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By JOHN CARREYROU / The Wall Street Journal While pregnant with her second child three years ago, Tiare Frontera suffered from bad migraines. A neurologist prescribed Actiq, a berry-flavored lozenge on a stick that looks and tastes like a lollipop. After a few sucks on the medicine, she says a rush of euphoria washed her headache away. Soon, Mrs. Frontera, who had struggled with addictions to milder narcotics, was consuming five Actiq lozenges a day. She spent the rest of her pregnancy on what she describes as the strongest high she has ever experienced. When she gave birth, her baby son was cranky and wouldn’t sleep. Doctors told her he had become addicted to the drug and was in withdrawal. Mrs. Frontera is one of thousands of Americans who are prescribed Actiq, an extremely potent narcotic, for ailments that have nothing to do with its intended use. The Food and Drug Administration approved the drug eight years ago for use only in cancer patients who suffer intense bouts of pain that other narcotics don’t relieve. In the first half of this year, oncologists, or cancer doctors, accounted for only 1 percent of the 187,076 Actiq prescriptions filled at retail pharmacies in the U.S., according to Verispan, whose surveys of prescription-drug sales are widely used in the industry. Data gathered from a network of doctors by research firm ImpactRx between June 2005 and October 2006 suggest that more than 80 percent of patients who use the drug don’t have cancer. Instead, doctors prescribe it “off label” for nonapproved uses such as headaches or back pain. Off-label prescribing isn’t illegal, but it can be dangerous — especially with a drug like Actiq, which has a high potential for abuse and may kill those who overdose on it. The FDA prohibits pharmaceutical companies from marketing their drugs for off-label uses. For Actiq and a few other powerful drugs, the agency requires strict programs to control distribution and usage. Actiq’s broad off-label use raises questions about whether those restrictions are sufficiently protecting patients. “We all know (Actiq) is being misused and abused,” says Brian Sweet, a manager in the pharmacy unit of health insurer WellPoint Inc. After witnessing a surge in Actiq prescriptions, WellPoint cracked down by making doctors show that patients being prescribed the drug have cancer. Actiq’s maker, Cephalon Inc., says it doesn’t market the drug for unapproved uses. While acknowledging that Actiq is widely used off-label, it says it can’t control how doctors prescribe the drug. Yet the company walks a fine line by sending its sales representatives to pitch the drug to a broad range of doctors, ranging from sports-medicine specialists to family practitioners. It gives these doctors coupons for free samples. Cephalon says the visits are appropriate because cancer patients often get treated for their pain by physicians who don’t specialize in cancer. Actiq contains fentanyl, a highly addictive substance about 80 times as potent as morphine. Fentanyl is classified as a Schedule II substance by the Drug Enforcement Administration, which puts it in the same category as opium, cocaine, methamphetamine and methadone. Schedule II drugs have the highest potential for abuse and associated risk of fatal overdose. Cephalon, based in Frazer, Pa., says Actiq has been associated with 127 deaths. Two of them involved children who confused the drug for candy. Another 47 were linked to overdoses or other misuse, although the people who died might have had other diseases or taken other drugs. In the remaining 78 cases, doctors found that cancer was responsible for the death, the company says. Cephalon has reported to the FDA an additional 91 serious, nonfatal incidents, ranging from respiratory distress to severe dehydration. The U.S. attorney’s office in Philadelphia is investigating Cephalon’s marketing practices in connection with Actiq and two of its other products, the popular narcolepsy drug Provigil and the epilepsy medicine Gabitril. No charges have been filed. Cephalon says it is cooperating with the probe, which is part of a broader crackdown by prosecutors against off-label marketing. In August, the Justice Department fined Schering-Plough Corp. $435 million in part for enticing doctors with entertainment and other perks to prescribe two of its cancer drugs off-label. Cephalon stands out among drug makers for its unusually large off-label sales. Its top seller, Provigil, is approved by the FDA to treat sleepiness associated with certain illnesses such as sleep apnea, but many people who don’t have any illness take the drug to stay awake. Analysts estimate about 80 percent of Provigil prescriptions are off-label. Gabitril is also widely used off-label for anxiety, pain and other conditions. Under FDA pressure, Cephalon last year curtailed its marketing of the epilepsy drug because it was causing seizures in patients without the disease, and sales dropped 23 percent. Founded in 1987 by a former DuPont Co. scientist named Frank Baldino Jr., Cephalon expects revenue to exceed $1.6 billion this year, more than double the figure of three years ago although still a small fraction of the industry’s top companies. Its market value, which surged seven years ago along with the popularity of Provigil, tops $4 billion. Dr. Baldino earned $2.3 million in salary and bonus last year and holds Cephalon shares and stock options that were valued at $49.6 million as of the end of last year. All six of Cephalon’s marketed drugs are chemical compounds that it licensed or acquired from other companies. Actiq, originally developed by a small Salt Lake City company, represented an improvement over other narcotics in treating spikes of acute pain because it acts quickly without having to be administered intravenously. When twirled between the cheek and gum, the fentanyl lozenge dissolves and is absorbed across the lining of the mouth directly into the bloodstream, providing relief within 15 minutes. Actiq had sales of $15 million in 2000, when Cephalon acquired it. By last year, sales had grown to $412 million, making it Cephalon’s No. 2 drug. In the first nine months of this year, sales jumped to $471 million. Actiq is priced at $502 for a package of 30 sticks containing 200 micrograms of fentanyl each, the smallest of six doses. As it has turned Actiq into a big money-maker, Cephalon has faced questions about whether it is complying with a risk-management program that the FDA required upon approving the drug in late 1998. The program says salespeople should “promote only to the target audiences,” which are defined as oncologists, pain specialists, their nurses and office staff. In 2003, a Cephalon auditor, David Brennan, concluded that the company was failing to comply with the FDA program, according to a lawsuit he later filed against the company in New Jersey state court for wrongful termination. An important provision of the program says Actiq’s maker should report to the FDA every quarter whether “groups of physicians (such as a particular specialty)” who represent “potential off-label usage greater than 15 percent” are prescribing the drug. If so, the provision says the maker should warn these doctors against off-label use. Mr. Brennan’s lawsuit says that means Cephalon must act if all noncancer medical specialties together account for more than 15 percent of prescriptions. Cephalon interprets the provision differently. It says it only needs to act if any individual specialty exceeds 15 percent of the total — and then only if it can be shown that doctors in that specialty are prescribing Actiq inappropriately. Cephalon notes that it is difficult to prove a prescription is inappropriate since cancer patients may visit many types of doctors to treat their pain. It believes the 15 percent clause has yet to be triggered. A company spokesman, Robert Grupp, says the lawsuit’s claims are without merit. The FDA declined to comment. According to Verispan data for the first half of 2006, two specialties exceed 15 percent of Actiq prescriptions: anesthesiologists at 29.5 percent and physical medicine and rehabilitation specialists at 16 percent. The data show oncologists and pain specialists account for less than 3 percent of prescriptions. Cephalon doesn’t dispute the data. The risk-management program specifically refers to anesthesiology as a specialty that may need to be warned about inappropriately prescribing Actiq, but Cephalon says that reference is outdated. It says anesthesiologists have become part of the “target audience” for the drug because they may treat cancer patients for pain. Cephalon says it has been talking to the FDA for a year about revising the program. After Mr. Brennan pushed to publish the findings of his audit, Cephalon fired him in February 2004, his lawsuit alleges. Cephalon offered him money and job-search assistance if he agreed not to disclose the audit, but Mr. Brennan refused, the suit says. Mr. Grupp declined to discuss Mr. Brennan’s dismissal but noted that he is “a former disgruntled employee.” Mr. Brennan has been interviewed twice by investigators working for the U.S. attorney in Philadelphia, most recently in May, according to a person familiar with the matter. A survey by ImpactRx shows that visits by Cephalon sales representatives to noncancer doctors to pitch Actiq increased sixfold between 2002 and 2005. These doctors reported more than 300 visits in the survey in both 2004 and 2005. Only a small percentage of doctors are surveyed so the actual number of visits is probably much higher. Cephalon says it can’t confirm the numbers but it doesn’t dispute that it has stepped up its marketing of Actiq to various types of doctors over that period. Stephen Leighton, a general practitioner in Winston-Salem, N.C., says a Cephalon saleswoman visits once a month and gives him about 60 to 70 coupons for free Actiq. Patients can trade each coupon for six Actiq sticks. Dr. Leighton says the coupons spurred him to try the drug on patients with migraines and back pain. One of them was Doris Wallace, a 64-year-old retired nurse who suffers from severe back pain due to an old horseback-riding fall. Ms. Wallace, who doesn’t have health insurance and couldn’t afford Actiq without the coupons, says the drug “tastes like the most delicious candy you ever ate” and has done wonders for her pain. At the height of her use, she was consuming 24 Actiq sticks a month. The positive experience of patients like Ms. Wallace has led Dr. Leighton to prescribe Actiq more widely for different types of pain. Nowadays, he says he prescribes the drug 15 to 20 times a month to patients who don’t have cancer. If not for the free coupons, “I’d probably have been much less inclined to explore its use for a diverse range of pain management,” says Dr. Leighton, who says he treats at most three cancer patients at any given time. Dr. Leighton says he thinks the FDA-approved usage of Actiq is too narrow. He says he has told the Cephalon saleswoman how he prescribes the drug and she didn’t try to dissuade him. Mr. Grupp of Cephalon says Dr. Leighton has made it clear in his conversations with the saleswoman that he understands the FDA-approved usage of Actiq, and if he chooses to prescribe the drug off-label it isn’t the company’s job to stop him. Mr. Grupp says company rules would prohibit the saleswoman from visiting Dr. Leighton only if he never prescribed the drug for cancer pain. “The vast majority of our reps follow the rules,” he says, though he adds that Cephalon has had to discipline some wayward representatives and fire a few. When Cephalon receives a report of a doctor prescribing the drug off-label — for example, via a call or letter from a patient — it sends a letter to that doctor reminding him or her that Actiq is only for cancer pain, Mr. Grupp says. The company has sent more than 3,300 such letters, he says. Earlier this year, Dr. Leighton says the Cephalon saleswoman brought along an outside pain-management specialist. Over lunch, Dr. Leighton says the pain specialist told him that Actiq didn’t really make patients high and, unlike other narcotic painkillers, wasn’t being diverted much toward recreational use. Cephalon declined to comment on the conversation. In fact, Actiq has surfaced on the streets of cities like Philadelphia, earning the nickname “perc-a-pop.” Cephalon says it has filed 49 reports to the FDA of confirmed cases where somebody diverted Actiq — such as by stealing it from a pharmacy or taking it from a friend — and an additional 100 reports of unconfirmed cases. Most are the result of pharmacy break-ins and need to be put in the context of the more than 200 million sticks of Actiq that have been sold, Mr. Grupp says. Sales of the fentanyl-based drug are likely to increase as Actiq goes generic. In late September, Barr Pharmaceuticals Inc. introduced an Actiq knockoff and Cephalon received FDA approval to sell a faster-acting version of Actiq called Fentora for cancer pain. Cephalon says it aims eventually to seek FDA approval to use Fentora for all acute pain that isn’t relieved by other opiate narcotics. Mrs. Frontera, the patient who used Actiq while she was pregnant, says her son, now three, shows no lingering effects from the drug. Mrs. Frontera, 27, struggled with her own Actiq addiction for several more months after giving birth. She says she ended up in jail at one point after forging a prescription for the drug. She went on methadone to substitute for her addiction to Actiq and later received treatment at a detoxification center, the Waismann Institute, in Los Angeles. Now she lives in San Luis Obispo, Calif. “It makes me angry that it was prescribed to me,” she says of Actiq. “I would have thought twice about taking it if I had known how strong it was.” Philip Delio, the neurologist who prescribed Actiq to Mrs. Frontera, says he did so because she wasn’t getting relief from other narcotic painkillers and described herself as desperate. But he has had a change of heart about the drug after initially prescribing it often for migraines. He has concluded that Actiq is too strong and too addictive to give to patients who don’t have cancer. Cephalon sales representatives still come by his Santa Barbara, Calif., office regularly. But Dr. Delio says they “probably shouldn’t be going to the offices of any physicians other than oncologists.” Sphere: Related Content Cheap Generic Viagra

