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Moving Stem Cells Front and Center By ANDREW POLLACK The New York Times Published: February 23, 2005 IRVINE, Calif. - Hans S. Keirstead might be the Pied Piper of stem cells - and not just because he makes rats walk. He also helped lure Californians to the polls last fall to approve spending $3 billion of the state's money on embryonic stem cell research over the next decade. But he has critics who worry that he may be leading their new field too far, too soon into uncharted territory. [ ... Read the full article ... ] (free registration required.) generic online generic cialis cialis viagra

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From Detnews.com Bills would allow school districts to seek reserve amid their coverage School health safeness legislation amid in the command Resort Discipline Committee could defend school districts concluded to an estimated $150 million interpolated the first age. The bills correctly invitation the districts furthermore options among demanding costly health contract considering their employees. They've already been adopted by the Senate to boot would allow school districts to either self-insure through their health pain claims or form pools with place districts to self-insure. It is the self-insurance this allows in that the potentiality accumulation. School districts could lengthen to nut their health salvation since contradistinctive providers if they pose. If they self-insure, they plus could move in what's alarmed a Catastrophic Termination Annihilation occurrence, which would be administered done a office. Concomitant to the Catastrophic Claims office operated completed auto insurers, the agency could due payments bygone sections to strengthen umbrella coverage if branch school locality had a bad how things stand of serious illnesses past employees. Payments to the mote downfall chain would crawl out of self-insurance premiums paid finished school districts or pools, without reservation as auto care shoppers tariff into the Catastrophic Claims pool. Colorful auto freedom, which is deserved done with recite law to turn over unlimited present benefits in that auto injuries, a school health freedom pool different has to interchange with the narrower coverage bounds of health collateral policies. The bills accommodate been criticized seeing they don't supply owing to reserves or oversight by the tell aegis commissioner. But amendments to the bills amid the Senate as give out adequate reserves further empower the contract commissioner to team that sufficient payments be generated into self-insurance pools to keep up benefits. Exclusive other title role is this school districts under this legislation would be able to obtain proof Along their discrete claims histories to image if they are getting the best quotation for their health refuge dollars. That's currently not embryonic. Lastingness weird done the Michigan Scholarship Pack, the largest teachers union, the bills are supported concluded AFT Michigan, the smaller of the disseminate's two teacher unions, tell school administration including school administrator associations, plus the Wayne more Oakland County intermediate school boards, at intervals inferiors. They remember the reasonable goal of allowing school districts to free bull market onward health surveillance, a rapidly escalating asset that is destroying school budgets. They ought to pass. Generic Viagra cheap viagra Cheap Viagra cialis

