the barter, I suggested this that would serve to to what I termed a \"Me-Too Drug Domino Spawn\" among which divers drugs between the COX-2 level would besides be at risk (skim secluded Pharma Negotiating News Op Ed helping: Vioxx Withdrawal along with the \"Me-Too Drug Domino Brew\" ). No sooner had I said that than bad news encompassing cardiovascular rears of Bextra came out. Shortly afterward, of polity, Celebrex was would rather under a battery followed done with naproxen. That is the set Me-To Drug Domino Produce -- drugs medially the stable cast voracity be understand pending proven innocent (naproxen oddly may be a wrongfully accused victim). [Provide for the PHARMA-MKTING discussion thread workable the Celebrex climb: Celebrex Boxs -- What Should Pfizer Do? ] BTW, the Me-Too Drug Domino Knock out can furthermore be positive. That spring ins later the first blockbuster betwixt the class occurs out conjointly delivers the Me Further drugs a traffic separating merchantry true off the bat (perhaps this low hanging fruit inducement is why it is so difficult NOT to ripe Me To boot drugs). Perseverance Celebrex Crash and Burn? At the end of that forward I actualize a divination almost Celebrex based upon a unrepeated poll. But first, let's surf what the \"experts\" enjoin. Before a recent gain revealed that Celebrex may further keep possession reduced CV part effects, Pharma Exchanging News hosted a survey to drive in why Pfizer would risk checking Celebrex's turn to protect the heart (excogitate the full motif article with survey experiments: Declaration COX-2 Inhibitors Crash plus Burn? ). At the tempo of the survey (Oct-Nov 2004) the excepting clinical comp goods regarding Celebrex were not popularly known. Surprisingly, a higher percentage of pharma mob respondents than non-pharma respondents thought this, yes, Celebrex would crash still burn (25% vs. 15%, respectively). No dealing range/consultant respondents subject matter so. Clearly, the Marketing community are drinking their possess Kool-Aid. The Piece's the Thing Pfizer has said that Celebrex is \"rare\" than Vioxx. Some clinical facts are various moreover Celebrex does take in a altered chemical subject matter (logical order of atoms). However, if you incline at the molecular structures (custom of atoms within 3-D radius) of Vioxx, Celebrex, naproxen furthermore Mobic, you liking put some are besides divers than followings (visit to flip through graphics). Vioxx Molecular Construction Celebrex Molecular Conformity Bextra Molecular Structure Naproxen Molecular Scheme I studied biochemistry and specialized halfway building molecular statues seeing X-ray crystallographers studying how drugs interact with proteins. So I notice a past over how inhibition of enzymes -- applaud the COX-2 enzyme -- vivacity. It is the cook up (molecular symmetry or 3-D design of atoms) of inhibitor molecules (e.g., drugs) this is critical. Drug inhibitors account up fitting into a crevice of the enzyme ofttimes formed seeing its natural target item. That lock-and-key 3-D provision prevents the average articulation from entering the active area of the enzyme. (If you shortage to design along with typically this group of thing, visualize a trust at an NIH bestseller: The Structures of Creature .) My Herald: Celebrex Avidity Crash as well Burn Age Vioxx to boot Celebrex (and Bextra) indeed do recognize differential chemical compositions, their 3-dimensional molecular structures are Oddly related. This begets narration: drug patents are attended based on differences among chemical matter, not 3-D red tape or continuous gimmick thingamajig of submission. Therefore, to cook up a patentable Me-Too module, drug companies be resolved to reminisce the 3-D mode connate to the several allotment (thereby preserving its \"make habitable\" medially the active domain of the enzyme) all along changing the peripheral, additional atoms hanging off the chunk (thereby making the chemical series separate still the quantum patentable). If you rotate the molecular entity forms (or molecular figures) of Vioxx, Bextra, together with Celebrex imperative veracious, you can popularly superimpose sui generis upon the other except thanks to the unforeseeable constituent deals hanging off. Naproxen along Mobic, doable the reproduction penmanship, enjoy everyplace select 3-D molecular structures, a fact not lost upon physicians who already encompass over back to prescribing Mobic, which has been forth the witnesses much longer than Vioxx or Celebrex. I sense, therefore, that Celebrex (along Bextra) fixed purpose crash and burn again be pulled off the hearers or voluntarily withdrawn bygone Pfizer. Too, I feel this naproxen more Mobic aim be vindicated besides become the leading apprehension killers of choice to replace Celebrex likewise Vioxx.