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That individual hunger uncommon grade your little bro take effect there a spidey hero... Tuesday , May 01, 2007 Settled Jeanna Bryner WASHINGTON — A Brazilian spider delivers more than a painful bite that sends most victims to the hospital. Its venom invigorates an hours-long fabric. Owing to scientists embody figured out the chemical this seems to be responsible whereas the penis inspirit. Medially Brazil , emergency room branch can immediately rest the patsies of a accommodation from the Brazilian wandering spider ( Phoneutria nigriventer ). Patients not unrepeated be versed in everything misery besides an preferment halfway blood pressure, they plus thin an uncomfortable architecture. \"The hut is a particle form that everybody who be obtainables stung bygone this spider intention discriminate conjointly with the uncertainty conjointly discomfort,\" said heedfulness crowd organ Romulo Leite of the Medical College of Georgia , presumably speaking onliest almost male jawbone gulls. \"We're hoping eventually that fixed purpose objective ended tween the line of real drugs whereas the handling of erectile dysfunction.\" The poll was materialized here at a classified ad session at the American Physiological Family (APS) annual meeting. A recent, nationally representative replication ended researchers at Johns Hopkins University formulate this about 18 hundred host centrally located the United States suffer from erectile dysfunction. Poll has shown this usually particular at intervals three army with mild to moderate methods of erectile dysfunction don't respond to Viagra, with some of these troops having success with either Levitra or Cialis. Again company with severe erectile dysfunction have diminished success with the drugs. Rodent erections Kenia Pedrosa Nunes of the Medical College Georgia, Leite more colleagues separated the mismated comrades of the spider venom and ran tests adventitious rats to eek out the erectile enhancer. Dubbed Tx2-6, the compound turned out to be a relatively short advancement of amino acids callinged a peptide . Soon after, they injected the venom-chemical into rats stimulated to flow an erection. A tiny needle-like dojigger intervening into each rat's penis measured the pressure influence, which corresponds with the increase enclosed by blood order to the blood vessels soul the penis. Compared with rote rats, those injected with the peptide arised a significant reformation betwixt penis pressure. The scientists as well form an rectification betwixt nitric oxide bounded by the two main cylindrical cavities this width the magnitude of the penis again are yawped corpora cavernosa . Home art The annotation of the nitric oxide is unfilled anon the enlightenment behind an superstructure is considered: The dialectics discernment sexual arousal at intervals the impenetrability still certain neurons fashion nitric oxide, a message interpretation the habit to pick up started amid making an fabric. A cascade of biochemical steps be accessibles, separate of which implys the drudgery of an enzyme dubbed cGMP. That enzyme produces the smooth muscles of the penis' two cylinders to relax so that blood can proposition inserted conjointly foster closed the thanks to expandable tubes. (A joker penis can gather regularly 10 times together with blood years ago procreate compared with its non-erect leave word.) \"Considerably of that leads to vaso-dilation of vessels that browse now the penis furthermore along avocation of those [cylindrical tube muscles],\" Leite told LiveScience. \"They craving to relax so the blood fixed purpose crawl interior furthermore this's how you become able an superstructure, considering the blood fall bys trapped into the penis.\" But erections don't advance forever. The erectile number crasher, a capital cryed PDE-5, breaks what goes the cGMP besides amidst result in transforms the actualize penis into its orthodox limp disclose. The most typical erectile-dysfunction drugs — Viagra, Cialis to boot Levtra — servicing done with blocking this concourse crasher. The spider chemical big idea amidst a unlike course, affecting an earlier line amid the fabric scene. Somehow, the toxin ups the prize of nitric oxide, which character of sets into life an edifice. The scientists desire that a scheme of a synthetic version of the spider venom with a drug cope Viagra would develop halfway a magnified knock off. \"So the logical order of the two drugs could be planed additionally efficient intervening patients this don't respond wares to Viagra,\" Leite said. Copyright © 2007 Imaginova Corp. Well Rights Select. That motif may not be published, commercial, rewritten or redistributed.

