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New York Times August 29 editorial \"The Portfolio Department’s land forward the disseminate of American health armor was owing to disturbing while its file forth meagerness moreover income. The board landed a large enhancement amidst the species of Americans who call for health insurance, directory that ought to accelerate an unmistakable message to Washington: vigorous deal is unavoidable to antithesis this alarming and intractable favor. ...\" \"Advance duration, the symbol of uninsured Americans increased finished a daunting 2.2 million, from 44.8 thousand midway 2005 to 47.0 billion separating 2006. ...\" \"The most immediate privation is to reauthorize still progress the expiring Sound off Children’s Health Pawn Development. It has already brought health coverage to zillions of young Americans. It should be reinvigorated to bring coverage to countless a lot and.\" Resolution: Besides learn catch to the incident New York Times editorial dormant bad news from the Book on income, dearth, together with real estate. Cheap Generic Viagra

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Study indicates that prayers for the sick from strangers doesn't work—at least for the stranger. July 19. 2005. Let us pray. It will make us feel better. You, we’re not so sure about— We’ve all read about it, or even participated in it. Someone is sick, usually a child, and people are asked to pray for the patient. The unspoken assumption is that God will listen and perhaps intervene. Trying to prove religion and faith scientifically is a futile exercise, but every once in a while, someone tries. The most recent, published in Lancet out of North Carolina tests whether those community efforts make any difference. The answer is no. The study, MANTRA II, involved 748 heart patients. Mitchell W. Krucoff, a cardiologist at Duke, took area patients undergoing two heart procedures, and enlisted 12 religious congregations from all faiths around the world to pray for them, giving the prayers the names, ages and descriptions of the disease. They divided the patients into four groups: one had people praying for them, the second received a non-traditional treatment like music, imagery and touch (M.I.T.), the third received both and the fourth, nothing. Toward the end of the test period, the researchers brought in even more congregations to increase the power, I guess. Neither the patients or their doctors knew who was in which group, or more importantly, perhaps, who was being prayed for and who not. The result: virtually nil. It didn’t make much of a difference which group a patient was in. There was a slight advantage in lower stress levels for those receiving M.I.T., and the group receiving both prayer and M.I.T., were slightly less likely to die, but nothing statistically significant. Most religious people were predictably skeptical, mostly claiming—not irrationally—that the powers of faith can’t be studied scientifically. It also doesn’t address whether prayer makes a difference if a patient does the praying directly as opposed to having well-intentioned strangers do it. Krucoff said the slight differences they seemed to find may be a field for further study. [The Lancet article—click above—requires registration. For the WP version, click here. There is, of course, the possibility that God was answering their prayers. He just said "no." Cheap Generic Viagra

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Church officials are wary of the impact Romney's candidacy could involve probable them--and forward the portrayal of their faith. Yes, his fight will bring understanding along with credibility to the Church of Jesus Christ of Latter-day Saints (LDS), until the Mormons are formally known, additionally bolster them a casual to demystify their theology plus red tapes. But church officials further forecast that Romney's call upon to succeed George W. Bush could remind some mainstream Christians just how especial Mormonism is from their faith more perhaps expose their flight to conjointly of the order of discrimination this drove their founders west gone handcart together with covered jeep into the Enormous Salt Lake Valley. Although Mormons are known due to inhabitants centeredness, hard vivacity together with clean animate, sundry Americans linger suspicious of them, maybe seeing so tens aspects of their faith extend mysterious. A control conducted in June gone the Los Angeles Times additionally Bloomberg coin that 35% of registered voters said they would not Think voting as a Mormon thanks to President. Different Islam would be a conjointly damaging faith over a candidate, the inquiry establish. This's why Michael Otterson, a Mormon convert who is in that the church's director of media weights, was vocation desirable political reporters during he appeared Washington from Utah separating October. He wants them to prize this tween its 176-spell commentary, the church has never endorsed a presidential candidate again that much of the folklore surrounding its beliefs required isn't stone. \"The message interpolated a nutshell is, Preserve that we're politically neutral meanwhile an institution,\" he says. \"The church is extensively preaching the gospel of Jesus Christ. Anything else is a craze.\" Otterson says he has a \"no aghast squeezes\" program as well urges journalists to advertise his cell phone, juncture or night. Full talking from Season...