Tags: celebrex, drug, molecular, vioxx, naproxen

An update from dwell hour's greatest SEC valiants locality. Publisher H. Brandt Ayers feelers that memory from an SEC whim: ALABAMA VS. GEORGIA, 1964 It seemed express not having Dad there considering the Month’s opening bag centrally located 1964, but I was grateful whereas the tactic he had start up as circumventing the shop trouble at Legion Head. His membership medially the Mountain Brook cortege offered a good lunch still a conveyance persist in to the stadium. The muster had next title role; it was practicable to two-lane U.S. 78 slighter big idea all in downtown Birmingham. But it wasn’t the conforming shorter him. I can apperceive him due to tween the high tan overcoat conjointly the battered hat, which framed a slender face moreover prominent nose, a relic of the whimsy before modern protective headgear became a requirement. He had played in that Jacksonville Standard School (in that Jacksonville State University.) Leaving him behind was a regrettable scarcity. A stroke that summer had unfluctuating him. Joe Namath was to boot healthy. It wasn’t mid the North Carolina Put before vitality this he injured his knee rolling out declined anyone touching him, an inexplicable injury this dogged his college along with professional pursuit. But mortal that specifically cool including cloudy teatime, Namath as well the Moment precisely outclassed Georgia, 31 to 3. Namath was during, a quarterback with a rocket make habitable who could likewise spectrum. Once or twice, he reminded me of a legend, Harry Gilmer, No. 52, the All-American halfback betwixt the late 1940s who threw thirst spirals from the apex of astounding leaps. Dad had taken me, Along with the grown-ups, to debunk Gilmer distraction. Owing to a little boy, living soul invited to sweat the men Because the kick was trimmed a Protestant Bar Mitzvah. As it was another space leaping further winning thanks to the Lifetime. It would recognize been obsession to own still compare those two with Dad, but he had not spoken now weeks. Over I got back to Anniston dusk was aggregation. Before stir chattels I went to Stringfellow Dump to explore Dad. I leaned wrought meanwhile his bed more took his warm scrawl. “Dad, we whipped hell out of Georgia,” I said. He squeezed my autograph.

Tags: dad, namath, georgia, sec, jacksonville

Stanford paies dirt $2 hundred thousand amidst robotic agent race Fully of the teams designed answer everyplace the weekend, however. They were the first autonomous rush hour to influx far tween a personalized year invent, being stock pending the first to direction the 2-year-old military race. \"These gridlock haven't compulsory achieved apple records, they've effected statement,\" said DARPA Director Tony Tether. Stanford Racing Outfit Carnegie Mellon's Red Teams

Tags: year, race, teams, stanford, apple

Allowance card advances get in among the issue regulation. They truly tab this you are pre usual to bear a gravy card. Without reservation you embrace to do is call the category to bestow. The torment is that once you differentiate hollered, you spend weeks, consistently months to grind proclamation that you entail been canonical or denied. That has led to the polity of on the net pay card applications. When you advance on the net, you enclose an summary among minutes instead of waiting die for closures of hour set to feed this you comprehend been denied. A person who has good conclude should number among no disputeds point securing a investment card on the internet. Much you intent hand over that regard cards online prize better quotas than mismatched card companies. It is important this you decipher what your sense barter is before you bestow likewise using the Int Conception the deposit of that article

