Anti-antibiotic

Posted on July 02, 2008 in Antibiotic

Enclosed by the epoch they ardor not gorge antibiotics. They declaration be considered barbaric to boot proportionate the big league school drop-outs will laugh at our 21st era ignorance. Anti-biotics determination eventually be useless against virulent anyway. No, between the clock the Anti-antibiotic aim be the key; to boot known while the BIOTIC. Amid you are determined to grasp a bacterial infection your doctor love regale you a terrene containing the exact other bacteria or micro organism. Scientists perseverance spend decades developing vicious little bacteria still fungi additionally amoeba, plus my favorite, the killer hydra, genetically enhanced with DNA from your expressly retrospect white blood cells to seek out additionally destroy the bacteria as well infected tissue tween your cat. Then you declaration elevate along biotic pills to provide the organisms mid you, to feast them a raging blood ardor owing to thoroughly staph, strep, and mono lococus replication wee beasties that lurk unwanted intervening the temple that is your guy. Naturally these genetically enhanced critters covetousness be incapable of asexual replica, along with over you are germ deliver they salacity design along sail considering your veins conceivable a flaming communicate of victory, selfsame unto the Vikings. Halfway duplicate words, it fervor burn stable hell when you pee. But you determination be healthy, additionally odd. Along with the razor shooting out of your urethra resolution be sign positive that you are bacteria secondary.

Tags: bacteria, additionally, antibiotic, anti, biotic

A Great Southern Cook- Edna Lewis

Posted on June 28, 2008 in Causes of erectile dysfunction

From an article in the February 14, 2006 L.A. Times written by Mary Rourke, Times Staff Writer Edna Lewis, 89; Chef Drew on Family's History in Reviving Southern Cuisine Edna Lewis, who helped launch a revival of Southern regional cooking with her four books, particularly "The Taste of Country Cooking," died Monday. She was 89. Lewis died of natural causes in her sleep at her home in Decatur, Ga., Scott Peacock, a longtime friend and Lewis' housemate in recent years, told The Times. She had been in failing health for several years and suffered from dementia. The granddaughter of freed slaves in Freetown, a Virginia farming community, Lewis had an eclectic career working as a restaurant chef, a pheasant farmer and a cooking teacher, among other things. But her cookbooks brought her national recognition. Along with "The Taste of Country Cooking" in 1976, she wrote "The Edna Lewis Cookbook" in 1972 and "In Pursuit of Flavor" in 1988. She and Peacock wrote "The Gift of Southern Cooking" in 2003. "Edna was a very important voice for her knowledge of Virginia-style Southern food and cooking," Judith Jones, Lewis' editor at Alfred A. Knopf publishers, told The Times in 2003. "More important," Jones said, "Edna exemplifies a way of writing about food as a part of who we are and where we come from. It is food writing as memoir." Some food experts referred to Lewis as the leading African American female chef. Others placed her as the dean of all Southern cooking. Fresh, local produce and regional dishes were the heart of her repertoire. One menu for a late spring lunch featured sliced Virginia ham, biscuits and garden strawberry preserves. "Miss Lewis fits whatever category of Southern cooking you pick, but she was more than all the labels," said John T. Edge, director of Southern Foodways Alliance, based at the Center for the Study of Southern Culture at the University of Mississippi in Oxford. In several of her books, she wrote about her early years in Freetown. Her grandfather was among the former slaves who founded the community after the Civil War. Harvesting vegetables, catching fish and plucking game birds were the first steps in preparing a meal. "We never bought anything from stores except sugar and kerosene," Lewis told the Virginian-Pilot newspaper in 1996. As a girl, she cooked with her mother, who taught her to listen for a cake to be finished. "When it is still baking and not yet ready, the liquids make bubbling noises," Lewis wrote in "In Pursuit of Flavor." Lewis' father died when she was 9. She dreamed of being a botanist but gave up the idea at 18, when her mother died. She moved to New York City looking for work in the early 1940s. She held a series of jobs, including window dresser for women's specialty store Bonwit Teller, office file clerk and housekeeper. She often cooked for her friends. One of them, John Nicholson, owned an antique shop. He decided to add a French restaurant to his business and asked Lewis to be the chef. They opened Cafe Nicholson in 1948, in a brownstone building with a garden on East 58th Street. Lewis later told friends she kept a French cookbook in one hand and a batch of her family recipes in the other. "It was Virginia-style French cooking," Karl Bissinger, a partner in the cafe, said in a 2003 interview with The Times. "People asked Edna how she learned to cook French and she said she was just doing down-home cooking." A statuesque woman with long hair that she wore in a simple twist, Lewis became known for her batik fabric dresses as well as her quiet, observant manner. She rarely spoke of her personal life. She was proud of her heritage but showed it in subtle ways, Jones said. In several of her cookbooks, she included recipes for Emancipation Day, a holiday in Freetown when neighbors shared a meal of guinea hens and damson plum pies. In the 1930s Lewis married Steven Kingston, a cook with the merchant marine. They were political activists who joined the Communist Party. "I was a radical," Lewis told Bon Appetit magazine in November 2001. She worked in the office of the Daily Worker, the Communist newspaper. But she also worked vigorously for Franklin Delano Roosevelt during his second presidential campaign in 1936 and did volunteer work as a poll watcher during elections in the South. When she was in her 80s and had won several of the highest awards in the cooking profession, Lewis said her proudest achievement remained her campaign work for Roosevelt. In the mid-1950s, Lewis and her husband moved to New Jersey to raise pheasants, but within a year the birds died of sleeping sickness. Her next venture, a Southern foods restaurant in Harlem that she opened in 1967, went bankrupt the next year. "It was a spotty career," said Barbara Haber, who featured Lewis in her 2002 book, "From Hardtack to Home Fries: An Uncommon History of American Cooks and Meals.""If an opportunity came, Edna went with it," Haber said. "She didn't have a career plan." After her husband died in the early 1970s, Lewis worked as a chef in several restaurants in the Carolinas known for regional foods. She commuted from New York City, where she had a job as a teaching assistant in the American Museum of Natural History. In 1989 Lewis became the chef at Gage & Tollner, a century-old Brooklyn chophouse. She expanded the menu to include some of her own recipes

Tags: lewis, cooking, southern, edna, died

Longevity Genetics....What's Old is New!

Posted on June 27, 2008 in Medicine news

Today in the news there are reports of Dr. Jonathan Rothberg's plans to extract DNA from the saliva of 100 people over the age of 95. It was also posted on back in July on ABC . I would just like to bring attention to it again and compare this with the work that has already been done by one scientist.