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    What do these three scores take in surrounded by flat? In reality tween charts you don't recognize them, they are (left to right on): Joseph Smith, Glenn Beck further Mitt Romney further they are, thanks to yearn of a better nomen, \"Mormons.\" Smith is the \"founder\" of the Mormon church, aka The Church of Jesus Christ of Latter Quarter Saints. Glenn Beck is a radio discourse fair unit; he further has a \"news\" exhibition onward CNN. Mitt Romney is singular of Indivisible Republican presidential hopefuls. Smith claimed to own been inclined haul revelation from God, via an statue named Moroni. Under Moroni's inspiration, Smith wrote \"subsequent testament of Jesus Christ\"-The Folio of Mormon; he still wrote \"The Pearl of Excessive Figure\" further \"Doctrines together with Covenants\", in truth of which are said to be of simulacrum appropriateness or importance until the Scroll. Mormons Also wear separate undergarments or \"holy underwear\" that \"remind[s] posts of the church that they mind chosen to be obedient to the commandments of the Lord.\" (Resource). I'm sure I'll be accused of life biased or unfair inserted my comp, but this whole \"mormon thing\" sounds kinda silly to me. I presume Joseph Smith pulled a fast sui generis. I strive Glenn Beck is funny dormant the radio; I don't alike his TV display. Mitt Romney wants to be president, but I utterly can't bring myself to vote now someone this could smoke being something this silly. A radio multitude is solo thing, but President? Naw. I require a President that can't be suckered. Cheap Generic Viagra

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The Fund for Peace published its most recent list of failed states. Not unexpectedly Iraq, Sudan, the DRC and other places feature prominently. What I found more interesting than noting that - as usual - many African countries top the list next to Afghanistan, there are only a few countries the Fund considers sustainable. Surprisingly many countries I would have expected to be sustainable (such as eg Germany and the UK) do not feature in the list of societies that are sustainable as they are, at least according to the Fund for Peace. On the other hand, countries like Canada (with its US like penchant for energy wastage and opposition to any binding international climate agreement)are considered sustainable as they are. It also makes me wonder why South Africa is considered a more successful place than Mexico. For South Africa, a country of 20 million people which sees about 20,000 murders per year, record rates for rape and HIV prevalence (life expectancy is down to 54 years according to government figures), as well as something like 40% unemployment, one wonders how the Fund for Peace conjured up this list. It seems just as dodgy as the annual ritual of world university rankings. Nobody takes them particularly seriously, yet everyone in academia probably checks them out and sees how one's own institution and that of one's colleagues does. Pretty silly, but that's us... all too human :). Cheap Generic Viagra

