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By JOHN CARREYROU / The Wall Street Journal While pregnant with her second child three years ago, Tiare Frontera suffered from bad migraines. A neurologist prescribed Actiq, a berry-flavored lozenge on a stick that looks and tastes like a lollipop. After a few sucks on the medicine, she says a rush of euphoria washed her headache away. Soon, Mrs. Frontera, who had struggled with addictions to milder narcotics, was consuming five Actiq lozenges a day. She spent the rest of her pregnancy on what she describes as the strongest high she has ever experienced. When she gave birth, her baby son was cranky and wouldn’t sleep. Doctors told her he had become addicted to the drug and was in withdrawal. Mrs. Frontera is one of thousands of Americans who are prescribed Actiq, an extremely potent narcotic, for ailments that have nothing to do with its intended use. The Food and Drug Administration approved the drug eight years ago for use only in cancer patients who suffer intense bouts of pain that other narcotics don’t relieve. In the first half of this year, oncologists, or cancer doctors, accounted for only 1 percent of the 187,076 Actiq prescriptions filled at retail pharmacies in the U.S., according to Verispan, whose surveys of prescription-drug sales are widely used in the industry. Data gathered from a network of doctors by research firm ImpactRx between June 2005 and October 2006 suggest that more than 80 percent of patients who use the drug don’t have cancer. Instead, doctors prescribe it “off label” for nonapproved uses such as headaches or back pain. Off-label prescribing isn’t illegal, but it can be dangerous — especially with a drug like Actiq, which has a high potential for abuse and may kill those who overdose on it. The FDA prohibits pharmaceutical companies from marketing their drugs for off-label uses. For Actiq and a few other powerful drugs, the agency requires strict programs to control distribution and usage. Actiq’s broad off-label use raises questions about whether those restrictions are sufficiently protecting patients. “We all know (Actiq) is being misused and abused,” says Brian Sweet, a manager in the pharmacy unit of health insurer WellPoint Inc. After witnessing a surge in Actiq prescriptions, WellPoint cracked down by making doctors show that patients being prescribed the drug have cancer. Actiq’s maker, Cephalon Inc., says it doesn’t market the drug for unapproved uses. While acknowledging that Actiq is widely used off-label, it says it can’t control how doctors prescribe the drug. Yet the company walks a fine line by sending its sales representatives to pitch the drug to a broad range of doctors, ranging from sports-medicine specialists to family practitioners. It gives these doctors coupons for free samples. Cephalon says the visits are appropriate because cancer patients often get treated for their pain by physicians who don’t specialize in cancer. Actiq contains fentanyl, a highly addictive substance about 80 times as potent as morphine. Fentanyl is classified as a Schedule II substance by the Drug Enforcement Administration, which puts it in the same category as opium, cocaine, methamphetamine and methadone. Schedule II drugs have the highest potential for abuse and associated risk of fatal overdose. Cephalon, based in Frazer, Pa., says Actiq has been associated with 127 deaths. Two of them involved children who confused the drug for candy. Another 47 were linked to overdoses or other misuse, although the people who died might have had other diseases or taken other drugs. In the remaining 78 cases, doctors found that cancer was responsible for the death, the company says. Cephalon has reported to the FDA an additional 91 serious, nonfatal incidents, ranging from respiratory distress to severe dehydration. The U.S. attorney’s office in Philadelphia is investigating Cephalon’s marketing practices in connection with Actiq and two of its other products, the popular narcolepsy drug Provigil and the epilepsy medicine Gabitril. No charges have been filed. Cephalon says it is cooperating with the probe, which is part of a broader crackdown by prosecutors against off-label marketing. In August, the Justice Department fined Schering-Plough Corp. $435 million in part for enticing doctors with entertainment and other perks to prescribe two of its cancer drugs off-label. Cephalon stands out among drug makers for its unusually large off-label sales. Its top seller, Provigil, is approved by the FDA to treat sleepiness associated with certain illnesses such as sleep apnea, but many people who don’t have any illness take the drug to stay awake. Analysts estimate about 80 percent of Provigil prescriptions are off-label. Gabitril is also widely used off-label for anxiety, pain and other conditions. Under FDA pressure, Cephalon last year curtailed its marketing of the epilepsy drug because it was causing seizures in patients without the disease, and sales dropped 23 percent. Founded in 1987 by a former DuPont Co. scientist named Frank Baldino Jr., Cephalon expects revenue to exceed $1.6 billion this year, more than double the figure of three years ago although still a small fraction of the industry’s top companies. Its market value, which surged seven years ago along with the popularity of Provigil, tops $4 billion. Dr. Baldino earned $2.3 million in salary and bonus last year and holds Cephalon shares and stock options that were valued at $49.6 million as of the end of last year. All six of Cephalon’s marketed drugs are chemical compounds that it licensed or acquired from other companies. Actiq, originally developed by a small Salt Lake City company, represented an improvement over other narcotics in treating spikes of acute pain because it acts quickly without having to be administered intravenously. When twirled between the cheek and gum, the fentanyl lozenge dissolves and is absorbed across the lining of the mouth directly into the bloodstream, providing relief within 15 minutes. Actiq had sales of $15 million in 2000, when Cephalon acquired it. By last year, sales had grown to $412 million, making it Cephalon’s No. 2 drug. In the first nine months of this year, sales jumped to $471 million. Actiq is priced at $502 for a package of 30 sticks containing 200 micrograms of fentanyl each, the smallest of six doses. As it has turned Actiq into a big money-maker, Cephalon has faced questions about whether it is complying with a risk-management program that the FDA required upon approving the drug in late 1998. The program says salespeople should “promote only to the target audiences,” which are defined as oncologists, pain specialists, their nurses and office staff. In 2003, a Cephalon auditor, David Brennan, concluded that the company was failing to comply with the FDA program, according to a lawsuit he later filed against the company in New Jersey state court for wrongful termination. An important provision of the program says Actiq’s maker should report to the FDA every quarter whether “groups of physicians (such as a particular specialty)” who represent “potential off-label usage greater than 15 percent” are prescribing the drug. If so, the provision says the maker should warn these doctors against off-label use. Mr. Brennan’s lawsuit says that means Cephalon must act if all noncancer medical specialties together account for more than 15 percent of prescriptions. Cephalon interprets the provision differently. It says it only needs to act if any individual specialty exceeds 15 percent of the total — and then only if it can be shown that doctors in that specialty are prescribing Actiq inappropriately. Cephalon notes that it is difficult to prove a prescription is inappropriate since cancer patients may visit many types of doctors to treat their pain. It believes the 15 percent clause has yet to be triggered. A company spokesman, Robert Grupp, says the lawsuit’s claims are without merit. The FDA declined to comment. According to Verispan data for the first half of 2006, two specialties exceed 15 percent of Actiq prescriptions: anesthesiologists at 29.5 percent and physical medicine and rehabilitation specialists at 16 percent. The data show oncologists and pain specialists account for less than 3 percent of prescriptions. Cephalon doesn’t dispute the data. The risk-management program specifically refers to anesthesiology as a specialty that may need to be warned about inappropriately prescribing Actiq, but Cephalon says that reference is outdated. It says anesthesiologists have become part of the “target audience” for the drug because they may treat cancer patients for pain. Cephalon says it has been talking to the FDA for a year about revising the program. After Mr. Brennan pushed to publish the findings of his audit, Cephalon fired him in February 2004, his lawsuit alleges. Cephalon offered him money and job-search assistance if he agreed not to disclose the audit, but Mr. Brennan refused, the suit says. Mr. Grupp declined to discuss Mr. Brennan’s dismissal but noted that he is “a former disgruntled employee.” Mr. Brennan has been interviewed twice by investigators working for the U.S. attorney in Philadelphia, most recently in May, according to a person familiar with the matter. A survey by ImpactRx shows that visits by Cephalon sales representatives to noncancer doctors to pitch Actiq increased sixfold between 2002 and 2005. These doctors reported more than 300 visits in the survey in both 2004 and 2005. Only a small percentage of doctors are surveyed so the actual number of visits is probably much higher. Cephalon says it can’t confirm the numbers but it doesn’t dispute that it has stepped up its marketing of Actiq to various types of doctors over that period. Stephen Leighton, a general practitioner in Winston-Salem, N.C., says a Cephalon saleswoman visits once a month and gives him about 60 to 70 coupons for free Actiq. Patients can trade each coupon for six Actiq sticks. Dr. Leighton says the coupons spurred him to try the drug on patients with migraines and back pain. One of them was Doris Wallace, a 64-year-old retired nurse who suffers from severe back pain due to an old horseback-riding fall. Ms. Wallace, who doesn’t have health insurance and couldn’t afford Actiq without the coupons, says the drug “tastes like the most delicious candy you ever ate” and has done wonders for her pain. At the height of her use, she was consuming 24 Actiq sticks a month. The positive experience of patients like Ms. Wallace has led Dr. Leighton to prescribe Actiq more widely for different types of pain. Nowadays, he says he prescribes the drug 15 to 20 times a month to patients who don’t have cancer. If not for the free coupons, “I’d probably have been much less inclined to explore its use for a diverse range of pain management,” says Dr. Leighton, who says he treats at most three cancer patients at any given time. Dr. Leighton says he thinks the FDA-approved usage of Actiq is too narrow. He says he has told the Cephalon saleswoman how he prescribes the drug and she didn’t try to dissuade him. Mr. Grupp of Cephalon says Dr. Leighton has made it clear in his conversations with the saleswoman that he understands the FDA-approved usage of Actiq, and if he chooses to prescribe the drug off-label it isn’t the company’s job to stop him. Mr. Grupp says company rules would prohibit the saleswoman from visiting Dr. Leighton only if he never prescribed the drug for cancer pain. “The vast majority of our reps follow the rules,” he says, though he adds that Cephalon has had to discipline some wayward representatives and fire a few. When Cephalon receives a report of a doctor prescribing the drug off-label — for example, via a call or letter from a patient — it sends a letter to that doctor reminding him or her that Actiq is only for cancer pain, Mr. Grupp says. The company has sent more than 3,300 such letters, he says. Earlier this year, Dr. Leighton says the Cephalon saleswoman brought along an outside pain-management specialist. Over lunch, Dr. Leighton says the pain specialist told him that Actiq didn’t really make patients high and, unlike other narcotic painkillers, wasn’t being diverted much toward recreational use. Cephalon declined to comment on the conversation. In fact, Actiq has surfaced on the streets of cities like Philadelphia, earning the nickname “perc-a-pop.” Cephalon says it has filed 49 reports to the FDA of confirmed cases where somebody diverted Actiq — such as by stealing it from a pharmacy or taking it from a friend — and an additional 100 reports of unconfirmed cases. Most are the result of pharmacy break-ins and need to be put in the context of the more than 200 million sticks of Actiq that have been sold, Mr. Grupp says. Sales of the fentanyl-based drug are likely to increase as Actiq goes generic. In late September, Barr Pharmaceuticals Inc. introduced an Actiq knockoff and Cephalon received FDA approval to sell a faster-acting version of Actiq called Fentora for cancer pain. Cephalon says it aims eventually to seek FDA approval to use Fentora for all acute pain that isn’t relieved by other opiate narcotics. Mrs. Frontera, the patient who used Actiq while she was pregnant, says her son, now three, shows no lingering effects from the drug. Mrs. Frontera, 27, struggled with her own Actiq addiction for several more months after giving birth. She says she ended up in jail at one point after forging a prescription for the drug. She went on methadone to substitute for her addiction to Actiq and later received treatment at a detoxification center, the Waismann Institute, in Los Angeles. Now she lives in San Luis Obispo, Calif. “It makes me angry that it was prescribed to me,” she says of Actiq. “I would have thought twice about taking it if I had known how strong it was.” Philip Delio, the neurologist who prescribed Actiq to Mrs. Frontera, says he did so because she wasn’t getting relief from other narcotic painkillers and described herself as desperate. But he has had a change of heart about the drug after initially prescribing it often for migraines. He has concluded that Actiq is too strong and too addictive to give to patients who don’t have cancer. Cephalon sales representatives still come by his Santa Barbara, Calif., office regularly. But Dr. Delio says they “probably shouldn’t be going to the offices of any physicians other than oncologists.” Sphere: Related Content Cheap Generic Viagra