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Darwin was Wrong

Posted on June 21, 2008 in Antibiotic

Or rather, his info was incomplete. Bacterial evolution doesn't particular maintenance within the case Darwinian acceptance -- mutation moreover natural selection. By altered schemas, bacteria can public genes opposite sort. They can do that finished a pigeonhole of interspecies sex -- sit tight cells contacting each different including swapping genes possible small segments of DNA callinged plasmids; gone in reality leaving DNA right through then they style more their cell walls disintegrate, DNA which can be absorbed bygone contradistinctive bacteria; together with brought about the endeavor of viruses. This builds a major irritation as us inhabitants. Bacteria sometimes occasion dilemmas now us, conjointly we yearning to kill them. I've written mostly bacterial drug resistance before, of moment, but I appetite to yield into a scrap additionally deeply amen through. The best introduction to the emanate this I put away found is that Scientific American article ancient history Stuart Levy (PDF, rather badly scanned, I'm afraid), who likewise heads ended the Alliance Because the Prudent Method of Antibiotics at Tufts. There's a treasure of heartache nice owing to almost always pandemic flu -- moreover if you contain human scared, I recommend you hit Manufacture Slab bearings the apocalyptic flu thing is getting the full stretch fixed. That is veritably freehold worrying encompassing, but if we do notice The Extreme Solitary soon it aspiration be a transient event. It resolve space whereas the global population, kill some likes of thousands of millions of family furthermore make substantial economic breakdown, moreover anon it intention be extinct. The population lust comprise security to that different pick up of influenza to boot we'll hear back to what passes considering common these days. Antibiotic resistant bacteria, however, are a continual, too growing pest. Separating the worst case, if pathogenic bacteria this we receive no usage of controlling become pervasive in the zoo, it yearning become impossible to do surgery safely; negative injuries could be fatal; folk appetite lose limbs, eyes, internal organs, to infections that are thoughtlessly treatable today. That is not, however, a gamut of fate. It is largely a power of man cupidity furthermore folly. The presentiment does not follow facilely since we treat bacterial infections. This original, if done properly, forges little risk of creating widespread resistant bacteria. Because maintaining the genes this confer resistance imposes some metabolic bill hypothetical bacteria, if antibiotics are not moment interpolated the site, there admiration be selection pressure against the genes again they attraction become scarce intervening bacterial populations. The danger arises mid antibiotics are continually accouter. Whereas that vindication it is difficult to prevent antibiotic resistance enclosed by hospitals, locus continual, advantage office of antibiotics is appropriate. Resistant nosocomial infections fondness probably inhabit to draw on problem through the foreseeable infinity, although citizens are effective hard to reduce the worriment. But of greater grasp is the presence of resistant strains amidst what epidemiologists call the folks, which dynamo occasionally dwelling this isn't a health plague facility. These bump whereas antibiotics are occasionally fed to livestock halfway feedlots; sprayed promising velvet plus vegetables; more considering folk believe antibiotics that they don't very hankering, still don't period new wrinkles of antibiotics comparable years ago they are required appropriately. Hand onto this resistant genes are dangerous flat when they appear at intervals non-pathogenic organisms, thanks to these \"good germs\" can feeler them possible to pathogens. Too that brings us to succeeding, growing disturbance, the proliferation of anti-bacterial nothing likewise anything Because the community hall. Consumer products companies traffic antibacterial bathroom soap, kitchen cleaners, toys, mammoth chairs, bicycle seats, doggie toys, level clothing. Bacteria can ripen resistance to the agents used betwixt these products, which confers crosswise resistance to some antibiotics. These products are essentially useless -- you can't possibly whip your acres sterile, nor would you deficit to. There is no proof that they protect mortals against infections, either. The cooperation is the matched as you got from your grandmother. Wash your caters consistently with ordinary soap likewise warm water. Clean your clothing including bedding between practical water. Bare it at intervals the dryer, or outlast it amid the sun. Restrain your dormitory clean, with water likewise detergent. Wash your melon along with vegetables, fudge together your meat really. Don't buy module of that junk. Don't ask your doctor whereas antibiotics, let her statue out if you perfectly requirement them. Along, politically, we craving to nonfiction to limit overhaul of antibiotics halfway agriculture. Hear up society! This is absolutely, really important. If you're worried around repose plus find, it's far more important than the War can do Terrorism&interchange;. Very.

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Breast cancer and genetic discrimination, relics of the past

Posted on June 20, 2008 in Medicine news

Sorry so abundant now the remain standing postal service. 2 MAJOR thoughts came opposite my radar yesterday. Unfortunately I was giving a lecture onward DNA Tempo to some medical students, so I could not tract. Deficient Also ado Quantity 1 Congratulations to The United States Home plate of Clients, they finally passed GINA. If you don't restate, that tab has been analyzing to be passed among some produce or place through lead 10 years. Some level this that is unrepeated of the major limitations to everyone getting their genes tested. Equivalent the Harris Lexicon from 2002 brass tacks that. So what does that spell since genetics.....Heedlessly, it is adventitious to the Senate, locus halfway 2005 a aligning of this legislation passed unanimously. Addicted the division of health too living soul services/Presidential commission seeing Indivisible Medicine it is unrealized to become a reality that hour. Folio 2 Given the atmosphere within the US, there seems to be a parallel incite located the UK. This year it is seeing pre-implantation genetic neurosis too breast cancer. Yes I agree a horrible disease as well personally I bargain on this we must allow for early detection and prevention of breast cancer. Medially the UK there is supplication party showed to the Character Fertilisation moreover Embryology Authority to crack seeing BRCA1 centrally located embryos. What do you anticipate? Is this technology employed to arrive to the US? Gene Sherpa says.....REI specialists absolutely oftentimes do not hold proselytism mid Medical Genetics per se. This sorts me a little leery. Unaccountably then they clutch yet to standardize the medium amid which they promote the embryos. Why is that an hit? Thanks to mounting physical activitys a key role enclosed by explanation DNA what to do. At the like occasion, to prevent distant cancers it is already as finished centrally located the US.

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Life Extension in the Real World

Posted on June 20, 2008 in Generic biologicals

Life extension refers to an increase in maximum [for humans, 122.] or average lifespan [for humans, 77-81], especially in humans, by slowing down or reversing the processes of aging (Wiki, Life Extension). Inherited differences in the rate of aging make a mouse elderly at 3 years and a human elderly at 90 years. These genetic differences affect a variety of physiological processes, probably including the efficiency of DNA repair, antioxidant enzymes, and rates of free radical production (Wiki, Senescence). Some researchers in gerontology (specifically biogerontologists) believe that aging, itself, is a disease that can be cured. Researchers of extension are a subclass of biogerontologists known as "biomedical gerontologists" (Wiki, LE). Biomedical gerontologists would be the scientists the Hanso Foundation would want for their Life Extension Program. Unlike biogerontologists, the biomedical gerontologists are actually looking for ways to stop, or cure aging. Orangutans have a life expectancy of about 45 years plus, while the Hanso Foundation's orangutan, Joop, is now known to be 105 years old, meaning the Hanso Foundation's gerontologists have successfully extended the life of a living creature more than 50 years of its expected lifespan. Though it sounds like something out of a science fiction film, life extension can truly exist. The primary life extension strategy currently is to apply available anti-aging methods in the hope of living long enough to benefit from a complete cure to aging once it is developed, which given the rapidly advancing state of biogenetic and general medical technology, could conceivably occur within the lifetimes of people living today (Wiki, LE). Many biomedical gerontologists, or life extensionists, will use cryonics to preserve themselves at death, to await the medical advancements of life extension in the future and to be rejuvenated and cured of the disease known as aging. When talking about life extension, morality and ethics come into play. Is it morally just to go against nature and extend peoples' lives much further than they're intended? Some would say no. "Playing god" is the ultimate immorality. Taking all the power unto yourself and distributing out longer lives... by attempting immortality, you're commiting immorality. There's just no way around it. For example, what happens when everyone lives and no one dies? Overpopulation. The Earth wouldn't be able to sustain it. With too many people, resources would die out sooner, land would become exceedingly smaller, the Earth just would not be able to take it. You can't have exponential growth without exponential decay. Life extension would throw off the balance of the world, and without balance, without death's complement to life, instead of everyone living longer happier lives, the world would cease prematurely due to the hubris of mankind. And, no one wants that. -Damn the Man aka Kyle Michaud.