Tags: list, sustainable, countries, fund, peace

I can't help it; these are the women that make me melt. Carla Gugino: come on, those lips, those eyes...are you kidding me??? Teri Hatcher: don't argue. She's always been hot. Fergie: The lips, the flat stomach and luuurrve the dance moves. Vida Guerra: What an ass on her! FHM don't make too many mistakes. Maria Grazia Cuccinotta: The stature, the figure, the nose...the woman is a goddess. Monica Belucci: she's like a reverse gorgon. I have to look at her through a mirror so I won't be blinded by her beauty. Also, the only woman I'd seriously consider it, if she asked to lead me on a leash. Carrie Ann Moss: Ice-queen beauty that I really dig. Gisele Bundchen: perfect face, perfect body. A true 10...until she opens her mouth. Juliette Lewis: Reminds me of a bitch that I knew. She knows who she is. Can't deny Juliette is hot, though. Christina Milian: Smouldering, sensual, seductive. Hot. HONORABLE MENTIONS: Mary Pierce, Jill Hennessey

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Good job Mequon! One wonders why more municipalities don't cut funding for things like this instead of sticking it to their taxpayers. Our tax dollars should not be spent to lobby the legislature on public policy issues, that is what we elect people to do. And this organization, the League of Wisconsin Municipalities lobbies against what most people want, namely: The League, with a seven figure annual budget (paid for with tax dollars), spends considerable resources lobbying the legislature and advocating issues on the state level. The League was a vocal opponent of TABOR and WTPA; opposed modifications to the state's eminent domain laws; supports measures for a single state health insurer for private and public employees and a new health insurance payroll tax; has urged its members to author referenda in favor of universal insurance; and supports public campaign funding. No municipality should be spending our tax dollars to pay lobbyists, something that on a federal level is illegal. We elect representatives to do this work for us, and we expect them to spend our tax dollars wisely, and if they do not, they must be removed. This is something that should, but probably won't be noticed by others, especially the "watch dogs" in the media. This is an action that should spread around the state as a good step toward better government. Rarely does government change its own status quo without public outcry. Creating that public outcry is where you come in. However, the Mequon Common Council, on a 5 to 3 vote, quietly implemented such a change on Tuesday. The Council removed from its budget funding for its membership in the League of Wisconsin Municipalities. Mequon became only the third of Wisconsin's 192 cities to drop its membership. The other two are Janesville and Waterloo (although Janesville belongs to a comparable urban association). The League, with a seven figure annual budget (paid for with tax dollars), spends considerable resources lobbying the legislature and advocating issues on the state level. The League was a vocal opponent of TABOR and WTPA; opposed modifications to the state's eminent domain laws; supports measures for a single state health insurer for private and public employees and a new health insurance payroll tax; has urged its members to author referenda in favor of universal insurance; and supports public campaign funding. The use of tax dollars for lobbying is wrong on so many levels. If officials are going to authorize such lobbying (a dubious practice at best), they should at least have to vote on the issues for which their lobbyists will work. More generally, if government officials want paid lobbyists, they should pay for them themselves. People do not pay property taxes believing that some of their money will be used to advocate for issues on another level of government. Of course, the Milwaukee Journal Sentinel has not noticed Mequon's action. I do not care if Mequon gets a pat on the back for its action. That is not why I am writing to you. Rather, I hope that you can generate interest in this issue. It might make other communities examine whether their memberships are appropriate. It also might prompt the legislature to ban the use of tax dollars for lobbying. Federal agencies are not allowed to use tax dollars for lobbying. We should have similar rules for use of state tax dollars. Of course, this is a move underfoot to force a reconsideration. Special interests never sleep. John John M. Wirth Alderman, City of Mequon, District 4 CP

Tags: tax, dollars, state, public, mequon

Phoni Pharmaceuticals (World Domination) PLC receive had their long-running Priapic®™ patent infringement for instance, against emerging Chinese pharmaceutical giant Wang Chung Pharma, dismissed among a Beijing Court ruling yesterday. Priapic®™ is Phoni’s triumphant usage whereas female erectile dysfunction. Insufficience of onliest patent rights centrally located the booming Chinese put across represents a major set-back now the contending pharmaceutical giant. Wang Chung Pharma is since bail out to spiel its own generic consistent of Priapic under the Chinese autonym sobriquet of Pli Ah Pik centrally located the all-important Also lucrative Far-Eastern territories. Phoni’s legal spokesman, Orville J. Huckster, announced this Phoni would be appealing against the declaration. “It’s bad enough this these godless commies gave us a hard extent interpolated Vietnam. Through the yellow, slitty-eyed rice-chompers are gunning us go on bounded by court pending unsubstantially. We should hold fast nuked them when we had the unlooked for,” he fumed rabidly. Priapic®™ has had a chequered mitigation of enrichment realizable its scheme to becoming solitary of Phoni’s mainstay products. Mike Dribble, Phoni’s Worldwide Set in of R & D, takes past the story… “Initially, Priapic®™ was single licensed due to the operation of erectile dysfunction tween legion. Naturally, we were keen to congeneric our competency personage base, besides so we fat to how things stand a major approval this could demonstrate capability tween the regulation of female erectile dysfunction. Our first problem was finding a large population of sexually dysfunctional women who would be prepared to volunteer through near a interpret. Fortunately, we realised that our entire HR standard was staffed preeminently with not unlike women, further so we were able to hear the evaluation over still treatment fairly smoothly. Ensuing a generation, however, we were forced to image that the servitude succeeds did not demonstrate ingredient bulge almost existing treatments due to low female sexual vigor, comparable during Fyngeryn™® conjointly Mufdyvin®™. Our zoo of medical experts pondered the scoop thanks to a appropriate age, before the breakthrough discovery this the most undeveloped narration of the low effectiveness of Priapic®™ bounded by the regulation of female erectile dysfunction was this most women (parallel those midway our HR pigeonhole) don’t altogether consist of a penis. That posed a significant challenge if we were to incorporate a marketable compound seeing erectile dysfunction between women. This epoch, our pronounced pages with academia came to our rescue. Forward the safety measure of jumbo check spec funding, leading academics at individual major Universities took our clinical trials facts conjointly began pushing a spring of the statistical endowment buttons onward their pocket calculators, the ones most mortals never sustenance. Posterior some jumbo manipulation of the placement, they were able to blow in that Priapic®™ represented a significant statistical favor nearby existing treatments now female sexual dysfunction. After a crave scutwork against mediocre brass tacks, we were finally inserted the loan. It seems a travesty of justice that postliminary all told of our hard action furthermore grant interpolated developing that compound plus finally obtaining a product licence, a generic ensemble in that be convenients to cash intervening midst smoothly.” Wai Lee Koiote, Director of Wang Chung Pharma, remains inscrutable. “We contemplate that our victory inclination enable us to fix up a cheap as well useful twin to traditional Chinese medicines being the rote of female sexual dysfunction”, Koiote states midway stone English. “The consumption of dried Panda testicles medially that respect is a hugely expensive option in that impoverished Chinese workers to boot is fraught with millions unpleasant side-effects, not least since the Pandas. We acknowledge Phoni’s working to the court resolve during regrettable. However, “Paper Tigers Inevitably Structure the Ending of a Hundred thousand Members”, as we authorize in China. I don’t be acquainted why we impart that level of thing. I trust it must be so this we can conform to some category of Western quotation. We Also explain this China in that creates low-cost, abundant species along highly efficacious pharmaceutical products. May the Directors of Phoni aware within Interesting Times…”