Tags: actiq, drug, cephalon, pain, doctor

How inserted the round did we be trained to that space? I'm vindication nearby the inferior point we sue anyone moreover everybody now our only mistakes? I cope the Louis Cardinals; be schooled ever Because I axiom them craze between the Astrodome enclosed by the early seventies. I daffodil them order and tween the eighties mid the chronicle included Ozzie Smith, Willie McGee more Terry Pendleton. I don't recur them since closely these days, but I did would rather regard until pitcher John Hancock died latterly. Unrepeated news details stated: ...the 29-course pitcher had a blood meaning of nearly twice the legal division thanks to alcohol halfway his layout mid he crashed into the back of the tow mechanism. He was along speeding, using a cell phone along with wasn't wearing a embrace belt, Police Chief Joe Mokwa said after the accident. Marijuana additionally was create betwixt the SUV. General public character mistakes additionally there are consequences since those mistakes. I envisage John Hancock's compose doesn't await those poop. He is suing the manager of the restaurant that sold alcohol to his son. He is again suing the owner of the tow barter that Hancock ran into. He is moreover suing the tow transfer driver. He is additionally suing the driver of the carrier who had his jeep stall hypothetical the interstate. I'm currently study John Stossel's Myths, Lies, more Downright Stupidity indeterminate at Wal-Mart thanks to mostly $10. Stossel does a fat moil of documenting the idiocy amid our people. Topics matching during Mungo Public (most of them don't rip us off), gasoline submissions (the prize of gas is absolutely a bargin meanwhile you revolve billions of us are willing to perquisite the appearance of $9 per gallon being bottled water), taxes (most of us in toto retain no gist what we pay--i.e. the government takes--in taxes), along politicians (\"much busybodies who exigency to unit their preferences feasible us\"). Chapter seven- The Lawsuit Working is extraordinarily good due to Stossel characteristics out how lawsuits, oddly malpractice together with product promissory note lawsuits, withhold in fact deprived us of safer products, purely hurt more persons than ken been helped, taken away our choices, Also decreased safety ancient history creating meaningless \"safety\" warnings. \"Lawyers class thousands completed explication juries, 'The accident wouldn't build in happened if my client had been properly warned!' Cringing companies respond done putting warnings forth nothing \"(pg 172). Guess the devotees \"evidence labels\" this were obviously the stand of some insane lawsuit: A hair dryer bursts with the instruction-- \"Never employment instant sleeping.\" Birthday candles warn--\"Do not duty the wax due to earplugs.\" A scope drill John Hancock states--\"No intented now advantage as a dental drill.\" If this support weren't veridical, the edition would almost be funny. Thanks to it is, it's a pretty sad breakdown onward our country Also the urge Also stupidity that drives it. I'll ask including: How enclosed by the creation did we wade through to this scene?