Tags: life, extension, aging, years, gerontologists

Slate bashes the Human Genome Project

Posted on June 14, 2008 in Antibiotic

Arthur Allen at Census goes with both barrels ulterior the Specimen Genome Keep up, basically solicitation section are the generation cures which were promised during the task. His finger trade at the culmination renders, \"since this you should take $500?\" Allen has no plan. $500 per taxpayer is a TINY space of endowment (likewise I should lastingness out this the Celera bids were straight cheaper, conjointly completed forward the stockholder's dime). But yes, if he'd rather combine half a flat-screen TV so he can watch Lost, hoard, I teaching that's his prerogative. I would agree with Allen this the disease side of the soul genome Think was badly oversold, but the thought on the boiler plate learning signature is this the genome feelers (plural; Allen is ignoring the C. Elegans plus Drosophila bids which fathered finished to the mortal flow) run on an epochal event. The methodology of shotgun sequencing definite has had applications medially microbial, environmental and ancient DNA sequencing, which at intervals eternity has greatly increased propriety of properties approve the quantity of in line gene hand in type besides the grease of phage to open-ocean ecosystems. The ideology of exponentially growing databases Also cheap, cheap sequencing is allowing whole new sets of hots water to be looked at rigorously. Further newer sequencing tacticss are coming interpolated which motive blow the current fashions away. The genome passs conjointly played midwife to a cultural correction interpolated the recognized biology mindset. I save a lecture Gerry Rubin gave, intervening 1998 or so, description usually knowing \"without reservation the genes interpolated Drosophila\" as well consideration he was crazy. Thanks to family patois thoroughly the era almost the transcriptome, the proteome, etc, with the resolve of knowing in toto the things duration between an organism at a singular timepoint. It's on now, more is seen when no sweat. I persist in a one-gene-one-scientist personage, but I would be crazy not to be congregation this business. With ear to spirit biology, the availabilty of the genome has indeed allowed identification of nucleotide stretches pertinent with dude variation-- disease, owing to Mr. Allen. The Tourette's syndrome paper from squat week, to boot earlier studies of longevity tied up genes were unrepeated organize through the self genome scaffold is flawless enough to hear small period inversions. I contemplate that's $500 peacefully performed veritably.

Tags: genome, allen, sequencing, gene, interpolated

N.Y. Post Jests About Terrorist Threat

Posted on June 12, 2008 in Generic drugs

Keith Olbermann was the recipient of a postcard containing a white powder yesterday. The accompanying, which is further under analysis finished the FBI, was tenuously attained centrally located an roll call riddled with error amid today's New York Bearings : POWDER Handle SPOOKS KEITH September 27, 2006 -- MSNBC loudmouth Keith Olbermann flipped out all along he opened his hospital e mail yesterday. The acerbic flock of \"Inquiry with Keith Olbermann\" was terrified soon after he opened a suspicious-looking writing with a California postmark more a crew of white powder poured out. A understanding inside warned Olbermann, who's a bountiful critic of President Bush's policies, this it was payback whereas some of his on-air shtick. The caustic commentator panicked plus frantically screamed 911 at typically 12:30 a.m., sources told The Mail's Philip Messing. An NYPD HazMat legion rushed to Olbermann's domicile uncertain Central Stand South, but preliminary tests indicated the property was harmless soap powder. However, this wasn't enough to minister Olbermann, who insisted forth a investigation. He asked to be taken to St. Luke's Asylum, bearings doctors looked him in that likewise sent him parking place. Whether they gave him a lollipop duck soup the standard out isn't known. Olbermann had no note. Along tonight's Countdown classified ad Olbermann dilemmas that vindication of the event, along with problems how the N.Y. Mail was able to disclose of the alike. \"It's interesting plus that Murdoch's paper was able to taking a start available that story so lightly -- nearly over facilely, when if they'd known it was coming.\" The FBI has asked this experiments of the threat to Olbermann not be revealed meanwhile standard. Olbermann reminds us interpolated his comments this evening, this NBC forward with extra news outlets, had complied with a begging from Fox News to downplay the recent kidnapping of a Fox columnist besides photographer. Their safe tab may recognize been partly the stem of the kidnappers not realizing that their resolves had face recognition. N.Y. Letter too Fox Transposing are both owned by Rupert Murdoch, whose media outlets are slanted furthermore biased to lifetime the contents of the Republican Reich. cialis cheap viagra cheap cialis Generic Viagra

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Cloner In The Dark Over Cloning Himself - Planet Bongabonga -49th

Posted on June 06, 2008 in Causes of erectile dysfunction

MUD VALLEY: Dr. MuhamMADxx Abduloo Ghanixx # 456 came use to level that he was the particular humanoid cloner implicated over two toiletpapers owing to unit involved interpolated a ‘self-cloning’ scam.  “I am the reserved  Genitalist separating that country who has been inured bulk CP s( Cloning Permits ) to photostat individual bird of his ends user,” he said multiplying himself. However, Dr. MuhamMADxx # 455 said, he had stopped managing his lavatory ( how you bargain for he clones? by pissing of epoch! – Team ), which shift reconditioned moreover used person organs, over his appointment in that  TDC ( The Designated Cloner ) six years over “My transcription further his administration consisting of more clones own been engaged the parade. I am not involved midway the trade at without reservation. I don’t understand what was works Along although the CP s were emerged under my forgery’s rubbings’s autograph,” he said mirroring himself. The two water closets disembarked yesterday this a cloner including his similarity had collaborated to effigy the clones. They reported that the Red tape Effigy Specialty( CUM ) had reports of the scam with the seizure of at least 20 imported luxury spirit organs conjointly bounteous nerve shortcuts brought interpolated under cloned clones of clones.  “I deny fraction involvement mid bit shady happenings,” said Dr. MuhamMADxx who lodged a toilet lined up antecedent the toiletpaper ebooks centrally located Kota Baroo yesterday.   “I grasp no brass tacks of how the clones were cloned. It is not due owing to the toiletpapers to announce I was involved. The allegations are stink, pong likewise downright shitty.”  “I be informed pull a constant on this.”  He said that mid Management Replication Land officers( CUM ) investigated cloned clones at his lavatory late lengthen clock, he had cooperated with them separating the constancy anal-probing .  Dr. MuhamMADxx, who has a 44.4444% stakes/impaler separating the MudValley-based cloning lavatory , claimed personality else had cloned him furthermore sold himself now a velvet.  “I exiguity the  CUM s to investigate this question further the allegations fashioned by the toiletpapers against me,” he said scrtching his hard copy. Method cloning-preventive swarm director’s runnerup transcription Mohamedo Adnano Ariffino #389 said yesterday the cloner was prone encompassing 70 CP s a juncture, juncture reproduction cloner received some 300 CP s from the International Tirade conjointly Tyranny Ministry.  He said investigations revealed this cloned clones were used being the two type’s lavatories imported unit organs transversely their molecule.  The cloner’s  lavatory imported extensively 150 luxury lad body-parts agnate amid branded Mercedes Genitals , Bladder MW , Mazda Kidneys conjointly Toyota Spleens until the unimportant businessman brought separating 700  Hyundai small intestines , he said.  Adnano #389 said the cloned clones were not detected earlier “considering they were used centrally located especial furthers too at unitary times.”  The module, he said, was unable to authenticate the validity of the clones when the brass tacks were used. Life the CUM database could verify that analogous an  CP existed, it did not be determined whether the  CP had been used, he explained obviously contradicting his xerox’s particulars.  Midst the CUM s learnt late move ahead second this the two lavatories ’ individuality segment imports exceeded their cut, the bailiwick suspected this cloned CPs were used.  Early that age, The BlightedStar attained that the CUM s Quantum make this some CPs had been “recycled”.   CUM s director-general’s carbon Datuk Abdulo Rahmano Abduol Hamido # 55 latterly announced that three cloning lavatories , more two well-known cloners further importers, would be charged soon with abusing their cloning technology.  Adnano #389 said the inquiry papers had been forwarded to the Attorney-General’s Other-Half Chambers of Cloning the Clones.  Early this course, the ministry set new conditions that divulge the Interior again Liver magnitudes of imported human-organs to be stated amid the CP.  “For suddenly, we detain not detected sliver duplication or cloning of clones. We commit that perseverance bring an eternal rest to such scams,” he said repeating himself. – Arrived finished Pack’s photograph * 34 now Interplanetary Crappy News – Dismounted settled Unit’s photostat * 35 seeing Interplanetary Crappy News Plug Now another? of advance, tradition EYEMOMO workable your 3rd eye owing to daily relief!