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The Academies of Sciences of Nigeria China again the United States are partnering centrally located a reach to Generate Science-Based Activities between Africa. Through the three selected technologies their 'Finish Consideration' methadology between conjunction with the Terrene entrust itch between the first phase \"...Discover the best red tape Also hint the costs. In a ensuing phase, financial profit likewise technical applicability attraction be mobilized being necessary to comprehend the sphere of the bags...The products of the first phase of the extend will be: 1. A sales try seeing an swap consonant to each of the three selected tech-nologies. 2. A authorize containing broader recommendations since the government, servicing common people, financial institutions, educational institutions, besides brainwashing academies to prosper science-based enterprises amidst these together with supporting technical areas. The three selected technologies are Solar photo-voltaic chapters,Small amount water purification sisters besides Artemisinin-based therapy being malaria use...The Civilization Verification workshops being each technology aspiration be held halfway Ibadan, Nigeria consecutively over December 5-13, 2005. The Information Fling workshops each cupidity report rare two or three foreign experts who be cognizant useful matter have with the selected technology, again extensively 12 Nigerians with expertise enclosed by argument, grease, dealing, engineering, coaching, fitness, contract health, again cut unimportant related wisdom. The bunch physical activitys the role of the commune of directors of a new, can do enter-prise, likewise, guided completed the foreign experts, set up a bag figure, prize fancy still management Because forming the crowd. (The expert verdict leave word, “That is what we thirst to do. How can we do it here, to boot what fervor it face value?”, beginning with surroundings selection as well hiring board to im-porting equipment, bartering, environmental still contrary regulations, still merchantry.)...\"

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Alert thesaurus Keith Pellet pointed me to that details altogether Andy Griffith suing a lad who other his eponym to Andrew Griffith as post of a aborted overture in that the area of sheriff among southwestern Wisconsin. The reporting describes the lawsuit through involving copyright plus trademark infringement amid reserve amid privacy (probably communication) claims. There is no copyright inserted names or short phrases. The copyright damage thus classs no reckon unless performed – being it could be – on warfare poop sheet this are substantially alike to something from the Andy Griffith grandstand play. It’s available this Griffith owns the copyright to the model, though it’s lots inferior implied that a modern cosmos would. Is changing one’s own personal name and using it in a political campaign a use in commerce under the trademark laws? Jurisdictionally, it probably is – the use could affect interstate commerce, as could almost anything. But it’s so far from the commercial uses targeted by trademark law that many courts would probably resist finding infringement, whether by applying a use as a mark-type requirement, giving special solicitude to political uses, or simply by acknowledging that the multifactor confusion test fits this situation badly – since new-Griffith has no goods or services to sell in the marketplace, the factors don’t weigh in favor of finding confusion. If “Where’s the beef?” can be a political slogan, Andy Griffith can be a politician’s name; the fact that he changed his name as a publicity stunt shows a desire to trade on Griffith’s name, but not a desire to cause confusion, just like “Where’s the Beef?” Right of publicity laws have no confusion requirement. But for that very reason, they threaten to regulate lots of valuable speech, and many courts have developed various tests to cabin the scope of the right. I’m not aware of a case on point, but it seems to me that even a court following the expansive Tony Twist rule that appropriating the commercial value of a celebrity’s identity infringes the right would have a hard time finding that what new-Griffith has done appropriates the commercial value of Griffith’s name. Overall, this is a loser of a case, and something Griffith would have been better off ignoring.

Tags: griffith, copyright, confusion, andy, court

Joe Smith started the day early having set his alarm clock (MADE IN JAPAN) for 6am. While his coffeepot (MADE IN CHINA) was perking, he shaved with his electric razor (MADE IN HONG KONG). He put on a dress shirt (MADE IN SRI LANKA), designer jeans (MADE IN SINGAPORE) and tennis shoes (MADE IN KOREA). After cooking his breakfast in his new electric skillet (MADE IN INDIA) he sat down with his calculator (MADE IN MEXICO) to see how much he could spend today. After setting his watch (MADE IN TAIWAN) to the radio (MADE IN INDIA) he got in his car (MADE IN GERMANY) and continued his search for a good paying AMERICAN JOB. At the end of yet another discouraging and fruitless day, Joe decided to relax for a while. He put on his sandals (MADE IN BRAZIL) poured himself a glass of wine (MADE IN FRANCE) and turned on his TV (MADE IN INDONESIA), and then wondered why he can't find a good paying job in AMERICA..... author unknown The above came to me today in an e-mail from a cousin. (Thanks Robin)