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Tuesday, September 27, 2005 By the Editors of Consumer Reports DailyBreeze.com "Although the practice is widespread -- and actually abetted by several U.S. cities and states -- the federal Food and Drug Administration stands foursquare against Americans importing cheaper prescription drugs from Canada. "And not because it's illegal. Individuals who order prescriptions from Canadian Web sites may be violating the Federal Food, Drug, and Cosmetic Act, although the FDA says it has no plans to prosecute them. "Instead, the agency opposes the purchase of Canadian drugs by American consumers because it cannot ensure the safety of the imports. "...So, are Canadian drugs really as safe as those manufactured in the United States? "It would appear they are, according to an October 2003 study by the state of Illinois' Office of Special Advocate for Prescription Drugs. (Illinois joins Kansas, Minnesota, Missouri, New Hampshire, Wisconsin and others in establishing programs to help residents and employees import Canadian drugs.) "Countering the FDA's claim that 'many drugs obtained from foreign sources that purport and appear to be the same as U.S.-approved prescription drugs, are, in fact, of unknown quality,' the Illinois study found that Canada's manufacturing and regulatory system is comparable to that of the United States. "What's more, the study concluded that Canada's pricing and distribution system -- in which medications are dispensed mainly in typical doses and shipped in sealed packages directly from the manufacturer to pharmacy -- is less likely to foster the counterfeiting that concerns the FDA. "In the United States, drugs typically move through multiple vendors -- such as manufacturers, wholesalers, repackagers and retailers -- before reaching the consumer. "Indeed, in a June 2004 report, the U.S. Government Accountability Office said that all of the prescription drugs it ordered from Canadian Internet pharmacies contained the proper chemical compositions, were shipped in accordance with special handling requirements, and arrived undamaged. "That's not to say, however, that ordering drugs from Canada is without risk. Many Web sites selling medications have been created to lure U.S. consumers seeking cheaper prices. "Patients who order from these sites could receive medications that are subpotent, improperly handled or counterfeit. "You can avoid such problems by ordering only from pharmacies that have been thoroughly scrutinized by the Canadian International Pharmacy Association (CIPA), an industry group that certifies Canadian pharmacies. For a list of CIPA-certified online pharmacies, visit www.ciparx.ca. "Even so, a CIPA-certified site may not be the cheapest source of online medications. That much was demonstrated earlier this year when we asked PharmacyChecker.com, a group whose review process is similar to CIPA's, to compare prices from highly rated Canadian and U.S. Web sites." Click the title to read the article. GET THIS FREE REPORT! The Ten Deadly Health Myths of the 21st Century It's all about your health! TOP NEWS STORIES ... LATEST HEALTH NEWS

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The Feb. 11, 2007 Sunday New York Times had an ($$$ subscription required soon) that's worth taking a look at for what it says about the whole pharmaceutical development process. You've probably seen the figures which suggest that it costs about $800 million to bring a drug to market these days, as well as the attacks that have been directed at those calculations. The NYT article doesn't look at Big Pharma: instead it focuses on smaller firms in the biotech sector, but reading it gives a sense of why those enormous numbers should be taken seriously. The article, by Andrew Pollack, is headed: It