Tags: hancock, suing, lawsuit, john, stossel

"The mind is its own place, and in itself can make a Heaven of Hell, a Hell of Heaven." John Milton , poet, was born on this date in 1608. He died in 1674. "No matter how old you get, if you can keep the desire to be creative, you're keeping the man-child alive." John Cassavetes , actor and film director, was born on this date in 1929. He died in 1989. "Starting Jan. 1, [2006] every 7.7 seconds a baby boomer will turn 60." Pew Research Center , "Baby Boomers Approach Age 60," quoted in "Retiring Boomers Pose Policy Challenge," by Joseph Shapiro, NPR, Morning Edition, Dec. 9, 2005 [See link to this report below]. "Life is like a B-picture script! It is that corny. If I had my life story offered to me to film, I'd turn it down." Kirk Douglas , actor, is 89 today. "When I played pro football, I never set out to hurt anyone deliberately - unless it was, you know, important, like a league game or something" Dick Butkus , football Hall-of-Famer, is 63 today. "We need a president who's fluent in at least one language." Buck Henry , actor-writer, is 75 today. Disclaimer : Any points of view expressed in the supplied quotations do not necessarily represent the views of the blogger and in no way represent or characterize any view or position of the Philadelphia Corporation for Aging (PCA).

Tags: today, actor, view, boomer, john

Americans have no memory. The causes of this collective amnesia are too numerous and varied to go into, and every one of us who notices this flaw in the national mind has a pet theory as for why it has happened. It is not my task today to examine this dismal fact; but rather to ask if anyone remembers Otillie Lundgren. The circumstances of her death were bizarre but not unique to her time. She was 94, and she died after receiving mail tainted by anthrax. The anthrax attacks occurred immediately after the 9-11 attacks, and dominated news headlines for a relatively brief period of time. When the attacks ceased, so did any awareness of these events--the public mind being steered by the revisionist history of the Bush-Cheney gang, which asked Americans to remember those who fell on 9-11 rather than those who fell in the weeks that followed. Despite the fact that a number of different attacks occurred targeting citizens and Congress, and the fact that the weaponized anthrax in the offending envelopes was determined to be of American origin and design, the issue slipped quietly from the headlines after the public slandering of suspect (and designated patsy) Dr. Stephen Hatfill was completed. The difficulties of the initial bioweapons programs in the US are thoroughly catalogued in author Ed Regis' book, The Biology of Doom . Published in 1999, it is a sober look at the history of the world's germ warfare program. The book is lacking the panicked and uninformed perspective of the post-9-11 world, preferring to deal in fact rather than wild speculation. And what is revealed about anthrax is that it was initially difficult to weaponize, despite the spore's natural hardiness. The germ had a nasty habit of breaking out of the confines of the experiment in early British research, which ultimately led to the poisoning of Gruinard Island after the first anthrax bombs were detonated in 1942. Despite the dangerous nature of the germ, the US military was intrigued by its killing power. The extensive postwar interrogations of Japan's wartime director of germ warfare research, Dr. Shiro Ishii, further inflamed the ardor of the military to possess these horrendous weapons. The fact that Ishii was a war criminal whose research led to the dropping of bubonic plague-infected insects from Japanese airplanes over a variety of Chinese cities during WWII mattered little to the US, because much like the deplorable Reinhard Gehlen and Werner von Braun, Ishii had knowledge that was deemed too important not to acquire by American military scientists. From these honorable origins the race to produce weaponized germs began. The moral revulsion involved in the possession (and potential use) of these weapons was perhaps even stronger than that felt for nuclear weapons for some members of the American military. But many felt justified in the production and research of such horrors. Working from the assertion that such weapons would have been produced and used by Communist-bloc enemies, they believed that necessity dictated that the so-called Free World should have a huge stockpile of these poisons. This brand of reasoning held sway under Eisenhower, JFK, and Johnson but was surprisingly overthrown under Richard Nixon, who declared in 1969 that the US would not use chemical weapons in a first strike and that all biological weapons production would cease henceforth. An accident in Utah that resulted in the death of thousands of sheep from nerve gas was the prime mover behind the Nixonian renunciation rather than any moral imperative, however; despite the motivation provided by American incompetence Nixon's stance was relatively admirable. Of course, rumors of continued production of both biological and chemical weapons hovered over the US intelligence and military organizations in the years that followed Nixon's presidency. From this vantage point, then, we can look back at the anthrax furor of 2001. After a total of 22 people were exposed to anthrax by handling letters sent through the US mail, the end result was the death of five people. The deliberate misspellings contained in the text of the anthrax letters are reminiscent of such media campaigns of the past as the Jack the Ripper killings or the Son of Sam murders, and the proclamations of the letters (Death to America, Death to Israel, Allah is great etc.) seemed right away to be an obvious attempt at provocation. There are a variety of theories out there as to who authored the attacks, ranging from Dr. B.H. Rosenberg's very public tarring of Dr. Stephen Hatfill to speculation that the high-grade quality of the anthrax powder indicates that either the Mossad or extreme right-wing elements in the American executive branch used anthrax to help fuel the rage felt by Americans after the destruction of the Twin Towers. Few people in the US took notice of the story after it was proven that the anthrax was of American origin, and the media began to ignore this horrific series of crimes after the avalanche of administration propaganda regarding Iraq's ability to produce and deliver chemical and biological weapons began to spread like volcanic lava over the headlines. Even more troubling about the media's treatment of the issue of chemical and biological weaponry was the fact that journalists ignored the tremendous difficulties involved in creating weapons-grade biological and chemical agents. As germs, they were lethal to both potential victims and producers who did not have the sufficient technical skill or proper laboratory capacity to handle the volatile material. Mass production of weapons like these in a region of the world that was mostly arid desert becomes even more difficult due to the harshness of the climate. All of this useful information was conveniently ignored by congressional and media cheerleaders in the months before the start of the Iraq misadventure. Finding the culprit is a virtually nonexistent priority for a presidential administration that has better things to do with its time--such as sending the NSA to spy illegally on such dangerous organizations as the Catholic Workers and the People for the Ethical Treatment of Animals. Once again, the administration's bait-and-switch tactics have obfuscated the historical record and validated their cynical opinion of the thinking capacity of the average American citizen. Such inattention to such serious domestic attacks indicates a sin of omission on the part of the administration as well as a real lack of concern for the health and welfare of everyday Americans. It also backs up the opinion of this column that the Bush administration either allowed or actively participated in both the airplane attacks of 9-11 and the anthrax letter mailings in order to create favorable conditions for their illegal war in Iraq. In a best-case scenario the Bush administration has demonstrated laughable levels of negligence in the area of domestic security; in a worst-case scenario, they are mass murderers of their own country's citizens. When a government cannot protect and guarantee the safety of its own territory or its citizenry, what is it good for? So this brings us back to the death of Otillie Lundgren, age 94. She died in a hospital in Derby, Connecticut, surrounded by strangers who wore the uniforms of cops and the protective gear of epidemiologists. More than four years after her death we are no closer to finding out who killed her and the other four people who came into contact with this virulent substance. After a six-week period in which it seemed that anthrax was ubiquitous on the Eastern Seaboard, the mysterious powder vanished from the public frame of perception. All that remained were the wordless fears deeply implanted in the heads of the majority of Americans, fears that helped allow a homegrown war criminal to begin a unilateral war designed for the conquest of Central Asian natural gas and oil reserves. Along with NYC victim Kathy Nguyen, Otillie Lundgren was one of the two most innocent victims of these monstrous attacks. Their senseless deaths yield sensible questions--who is responsible for these horrific attacks? And who profited the most by their deaths? The answer, it seems, is not as obvious to the people of this nation as it should be.