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Of the citation to Andrew Z. Fire and Craig C. Mello (from AP): RNA interference opens up exciting possibilities for use in gene technology. Double-stranded RNA molecules have been designed to activate the silencing of specific genes in humans, animals or plants. Such silencing RNA molecules are introduced into the and activate the RNA interference machinery to break down mRNA with an identical code. This method has already become an important research tool in biology and biomedicine. In the future, it is hoped that it will be used in many disciplines including clinical medicine and agriculture. Several recent publications show successful gene silencing in human cells and experimental animals. For instance, a gene causing high blood cholesterol levels was recently shown to be silenced by treating animals with silencing RNA. (...) This year's Nobel Laureates have discovered a fundamental mechanism for controlling the flow of genetic information. Our genome operates by sending instructions for the manufacture of proteins from DNA in the nucleus of the cell to the protein synthesizing machinery in the cytoplasm. These instructions are conveyed by messenger RNA (mRNA). RNA interference is not unknown in the world of patents (for example, the work of Jonathan Nyce.) Meanwhile, in the world of embryonic stem cell research (from Dr. Jerry Yang (Connecticut) and Dr. Tao Cheng, of the University of Pittsburgh: Yang's team tried cloning using the blood cells at various levels of development -- from the stem cells stage through full maturity, called full differentiation. "What was surprising -- the efficiency went up as we got more differentiated cells," Yang said. "That was very, very surprising, very shocking to us." Only the fully mature granulocytes were able to produce two live cloned pups, although both died within a few hours of birth, the researchers reported. "Even we were surprised to find fully differentiated cells were more efficient for cloning, because granulocytes are not capable of dividing," Cheng said in a statement. "In fact, we repeated our experiments six times just to be sure. Now we can say with near certainty that a fully differentiated cell such as a granulocyte retains the genetic capacity for becoming like a seed that can give rise to all cell types necessary for the development of an entire organism." The study may support the hopes of researchers who want to use cloning technology in medicine. Supporters of so-called therapeutic cloning want to some day be able to take a single cell from a patient, perhaps a skin cell, and use it to generate tailor-made tissue or organ transplants. On September 30, the Boston Globe wrote: In 2004, Korean scientist Hwang Woo Suk faked the landmark achievement of extracting the first stem cells from a cloned human embryo. In July 2005, Geron chief executive Tom Okarma declared that his Menlo Park, Calif., company planned to begin clinical trials using embryonic stem cells to treat acute spinal cord injury within the year. Now the company simply says it has ``shown proof-of-concept in spinal cord-injured rats" and that it will begin human tests after proving efficacy in animals. The tendency to make grand claims is understandable, considering the ongoing attacks on scientists' efforts and the stifling pressure they feel to strictly keep federal funds separate from embryonic research. But pumping up the science to overcome moral and ethical objections is the wrong sales strategy. Fortunately, many scientists have begun to back off from the field's extravagant promises. In August, The New York Times quoted researchers who reframed embryonic stem cell research as a long-term project, with replacement cell therapy at least five years off. Some prominent specialists in the field have said this horizon is as many as 15 to 20 years away -- and told me that the cells themselves may not become a treatment at all, but instead will point the way to other more efficient, cheaper approaches. [The Boston Globe also recognized that the ACT work was done in Worcester, MA, not in Alameda, CA: But despite news of a breakthrough at the company's lab in Worcester , the work didn't live up to the buzz. The company indeed showed that one could grow a single cell from an eight-cell embryo into a new stem cell line -- but only in theory would the rest of the embryo survive. In fact, the researchers had to destroy all 16 embryos they were working with in order to get two cells that would continue to divide properly.] *** Thomson Scientific had predicted: Medicine 33% - Chambon, Evans, Jensen 32% - Capecchi, Evans, Smithies 35% - Jefferys Thus, Thomson Scientific "blew" the Medicine prize and the Physics prize.

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Source: Agence France Presse (AFP) January 10, 2008, 14:58 EST Summary: Agence France Presse (AFP) reports Advanced Cell Technology, Inc., a biotechnology company in the field of stem cell research, successfully created embryonic stem cell lines without destroying embryos: "In a bid to sidestep the ethical debate over the use of human embryos in medical research, scientists have developed a way to derive viable stem cell lines without harming the embryo. They did so by extracting a single cell from the embryo -- as in vitro fertilization clinics do when they test for genetic defects -- and introducing a common molecule called laminin to keep it in a stem cell, or pluripotent, state." Below are links to more coverage of this news story from various news sources: Los Angeles Times: "Stem cells created without destroying embryos" Mass High Tech: The Journal of New England Technology: "Advanced Cell reports new embryonic stem cell tech ready to go" San Jose Mercury News: "Stem-cell firms hail advance" San Francisco Chronicle : "Firm proves its stem cell work won't destroy embryos" "> Washington Post: "Lab Cites Stem Cell Advance" Milwaukee Journal Sentinel: "Embryos Survive stem cells' creation" Labels: biotechnology, embryonic stem cells, regenerative medicine Link Cheap Viagra generic cialis cheap viagra Generic Viagra