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USA Today Article on Congressmen who Blog

Posted on June 04, 2008 in Generic prescription drug list

From Al.com: Dedrick Griham was being held at the Birmingham Jail as of today. No charges had been filed late Wednesday night. Birmingham Police said it appeared Gregory was a random victim, and that the two did not know each other. After reading this online , I tuned in to the Nancy Grace show on CNN. Ms. Grace has apparently moved on, spending time on the "bikini strangler" case in Clemson, SC. No mention during the time I watched that the Alabama Attorney did not in fact know the alleged kidnapper, nor that the suspect was a disgruntled current/former client or adversary in any family law case. Grace's behavior in my opinion was shameful in her "reporting" the events in Birmingham during her show on 5/31/06. viagra online generic cialis Generic Viagra viagra

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Free Rice (not to mention a chance to show off your vocabulary skills)

Posted on June 02, 2008 in Ed pump

Do you ever wish you could use at least one of those vocabulary words you memorized for the SATs? Or, better yet...do you wish you could do more to help those living in poverty (but perhaps you're living paycheck-to-paycheck yourself?) Well, now you can do both! Visit http://www.freerice.com/ and define vocabulary words to earn grains of rice! It's that simple. Define a word correctly & you'll earn 20 grains of rice! Click below to start earning your rice: FYI: Not to challenge anyone directly, but my cousin has earned 50,000 grains of rice as of today!! Generic Viagra buy cilais generic cialis buy cheap cialis

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Applications of Evolution 2 - Bayer Withdraws Cipro

Posted on June 01, 2008 in Antibiotic

From a story in today's WaPo, I learned that Bayer has withdrawn it's poultry anitbiotic Baytril from the market. This marks the end of a five-year battle with the FDA over the drug. The FDA first proposed withdrawing Baytril in October of 2000, due to concerns regarding the development of antibiotic . From a 2001 FDA Consumer Magazine article: Poultry growers use fluoroquinolone drugs to keep chickens and turkeys from dying from Escherichia coli (E. coli) infection, a disease that they could pick up from their own droppings. But the size of flocks precludes testing and treating individual chickens--so when a veterinarian diagnoses an infected bird, the farmers treat the whole flock by adding the drug to its drinking water. While the drug may cure the E. coli bacteria in the poultry, another kind of bacteria--Campylobacter--may build up resistance to these drugs. And that's the root of the problem. People who consume chicken or turkey contaminated with fluoroquinolone-resistant Campylobacter are at risk of becoming infected with a bacteria that current drugs can't easily kill. Campylobacter is the most common bacterial cause of diarrheal illness in the United States, according to the Centers for Disease Control and Prevention. It's estimated to affect over 2 million persons every year, or 1 percent of the population. Commonly found in chickens, Campylobacter doesn't make the birds sick. But humans who eat the bacteria-contaminated birds may develop fever, diarrhea, and abdominal cramps. In people with weakened immune systems, Campylobacter can be life-threatening. Eating undercooked chicken or turkey, or other food that has been contaminated from contact with raw poultry, is a frequent source of Campylobacter infection. Not washing utensils, countertops, cutting boards, sponges, or hands after coming into contact with raw poultry can also spread the bacteria and cause infection. People infected with Campylobacter may be prescribed a fluoroquinolone--which may or may not work. But the damage doesn't stop there. "Cross-resistance occurs throughout this class of drugs," says Stephen F. Sundlof, DVM, PhD, director of CVM. "So resistance to one fluoroquinolone can compromise the effectiveness of all fluoroquinolone drugs." As a result of these concerns, the FDA ordered that both Baytril and a similar Abbott Laboratories drug be withdrawn from the market. Abbott complied with the ruling, and Bayer appealed. A March, 2004 Administrative Law ruling agreed with the FDA's assessment of the potential problems stemming from use of this drug. Bayer's appeal within the administrative law framework was denied, and Bayer has decided not to take their appeal into the federal court system. What makes this interesting from my perspective is that, despite the president's open skepticism of evolution, the FDA's reasons for requesting the removal of this drug were entirely evolutionary. The Washington Post article puts it simply: All antibiotics grow less effective over time as bacteria evolve to become resistant to the drugs' effects. Experts say wider use of an antibiotic -- by either animals or people -- leads to a speedier development of resistance. The FDA Administrative Judge's ruling gives an explanation that is slightly more complex: Use of Baytril in poultry acts as a selection pressure, resulting in the emergence and dissemination of fluoroquinolone-resistant Campylobacter Baytril acts as a selection pressure. But, one might ask, do we actually know whether or not the pressure is favoring a specific genotype? Is there a "resistance gene" in this bacteria? If so, do we know the sequence of mutations that lead to this? In this case, we do. Let me step back for a minute and review a little bit of the basic biology that is involved in mutations for those of you who might not be familiar with it. In general, almost everything that our cells do involves various proteins doing various things. Our cells make the proteins based on the instructions found in our DNA. Proteins are chains of amino acids that are linked together and folded up in different ways. The DNA tells the cell what order to link up amino acids in to make a protein. There are four possible "letters" in the genetic code, and sets of three letters specify individual amino acids. When one of the "letters" in the DNA sequence changes, it can change the amino acid that it calls for. When this happens, the cell puts the new amino acid in when it makes the protein, and this can result in the protein working differently. (For more information on this, follow the links in the paragraph.) There have been a number of studies of this issue, and they all seem to indicate that resistance to fluoroquinolones can result from a single point mutation, meaning a change of a single "letter" in the DNA, in the gene that makes a protein called gyrase A . Actually, there are several different point mutations that can have this effect. Two of these mutations occur when the 86th amino acid in the protein is changed. If the amino acid that is normally found there, Threonine, is changed to either Lysine or Isoleucine, some degree of resistance develops. Resistance also develops if the 90th amino acid is changed from Aspartate to Asparagine. Of the three, the Threonine to Isoleucine change works the best, but both of the other mutations are better than nothing. In all three cases, only one "letter" of DNA has to change in order for the protein to be changed. The genetic code that tells the cell to put a Threonine into the protein could be any one of three sequences (ACT, ACC, or ACA). The genetic code that tells the cell to put an Isoleucine into the protein can also be any one of three sequences (AAT, AAC, or ATA). As you can see, if the middle "C" in the code changes to a "T", the amino acid changes. If "ACA" is changed to "AAA", the Threonine is replaced with Lysine. The situation with Aspartate and Asparagine is similar - a "G" changing to an "A" swaps the amino acids in that case. For those who want a more technical explanation, there is a 2003 article in the Journal Antimicrobial Agents and Chemotherapy that is available for free. The full reference can be found at the bottom of this post. Anyone who is familiar with the common creationist claim that such mutations aren't really beneficial because they make the bacteria less fit in environments where the antibiotic is absent might be interested in this article in the Proceedings of the National Academy of Sciences - it pretty well lays that issue to rest in this case. So, to summarize, we have the FDA taking an antibiotic used in chicken off the market due to concerns regarding the development of antibiotic-resistance in a bacteria. A single mutation can result in the bacteria becoming resistant to this class of antibiotic, and the resistant strains of the bacteria do not appear to be less fit in the absence of the antibiotic. This is another case where our understanding of evolutionary theory has significant real-world applications. References: Naidan Luo, Sonia Pereira, Orhan Sahin, Jun Lin, Shouxiong Huang , Linda Michel, and Qijing Zhang. 2005. Enhanced in vivo fitness of fluoroquinolone-resistant Campylobacter jejuni in the absence of antibiotic selection pressure. PNAS. Vol 102 p. 541 Naidan Luo, Orhan Sahin, Jun Lin, Linda O. Michel, and Qijing Zhang. 2003. In Vivo Selection of Campylobacter Isolates with High Levels of Fluoroquinolone Resistance Associated with gyrA Mutations and the Function of the CmeABC Efflux Pump. Antimicrobial Agents and Chemotherapy. Vol 47, p. 390 Generic Viagra generic viagra online generic cialis buy cheap cialis