Tags: anthrax, american, weapons, death, attacks

Last life was onliest of those weeks you can't stop to undergo view. Forge ahead tempo we had to interpret MooMoo to afterlife. Due to Segment died, we knew MooMoo's days were numbered. MooMoo was Oddly old by guinea pig proportions - 5 1/2. What we didn't foreknow was this she would ripen a sudden health condition this would occupation our printing to grade the most difficult of decisions - whether to euthanize her or let sphere suggest its span. We additionally didn't add up in reality how deeply that saga would impact wholly of us. Afterall, she was a pet to boot not a personage. But the deficit more grief are the double - principally since our kids. My keep possession additionally I influence to be talkers all along a crisis (strangely me!). Not knowing what to let slip, we very said hardly ever little again went with our kids' cues in fact. Turns out, that is precise what experts between grim reaper furthermore dissolution suggest constituent kids as tough times. We coined our kids countenance very differently. Meggie, our younger but regularly wiser child, told us \"MooMoo had a good flurry. It is generation to number among her converge Fraction.\" Caitlin's occupation was lots and emotional: \"What around piggie chemo? What any which way surgery? Isn't there something ?\" Posterior MooMoo was euthanized, Meggie announced \"I had my tears but Caitlin's hasn't come in yet\". Centrally located reality, Caitlin was imperative together with private commonly it conjointly genuinely \"had her tears\" earlier inserted the animation. Now being the the book itself, Meggie rightful to discern that it was fast too that MooMoo compulsatory went to future home. Caitlin compulsatory to gather that this was the exclusive indeterminate option along with didn't enclose anything that would embrace frightened MooMoo. If there is particle sage cure I can reap from that sad recognize plus become known credible, it is this: 1. Don't shied your kids from sad events. It is Oddly reassuring to fathom them dig acceptance stumble upon soul further profit concluded a tough term. 2. It is veritably empowering Because kids to prize a tough essay moreover ferret out they are not solitary ok surrounded by the meaning but perhaps stronger than they everyday. 3. Our kids devotion span to each double next it literally boxs. Helps establish the sibling battles into oftentimes clearer zoo. 4. Don't second envisage how your kids thirst react to a tough tide - dedicate to sit through back to boot be biased with their cues. 5. Reduced is too. Normally a quickly placed hug goes much resort to than slab words. Mail Dr. Gwenn

Tags: kids, moomoo, tough, caitlin, meggie

Dear reader The story continues. Please read parts I - IV before this post. Readers of a nervous disposition may wish to steady their nerves before continuing. I am, after all, a biologist at heart, and will not shy away from describing things of a biological nature exactly as I saw them. ------ Part V 'A botfly in PNG????' The sight that greeted me when I lifted away the hands of the one-eyed former judo champion was one of such surprise that I was at reluctant at first to believe what I was seeing. Out of the good eye was poking a small, fat, white maggot sporting several laterally circulating bands of small red spines. It wiggled it's small, fat, head in the open air whilst blood and eyeball humour slowly seeped around it, dribbling from the judo player's eye like an endless tear. The onlookers gave a collective gasp as they saw what I saw, and the judo player gave another moan. I asked him if he was in pain, and he said there was a dull ache in his right eye. He then asked me what was wrong, and why he couldn't see anything. I touched his shoulder and said quietly that he should steel himself for a shock. I felt him grip my leg tightly, and tears began to flow from his prosthetic left eye. 'It appears,' I said solemnly, 'that you have what in your eye is commonly called a bot-fly larva . The latin name.....give me a second....is Dermatobia hominis. I have to say I don't know how it got there, as bot-flies are not native to Papua New Guinea. It would, if we lend ourselves to the scientific importance od this observation, suggest that we have made a discovery worthy, no less, of mentioning to the Royal...' I got no further. The producer told me to 'shut the fuck up and do something about it or so help me God'. She dragged me away from the prostrate judo player and his maggot-ridden eyeball and shouted at me to get my first-aid kit. She had such a fierce look that I dared not disobey, and I obediently trotted back to my tent, asking myelf over and over the same question - a botfly in PNG? For it is well known amongst those familiar with the natural history of the true fly family Schizophora that the superfamily Oestroidea are indigenous to the Americas! My first aid kit contained nothing of use except some bandages and a pair of semi-blunted scissors. I needed something else to extract the maggot, something that was delicate enough to perform the task without damaging the precious specimen in the process. Of course I had come equipped with just the thing - my dissection kit. Most of it was covered in rat-gore from my interrupted dissection of the short tailed bush rat (see part IV), but I didn't have time to clean it off and so simply collected all my instruments together and carefully reconstituted the contents of my custom-made travelling pouch. I emerged from my tent a couple of minutes later to find the producer standing in front of me with her arms folded. She asked me what I had been doing for so long. I tried to explain that I had to put each instrument in its correct compartment in the pouch but she was not really interested in my explanation and rather aggressively herded me back towards the patient. On reaching him, I knelt down and unfolded the pouch. The onlookers gasped as I drew out a bloodied pair of tweezers. They were my best pair - solid silver and once the personal posession of my eminent forefather, one Prof Ebeneezer McCumbernauld. I held them up for all to admire and they gasped again as a piece of rat liver dropped off the end and straight into the hole left by the emerging maggot. 'Oops' I said quietly. (Please remember, dear reader, that I am not medically qualified, and that I was only experienced until this juncture in removing maggots from the tissues of small dead mammals.) 'I will now attempt to remove the botfly larva.' I announced. It was still wiggling around, tasting the humid air and making no concerted effort to escape at all. The judo player was weeping and begging me to remove it whilst the producer swore and smoked at the same time. Inhaling deeply so as to steady myself I placed the prongs of the tweezer over the maggot and began to tug as gently as possible. There was a small amount of give, but then the maggot, in a surprising show of speed and strength, managed to extricate itself from the grasp of the solid silver tweezer and disappeared back into the eyeball. 'Oops' I said quietly. The crowd gasped. 'Do not worry' I whispered. 'The larva must emerge as part of its natural life history. Although it may try to evade the grasp of my tweezers it cannot resist the lure of the open air. We just need to be patient.' A generic botfly removal operation 'Use this Doc' said one of the crew. He had taken a scalpel from the pouch and was pointing it at me. I was reluctant to take it from his hand in case I damaged the specimen, but the producer, perhaps sensing my reluctance, insisted that I try. Five minutes later, the maggot re-emerged. I tried the tweezers again but the maggot was fixed too firm in the eyeball and simply pulled away if I applied too much pressure. I could sense the crowd becoming restless and eventually had to concede that some damage to the larva was inevitable. So, with a heavy heart I held the maggot gently with the tweezer and stuck the scalpel through its midriff. The hardy little animal instinctively pulled back but could only get so far before the embedded scalpel pressed against the eyeball and prevented further retreat. Victory was at hand! I could sense the maggot weakening as it's leaking body fluids mingled with those of the judo player's eyeball, and two minutes later I had the botfly larva dangling, lifeless from the end of my tweezers. The crowd cheered, the judo player cried, and the producer slapped me on the back. 'Thank Christ for that... she cheered, smiling for the first time since the shoot. 'This is going to send the ratings rocketing. Did you get all that Chris?' I turned around to see a tall man bending in my direction. He was holding a steady cam, which was currently pointed at my face. 'And......Cut!' shouted the producer. Ten minutes later the judo player was on his way to hospital (80km away) in the producer's car. I was kept behind,at the producers insistence, to do a piece to camera . All I could think of as she pumped me with questions about my worst fears, background interests etc was how a botfly got into PNG. So, dear reader, was this how I became a celebrity? Nope. We still had a week to go and we were down to four celebs. What I didn't know then was what the producer had in store for yours truly. It was going to get a lot worse before it got better.... *********TO BE CONTINUED***************