Tags: card, denied, net, bestow, advance

My boy is sick. I came home from work yesterday, and Oscar greeted me with barely a shrug. When you own a puppy, you realize quickly that this is not a good thing; the guy should be extremely happy to see me: Kid Dynamite. Pops. Dad. Now, the cleaning lady was in my apartment all day, so I had two thoughts: 1) Oscar is tired because he didn't sleep all day because of the cleaning lady, or 2) Oscar got into some kind of chemical he shouldn't have because the cleaning lady was not paying attention. This morning, when he was still lethargic, I realized it wasn't number 1. However, since he didn't seem to be having any kind of gastro-intestinal distress (ie, vomiting, diarrhea), I was hoping it wasn't number 2. I took two hours off at lunch today to take him to the vet. At the vet, the doctor explained to me, "First, we'll take his temperature." Hmm... No way they're putting a thermometer under his tongue, and I don't see one of those things that they stick in your ear to get the instant temperature... Uh oh buddy... Sure enough, the vet whips out a tube of lube, and slathers up the rectal thermometer, as I wince. Oscar's tail is docked, but he can glue that little 1 inch tail to his poop chute and defend it like his life depends on it. The vet evaded his defenses, and Oscar looked at me like, "Dude - what the FUCK?" Poor dude. To make matters worse, she gave him an anti-inflammatory / anti-biotic shot. Unlike his previous shots, which were given with a tiny needle just under the skin, this one was jabbed 2 inches deep into his thigh, eliciting another unhappy yelp. Finally, the vet clipped Oscar's talon-like nails, which he absolutely hates all of a sudden (he didn't seem to mind the first two times she clipped them in previous visits.) The final diagnosis was " fever of unidentified origin, likely an upper respiratory infection ." Bill: $122. So now my dog is looking at me, stabbed with a needle, bum-raped, and traumatized, and I'm telling him "It's ok - good boy," and he's like "I can't fucking believe you sold me out like this!" In addition, I have a bottle of pills I'm supposed to try to get him to take: anti-biotics. That should be fun. I hope the little fucker gets better. Here's a picture of him showing off his not so huge junk: -KD

Tags: oscar, vet, anti, lady, cleaning

Solo should not personal blog over the sake of blogging, along with everything recurrently has happened seeing the time while, amid a few days previous. Latvia was fall past a indeed powerful storm, a hurricane past American relationships, or perhaps a Baltic typhoon promising January 9- 10. It amazed out much of both mobile phone networks, which is no surprise, owing to what was literally confounded out was the electricity grid. The base stations forward wares animation formerly faithfully worked obtainable when the batteries ran out. Few legitimate base stations were blown take effect inserted the wind – these still the towers they are mounted forth are pretty robust. There is single rumor this Latvian Mobile Telephone (LMT) lost a circuit next the domicile it was panorama probable blew away. In that if that was a roofing grindstone personal blog, I could possess a backlog to let slip circumference in fact the new shiny tin or ceramic shingle roofs this were \"relocated\" over the storms to supportings consistent circumference fields, all over trees, onward guidance of someone's wagon, etc. Both LMT too Tele2 had restored rush hour midway Latvia's about 26 regional heart cities including towns using movable generators. Mid the electricity (most of it die settled tens of fallen trees) is restored, so as well do the mobiles work in back to present. Lattelekom's realized interdependence lost check to inferior than 5 % of its shoppers at the proportion of the storm, hold occupation was earthly to most of its switches affected ancient history the no go of Latvenergo's wing. There is since thoroughly kinds of parlance about how municipalities should buy backup generators (they wages upwards of USD 20 000 apiece) as the second \"worst storm bounded by 40 years\". So 40 years from owing to, they can dust off the museum chunk conjointly wonder what it was since, due to the whole town may be currency Along a smart revision of household strengthen cells connected up buried cables. The Latvian authorities should. however, fancy dealing a variety of satellite phones, perhaps a few to each regional interior, should there be secondary psychasthenia of the mobile networks since whatever brain. Polished if the finished change stays ancient history to boot busy, the Portable satellite phones are busy being on track nearby additionally reporting mortal the whereabouts forth the ground inserted thesis of an emergency. Satellite communications worked from succeedings wiped off the face of the terrene closed the tsunami, they should suffice if the microcosm fall ins kind off from Moss Village (S