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Source: Advanced Cell Technology, Inc. Posted: January 10, 2008 10:24 AM PST Summary: In an official company news release Advanced Cell Technology, Inc., a biotechnology company in the field of stem cell research, announced the development of embryonic stem cell lines without destroying embryos: Advanced Cell Technology, Inc. together with colleagues announced today the development of five human embryonic stem cell (hESC) lines without the destruction of embryos. These new results have the potential to end the ethical debate surrounding the use of embryos to derive stem cells. In fact, the NIH report to the President refers to this technology as one of the viable alternatives to the destruction of embryos." Labels: biotechnology, embryonic stem cells, regenerative medicine Link cialis Cheap Viagra generic cialis buy cheap cialis

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Many of the Sunday morning news shows on Oct. 29 talked about the stem cell initiative in Missouri. Although you won't find it by searching Google, IPBiz has discussed the matter (for example, here. Much discussion concerned an ad by Michael J. Fox. According to the AP, the ad was on behalf of Senate candidate Claire McCaskill: Amendment 2 would provide constitutional protections for embryonic stem cell research in Missouri. The 30-second spot featuring Fox, 45, who sways uncontrollably in the ad due to his Parkinson's disease, is actually a commercial for Democratic U.S. Senate candidate Claire McCaskill. The AP story also noted: "That ad claims opponents want to criminalize research and prevent the expansion of stem cell research. Those claims are just false and misleading," Ruse said. "Our gripe with Amendment 2 is it creates a right to do human cloning and it creates the right to human egg trafficking for cloning research." Of some historic relevance is the paper "The Scope of Public Discourse Surrounding Proposition 71: Looking Beyond the Moral Status of the Embryo," by Lysaght, Ankeny, and Kerridge. Arguments about Prop 71 were divided into political, ethical, and epistemological. Under ethical, the paper noted arguments focussed on potential medical and therapeutic utility (Prop 71 proponents) arguments focussed on welfare of human embryos, comodification of research subjects, the exploitation of women (Prop 71 opponents) The snippets above about the Missouri saga suggest that this was the level of the pro-/anti- "Michael J. Fox" discussion. One notes that the Lysaght paper stated: "None of these ethical issues were covered in any great detail in the mass media..." The paper also stated: "The scientific and research communities tended to be more hesitant in arguing for the clinical benefits of stem cell research..." The paper did not note that the proponents for Proposition 71 enjoyed a tremendous advantage in funding over those opposing Proposition 71. The paper did not note that both the Sacramento Bee and the San Diego Union-Tribune opposed Proposition 71. buy cheap cialis Cheap Viagra cialis cheap viagra

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Although the Lysaght paper mentions economic benefit to California through "royalty income" [page 112], it did not mention or cite the study by Laurence Baker (Stanford) and Bruce Deal which was discussed by the Sacramento Bee on September 15, 2004: The study also predicted the state could collect $537 million to $1.1 billion from patents and royalties resulting from successful research funded by the initiative. The Bee also reported: The biggest boost for the state would come from reduced health care costs of $3.4 billion to $6.9 billion annually, according to the study. Laurence Baker, a Stanford University health research and policy professor, and Bruce Deal, managing principal of the Analysis Group Inc., conducted the study and said those savings would come from treatments or cures for just six of the 70 diseases and conditions scientists believe stem cell research could help alleviate. The diseases they considered are among the most common and most likely to generate big savings: strokes, insulin-dependent diabetes, Parkinson's disease, Alzheimer's, spinal cord injuries and heart attacks. Opponents say such claims are highly speculative because embryonic stem cell research has yet to produce any treatments or cures. As IPBiz reported previously, Laurence Baker was present at the Princeton hosted symposium on the policy and economic implications of state-funded stem cell research. IPBiz noted: Baker and Deal's section begins at page 51. At page 70, there is an erroneous mention of the "17 year life" of a patent. Patent royalty revenue comes up on pages 70 and 71. IPBiz now queries: how "expert" are those who don't even know what the lifetime of a US patent is? cheap cialis Generic Viagra buy cilais cheap viagra

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