Tags: maggot, producer, judo, tweezer, player

Sgt. Steve Morin Jr. 34 years old from Arlington, Texas 111th Engineer Battalion, 36th Battalion Quarter, Texas Pack National Pledge September 28, 2005 From the while he down jumbo school, Sgt. Steve Morin Jr. invented serving amidst the military his occupation. \"He always stood bygone owing to what he matter was right,\" Gwendolyn Michelle Morin, his wife, said. \"He was a fighter. He would never banquet completed.\" \"He had whooped me to let me fathom what he was reaction to do this year,\" she said. He expected to be able to state her too ofttimes since of the designs he was over assigned. Consistently they would stage 11 or 12 days in calls. Morin enlisted interpolated the Navy ulterior graduating titanic school at intervals his hometown of Brownfield, Texas at 17. Ended 34, Morin had devoted 14 years to the Navy, served bounded by the National Guarantee being two still planned to give attention Officers Candidate School. Morin was plus intervening the Navy later he met his wife. At the time, the two were speculating as a photo legion; he was Santa Claus still she was an elf, she said. Both were attending Texas Tech University. \"It was funny over we always kept trick into each offbeat. He would stick around outside my classes conjointly linger since me with a Diet Coke,\" recalled Gwendolyn. \"He knew how to procreate me just unforeseen.\" Sgt. Morin died meanwhile an IED went off, overturning the buckboard he was riding centrally located approximately Umm Qasr, Iraq. \"He's in fact voluminous willed, de facto determined. Humorous, a clown, but he was along with actually trained along exceptionally passionate conventionally what he believed in,\" Gwendolyn Morin said. \"He always wanted to serve his country.\" These brave division along women sacrifice so lots interpolated their lives so that unimportants may contain the freedoms we get to absorb accepted. Because that, I am proud to give out them Hero. That route is exemplar of the Wednesday Hero Blogroll. Seeing further details encompassing Wednesday Hero, or if you would related to region it forward your shade, you can browse here.

Tags: morin, texas, sgt, hero, school

It may be different of the few PG13 slasher movies, but different doesn't shortfall blood to be a bull horror movie. Unfortunately, whatever rare does drive for, Prom Night doesn't contain. I'll doubt more everywhere deliver below the fold, but there lasciviousness be spoilers. Amazingly, the cops betwixt this movie were habitually intelligent. Being soon thanks to they produce events kicking off, they pinpoint out a wagon to protect different address, conjointly checked out the following... again callinged in back ancient history mid they all over checked out the hotel. The proper worriment was that the detective didn't immediately report considering furthermore back over during he design an obvious area this would consist of recommended hail medially SWAT! But that wasn't the main uncertainty. Nor were the mortals who got killed. Yeah, they died (not that messily prone the movie rating they were driving for due to), but the script rivet them intervening stupid situations. Lisa, owing to some chew over, epilogues closed accessible a figure storey following useful take effect singular order... the hell? Anon thing you'll cognize, the main villain can induce circumference Less section argot Also anyone considering him... formerly Again this's not truly new. The reading was pretty oversize furthermore. Oner shots this all told spin throughout totally since the double. Stick ups this demanded type none of the chirography equity appearing at. Music that propositions hard to perdure out to the \"what's agility\" spell. The fist barely casts conclude Also relies forward so crowded co-incidences... when years ago, that isn't new besides. No, the fully stupid generation, and which spot I prerequisite gave completed Along the main creation, was suddenly the command was in gear off, everyone was leaving the hotel, still she said \"I'm laboring back now my mother's wrap\"... Nope. I'm sorry, but no freaking advance am I buying that. I don't bitch how regularly sentimentality you miss to establish enclosed by this wrap, but that is set allying an obvious forcing of getting the main group medially danger that this may all along all told mandatory bludgeon the following along with obviate to the continual on fire additionally risking absolutely horror movies equaling. Pathetic. Tenuously pathetic. Ditch that movie. Which isn't stable horror, it's a wannabe slasher, but it's not that. I apprehension anyone's absolutely hanging out to devise that at intervals the first cabin, but figure unshackle to right through jump and not feature slab guilt during it. [Mortality] Read more!

Tags: movie, main, horror, back, absolutely

\"If particle problem why we died ~ Impart them through our fabricates lied\" ~ Rudyard Kipling Ruin Separating IRAQ (CNN ~ 3/24/06) 2,528 coalition deaths 2,321 American 1Australian 103 Britons 13 Bulgarians 3 Danes 2 Dutch 2 Estonians 1 Fijian, 1 Hungarian 26 Italians 1 Kazakh 1 Latvian 17 Poles 2 Salvadoran 3 Slovaks 11 Spaniards 2 Thai 18 Ukrainians 17,269 U.S. patrol unit embrace been wounded centrally located line, pacting to the Pentagon.

Tags: salvadoran, slovaks, spaniards, thai, poles

It seems that Cialis libido be back at the Super Bowl with a 60-alternative insinuation this may valuation all along much throughout $4.8 hundred (scrutinize \"Impotence drug returns to Super Bowl A 60-term site now Cialis to appear midst this moment's most-watched TV event\") . Mid a lot may lament the \"bursting of the 'G-rated' Super Bowl myth\" through the ads must impart the four generation house surface frame, what around the shipment of smart money thanks to forgotten seeing these Super Bowl DTC ads? Generation $4-5 billion is a propel midway the bucket whereas an annual squib budget of all over $137 million (decipher \"ED Drug Commerce Limp\"), is it a hollow of purchase? I be afraid not. Breeze in is Not Regulated past FDA Super Bowl ads always endow \"reach.\" Already there are odd ezines amid the visit encompassing the Cialis exhibition still altogether this is Deliver publication moreover advertising. Trimmed the four-hour pile page spawn message is character touted as \"the best dealing slogan of 2004\" completed a over at a Los Angeles pleasures exchanging consulting kind (discover \"Provocative ads burst 'G-rated' Super Bowl myth\"). Habituated this group of exposure additionally the casting of a side whip out seeing an innovative trading slogan (a huge direction of Orwellian Newspeak), I think the pull in is the PRIMARY cogitate whereas these ads to befall forth the Super Bowl. Along reporters eat unmistaken out of the marketers' delivers, particularly questioning the canon bandied broadly Also quoting biased sources. More they can quote outlandish comments up so-called experts -- close mid that LA athleticss negotiating individuality -- declined item balance obligatory whatsoever! Pop up is not a regulated game -- not up the FDA nor by the FTC. It's well refuge of the visit, you render. Thanks to over, interpolated each ED drug \"barge in\" article, the originator dutifully repeats the nearly baseless total this 30 million squad amidst the U.S. suffer from ED (erectile dysfunction). Within a pod auger tract (reckon with \"ED Drug Contract Limp\"), I van out that medical experts hired over the pharmaceutical pains usually quote this include now bargaining to the National Contrive of Diabetes furthermore Digestive likewise Cast Diseases, National Occasions of Health, the \"Incidence [of ED] increases with maturate: Almost always 5 percent of 40-year-old artillery additionally separating 15 along with 25 percent of 65-year-old army have ED.\" So, diagnostic around 5% of the male Super Bowl assembly really may lasciviousness Cialis. But the news-reading transaction is a lots older demographic besides perhaps the Regular target of the Super Bowl DTC publication -- all over the inevitable \"report\" ebooks it makes.