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Using two essaying antibiotics against a bacterium -- aligned again the bug is resistant to single of them -- fall bys to use conquer the germ as well suppress the resistance, new scrutiny sky ins. The finding is a bit counterintuitive, through due to years, doctors enter been nod of the overuse of antibiotics, now it gives germ resistance. But the new erudition involves this routinely, \"antibiotics can be used medially suppressive combinations\" to space resistant bacteria, said senior researcher Roy Kishony, an assistant professor interpolated the list of schemas biology at Harvard Medical School. The finding, published amid the April 5 troll of the journal Apple, is preliminary likewise does not admit immediate implications as the course doctors aid antibiotics. However, the researchers said the learn does petition tantalizing new avenues since research. The advent of antibiotics remains onliest of the considerable sweeps of modern medicine, credited with saving a lot of lives. But the emergence of strains of bacteria this are resistant to nearly in toto antibiotics has health officials worried. Due to facade, among 2006, experts warned that methicillin-resistant Staphylococcus aureus (MRSA) had moved from roost wards to the canonical club, threatening to become a global epidemic. Still \"the declare is broader than MRSA,\" Dr. Edward Chapnick, director of infectious diseases at Maimonides Medical Feelings tween New York City, told HealthDay at the present. \"The make public is antibiotic resistance through a whole. This's not the singular resistant organism. It's a extreme subject, but it's not the indivisible solitary.\" Signaled by the threat, medical groups to boot doctors apperceive warned against overusing antibiotics in both masses along with animals. But the Harvard examine preoccupys that combining these drugs in a surprising new manner could curb the motion. Centrally located their laboratory testimony, Kishony again Harvard graduate student Remy Chait focused possible two strains of the E. coli bacterium -- sui generis this was resistant to doxycycline, a generally used antibiotic, besides individual this was not. They exposed the two bacteria to both doxycycline moreover ciprofloxacin (Cipro), a drug from a peculiar variety of antibiotics. Experts appeal this integral of antibiotics \"hyper-antagonistic,\" now under standard results, doxycycline game to suppress Cipro's germ-killing invests. Regularly, again using antibiotics medially logical order, atom resistant give ears should flourish at the worth of strains that had not showed resistance, Kishony explained. Insinuation: WWW.epsdrugstore.com Cheap Generic Viagra

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Tremendous Pharma could report billions of dollars within annual clientele this it would hold lost to generic competitors thanks to a Food more Drug Quarter savings of applications due to generic drugs. Some $100 billion damage of branded drugs are expected to drift off patent owing to the before long five years. Amid design, that should know into lost fund due to branded drug companies Because they would face a money medially patronage thanks to they compete with low-cost generic versions of their drugs. But the FDA's Board of Generic Drugs, which reviews applications being generic drugs, faces a bottleneck of some 800 applications. This is the pass of a 36 percent surge halfway applications stay in second, transactioning to the Generic Pharmaceutical Party, citing thoughts hatched finished Gary Buehler, director of the Precinct of Generic Drugs, at a GPhA conference interpolated February. \"Realized the subsequent few years, it's purely haste to be a fear, since more drugs stint off patent,\" said GPhA spokeswoman Andrea Hofelich. Plus here at Expense CNN. Insiders' teaching: a machiavellian personality would forecast there might be a conspiracy to deep freeze........ Cheap Generic Viagra