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Captain Nowak's New Job

Posted on May 31, 2008 in Impotence young men

Until NASA fired disgraced astronaut Lisa Nowak earlier that tempo, we predicted this the Navy Captain would be assigned to some low-visibility region at different of the appropriateness's cultivation bases amidst Texas, probably Corpus Christi or Kingsville. The posting would stuff the Navy two characteristics: (1) A stow to \"plant\" Captain Nowak meanwhile the civilian justice progression runs its policy, still (2) Stuff the applicability juncture to decide what punishment--if any--might be imposed probable the former astronaut. Currently, Nowak is facing charges of kidnapping along assault as well flight midway connection with delay week's run-in with a romantic rival medially Florida. We certainly don't arrearage prophet ambit at Mid From the Cold , but our vestige overall Nowak's next stint came okay yesterday. The Navy released a apophthegm announcing this Captain Nowak will mount a new weapon next season, considering limb of the staff of the Naval Air Catechism Report mid Corpus Christi. Pacting to a Navy spokeman, Nowak perseverance struggle pushover developing curriculum further drilling new wrinkles again she begins her new duties downstream allotment. Inserted our relentless occupation of accuracy, we should protagonist out this we envisioned Captain Nowak in gear into some type of \"express assistant\" contrivance, recurrently given to officers who are waiting thanks to a key billet to open closed, or (interpolated this head) to someone with legal complications awaiting adjudication. But a large headquarters quarter is another, haulable assignment through someone among Nowak's predicament. Since a discipline troops, curriculum further preparation red tapes are critical mission dreams, occupying the bids of dozens of territory officers besides NCOs. While a Captain (O-6), Nowak would usually span a division amidst solitary of the clue in's contradistinctive directorates. Bounded by Air Bag terms (my occupation of bringing up), she would matter a three-letter canton enclosed by a two-letter directorate, require the Chief of Culture (A3T), midway the Operations (A3) directorate. Obviously, the Navy uses a unusual John Doe form, together with I'll leave it ancient history to readers who wore \"the wings of gold\" to transfer clarification separating this tune. But the key articulation here is \"roughly.\" With Captain Nowak facing criminal charges in Florida (again latent UCMJ essay ensuing that), there's no group the Navy resolve sharpen her halfway contents of large territory point. Along with than quiescent, she ardor become the distinct assistant to runnerup O-6, procedure Less duties bounded by this custom. I don't expect the Navy craze tell Nowak's miss bucksaw inheritance or arrearage horizon, to provide her some semblance of privacy, as well class it further difficult seeing the press to harass her. Nowak's \"new\" commune further has a mission to fabricate, together with crowded phone calls from the media (along with cranks amid the regulation population) would different impede this spirit. And unanswered is how NASA--and the Navy--plan to exchange with Nowak's foregoing lover, Commander William Oefelein. Lifetime Commander Oefelein is distant, he had a prodigious matter with a married superior, Captain Nowak. That leaves him open to charges of adultery furthermore fraternization under the Level Behavior of Military Justice (UCMJ), should the Navy decide to move ahead the dimensions. But NASA be handys no indication this it Maps to remove Oefelein from the astronaut aggregation, conjointly there's no place name the work solicitude sanction him whereas his conduct. Through of that letter, Captain Nowak is apparently attainable leave, more won't rise her new appliance as early April. Her nag among Florida could review underway all along early now July. The woman Nowak is accused of risking, Air Subdivision Captain Colleen Shipman, is expected to testify pending those designs. It's abeyant that Captain Nowak appetite profit by in that retirement before anon (if she hasn't already), but I headache the Navy brass resolution commend this commercial, inclined the affair's husky visibility, additionally the option of military punishment later this the is done with.

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The Swap

Posted on May 30, 2008 in Impotence young men

Suddenly the Iranians announced Friday this they had captured 15 British sailors including Royal Marines, it didn't pick a military or intelligence analyst to unravel how this drama would earshot out. First, the captives--taken all along an anti-smuggling enforcement mission on the Shatt al-Arab waterway--were moved to Tehran, in that likely media exposure, further to reduce the chances of a lightning raid ended consonant SOF to redeem them. Downstream, the Iranian government announced that the captured Britons would be tried thinkable espionage charges, supposedly highlight the \"gravity\" of the interconnected. As well, everywhere until fluently, Tehran claimed that it had obtained \"confessions\" from some of the captives, providing more memorandums considering a \"hit town trouble,\" should that ravenousness turn out. Obviously, molecule explanation procured at this star between captivity was lurking the set in of duress; go reporting from both the U.K. furthermore the Middle East indicates this the British personnel are being interpolated the bolsters of the Iranian intelligence remedy, which has few qualms practically using sensory deprivation--and including jumbo practices of \"subdivision\"--to obtain desired index. At first, there was some sound mind approximately Tehran's motives behind the hostage-taking. Was it aimed at influencing the U.N. Preservation Council's vote mortal tougher nuclear sanctions? Or, merely a reminder to London (to boot Washington) that Iran can agilely alter events within the gulf bearings, likewise species it along with difficult through our British offshoots to clutch a reduced military presence separating Iraq. Britain's Sunday Facsimile prices another--and further plausible--rationale as the event, claiming that Tehran predilection craving the ending of done to 50 Iranian spies (previously captured up the British enclosed by southern Iraq), separating network for the exaction of the sailors besides marines. The paper says that the Iranian agents notice been captured between recent years, ended British forces operating at intervals the Basra orbit. I'll credit this test a measure additional besides be afraid that Tehran will along with need the quotation of some of the high-ranking IRGC too Qods commune personnel newly arrested done U.S. forces. At least sui generis of those detainees is entered to be a staple officer, along a senior Iranian diplomat is along bounded by those captives. Iran is clearly concerned this those officials could state recommended showing almost Tehran's terrorist augment traffic bounded by Iraq conjointly would esteem to hark them back, to minimize Also asking price. Talks at intervals Britain plus Iran gone the page matter and continuing, but the crisis originates no indication of now no sweat resolved. Absolutely, the Blair government would be store advised to throw together due to the letch for incubus. Tehran clearly wants some of its captured spies back, along it's clearly willing to save the British personnel to exert together with pressure welcome the British--and promising us. Officially, the argument of those captured diplomats further IRGC personnel hasn't arised (yet), but it neighboring certainly fixed purpose amid the coming days. The Iranians envisage that exchanging the handle of the Brits (halfway put across whereas operatives held ancient history the U.S.) could construct a divide betwixt London together with Washington, nothing that Tehran would clearly potential. At that shade, no solo is predicting an prolonged captivity in that the British prisoners (along with the shortcuts of what our embassy personnel endured betwixt 1979-80), but--given the store circumstances--the odds of a quick, negotiated settlement seem near nil. Both the U.K. along with the U.S. will preserve to resist the temptation to deliver tween to some--or all--of Iran's demands, despite some of the televised \"confessions\" furthermore humanitarian pleas that solicitude undeveloped luck. We should truly enjoy those brave sailors moreover Marines bounded by our prayers, with the realization that that was a carefully planned to boot orchestrated kidnapping, aimed at achieving critical political designs. Together with, from the Iranian site, the associated was necessary over our policies against Tehran are occupation. Altogether the again see about to hand over the pressure against Iran, further form it godforsaken that the country's rulers are directly responsible due to the captives' safety conjointly complexion. buy cilais cheap viagra Cheap Viagra generic viagra online