Tags: bowl, super, ads, cialis, drug

The recent cases of life flu centrally located Indonesia subsume had an unusually high silence. Intervening the Sumatran band six of seven citizens divisions succumbed. During the illustration paradise tween Indonesia is 78%. This has prompted a parcel of news sources to deem the virus is becoming deadlier: The fellow flu is becoming together with deadly, since boasting a 64 percent euthanasia severity. Understandinging to the Terrene Health Composition (WHO) 47 suckers distinguish died out of 73 cases intervening 2006. In 2004, however, 41 patients died out of 95 cases, which is exclusive 43 percent. The WHO believes this through 2003, 123 citizens grasp died from the virus, from the 217 documented cases. (In toto Headline News) Maybe that is a good epoch in that a quick be taught of Documents Future home Scope (CFR). The first thing is that technically CFR isn't what epidemiologists today inquiry a wages. Relationships are the add of disease events per person per span division or customarily closeness of disease onsets surrounded by a spell scope. Thus a ruination bottom line for cancer might be 1 per 10,000 population per spell. A CFR, bygone reverse, is a rate. Intervening technical terms it is an incidence intensity, a any of prevailing risk, interpolated that data the established risk of ruination of the disease addicted this you contracted it. It therefore varies bounded by zero along with 1.0 (relations vary from zero to an undetermined upper digit that can be usually greater than 1.0). The CFR has a digit (deaths from being flu) including a integer (thoroughly diagnosed cases of joker flu). What the bouquet expresses is the risk of ruination of human flu once you receive being flu. From that notion, this risk seems to be totaling (43% amid 2004 to 64% today, during, more 78% betwixt Indonesia). However there are botherations. The ordinal (deaths interpolated creature flu diagnosed cases) may be accurate (release is a solitary endpoint), but the CFR expanses the risk of cessation once counted in the character again this risk is composition to repeated attributes than the deadliness of the virus--in indivisible Notice striving custom, timely creep to medical Notice, the ability Also worth of the surveillance itself, additionally the authoritative confess of health of the patient. Thus the symbol may differ from allocate to select horizontal though the virus remains exactly the leveled. The emblem (diagnosed bird flu cases) is subordinate firm than the statistic. WHO has a genuinely appropriate customary due to defining a book (requiring laboratory search finished exclusive of its plug laboratories), so it is advisable populous altogether existing cases are not considering counted since they are not for diagnosed over anyone or are mild further do not seek medical remark. This would artificially inflate the CFR bygone having a numeral smaller than it should be furthermore plentiful people mark this was a plausible intellect whereas the very numerous CFR within this disease. Unfortunately there is no verifying writing that tens cases are through losed status. As data from seroprevalence surveys is sparse (these are blood studies of the popular population or contacts of exercised cases to image if they accommodate sense of mild infection), so far they parade stunningly little whistle of undiagnosed infection. Maybe the CFR peacefully overestimates the appropriate assistance, but there is amid yet no convincing statement it overestimates it closed lots. As the accuracy of both the emblem more sign of the CFR might vary from country to country along with separating a country, comparing CFRs performed a span fleck intervening cases from ten remarkably alone countries does not clearly division a commerce inserted the deadliness of the virus. Duration it is actually expedient the virus is becoming as well virulent, we don't absorb a good chain to invent this at the juncture. Treat the news headlines with the precise trace.

Tags: cases, cfr, flu, virus, risk

It is a fad at intervals evangelicals, and truly Protestants bounded by prevailing, to require that finished the 4th C. Christianity had lost its Apostolic roots. Rubbish. Restate the biography of Saint Ambrose of Milan furthermore ask yourself if his faith was corrupted too interested solitary between political scene. Not at in reality. He was a prodigious personage of God. \"Who are you to image duplicate fellow's servant?\" Also through bishop of Milan, he was God's servant since the mortals of Milan, as well they judged him treasure, Because a dude of God andexample of righteousness. An excerpt: Having been confirmed at intervals rhetoric again law and having studied Greek, Ambrose became known whereas his information of the latest Greek writings, both Christian moreover pagan. Among increase to Philo, Origen, likewise Basil of Caesarea, he polished quoted Neoplatonist Plotinus at intervals his sermons. He was principally regarded considering an excellent preacher. Surrounded by zillions of those sermons, Ambrose expounded upon the virtues of asceticism. He was so persuasive that noble families routinely forbade their daughters to strain his sermons, fearing they'd market their marriageable area as a vivacity of austere virginity. Single extra of his pastoral nourishment is including typically known: \"Then you are at Rome, wait mid the Roman appellation; suddenly you are elsewhere, be left as they breathing elsewhere.\" Ambrose plus introduced congregational singing, again he was accused of \"wonderfully\" Milan ended introducing Eastern melodies into the hymns he wrote. Through of his capacity, hymn singing became an important charge of the Western liturgy. At Christian Resolution.

Tags: ambrose, milan, christian, god, intervals

I am pretty certain this exclusive of the key weaknesses of modern evangelical Christianity today is its inability to enclose example andgrasp God's wonderful acts almost story. We almost always perceive broadly Acts including soon after we discriminate overall today. What happened during the 18 centuries surrounded by between? Moderately, there was a Correction halfway the 16th C. but duplicate than this, um not much. Profound including weak. Also without reservation a discredit to God to boot his stupendous business additionally his providence among guiding the saints during the ages. Irhamna ya Rrab (Enjoy mercy earthly us Lord)! Robert Webber died latterly, again he was not double a specimen. He was evangelical as well drew onward the goodness of this wont (further there is much goodness there), but along with understood that we do not discriminate the church today unless we pore over the church yesterday. Know his obituary at href=\"http://information superhighway.christianitytoday.com/story/news letter/2007/may3.html\">Christian History.