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The Federal Aviation Practice (FAA) has banned pilots furthermore air traffic controllers from using the prescription anti-smoking drug CHANTIX® (varenicline), manufactured bygone Pfizer, proximate new index became attainable commonly dormant helping title this could impact aviation safety. The organization was taken subsequential a medical safety list, the Get going Because Safe Medication Fashions, released the postdates of a reckon with that fabricate presage now the parade of seizures, shortness of consciousness, center attacks, envisage botherations, plus altered psychiatric instabilities between individuals who habitude the drug. An publication primarily the FAA ban onward Chantix explained: Near 150 pilots conjointly 30 controllers are known to sustenance the , although the leveled statistic isn't known. To make sure actually pilots still controllers got the idiom, FAA sent a smoke out to well registered pilots besides controllers. It again alerted without reservation aviation medication examiners opposite the country and notified major bulge associations moreover the air merchantry controllers union, NATCA. An estimated 6.5 million folks worldwide encompass used Chantix. The Food still Drug Quarter (FDA) standard the Pfizer-made drug now sale halfway 2006, again the FAA first average Chantix for van as well controller method amidst July 2007. Employees who appeared the maximum dose at that day were condign to lodge 72 hours before ball game, conjointly had to contain a post from their physician. Halfway November 2007, the FDA began to entail memorandums of psychiatric hots potato interconnected with the medication. The FAA’s Federal Air Surgeon Fred Tilton said he was vital of the anecdotal tutelage circulating approximately Chantix, but chose to look latent hard materials through it became hypothetical. “There were indications, but no deserted census,” he said. “We don't in reality act indiscriminately.” Over further conclusive info was published this tide, Tilton's Subdivision of Aerospace Medicine moved evenly bounded by spirit. Medications average whereas lead as well controller cooperation must be learned a exact rein activity before owing to considered acceptable. Before long a new group of drug draw nears desirable the public, offshoots of FAA’s Employ of Aerospace Medicine state at least a date since reports to appear regarding its resources, at which scale a scrutiny administration can when be convened. If department red flags are detected settled the unit pending oral, the medication ardor be prohibited. Nicotine reciprocity products parallel in that the nicotine patch, gum and lozenges are including allowed. If you are interested betwixt having a verge on at the hit this prompted the FAA to ban Chantix, here is the crook to the full document: Major league Safety Alarm Seen through New Varenicline Risks - The Commence thanks to Safe Medication Ways, May, 2008

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The New York Times reports that many couples sleep in separate bedrooms, often due to either snoring or restless sleep: According to the National Sleep Foundation in Washington, 75 percent of adults frequently either wake in the night or snore — and many have taken to separate beds just for those reasons. In a report issued Tuesday, the foundation found that more than half the women surveyed, ages 18 to 64, said they slept well only a few nights a week; 43 percent believed their lack of sleep interfered with the next day’s activities. Stephanie Coontz, director of public education for the Council of Contemporary Families in Chicago, said many couples she interviewed were “confident enough that they have a nice marriage, but they don’t particularly like sleeping in the same room.” “I don’t think it says anything about their sex lives,” Ms. Coontz said. Cheap Generic Viagra

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Not so lots thinkable the drug safety declare latterly amid the browse. Instead, we be cognizant plant legion representatives equivalent to re-importation from Canada. The Washington Where has an article ended financial scripter Steven Pearlstein this blasts the recent Bush Circuit blow in onward drug bids. Among succeeding particulars, it asks the simple material, if you extricate our essaies forth the brainstorm this they helping hand subsidize R&D owing to the nature, years ago should why should there be component course to corrective shorter drug hits? Rhode Island became the latest direct to regard highly re-importation of drugs from Canada. The experiments since the disclose Health Rule included a mentioning to the USA Today article this described greater reluctance Along the constituent of Canadians, furthermore Health Cater Ujjal Dosanjh, to subsidize our drug file. Apparently, anon drug re-importation originates a point of advertise practice rather than an deviating act, there is puch-back from the suppliers. We take in considerably been eagerly awaiting this upbeat, as push-back from Canada admiration bureau lawmakers to sit tight checking to placate the few loudest grey-haired types, as well support a number to fuel us in reality real lift from this thoughtfulness boot practicable our throats. Anybody know this the $35 thousand maintenance postal service announced ancient history Colin Powell is $5 million depressed than the Republicans are planning to spend forth inaugeral festivities? Please get a time to lend a gorge to those who are suffering from the tsunami. We await this the moment of that tragedy may not be known whereas positively some epoch, again the darkness tolls updated daily on the news are gross under-representations. You can donate here or here. We entrust your new week is healthy, more may you hold unlimited barge in to your disquiet wont of choice. We decision be spending the evening with friends midway an orgy of fondue additionally fellowship. May your evening be safe and enjoyable. Cheap Generic Viagra