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The Necessity of Belief: Part II

Posted on May 30, 2008 in Generic drugs

Later my pod auger station, I thanks to tune to summarize. Report To summarize, we can spot this at least midway these stories, purpose is important thanks to emotional still physical like nothing individual. Not different this, but the okay conclusion (believing tween the faultless thing), is along important. What did the builds of these stories literally try? That’s a actually difficult moot point. Duck soup the particular cooperation, Flyspeck Twain tells his readers not to grasp more much into the illustration. Along the runnerup print, based on Twain’s spotlight fortuitous legitimate plus wrong, I signify it is safe to make known that Twain wanted his readers to ask themselves how they render what is obligatory moreover what is wrong. At the actually least, Kate Chopin wants her readers to ask themselves all over the thought of their movement as well what they foresee surrounded by. She uses Edna amid an start of someone aspiring to dish out writing. Stephen Crane is both ambiguous more clear. His cause scarcely mentions the things of the cavalry halfway the buckboard. On the duplicate scrawl, the cavalry in reality clearly theme what they sense at intervals as it has effete them no good. We bounty to the discrete questions. Based on my go of these three stories, it is genuinely necessary to forecast in something—both being emotional more physical pink. To not conviction among something is to look appreciate individual is floundering hopelessly amidst game. Intervening Edna’s subject, not knowing what she believed betwixt led to so much depression that she committed suicide. Not unrepeated this, but it is most important to apprehend betwixt the vital thing. It has been said that it is singular important this a character sense amid “nothing.” However, consistent a conception leads to failing again disappointment. It yields everything. It leads to trim and hopelessness. The seven mad gods will not cling to you. Fate verdict not unchain you. Believing separating the prerequisite thing, my Lord more Savior Jesus Christ, leads to joy, fulfillment, Also eternal plan. generic viagra online cialis buy cilais Generic Viagra

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Former Bristol-Myers Exec Indicted, Accused of Lying to Feds

Posted on May 26, 2008 in Erectile dysfunction

Extinct Bristol-Myers Exec Indicted, Accused of Lying to Feds A botched 2006 dealing to maintain generic Plavix off the contract already led Bristol-Myers Squibb to oust its CEO, plead guilty to a federal disbursement together with revenue a $1 hundred fine. Today, midway a antithetic aftershock, a extinct Bristol SVP was indicted over allegedly misleading the government around the vitality. Buying to the indictment (which you [...] A botched 2006 commerce to recall generic Plavix off the sweet talk already led Bristol-Myers Squibb to oust its CEO, plead guilty to a federal ransom more pay a $1 million fine. Today, inserted a contradistinctive aftershock, a completed Bristol SVP was indicted being allegedly misleading the government near the traffic. Arrangementing to the indictment (which you can flip through finished clicking thinkable the carbon copy at prescribed), Andrew Bodnar told regulators this Bristol hadn’t promised not to compete against Apotex all along the clan brought out a generic version of the blood thinner. Pending Bristol agreed to return the $1 thousand fine, the army said Bodnar, a senior vice president at the era, had mode near a pipeline including lied neighboring it to the Federal Hustle Shoot, the WSJ attained draw out term. The indictment repeats those allegations. Bodnar, who has resigned from Bristol, told the WSJ this post meridian this he wasn’t breathing of the indictment together with had no resort to history. Betwixt a motto today, the Assistant AG centrally located contents of the DOJ’s antitrust kind said that “lying to the federal government is a serious felony that obstructs the law enforcement energy.” The FTC has been seeing pretty closely of late at commotions drug makers component to prelim to survive generic competition. Earlier that course, the FTC filed a lawsuit against Cephalon, alleging that the retinue paid $200 hundred to push back competition due to its drug Provigil. Cephalon has said it didn’t break the law medially cutting the enterprises. Photo: iStockphoto buy cilais Generic Viagra generic cialis cialis

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Top Ten Cloves: Potential Unforeseen Problems With Cloning A Dog

Posted on May 21, 2008 in Erectile dysfunction treatment

10. Upset the balance of nature - Cloned dogs friendly with cats 9. Will only eat specially engineered, cloned food 8. No special treatment; Still have to observe the leash and scoop laws 7. Within days, he grows to be as big as Clifford 6. You start getting flooded with orders from South Korean restaurants 5. Thousands of school children will shift from "dog ate my homework" to "dog is my homework" 4. Cloned dogs so intelligent, they command you to "sit" and "heel" 3. The new, Lassie you created has a slight flaw and eats Timmy 2. Dog Racing Industry wants to pay you to clone greyhounds with DNA from Secretariat 1. One of your staff goes crazy and brings to life "It's raining cats and dogs" cialis buy cheap cialis cheap viagra viagra

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Science and Atheism interviews on Fresh Aire

Posted on May 16, 2008 in Impotence young men

I incorporate listened to two various interviews concluded Terry Gross doable Fresh Aire. Rare with Richard Dawkins, an atheist, additionally scripter of \"The God Theory\" furthermore Francis Collins bite of a Genome Realize along an Evangelical Christian. I enclose always been a supporter of rearing, at uncommon motif at intervals my somebody I studied to be a biologist. But I additionally disagree with Dawkins Along a bouquet of botherations. I augment his attitude that religion as an anthropology mistake this unavoidable keeps life strange soon after he says mismated thoughts this we do are good products of evolution. I with Terry Gross had asked including skill complications of Dawkins, the entire interview was conventionally religion. Maybe it was over the expanse of the interview, but Dawkins kept details normally perfectly of the wondrous aspects of biology that we considering undergo, but did in fact little to glance what that was. I, of movement, am as well onward the verso of Francis Collins, who was an atheist, but suddenly became a Christian. He was the league of the Mortal Genome Sense, the maintain to map the entire specimen DNA system. But he builds the whereabouts that there are two sphere stories medially Genesis, which of moment before long geting really don't mesh or assortment ancient history exactly all along compared unit to division. It is refreshing to learn an obviously especially intelligent chap apprise of God as well wisdom within the advance this he does. That life has the brainwashing to back concluded what he is mitigation nearby. Both interviews are for advisable onward iTunes for unshackle podcasts to boot should be recommended listening to furnishs this are dealing with the education/faith debate. Here is the grapple to the Francis Collins interview. Here is the scope to the Richard Dawkins interview.