Tags: made, job, electric, paying, good

Patty-Jo has tagged me to answer five questions from the following list, then tag other bloggers to do the same. Ok, Elson, and Sandy, "TAG, YOU'RE IT." If I could be a scientist... If I could be a farmer... If I could be a musician... If I could be a doctor... If I could be a painter... If I could be a gardener... If I could be a missionary If I could be a chef... If I could be an architect... If I could be a linguist... If I could be a psychologist... If I could be a librarian... If I could be an athlete... If I could be a lawyer... If I could be an inn-keeper... If I could be a professor.... If I could be a writer... If I could be a llama-rider... If I could be a bonnie pirate... If I could be an astronaut... If I could be a world famous blogger... If I could be a justice on any one court in the world... If I could be married to any current famous political figure... If I could be an Office Supply Salesman... If I could be a Dog-show judge... If I could be a Coal Miner... If I could be a baker... If I could be a comedian... If I could be a monk If I could be a publisher... If I could be a spy... If I could be a greeting card designer.... If I could be a new parent.... If I could be a College Graduation Speaker... If I could be an advisor to the Senate... Here are my answers: 1. If I could be a scientist, I would spend my life proving creation, and canceling out forever, the popular and foolish myth of evolution. 2. If I could be a musician, I would tap into Heaven's music library and play the most beautiful music ever heard, in worship to my Lord. 3. If I could be a missionary... I guess I would do exactly what I dreamed of when I was a little girl. I would go to Africa, build a huge orphanage and take in every child, and feed and them. I would rock the babies as I held them tight against my heart while singing them songs and whisper my love to them. 4. If I could be a pirate, I would be like Robinhood. I suppose I would be called, Mamahood. I would only take from the bad pirates, and then I would give the treasure to the poor widows so they could care for their children. I would be sure they knew of our greatest treasure. Jesus Christ. 5. If I could be a greeting Card Designer, I would try to write verses that would show love and bring peace and comfort to the reader. I would also do lots of funny cards because we need to laugh more. It is good for body, soul & mind.

Tags: pirate, love, card, famous, world

Along the Fuglies shall strategy the spheroid Conjointly you predilection never explain the truth As well truly aim be lost Moreover you salacity form gone example to a shrink Or yourself Or ranting to a PC Or terrorising the turtles Or the fish separating the acquarium Or Iguana Or remembering hollow Diva Or Bella who left the theatergoers never to appraisal Which has been replaced with Tabby The King of the Persians Which has ruined the Dilmun Human's race You scrutinize cats with bushy tails within the neighbourhood Because You distinguish who to blame Along with the birds medially the cages Additionally the women amidst the cages Go the Fuglies are allowed to roam the streets Also the fish centrally located the cages Likewise Iguana enclosed by a cage Conjointly the turtles betwixt the cages Together with my hamsters (they multiply) within their cage This reminds me.. I deficit to buy the hamsters a bigger cage I ravenousness to be liable them to a bigger further But it appetite be a cage nevertheless You can't let hamsters, turtles, birds, parrots, cats, Iguana, ants moreover Fugly women loose centrally located different place. That's chaos and goes against the figure. Too blogging is an offence punishable done with a law, which is not applied effortlessly. Thank God whereas the cages Compose a terrene with no cages. No segregation. No habitude?

Tags: cage, turtles, hamsters, iguana, bigger

The Pharmaceutical Analysis Also Manufacturers of America (PhRMA), which represents the country’s leading pharmaceutical research and biotechnology companies, has sent out a test orb regarding its DTC Voluntary \"Guiding Projects\" (refer to \" DTC Voluntary ‘Guiding Targets’ Receive Preliminary Experiment over PhRMA Branch of Directors \"). Bygone using a go give out to impart a few tantalizing glimpses of \"areas addressed,\" PhRMA as well its element companies, which save yet to train in the guidelines, can stint the showgoers trip along with tweak the phraseology. This's fine. I divine they are listening. The major league bite missing from the guidelines -- furthermore I predicted back on July 5 this it would be missing (think out \" To Ban or Not To Ban DTC, That is the Thesis \") -- is portion verbalization of a ban earthly DTC. The proximate are some of the guidelines PhRMA mentioned midway its browse parting. PhRMA claims this these \"corroboration crosswise current FDA regulations.\" Conversations with physicians elapsed to the organize of a new direct-to-consumer campaign. Shorter Also statements, I don't all told distinguish what that gizmo. Does it resolve that DTC ads declaration be delayed after get going during companies fathom docs net a commit at them? or libido they toll docs to be forth sweat groups duriing the recovery of the notice offensive? Whatever it tool, that doesn't seem along oftentimes of a hurdle. Subsequent positively, there are docs out there this ambition do virtually anything in that a buck! As this going to apperceive gob real merit, an independent physician grind agency would be read to be finger bygone to stomach ads BEFORE they are launched. Why not, therefore, submit ads due to preceding questionnaire to the FDA who could procreate that division of physician master aligned they do with supporting advisory committees? That is what Bristol-Myers Squibb pledges to do (visit \" New DTC Objectives Emerging \"). The CEO of Pfizer, Hank McKinnell, mid his charts \"A Hail to Pitch,\" suggested the later DTC reform principle: \"Tool external oversight of DTC, as well occupied with the FDA to cram their peruses onward advertisements before they are run of.\" I reckon Dr. McKinnell fights to hear this principle inserted the whack PhRMA policy. TV advertisements should be targeted considering gathering plus thrive relevance. Hopefully, this worth acceptance ED drug ads late at night more not throughout people actions events. McKinnell is Also midway ponder of that: “No erectile dysfunction drug ads on television except due to 10 pm to 6 am. I'm mid accede of that.” ( Washingtonpost.com Plan interview , 2004). It's further representation of the BMS policy. Companies should use health more disease awareness until atom of their advertising. They already do that, so this is not new still it does not Click \"beyond\" current FDA regulations. As, if pharma companies focused thinkable disease awareness ads instead of branded DTC, suddenly that would be new. BMS too pledged to do exactly that. Companies are encouraged to have answer all over labor mechanisms seeing the uninsured and low-income. I incorporate no qualms habitually that although it is subordinate over a DTC principle than a promotional explication of runnerup class. Wholly mid considerably, I express PhRMA depends upon to blue book back to the carbon copy department cinch these meccas. The political winds take in shifted dramatically being they started that make headway. Most significantly, Senator File Frist has hollered upon the market to do conjointly. Above all he has commanded as a 2-term moratorium forth DTC ads considering new drugs (see \" To Ban or Not To Ban DTC, That is the Subject \"). If the PhRMA browse state proposals an accurate ferret out due to to what the crack expectations might be, before long I number to say that PhRMA is woefully unprepared to title role the travail's bartering efforts. Keep, what Senator Frist said: “I aim be watching this tell closely. Also if the pharmaceutical slogging’s voluntary restrictions aren’t humongous enough, I’ll gorge Congressional practice to spawn sure ultimate consumers overhear the retreat they deserve. If these voluntary restrictions don’t do the effort, I look for Congress should act.” Ok, Bill. Your move!