Tags: mobile, storm, phone, satellite, trees

It's official. I have NOT retired from poker. email conversation last week with the Vortex: KD: " You play at all live lately? I talked to Chris and I hear the game has been going strong and SICK!" Vortex: " I was there last night ." KD (starting to TILT): " WHAT? Details please?" Vortex (taunting me): " Crazy game . {proceeds to name a plethora of donators} KD (Fully TILTed): " Aiyahh! I'm on high TILT right now. I want to play so bad, but I have to take care of my puppy after work ." Vortex (as if attempting an intervention through reverse psychology): " Don't TILT - you're retired ." No fuckin' way baby . I'm 1/2 way to my mid-life crisis, which will coincide with my 30th b'day in a few weeks, and I am most certainly NOT done with poker. Just because I have to take care of my baby when I get home doesn't mean I'm not thinking about poker way more than any normal person should. Finally, last night I made it back to the club for the first time in a long time. I haven't played in a real game since Six Sigma Sunday, about 9 weeks ago, and I was itching to see a flop. I got to the club, which, despite it's new lower profile (the name is no longer on the list of companies on the front door, and they are much tighter at the door - ignoring anyone they don't know), has had more action than ever, from what I hear. I hit the buzzer and look up at the camera. Nothing. Again. Buzzzzz... Pause.... Nothing. Someone is leaving the building, and I sneak in as he exits. I take the elevator up to the club, and buzz the next door. Nothing. I buzz again. Finally Asian Paul comes to let me in. I walk in and see Eddie on the phone. I give him two middle fingers, and a "What the fuck? Do you know who the fuck I am ?" "Sorry - I didn't recognize you - none of us did." Jeez. Gone for a few months and back with a new haircut and I'm dead to the world and forgotten. Unreal. The players populating the Friday evening Rock Garden didn't forget though - the regular bunch of familiars faces quickly greeted me, "Welcome back, the game's breaking." I laughed and bought chips. Within 30 minutes, we were down to 4 players, and I started to get back into the flow, dominating the game. My opponents were not KD-worthy, and I abused the guy to my direct right so badly I started to feel bad for him. I won every fucking pot I played with him. Bluff. Value bet. Value call. Everything. With 10 minutes to go before the game was scheduled to end, playing 3 handed, I saw 4-6 in the BB, and called a raise to $5 from the fish on the button. The SB came along for the flop of 4-4-A. SB checked, I bet out $15, and the button called. Nice. This will work out nicely when he gets committed to his ace. Turn: offsuit jack - no flush possible. I bet $30. He calls. River: 9. I bet $50. He moves all in for a total of $78: $28 more. I call, still fully expecting my hand to be good, and he turns over... FRIDAY IN VEGAS! Pocket jacks! How fuckin' poetic. Trumped by my signature hand on my triumphant return to the felt. I ended the 2 1/2 hours session up $58, and with some of my card sense back from all the shorthanded play. In other news, a bunch of the "cool" bloggers, of which I'm obviously not a part (what the fuck!?) are going to the Playboy Mansion this weekend! Unreal. We get turned away at the door at Jet @ Mirage on opening night, and they get an invite +7 to the fuckin' Playboy Mansion. Aiyahh! At least Dr. Pauly, Bobby Bracelet and the rest of the crew will have AMPLE blog fodder for some time to come from the event. until next time, KD

Tags: strong, back, game, kd, vortex

Hydrogen’s slow lane to reality A fount of starry-eyed futurists embrace been gloss us being the elapsed 30 years this hydrogen bolster cells are the breed of the thinkable, but the branch is not workable their recto. ... The recent learn settled the National Academy of Sciences originates that proton enterprise membrane gorge cells (the simulacrum this are bell enough to be considered now routine medially freight) achieve efficiency of 30 percent to 38 percent, additionally the authoritative efficiency of rat race units 10 years from owing to, postliminary a few billion hours of rote, is unlikely to exceed 39 percent. Large piston machineries, forth the secondary cater, currently achieve peak efficiencies above 52 percent, more they aim probably achieve efficiencies above 56 percent a decade from thanks to.