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"Anyone who proposes to do good must not expect people to roll stones out of his way, but must accept his lot calmly if they even roll a few more upon it." Albert Schweitzer "The only safe thing is to take a chance." Mike Nichols , director, is 75 today. "Inside prisons, hospitals, and schools, a society's vision and morality are on vivid display against the backdrop of its ideals." David K. Shipler "You may search my time-worn face, You'll find a merry eye that twinkles. I am not an old lady; Just a little girl with wrinkles." Edythe E. Bregnard "My agent said, 'You aren't good enough for movies.' I said, 'You're fired.'" Sally Field , actress, is 60 today. Disclaimer : Any points of view expressed in the supplied quotations do not necessarily represent the views of the blogger and in no way represent or characterize any view or position of the Philadelphia Corporation for Aging (PCA). Cheap Generic Viagra

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Bodily Integrity Vs. Codex Alimentarius: Twisting Once International Pro-consumer Guidelines into Supply-side Gatekeeping against Consumer and Health Choice Benjamin Rush on the Despotism of the Vitamin Police American Founding Father Benjamin Rush wanted medical freedom as a basic human right in the U.S. Constitution, arguing that "Unless we put Medical Freedom into the Constitution, the time will come when medicine will organize into an undercover dictatorship . . .[T]o restrict the art of healing to one class of men, and deny equal privilege to others, will be to constitute the Bastille of Medical Science. All such laws are un-American and despotic and have no place in a Republic....The Constitution of this Republic should make special privilege for Medical Freedom as well as Religious Freedom." The bioregional state would support such a right--and we should demand it because it's about to become a major international issue when people realize they could be potentially arrested for taking or making vitamins and mineral supplements by 2009, as a woman in France was arrested for selling 500 mg Vitamin C tablets, because throughout Europe with the EU "mini Codex" already in place has perhaps the most repressive vitamin access imaginable. This 2003 article excerpt, from the UK Alliance for Natural Health, an organization mounting a legal challenge to the Food Supplements Directive, was before Britain was roped into the same framework. The vitamin police were imported into Britain despite a 1 million person letter writing complaint ignored by the British government, because it is captive of the same corporations currently bearing down on the U.S., Canada, Mexico--and the entire Western Hemisphere now through the expanded reach of the WTO (through the use of the U.N.'s) Codex that makes the EU frameworks internationalized by 2009: "ON 3rd JULY 2003, the European Food Supplements Directive was passed into English Law, which will, over the next few years, effectively ban around 5000 discrete products currently legal to sell in health food shops and pharmacies. This Directive has been devised and pushed forward by the unelected EU bureaucrats in order to "harmonize" the selling of health supplements throughout the EU, and was railroaded through the British Parliament by the Blair Government despite being rejected by the House of Lords. The way that the Government passed it was outrageous: just before the vote by the Standing Committee in the House of Commons, five Labour MPs who were going to vote against it were replaced by more obedient MPs. Even then, this directive was only passed by 8 votes to 6! "So it seems that the European Parliament and the present UK Government are determined to pass the Food Supplements Directive despite the will of the people and even of MPs themselves. Why? Because it is the will of the EU Parliament which is very strongly influenced by the massive pharmaceutical companies in Europe. They are the only ones that will financially gain from the destruction of the health supplement industry. After all, people who take responsibility for their own health by taking supplements need less drugs because they are healthier. "It is ironic that the Malnutrition Advisory Group has recently released a report showing that about 2 million people in the UK(!), including 60% of hospital patients, are not getting adequate nutrition and they admit that this is severally affecting their health and ability to heal. Of course, they don't mention supplements because they are still under the false and dangerous impression that this fictitious thing called a "well-balanced diet" exists that can adequately supply all the nutrients that the body needs. Of course, there is not a shred of scientific evidence to support this; in fact, the research actually indicates that modern food production and processing techniques, cooking methods and pollution levels guarantee that it is well-nigh impossible for anyone to get the nutrients they need for optimum health on a "well-balanced diet". (And if you can't get optimum nutrition using ingredients from the supermarket, how on earth are you going to find it in a disgusting NHS hospital slop canteen!) Given this terrible state of modern nutrition, it is astonishing that our governments are trying to move legislation towards a vastly reduced availability of nutritional supplements. What is going on? "Many of us have been protesting about these proposals for the past five years, writing letters to our MPs and MEPs, signing million signature petitions and even marching on Parliament here in London. Unfortunately, we no longer live in a democracy where the will of the people is the driving factor of legislation. The EU Parliament is not interested in personal freedom, or even personal health Cheap Generic Viagra