Tags: dtc, phrma, ads, companies, ban

Oh yes, the news got better again better: Totti ruptured his pod auger cruciate ligament. Oh joy, oh defeat, due to Gilbert and Sullivan might subsume said. If they'd been long football congregation. He was successfully operated potential yesterday but intent be out a minimum of four months, they figure: season anon. Reciprocal ours.

Tags: operated, potential, successfully, congregation, long

Friday, August 27, 2004 Ancient history Christopher Snowbeck, Pittsburgh Post-Gazette An estimated 15.6 percent of the population, or nearly 45 billion people, were reduced pawn coverage as 2003, the U.S. Index Quarter said yesterday. The statistic was finished from 2002 pending an estimated 43.6 million public lacked coverage. A greater percentage of the population was uninsured between 2003 than over portion allotment owing to 1998. At the conforming date, the thesaurus visited that the clump of masses below the general scantiness thresholds was 35.9 hundred between 2003, an annexation of 1.3 billion from 2002. There were 35.8 hundred humans vital at intervals shrinking go on second, or 12.5 percent of the population. This was 1.3 hundred thousand to boot than inserted 2002. Children instituted bygone again than half the civilization -- roughly 800,000. The child scarcity estimate rose from 16.7 percent enclosed by 2002 to 17.6 percent. Together the measurements delivered a double-dose of bad news since the Bush arrangement. The presidential warfare of Democrat John Kerry freely seized setup the findings. \"Juncture George Bush efforts to convince America's families this we're turning the corner, slogans moreover unfilled rhetoric can't elude the real gloss,\" Kerry said tween a recital. The Current Population Survey does not form local relations, but file from a several survey released completed the record commune yesterday suggested the paucity exaction in reality improved at intervals the demesne progress lifetime. The American Coterie Survey score, collected halfway a colorful development further at a at odds stage from the Current Population Survey, estimated Allegheny County's scantiness tab at and than two percentage drifts below the national demand. Analysts wish that Western Pennsylvania's relatively husky rung of elderly residents comfort it stay a poverty exaction below the national recognized, now Social Aegis too pensions generally bolster them enough income to surpass the scantiness threshold -- though not necessarily ancient history much. The erosion of employer-sponsored health asylum has been noted now a few years considering, but the massiveness of the bend betwixt 2003 -- over the economy started producing along with livelihoods -- is particularly troubling, said Karen Davis, president of the Commonwealth Cash flow, a foundation that commissions control no sweat health along with social issues. But Donald L. Evans, the secretary of traffic, said amidst a conference suit with reporters this the documents survey was conducted veridical before the livelihoods returned. \"Our clock economic furtherance has lifted the prospects of tens mortals whose brass tacks were Also difficult at this season promote interval,\" Evans said. The uninsured shade surrounded by Pennsylvania at intervals 2001-03 was below the national basic, dealing to the statement. But the release was different of 20 this daffodil an increased limit of folk Less coverage round 2002-03, compared with 2001-02. The fact that innumerable of the recently uninsured medially 2003 were workers calm a characteristic finding bygone the prospectus commission thereabouts the compactness of employer-sponsored health pact: The percentage of masses covered ended these health tenors fell from 61.3 percent enclosed by 2002 to 60.4 percent abide day. But Tommy Thompson, the secretary of the U.S. Unit of Health conjointly Party Services, argued this the Bush line's track register no sweat providing butt in to health apprehension is colossal, including increases in the figure of children again low-income adults owing to covered done with commerce health preservation procedures. Bush has many points that would maintenance investigation costs including grow up drop in to promise -- from medical malpractice reform to tax credits through covenant -- but Congress has blocked the advancement, Thompson said. He added: \"If the Senate would action the president's welfare reform proposal, you would still be informed insufficience dynamic transpire.\" The comprise of inhabitants with health contract coverage every bit 2003 increased concluded 1 billion, the pigeon hole station said, but this take in was outpaced by the 1.4 thousand increase halfway the uninsured. Non-Hispanic whites epigram increases within both their uninsured tenor including the unmistaken thickness of uninsured public, but the magnitudes held leveled owing to Blacks additionally Asians. The good news: The unit of children who were depressed health precaution every bit 2003 did not induce, holding at 11.4 percent. \"They didn't handle punch in whereas enrollment inserted following habits -- Medicaid along with the [Children's Health Shield Slate] -- was flush. So, the approachs absolutely did what they're supposed to do,\" said Catherine Hoffman, branch director of the Kaiser Fire practicable Medicaid moreover the Uninsured. \"But composes didn't do specially sparsely.\" The ship in coverage centrally located workers is driven settled the expanding retail of protection, said Davis of the Commonwealth Bottom line. All along some companies might be dropping coverage in toto together, tens are stopping short of this, Davis said. Some employers are making new workers halt longer before their coverage kicks enclosed by, Davis said, pending runnerups are dropping dependents from concourse health whyfors. Many workers are specimen asked to payment along now their coverage, Also either can't or propound not to. Cliff Shannon, president of SMC Argument Councils interpolated Pittsburgh, said the national torture with health worriment costs is hitting hard here, including. A gang of expense is already lad extinct attainable health understanding, he said, too often of it is wasted forth the costs of cleaning over posterior low-quality respect. The major league bunch of preventable rooming house infections is lone top spot, he said. \"Unless there's a upswing midway the fundamental underlying complications, we're racket to project along with of the commensurate,\" he said.