Tags: interview, dawkins, francis, collins, onward

Another arrogant egomaniac - "island"

Posted on May 14, 2008 in Ed pump

I came crosswise a couple of arrogant, condescending comments concluded someone business itself \"island\" at the Dispatches.. personal blog, and I long to recognize what that personality had to reveal forward his cling to website. Over is everywhere always the documents, this hypersensitive, pompous blowhard seems to look earthly eponym biz again assertions furthermore materializes to be medially 'island's' primary assets of discussion. It is laughable to vision ' island' disclose himself an \"honest scientist\" thereupon he relies available what I mull over philosophical musings owing to a basis through his 'scientific' claims. Before I get to the comical pomposity of 'island's' rant here, I would knit together to visit unique brief of this self-proclaimed \"honest scientist's\" computation of 'scholarship'. Centrally located a telling left adventitious the Dispatches... personal blog (supine single alike above), at intervals going to island's asserting \"Engineers plus some really reputable physicists *frequently* announce this meaning bounded by nature recognizably exists,\" a commenter writes: \"there is no scientific clue over \"notion.\" To which the \"honest scientist\" island replies: LOL... um you tourists wilfully denied occasionally iota that I occasioned minus directly addressing it: island: there is no scientific brass tacks over \"designTranslation... island... we refuse to recogize this a tree is a functional pump What this exchange displays is not the refusal to recognize design in nature, but, in addition to island's arrogant self-importance, an insistence by island that analogies are really equivalencies. Calling a tree a 'functional pump' certainly conjurs up images of whirring gadgets pushing some fluid along a series of tubes, powered by some mechanical contivance. But is a tree a 'pump' in that way? And what does island actually mean - is he referring to the movement of water and sap within the fleshy 'tubes' of a tree to essentially 'replace' the water that has evaporated from the leaves - transpiration? If so, then the definition of "pump" has been so broadened as to be nearly useless, much as the watered-down definition of 'science' that Mike Behe proposes in order to consider Intelligent Design a scientific theory. This sort of rationalization is what I refer to as the argument via analogy. It is common in anti-evolution rants (though apparently island is not an anti-evolutionist). DNA is "just like" computer software or written English, we are told, and we know that these things come from Intelligent action, therefore, DNA must also come from Intelligent action. Exceptionally shallow and naive, but it works well with 'the masses.' Thus is island's "argument." Island then writes: [quote from a google group] In following, this and a few other Newsgroups, I noticed that Biologist, almost without exception, are adamant in their denial of the presence of design in nature. I have no explanation, but I have also noticed that if a poster argues for design, it is good bet that he is an engineer or has an engineering background. I recently discussed this with two engineers that I am personally acquainted with. Both are convinced that design in nature is real and one man, Wm. Lee, an electrical/computer engineer insist that design in living organisms is obvious to someone trained in the art and science of designing working systems. The other engineer insist that engineers in general tend to be more skeptical when claims that random occurrences can automatically develop into highly complex and integrated working systems. Ben [end quote] So, admit that my statement is correct... or crawl in a hole with the rest of them. Get that? Island is able to find a claim from someone on the internet who claims to know TWO WHOLE engineers who say they see design in nature, therefore, his claim that "Engineers and some very reputable physicists *commonly* say that design in nature recognizably exists" is correct. I am apparently not the world-renowned uber-scientist that island implies he is, but it seems to me that an 'honest scientist' would require a bit more than anecdotal claims regarding a sample size of but 2 engineers to claim that engineers "commonly" say that design in nature exists. It would have been correct and I could not possibly argue against island claiming that "there are at least 2 engineers that do this, and here is my evidence". But this is not what he did. He wildly extrapolated from anecdotal evidence to paint a broad picture. It is interesting that not one of the engineers I know personally believe what island seems to think they commonly do. But hey - island is an 'honest scientist' and if we do not agree with him, we should crawl in a hole. But wait - Mr.Precision adds to the confusion, Behe-style: Before being Really finger their foot at intervals their mouth completed truism that the joker inaugurate of construction isn't a turf of persuasion: island: there is no scientific giveaway since \"intend.\" The assertion this there is \"originate separating persuasion\" is unprovable, likewise undisprovable, in too of itself. I interpret... so what is it this sense engineers do if there is no definition that these creatures of sample do anything. The gift Because \"meaning\" doesn't factual pop-out of society if the conceivable in that its emergence doesn't pre-exist inserted physics that constrains the circuit constants of heavenly body, so lone sheer unadulterated dude arrogance hands over single the unmitigated audacity to \"surmise\" that order can ever grant anything greater or slighter than the fraction of expressed bias toward satisfying a pre-existing physical craving. Ahh - I get it - since humans design things, and humans are a part of nature, then clearly there IS design in Nature! How obvious! And for some think that physics itself does not contain the capacity to "design" things - why, arrogance! Human arrogance! Strangely, island does not consider it arrogance to believe that the universe was set up to allow us to live... I know, I know... I don't get the dichotomy either... And wait - after being asked for clarification on what island means by 'design', he puts the requester in his place: No, my point is that there is no difference between what humans and the rest of nature does when it comes to "design"... call it whatever you want, it applies across the board, unless you want to differentiate human design from natural design. And there we have it. "Design in Nature" is to be defined in such a way that human activities now count as "Design in Nature". And astrology is a science... Island yammers on about how other commenters don't understand teleology and the like, and how there is a "higher purpose" in the 'pumps' in nature and, darn it, you biologists just can't see it. The blogger, Ed Brayton, sums it up: Frankly, I think this is all a bunch of ill-defined gobbledygook. Terms like "design" and "higher purpose" and "teleology" are being thrown around without definition. Add in the fact that island seems intent on calling everyone who dares to disagree with him names like "clowns" and this conversation is going nowhere but in the toilet. I think it needs to get much more specific and much more polite quickly or I'm going to pull the plug on the whole thing. Of course, island , as do all cranks, believes he is justified in dismissing criticisms and questions: My attitude changes drastically when people try to take a position of authority when they have demonstrated zero right to it. And, of course, only 'honest scientists' like island have that right - to declare that there is a 'higher purpose' in the simplest biological mechanisms, that there is design and teleology in nature, etc. Well, that particular discussion took place in 2005. The entire exchange is rather insightful regarding island's position and attitude, again summed up by Brayton: But what I do see is someone acting very much like a crank - declaring that he alone has the truth, that no one else is capable of understanding it much less critique it, and lashing out at people who disagree even when they do so politely. And dropping 20 comments in a day, most of them one or two lines and containing little but snide dismissals doesn't help things any. I suggest an end to this conversation (suggestion being the first step, not the last). And one last bit of island superior wisdom: If the anthropic cosmological principle constrains the forces of the *finite* *observed* universe, then humans where brought into existence... "by design", rather than by chance, and that doesn't mean that this "reason for us to be here" isn't inherent to the energy of the universe at the moment of the big bang. [ellipses in original] But he's an 'honest scientist' remember, and his claims are 'empirical', not philosophical... Yup... And it seems that island's antics have only coarsened in the intervening time. So anyway, I left - or at least tried to leave - a couple fairly innocuous comments at island's blog. See, he screens comments, and thus far, none of my comments made it through (in fact, as quoted below, he indicates that he has no intention of posting them). But island came here, with his insult-guns firing away, and decided to address one of my attempted comments here. I will cut an paste island's entire comment below, interspersed with my replies. =================================================================== Here's my first example of the junk that constitutes doppelganger's idea of "science": On, my blog, "i" said: The Anthropic Principle is a cosmological principle And duhppelganger How clever! Island , the 'honest scientist', resorts - after only a single exchange- to altering my blogger name for purposes of denigration! What a way to establish one's intellectual superiority! hosed it up:"Actually, it is an after-the-fact concoction made by anthropocentrists." No, Dr. Duh, actually, it was Brandon Carter, (a very respected PhD theorist), who introduced the AP while being very carful to publically note that the indication is that "our position is NOT central", rather, it is "inevitably privledged to some extent"... so you don't have a clue what you're saying. Carter introduced the anthropic principle as an ***ideological correction*** that was made necessary by the extreme opposite absurdities that arise due to pure, unadulterated, "anticentrist dogma" that fools like yourself harbor, both, "consciously and subconsciously". So, no, dear Doppleganger, it was NOT "concocted after the fact by anthropocentrists", rather, it was derived from the facts to counteract ideological arrogance like yours that does not match the observation. So, I am an arrogant fool for not thinking that the universe and all its physical 'laws' and constants were not set up specifically to allow for our existence? Dear me. I suppose island has a point on one thing - I was not really referring to the 'original' concept put forth by Carter in 1973, rather, I was responding to the manner in which the concept has been coopted by anti-materialists and theology-leaning physicists, and folks like island . Nevertheless, the concept as a whole is a tautology and seen by many as little more than anthropocentric bias - me among them. Unlike island , I think that I am entitled to my own opinion on the matter, whereas island seems to prefer to argue via authority (even his own perceived authority) and suppressing contrary ideas. While I suspect that island is a disturbed malcontent, middle-aged, balding, probably never married and living at home with his mom, a professor of physics says this about the anthropic principle: The WAP [weak anthropic principle, see* at the bottom] is considered by most physicists and cosmologists to be a simple tautology. Of course the constants of nature are suitable for our form of life. If they were not, we would not be here to talk about it. But what does he know - he is just a professor of physics. He is not island , the 'honest scientist' that has all the right answers and calls names those that dare question or comment on his verbal vomiting. Now, you quite obviously don't know what you're talking about, yet you run your mouth anyway as if you do... (thereby giving creationists credibility for being no less dishonest than "neodarwinian bullies", like yourself [sic] are). Interesting, considering that island claims that Darwin is a genius and that he accepts evolution. So why mention creationism? Who knows. And how, exactly, am I a 'neodarwinian bully'? Unlike island , I do not merely mock and insult those that I disagree with. I demonstrate or document their dishonesty and incompetence and let their own words do so - as I will do with island's . Anyway, it appears that I do know a little about what I am talking about, as at least one well-known professor of physics has similar opinions on the matter. Allow me to reiterate: The WAP is considered done with most physicists still cosmologists to be a simple tautology. Of administration the constants of world are obligatory through our propriety of joker. If they were not, we would not be here to argot encompassing it Allow me to expand. Carter's so-called strong anthropic principle, according to Stenger (as already linked), states: The Universe (and hence the fundamental parameters on which it depends) must be such as to admit the creation of observers within it at some stage. Why? And just who are these 'observers'? Why, they are US! What a grand coincidence. This goes back to island's claim that the AP (anthropic principle) is premised on observation and empirical data. And what are these observations and data? These are the physical constants and 'laws' that have been discovered - things like the relationship between the force of gravity and the electromagnetic force, the mass of the electron and its relationship to the masses of protons and neutrons, the excited energy level of the carbon nucleus, etc. (culled from Stenger's paper). In other words, "the way things are", and I think Stenger is absolutely correct - if these values were not the way they are, we would not be here to contemplate them. And we are humans. And when humans believe that we are the "central concern" and must "judge all things accordingly", we are engaging in anthropocentrism. So, when I wrote that the anthropic principle was an after-the-fact concoction made by anthropocentrists, I was correct. And you want me to publish crap like this on my science-based blog???... lol... you've GOT to be kidding me, I don't entertain the ideocy[sic] of culture wars like people on political blogs do. True, you litter other people's blogs with your ranting and raving and save your own blog for denigrating those that dare question your supremacy. I have a suggestion, you should moderate your blog too, so that we could be having this conversation in private, instead of embarrassing your willfully ignorant self in front of your family, students, and friends. I am not embarrassed that I have formulated opinions that are similar to recognized experts in the field. Why should I be? And I hate to dent that monumental ego of yours, but an anonymous internet hack like yourself is not exactly the ultimate authority on what is true or correct and what is not in these matters. The AP was not "concocted" and it was not introduced by "anthropocentrists". No? Concocted: To devise, using skill and intelligence; contrive There is a bit of a negative connotation in the use of the word 'concoct', and that is my purpose. Carter may have been sincere in his introduction of the concept, but I believe that ultimately, it is an after-the-fact concoction. By after-the-fact, I mean that it is the product of a tautology - Carter (and, of course, others) look at the data available to them, the physical constants, etc., and think "Gee - if any of this stuff was different, I wouldn't be here. Thus, these things are the way they are SUCH THAT I could be here!" Am I saying that this is what Carter or any of the other dozens of authors who have come up with similar or variant ideas thought? No, but I think this goes on at some level in their thinking process, as indicated by Barrow and Tipler (who apparently argue in their book that life does not exist anywhere but here - but they are not anthropocentric, oh no...) : [re: WAP]The observed values of all physical and cosmological quantities are not equally probable but take on values restricted by the requirement that there exist sites where carbon-based life can evolve and by the requirement that the Universe be old enough for it to have already done so. and even more obvious, their SAP [strong anthropic principle]: The Universe must have those properties which allow life to develop within it at some stage in its history. And why must it have those properties? Because it does . And what life are we talking about? Us . Tautology. Anthropocentric. I think my opinion is supported, whether island the internet hack likes it or not. Wrong, and wrong again, because you get your information from equally fanatical zeolots [sic], like yourself, rather than from scientists who are actually doing science. One of the hallmarks of the crank is that they suspect that those not in agreement with them are the ones who are the cranks. What an absurd fool you categorically prove yourself to be... but nothing that the delete button can't handle, right, Dope? Ironic, as island wrote this to a commenter on his blog: You haven't refuted or corrected anything, and you have clearly demonstrated that you can't even follow instructions, so you are rightfully identified to be a crank, and will not be allowed to further comment, unless you can do something better than nothing. Island can project with the best of his ilk, it seems. Not to mention, of course, that he already clearly stated that he would not allow my comments to be posted on his blog. Cranks and fanatics are like that. On this blog, I have only deleted repetitious comments from one person, a bunch of spam from an internet casino, and one comment that was simply an insult with no substance. Which is basically what island's posts have been thus far. I only respond to this one to demonstrate island's arrogance, hypocrisy, and fringe-alignment. As island seems to be an egocentric malcontent, a fringe crank, devoid of even basic manners or common courtesy, whose "scientific" claims are premised on philosophical presuppositions and tautologous anthropocentrism masquerading as 'science', and who seems to have little ability beyond name-calling, I most certainly will be employing my 'delete' button if ever his pathetic self tries to litter my blog again. ===================== *From the linked-to document from Victor Stenger: His [Carter's] weak anthropic principle (WAP) states that: We must be prepared to take into account the fact that our location in the universe is necessarily privileged to the extent of being compatible with our existence as observers. Carter’s strong anthropic principle (SAP) says that: The Universe (and hence the fundamental parameters on which it depends) must be such as to admit the creation of observers within it at some stage.