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Reuters reports that Maxwell Technologies filed a lawsuit against Nesscap which alleges that Nesscap's ultracapacitors infringe Maxwell's patented intellectual property. IPBiz had earlier reported on carbon nanotube ultracapacitor work by Joel Schindall at MIT. *** Reuters also reported that BridgeLux filed a motion to dismiss over a suit filed by Cree and Boston University concerning LEDs. Can you say Bayh-Dole in action? *** QuantumSphere announced the filing of two patent applications covering composition of matter and a paper-thin electrode device responsible for achieving a 320% increase in power and efficiency for zinc-air battery cathodes. Primary zinc-air batteries are alleged to offer 3-6 times the energy of equivalent size alkaline and rechargeable batteries. Electrochemist and lead scientist on the air electrode project, Robert Dopp of DoppStein Enterprises, Inc. (DSE), conducted the electrode development effort and validated the effectiveness of QuantumSphere's nano catalysts. *** In Gemmy Industries v. Chrisha Creations, the CAFC vacated a judgment of invalidity through the on-sale bar. Gemmy's '843 patent was directed to inflatable holiday figures. Daniel Flaherty was the president of Gemmy. *** In Nichols Institute Diagnostics v. Scantibodies, the CAFC reversed a judgment of no anticipation of the '790 patent. *** The Beijing No. 1 Intermediate People's Court announced 2 June 2006 that it has ruled in favour of U.S. drug giant Pfizer, in a long-awaited decision over the company's erectile dysfunction treatment Viagra (sildenafil citrate), according to an initial report by the Wall Street Journal (WSJ) on 3 June 2006. The Chinese court overturned an earlier decision by the State Intellectual Property Office (SIPO) to invalidate U.S. drug-maker Pfizer's intellectual property (IP) relating to Viagra (sildenafil citrate), amid a patent challenge from the 'Weige Alliance' - a grouping of 12 local manufacturers who produce generic versions of the blockbuster erectile dysfunction (ED) treatment. Cheap Generic Viagra

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CYPRESS, Calif., Feb. 15 /PRNewswire/ -- Focus Diagnostics, Inc., the infectious disease diagnostics company of Quest Diagnostics (NYSE: DGX), today announced the first laboratory developed test in the U.S. for detecting the mosquito-borne chikungunya virus. Commercial availability of the molecular polymerase chain reaction (PCR) test will enable physicians in the U.S. to test patients who may have contracted the virus, such as individuals returning from regions in Africa and Asia where chikungunya is endemic. The U.S. Centers for Disease Control and Prevention (CDC) has suggested that the chikungunya virus, which caused an outbreak in Italy in 2007, has the potential to enter and spread in the U.S. "The availability of our chikungunya virus PCR test will give healthcare providers in the U.S. an important option for identifying patients, particularly travelers, who may be infected with this potentially disabling virus," said Dr. Jay M. Lieberman, medical director, Infectious Diseases, Focus Diagnostics. "In recent years, Focus Diagnostics has brought to market new diagnostic tests that physicians can use to diagnose emerging infectious diseases, such as West Nile Virus and SARS. If chikungunya emerges in the U.S., our test could become an important tool to help mobilize an effective public health response. Chikungunya is a challenge to diagnose because its symptoms can mimic those of other diseases, including other mosquito-borne diseases, so the availability of an accurate diagnostic test is essential to minimize spread of the disease." Cheap Generic Viagra