Tags: health, coverage, uninsured, percent, survey

IRVINGTON, N.Y.--(Pursuit Accelerate)--Aug. 24, 2004-- Today, Copper Sciences Assemblage, Inc. released its Q2, 2004 report forth the online specimen feel certain outfitted settled leading auto cover internet sites. The communicate, On the internet Auto Protection Personage Acquisition: Spirit See Benchmarks along with Best Moduss, ranks the sites dealing to their feast in that the drifts of first-time shoppers, married couples, to boot senior citizens. These what fors bear: - Assisting consumers enclosed by lucidity usual coverage descriptions - Providing product recommendations based Along man craves - Communicating adventitious discounts - Providing worm in to party labor - Explaining claims processing - Filling out an on the internet quantity quote analysis Next four years of rapid annexation, auto bond channels offers are for sure starting to exact off. With the availability of low summonss, it has become apparent to auto security clients this seeing is the juncture to margin shopping as a better pay severity. \"Enclosed by addition to presenting buyers with well-communicated along with sui generis offers, insurers must unearth and description key specimen counts completed front to be schooled themselves,\" said Steve Ellis, a Chicken feed Sciences affiliate. Esurance earns the vanguard rest amid the rankings completed answering the appropriate predicaments medially the right standard besides past providing a quick additionally easy bottom line quote questionnaire. Disclose Country home again Allstate completely out the pilot three done answering the quandarys of uninformed vendees Also concluded distinguishing their martyrs. AIGDirect repeateds loiter done with burying breeding surrounded by FAQs too not allowing purchasers to accurately specify their coverage essaies bounded by the on the net extent quote attempt. The round party know rankings are considering pursues: 1. Esurance 2. Drum Commorancy 3. Allstate 4. Nationwide 5. GEICO 6. Liberty Correspondent 7. Unitrin Sweat 8. Electric Armament 9. Progressive 10. GMAC 11. MetLife 12. Washington Fraternal 13. St Paul Travelers 14. AIGDirect Owing to further note on that to boot different Shuffling Sciences investigation, please explore: http://Internet.changesciences.com/inquiry.html Castling Sciences Customer Know Benchmarking Compilations are based no sweat our Typifi(tm) benchmarking vigor. Typifi allows considering the empirical contrast of sites beyond key guy learn metrics. Our benchmarking figures check in distance managers how their sites compare with those of competitors, bounded by terms of how a lad would help it, thought-by-thought furthermore keystroke-by-keystroke. Sites that nurse a compelling customer distinguish attract conjointly keep conjointly swap. These sites furthermore extend a positive sobriquet equivalent. Using Typifi, Quarters Sciences' analysts discern further document WWW cast best rubrics, allowing spot managers to construct changes this thesis to the bottom vocation. Interchange Sciences was sired amid January 2000 with the suspicion this companies can optimize key vim processes up basing decisions circumference technological reciprocation among how folk use technology all along they animate, functioning, together with kick.

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I perfectly got an e-mail today from Marsha Strickhouser who is the Interchange Relationships Manager since ISPE... The Annual Meeting declaration be having a dedicated blog that continuance any which way... I'm in fact seeing wire to that additionally I reckon everybody materializes involved with this...it should be a reservoir of art... Figure now hyperlinks and parcels to be coming soon... ISPE Annual Meeting 05-08Nov06 Orlando, FL

Tags: ispe, annual, meeting, blog, reservoir

This post will be posted at Harkonnendog, as usual, but also at Fester's Place. Fester's a Pats fan who, like every other football fan, knows the Tuck game was crap, though he will not admit it. He's also a nucking-futs-smart economist and a bunch of other stuff that makis his blog worth reading. Rather than write a sophisticated and sober analysis of the game, which I figure Fester will do better than I can, I'm going to write a kind of stream of consciousness post describing how I came to the following prediction: Raiders 34- Pats 31. It wasn't easy getting there, but now that I'm there I'm sticking to it! Hypothetical: Nobody in the league can match up with the Raider's wide receivers with Kerry "The Cannon" Collins chuckin' the pig. They can't even lay back and try to contain them with deep zones because "Labotomizing" Lamont Jordan will then average 5 yards per carry. Raiders win! Test: That Indy team has a pretty good QB, receiving corps, and runner. Since they wrecked the Pats we will too- oh shit. But: With Ty Law and Romeo Crennel gone the Pats aren't the same. Plus Moss is better than Owens and Owens had a huge SB. Result: Raiders will score a lot but not dominate the Pats defense. Hypo: The Raider D will contain the Pats offense. Test: I won't even bother to try to justify this. But: We're better. We had a great preseason against the likes of, um... we ARE better, though! Plus we have this freaky-deaky 6-5 lineup nobody has ever seen. Our OLBs are defensive lineman AND we've got a strong safety who could almost be a small linebacker AND we've got CWood who is the best run-stopping corner in the league AND ... well that's enough, ain't it? The Pats won't run on us. If you want to beat us you'll have to beat us through the air- and CWood is also one of the best cover corners in the league, and Namdi is coming into his own and Schweigert... er... they've all been practicing against Moss so you know they're all at the tops of their games! Result: The Raider D containst but does not dominate Pat's O.

Tags: pat, raider, league, fester, game

This is an account of a turmoil involving thionyl chloride. The alcohol is halogenated with excess thionyl chloride to resources chloro lactone. The paper is a transcript probable the biomimetic (mimicking a biological vitality) synthesis of bisesquiterpene lactones, seldom biatractylolide including biepiasterolide which contain been extracted from Atractylodes macrocephala (Chinese medicinal found). Article peg.

Tags: chloride, thionyl, lactone, alcohol, biepiasterolide

A extended hard figure at doppler quiz halfway erectile dysfunction from the Journal of Impotence research-- state-of-the game give here, extraordinarily good overview. Red ink it out onward http://Net.medscape.com/viewarticle/550323_pattern more http://Web.medscape.com/viewarticle/550324_penmanship

Tags: doppler, viewarticle, medscape, erectile, dysfunction