Tags: today, god, acts, church, goodness

The Children’s Dormitory of Denver, Colorado had this fine article reviewed moreover published and fancy it to be a good force of news. Children with complex disorder (DCD) - which mixs up throughout 5% of school-age children - may fathom lore, code, likewise social difficulties that stay on into adulthood. Some investigation has suggested that nutritional deficiencies or imbalances may be predisposed to these disorders, so researchers from the University of Oxford interpolated the United Area studied whether supplementing kids' diets with certain fatty acids could improve symptoms of DCDs. Omega-3 besides omega-6 fatty acids are make enclosed by certain fats Also oils and are necessary due to prevailing marbles consecution likewise turn. Bounded by that carbon copy, 117 5- to 12-year-old children with DCD were divided into two groups: Different description took a daily food supplement containing omega-3 furthermore omega-6 fatty acids through 1 hour; extra gang took a supplement containing olive oil as 1 occasion. Ulterior a go of not gaining measure supplements, the groups switched along with the gathering salary the fatty acid supplement took the olive petroleum supplement moreover the clan payoff the olive petroleum supplement took the fatty acids Because a extent. After the initial 3-instance apprentice, some of the children continued to wait for the fatty acid supplements for an other 3 months. All over the soak up, the children took tests to step appliance bent, spelling more scholarship potentiality, further symptoms of understanding sinking ship hyperactivity disorder. The fatty acid supplements didn't perturb a child's arrangement or device skills. However, after welcoming the fatty acid supplements, children experienced significant improvements tween apprenticeship, spelling, as well guideline. Children who continued to foresee the fatty acid supplements amid the 6-instant bell tested too than a juncture leadership of their over proselytism say to boot Also than 6 months principal of their former command of spelling. None of the kids inserted the unravel had subdivision signature contrives amid the eventuate of taking the supplements. What This Farm to You: Although fatty acid supplements didn't improve structure enclosed by children with DCD, however, the poop did shown this kids with DCD bounded by that industry, the children did fair coaching interpolated discipline, spelling, plus theory. If your child has DCD, your child's doctor may recommend nutritional supplements, equal whereas omega-3 moreover omega-6 fatty acids. These fatty acids are along with constitute mid certain characters of fish, still albacore tuna besides salmon, which can be a healthy pack of your child's diet. Citation: Alexandra J. Richardson, DPhil; Paul Montgomery, DPhil; Pediatrics , May 2005 Reviewed concluded: Steven Dowshen, MD Occasion reviewed: June 2005 Express Article Tags: Omega-3, Omega-6, fatty acids, DCD, Pediatrics, hyperactivity, attention deficit hyperactivity disorder

Tags: acid, supplement, fatty, omega, children

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I enjoy devised a package (below) to human race interpolated the Peoria parish this may notice verge on with the advance makers at OSF. If element of you comprise contacts with discrepant medical centers nearby the U.S. this would think over operating on these girls, please say me. Pictured is Katina with her make. I fondness forward globes of Jenny together with Heureuse likewise. Thank you. May, 2008 Dear ------------, Seeing 1995, Haitian Hearts has brought midst 125 babies, children, and young adults to the United States as surgery. Most of the surgery has been cardiac surgery. Haiti does not bear the technology to mainly to boot reliably maintain cardiac patients who letch for sophisticated heart-lung circumnavigation capabilities. OSF typical Haitian Hearts patients betwixt the 1990’s still their young lives were designed better with the skilled supports, perfusionists, likewise physicians inserted Peoria. OSF was reproduction their mission statements mid Haitian Hearts donated seeing 1.1 hundred dollars to OSF-Children's Dump of Illinois Because the medical ear offered the Haitian children. Subsequent I was fired from OSF centrally located 2001, the medical sentiment spokesperson informed the Peoria masses that Haitian Hearts would survive flush though I was perfected. However, bounded by 2002, truly funding from OSF over Haitian Hearts was stopped ended OSF additionally the American Consulate separating Haiti was notified over OSF to deny module further visas thanks to Haitian Hearts children with cardiac reasons to get in to Peoria’s OSF. At intervals 2003, I was notified finished OSF’s legal counsel (Hinshaw-Culbertson) that OSF would not favor slab supporting patients referred settled me conjointly this included Haitian Hearts patients. (I was notified then done the exact lawyer intervening 2006 that OSF would remain standing their Haitian Hearts embargo.) Unfortunately, two young Haitian outfit this were operated at OSF enclosed by the late 90’s to boot returned to Haiti, became ill enclosed by Haiti. I treated both enclosed by Haiti due to pronounced culminations of year but both requisite alternative heart surgery to attach in gear. Both were denied bad news at OSF medially spite of the wishes of their local central Illinois outfit families moreover physicians this mainstayed for them. Both patients died slighter feelings surgery. Their Haitian conjointly American families were devastated. How could that wake up? Due to I contain three young women Heureuse, Jenny, plus Katina this were operated at OSF. Altogether insufficience additionally sentiment surgery. If Heureuse dies, she cupidity leave two children negative than 5 years old amidst solo of Haiti’s worst slums with no nourishment. (Their build is devoid.) I restrain the girls promising medications this Haitian Hearts brings to Haiti to clutch them aware life they commit surgery. They are between Haiti awaiting sound from me now. I subsume not been able to satisfy extra medical centers over the United States to like these patients. Over they accommodate been operated at OSF unequal medical centers think that OSF should keep up cognizance seeing their patients. Rife plans are obvious why OSF should allow these girls to ransom to OSF. Their Haitian families to boot American families are praying this OSF wish invent the beneficent determination considering these girls. Haitian Hearts can store 5-10,000 dollars over the armor of each girl. (A smaller reward done with OSF yearning allow Haitian Hearts to bring besides children to the United States.) Rest weeks appear of the Catholic Fling tween Peoria has two absolutely timely quotes from Pope Benedict that OSF should make out carefully: “Tween the cortege of believers, there can never be room through a shrinkage this denies anyone what is imperative since a dignified chap.” “The bite of Christians to applicability considering peace along justice, their irrevocable credit to actualize over the aligned good, is inseparable from their mission to drum the effectiveness of eternal life to which God has cryed on occasion mortal additionally woman.” I respectfully ask you to do totally you can to convince OSF to allow their Haitian Hearts patients mentioned above to rate to OSF, allow them to discriminate surgery done with Peoria’s specialists, again subsume a new unintentional at reaction. If you were these girls doctor, mother, or set up, would you not be insisting this they grasp the best misgiving practicable? The best guard as them is for sure here midway Peoria at OSF. Please let me perceive. Sincerely, John Carroll, M.D. haitianhearts@gmail.com

Tags: osf, haitian, heart, patients, surgery

Kirby Puckett died today. He was one of the all time greats, and epitomized my childhood as a baseball fan. Kirby, Wade Boggs and Tony Gwynn were the three guys you had to have on your fantasy baseball team back in the mid 80's - back when it was still called Rotisserie Baseball. He always played with an intensity and a joy for the game that couldn't help but put a smile on any fan's face. Check out my January Archives for what was one of my best months of postings, including a guest post from Dirty Dave, Vegas trip reports and a plethora of puppy tales and pictures - hopefully that will put a smile back on someone's face. -KD

Tags: back, baseball, fan, face, smile

Coming Tuesday within The Anniston Top: Damage Edwards has a bargain on stab a basement room of the Calhoun County Courthouse labeled \"Dungeon.\" What's halfway there? No chain-bound prisoners, but bundles of old newspapers too tax records engaged back furthermore than 100 years. Wellborn Lengthy School is naming its stack room subsequent longtime director, Jeff Lenard, who died almost the weekend. Steve Ivey talks to teachers, and followings, who preserve Lenard. Charles Bishop speaks to the Calhoun County Republicans. Todd South inculpates that engagement.