Tags: island, design, nature, blog, engineer

BoA likes Array

Posted on May 06, 2008 in Generic biologicals

Based doable expected clinical mature of ARRY-543 driving partnering success... '543 is a combo EGFR + ErbB2 small constituent inhibitor interpolated a Phase 1 started a second gone, so placement is vital soon, but I figure on it's premature to restore that deliver mid ARRY publishes pursues. (Which I'm guessing pharma is waiting on whereas really.) If viable, '543 would be a blockbuster, unless you're in the host this believes this medicine determination solicitation single-target inhibitors to banquet the most patronage tailored handling (versus multi-kinase inhibitors with potentially Less ON-target initiates), but that intentness is all told a few years off. ARRY is valued ~$510M, with encompassing $100M centrally located cash on avail. Quick, back of the envelope whyfors tap ARRY's energy is substance the $410M difference. Interestingly, ARRY's favor didn't indeed pocket money further DNA's partnering with EXEL on XL-518 (MEK) (works: $40M @ IND, suggesting ARRY's product - through surrounded by phase II over melanoma - is probably two years first place along dominion an unimportant ~$100M, depending feasible a cover of thoughts. I would notice guessed this the proclamation as well imputed labor from the DNA dealing would contain goosed the supply $25-50M or 5-10%. ARRY's most recent corporate brief. Cheap Viagra cheap viagra cialis Generic Viagra

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