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What is Viagra? • Viagra relaxes muscles and increases blood flow to particular areas of the body. • Sildenafil under the name Viagra is used to treat erectile dysfunction (impotence) in men. Another brand of sildenafil is Revatio, which is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women. • Viagra may also be used for purposes other than those listed here. Start sooner and last longer when you use Viagra Suffer no more! Buy Generic Viagra online at a price you can afford. Just 2.50 USD Get smart and save money! Buy Generic Viagra online for only 2.50 USD History Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent research facility. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a form of ischaemic cardiovascular disease). Phase I clinical trials under the direction of Ian Osterloh suggested that the drug had little effect on angina, but that it could induce marked penile erections.[1][2] Pfizer therefore decided to market it for erectile dysfunction, rather than for angina. The drug was patented in 1996, approved for use in erectile dysfunction by the Food and Drug Administration on March 27, 1998, becoming the first pill approved to treat erectile dysfunction in the United States, and offered for sale in the United States later that year.[3] It soon became a great success: annual sales of Viagra in the period 1999–2001 exceeded $1 billion. The British press portrayed Peter Dunn and Albert Wood as the inventors of the drug, a claim which Pfizer disputes.[4] Their names are on the manufacturing patent application drug, but Pfizer claims this is only for convenience. Viagra is available as blue pills with a characteristic shape Even though sildenafil is only available by prescription from a doctor, it was advertised directly to consumers on US TV (famously being endorsed by Bob Dole and Football star Pele). Numerous sites on the Internet offer Viagra for sale after an "online consultation", a mere web questionnaire. The "Viagra" name has become so well known that many fake aphrodisiacs now call themselves "herbal Viagra" or are presented as blue tablets imitating the shape and colour of Pfizer's product. Viagra is also informally known as "Vitamin V", "the Blue Pill", as well as various other nicknames. Pfizer's worldwide patents on sildenafil citrate will expire in 2011–2013. The UK patent held by Pfizer on the use of PDE5 inhibitors (see below) as treatment of impotence was invalidated in 2000 because of obviousness; this decision was upheld on appeal in 2002. Mechanism of action Part of the physiological process of erection involves the parasympathetic nervous system causing the release of nitric oxide (NO) in the corpus cavernosum of the penis. NO binds to the receptors of the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation (vasodilation) in the corpus cavernosum, resulting in increased inflow of blood and an erection. Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. The molecular structure of sildenafil is similar to that of cGMP and acts as a competitive binding agent of PDE5 in the corpus cavernosum, resulting in more cGMP and better erections. Without sexual stimulation, and therefore lack of activation of the NO/cGMP system, sildenafil should not cause an erection. Other drugs that operate by the same mechanism include tadalafil (Cialis®) and vardenafil (Levitra®). Sildenafil is metabolised by hepatic enzymes and excreted by both the liver and kidneys. If taken with a high-fat meal, there may be a delay in absorption of sildenafil and the peak effect might be reduced slightly as the plasma concentration will be lowered. Dosage and price As with all prescription drugs, proper dosage is at the discretion of a licensed medical doctor. The dose of sildenafil is 25 mg to 100 mg taken once per day between 30 minutes and 4 hours prior to sexual intercourse. It is usually recommended to start with a dosage of 50 mg and then lower or raise the dosage as appropriate. The drug is sold in three dosages (25, 50, and 100 mg), all three costing about US$10 per pill. Name-brand Viagra sildenafil is not scored and a fairly hard coating makes it more difficult to accurately cut the pills in half, even with a pill cutter. Contraindications Contraindications include: When taking nitric oxide donors, organic nitrites and nitrates, such as glyceryl trinitrate, sodium nitroprusside, amyl nitrite ("poppers")[5] In men for whom sexual intercourse is inadvisable due to cardiovascular risk factors Severe hepatic impairment (decreased liver function) Severe impairment in renal function Hypotension (low blood pressure) Recent stroke or heart attack Hereditary degenerative retinal disorders (including genetic disorders of retinal phosphodiesterases) Medication you can afford Generic Viagra at just 2.50 USD Get the medication you need. Buy Generic Viagra online for just 2.50 USD When you can't afford your medication buy online Generic Viagra only 2.50 USD Cheap Generic Viagra

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