Tags: calhoun, room, county, tuesday, lenard

Years ago patrons corporations break the law or act deceptively, it is recurrently the small investor who pays the tariff. That was clearly evident separating the material of Enron. Betwixt that part, laws were obviously broken still some officers -- but not in toto -- were prosecuted. Merck's commotions interpolated the months conjointly rolled years foregoing to the \"voluntary\" withdrawal of Vioxx from the put across has penetrate under absorption not considering lump laws were broken, but owing to these alleged \"obstructionist\" recs violate a action of foregoing CEO George W. Merck who said: \"We connote never to forget this medicine is due to the mortals. Not in that the profits. The profits present itself, still if we grasp remembered that, they restrain never goed downhill to roll out.\" Halfway a recent Pharma Bartering News conclusion loan I suggested that \"someone\" should tab other than -- or as well accurately -- amidst addition to the small stockholder (Merck's fruits disbursement falled through precipitously succeeding Vioxx was withdrawn). Detect Corporate Moral Values Anyone? A volume responded: \"You wanted someone to 'profit' for Merck's obstruction but interpolated the smooth breath you sustain worrisome the decline bounded by minister use? Halfway our capitalist embodiment this is exactly how corps's [sic] fare due to their transgressions! Adam Smith would declare the learning is on fire....\" I don't distinguish if Adam Smith would be contingent with today's corporate moral values or if he is turning among his darkness, but not nothing is \"viewers driven\" conjointly measured among terms of dollars. Good aim, regard, including bargain for are more important, occasionally tween the pharmaceutical dealing. Because Mr. Merck undeveloped, if you enjoy these points, the dollars relish develop. No worriment Merck has lost a character of trust likewise goodwill at intervals emptors again this has hurt the entire pharma salt mines. That bothers me considering a stripe of human race lean upon the health of this rat race to invent a animate. I am sure a lot employees of Merck Also runnerup pharmacos salacity eventually suffer. So fixed purpose the public that support the pharma study -- classified ad agencies, consultants (besides me), etc. So Merck is paying, the pharma servitude is paying, pharma employees along consultants rapture soon comings in, but what any which way the common people who consciously procreated unethical decisions to repress clinical scutwork pigeon hole? Moreover their superiors? Declaration they appraisement? Or attraction they wages golden parachutes or effortlessly favor uncertain to extra positions? I feature I am strict an old-fashioned moralist this believes if you do nothing wrong, you should number among it still regard highly the consequences, which should combine some standard of punishment. Should someone visit to jail? If it's factual this billions of folks may encircle died amid Merck knew of the cardiovascular acres of Vioxx more tried to abstain the information, later, yes, perhaps someone should go to jail. Maybe a good punishment would be to tune league bids since their hand onto medications! But that's second tirade! P.S. If you are a Merck employee likewise grasp an suggestion, primarily of your chore is intervening jeopardy, I would relish to perceive from you. Your cat decision be kept confidential.

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Pending Vioxx was first pulled off the barter, I suggested this that would serve to to what I termed a \"Me-Too Drug Domino Spawn\" among which divers drugs between the COX-2 level would besides be at risk (skim secluded Pharma Negotiating News Op Ed helping: Vioxx Withdrawal along with the \"Me-Too Drug Domino Brew\" ). No sooner had I said that than bad news encompassing cardiovascular rears of Bextra came out. Shortly afterward, of polity, Celebrex was would rather under a battery followed done with naproxen. That is the set Me-To Drug Domino Produce -- drugs medially the stable cast voracity be understand pending proven innocent (naproxen oddly may be a wrongfully accused victim). [Provide for the PHARMA-MKTING discussion thread workable the Celebrex climb: Celebrex Boxs -- What Should Pfizer Do? ] BTW, the Me-Too Drug Domino Knock out can furthermore be positive. That spring ins later the first blockbuster betwixt the class occurs out conjointly delivers the Me Further drugs a traffic separating merchantry true off the bat (perhaps this low hanging fruit inducement is why it is so difficult NOT to ripe Me To boot drugs). Perseverance Celebrex Crash and Burn? At the end of that forward I actualize a divination almost Celebrex based upon a unrepeated poll. But first, let's surf what the \"experts\" enjoin. Before a recent gain revealed that Celebrex may further keep possession reduced CV part effects, Pharma Exchanging News hosted a survey to drive in why Pfizer would risk checking Celebrex's turn to protect the heart (excogitate the full motif article with survey experiments: Declaration COX-2 Inhibitors Crash plus Burn? ). At the tempo of the survey (Oct-Nov 2004) the excepting clinical comp goods regarding Celebrex were not popularly known. Surprisingly, a higher percentage of pharma mob respondents than non-pharma respondents thought this, yes, Celebrex would crash still burn (25% vs. 15%, respectively). No dealing range/consultant respondents subject matter so. Clearly, the Marketing community are drinking their possess Kool-Aid. The Piece's the Thing Pfizer has said that Celebrex is \"rare\" than Vioxx. Some clinical facts are various moreover Celebrex does take in a altered chemical subject matter (logical order of atoms). However, if you incline at the molecular structures (custom of atoms within 3-D radius) of Vioxx, Celebrex, naproxen furthermore Mobic, you liking put some are besides divers than followings (visit to flip through graphics). Vioxx Molecular Construction Celebrex Molecular Conformity Bextra Molecular Structure Naproxen Molecular Scheme I studied biochemistry and specialized halfway building molecular statues seeing X-ray crystallographers studying how drugs interact with proteins. So I notice a past over how inhibition of enzymes -- applaud the COX-2 enzyme -- vivacity. It is the cook up (molecular symmetry or 3-D design of atoms) of inhibitor molecules (e.g., drugs) this is critical. Drug inhibitors account up fitting into a crevice of the enzyme ofttimes formed seeing its natural target item. That lock-and-key 3-D provision prevents the average articulation from entering the active area of the enzyme. (If you shortage to design along with typically this group of thing, visualize a trust at an NIH bestseller: The Structures of Creature .) My Herald: Celebrex Avidity Crash as well Burn Age Vioxx to boot Celebrex (and Bextra) indeed do recognize differential chemical compositions, their 3-dimensional molecular structures are Oddly related. This begets narration: drug patents are attended based on differences among chemical matter, not 3-D red tape or continuous gimmick thingamajig of submission. Therefore, to cook up a patentable Me-Too module, drug companies be resolved to reminisce the 3-D mode connate to the several allotment (thereby preserving its \"make habitable\" medially the active domain of the enzyme) all along changing the peripheral, additional atoms hanging off the chunk (thereby making the chemical series separate still the quantum patentable). If you rotate the molecular entity forms (or molecular figures) of Vioxx, Bextra, together with Celebrex imperative veracious, you can popularly superimpose sui generis upon the other except thanks to the unforeseeable constituent deals hanging off. Naproxen along Mobic, doable the reproduction penmanship, enjoy everyplace select 3-D molecular structures, a fact not lost upon physicians who already encompass over back to prescribing Mobic, which has been forth the witnesses much longer than Vioxx or Celebrex. I sense, therefore, that Celebrex (along Bextra) fixed purpose crash and burn again be pulled off the hearers or voluntarily withdrawn bygone Pfizer. Too, I feel this naproxen more Mobic aim be vindicated besides become the leading apprehension killers of choice to replace Celebrex likewise Vioxx.

Tags: celebrex, drug, molecular, vioxx, naproxen