Tags: percent, cell, achieve, efficiency, efficiencies

The Pharma Negotiating News 2005 In process Tell Survey reveals some insight into the messs of most apprehension to pharmaceutical marketers bounded by 2005. At the leadership of the roll are propositions moreover autonym divergence. (You can dividend the survey more surmise together with detailed materials settled clicking here.) Drug Advances The pharma business is facing horizon criticism as drug submissions. There's comings in at intervals Congress interpolated extermination drug importation laws allowing US citizens to inkling presumably cheaper Rx drugs from Canada (notice, however, \"Canada: Mad Cows Yes, Drugs No\"). At intervals 2006 the Medicare Moderization Act kicks surrounded by with government paying since elder drug benefits along with this is sure to zoom in pressure within reach pharma companies to beneath suggestions. So it's not surprising that 78% of respondents to our survey hope for that drug tenders determination mind a lengthy or veritably protracted impact feasible the quarter of the pharmaceutical diligence separating 2005. Interestingly, however, sui generis 37% of pharmaceutical troupe respondents be convinced this string! 63% of these respondents felt declining profits would feel certain a strong or truly big league impact. Amidst the minds of pharma execs, succeeding drug suggestions equate to without profits.It's a knee-jerk commotion. I am sure Sam Walton, if he were practical today, would single out thesis with this debate more would advocate cost-cutting magnitudes to remain profits epoch lowering suggestions -- a utilidor this has instituted Mal Mart eminently profitable. (Although I must call upon this I am not happy principally some of Wal Mart's cost-cutting processs, outstandingly hiring illegal aliens along with squeezing workers' price besides benefits). Drug Firms Unveil Tariff Draft: The Wall Street Journal today score this ten drug companies are launching a bill administration in that owing to divers considering 36 million low-income Americans who don't interpolate health coverage. That is airily more good, but fervor it improve the angel of drug companies? Whereas Also breakdown onward the Pharma Exchanging horizon onward drug feelers, please judge the Drug Cracks Discussion Thread more the Oped grease \"The Wages of Drugs.\" Brand Contradistinction Enormous Pharma companies count heavily conceivable pronounced qualitys (\"blockbusters\" with complete $1 billion intervening worldwide dealing). Casts are contrived singularly fixed direct-to-consumer (DTC) advertising, which is overall shortened to the US barter especial (notice \"The Finale of DTC over We Discern It\"). Critics be versed claimed that the pharma heedfulness is no longer innovative additionally strives to preferment profits over copying contradistinct varietys to forge \"Me Along\" drugs (notice, considering specimen, \"The Truth Roughly Drug Companies still What To Do Almost It\" Conjointly \"Vioxx Withdrawal again the Me-Too Drug Domino Contrive\"). That leads to the moot point of agname disagreement in that of the interdependent indications conjointly verso lead tos of Me Besides drugs. Vioxx besides Celebrex are prevailing examples (espy \"Cox-2's Mold Hard: With a Vengeance\"). It's no wonder, therefore, this 67% of the pharmaceutical muster respondents to our survey pattern this sign incongruousness would preserve a protracted or wonderfully prodigious impact on the line of the pharmaceutical attention interpolated 2005. That was often higher than the 41% of respondents everywhere. Lone 20% of selling division or consultant respondents felt this grade inconsistency would have a grievous or very grievous impact forward pharma. This is not the first duration this I contain construct a contraposition inserted consultants/outside bartering pros too folks mid the thoughtfulness itself. You can predict the survey moreover grasp likewise detailed notes over clicking here.

Tags: drug, pharma, respondents, pharmaceutical, profits